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23 p, 9.1 MB MicroRNA-200, associated with metastatic breast cancer, promotes traits of mammary luminal progenitor cells / Sánchez-Cid, Lourdes (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Pons, Mònica (Institut de Biologia Molecular de Barcelona) ; Lozano, Juan José (Instituto de Salud Carlos III. Centro de investigación biomédica en red. Enfermedades hepáticas y digestivas (CIBER-EHD)) ; Rubio, Nuria (Institut de Química avançada de Catalunya (IQAC-CSIC)) ; Guerra-Rebollo, Marta (Institut de Química avançada de Catalunya (IQAC-CSIC)) ; Soriano, Aroa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Paris-Coderch, Laia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Segura, Miquel F. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fueyo, Raquel (Institut de Biologia Molecular de Barcelona) ; Arguimbau, Judit (Institut de Biologia Molecular de Barcelona) ; Zodda, Erika (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Bermudo, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Alonso, Immaculada (Hospital Clínic i Provincial de Barcelona) ; Caparrós, Xavier (Hospital Clínic i Provincial de Barcelona) ; Cascante, Marta (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Rafii, Arash (Weill Cornell Medical College. Education City (Ar-Rayyan, Qatar)) ; Kang, Yibin (Princeton University. Department of Molecular Biology) ; Martínez-Balbás, Marian (Institut de Biologia Molecular de Barcelona) ; Weiss, Stephen J. (University of Michigan. Life Sciences Institute) ; Blanco, Jerónimo (Institut de Química avançada de Catalunya (IQAC-CSIC)) ; Muñoz, Montserrat (Hospital Clínic i Provincial de Barcelona) ; Fernández, Pedro L. (Universitat de Barcelona. Facultat de Medicina) ; Thomson, Timothy M. (Institut de Biologia Molecular de Barcelona) ; Universitat Autònoma de Barcelona
MicroRNAs are critical regulators of gene networks in normal and abnormal biological processes. Focusing on invasive ductal breast cancer (IDC), we have found dysregulated expression in tumor samples of several microRNAs, including the miR-200 family, along progression from primary tumors to distant metastases, further reflected in higher blood levels of miR-200b and miR-7 in IDC patients with regional or distant metastases relative to patients with primary node-negative tumors. [...]
2017 - 10.18632/oncotarget.20698
Oncotarget, Vol. 8, Num. 48 (October 2017) , p. 83384-83406  

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