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10 p, 1.8 MB Density, heterogeneity and deformability of red cells as markers of clinical severity in hereditary spherocytosis / Huisjes, R. (Department of Clinical Chemistry and Hematology. University Medical Center Utrecht. Utrecht University) ; Makhro, A. (Red Blood Cell Research Group. Institute of Veterinary Physiology. Vetsuisse Faculty. Zurich Center for Integrative Human Physiology (ZIHP). University of Zurich) ; Llaudet-Planas, Esther (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Hertz, L. (Theoretical Medicine and Biosciences. Medical Faculty. Saarland University) ; Petkova-Kirova, P. (Theoretical Medicine and Biosciences. Medical Faculty. Saarland University) ; Verhagen, L. P. (Department of Clinical Chemistry and Hematology. University Medical Center Utrecht. Utrecht University) ; Pignatelli, S. (Department of Clinical Chemistry and Hematology. University Medical Center Utrecht. Utrecht University) ; Rab, M. A. E. (Department of Clinical Chemistry and Hematology. University Medical Center Utrecht. Utrecht University) ; Schiffelers, Raymond M. (Department of Clinical Chemistry and Hematology. University Medical Center Utrecht. Utrecht University) ; Seiler, E. (Red Blood Cell Research Group. Institute of Veterinary Physiology. Vetsuisse Faculty. Zurich Center for Integrative Human Physiology (ZIHP). University of Zurich) ; Van Solinge, W. W. (Department of Clinical Chemistry and Hematology. University Medical Center Utrecht. Utrecht University) ; Vives Corrons, Juan Luís (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Kaestner, L. (Experimental Physics. Saarland University) ; Mañú Pereira, María del Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bogdanov, A. (Red Blood Cell Research Group. Institute of Veterinary Physiology. Vetsuisse Faculty. Zurich Center for Integrative Human Physiology (ZIHP). University of Zurich) ; Van Wijk, R. (Department of Clinical Chemistry and Hematology. University Medical Center Utrecht. Utrecht University) ; Universitat Autònoma de Barcelona
Hereditary spherocytosis (HS) originates from defective anchoring of the cytoskeletal network to the transmembrane protein complexes of the red blood cell (RBC). Red cells in HS are characterized by membrane instability and reduced deformability and there is marked heterogeneity in disease severity among patients. [...]
2020 - 10.3324/haematol.2018.188151
Haematologica, Vol. 105 Núm. 2 (31 2020) , p. 338-347  
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