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5 p, 216.6 KB Altered Anesthetic Sensitivity of Mice Lacking Ndufs4, a Subunit of Mitochondrial Complex I. / Quintana Romero, Albert (University of Washington. Howard Hughes Medical Institute and Department of Biochemistry) ; Morgan, Philip G. (University of Washington. Department of Anesthesiology and Pain Medicine) ; Kruse, Shane E. (University of Washington. Howard Hughes Medical Institute and Department of Biochemistry) ; Sedensky, Margaret M. (Center for Developmental Therapeutics, Seattle Children’s Research Institute)
Anesthetics are in routine use, yet the mechanisms underlying their function are incompletely understood. Studies in vitro demonstrate that both GABAA and NMDA receptors are modulated by anesthetics, but whole animal models have not supported the role of these receptors as sole effectors of general anesthesia. [...]
2012 - 10.1371/journal.pone.0042904
PLoS one, Vol. 7, Num. 8 (2012) , p. e42904  

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