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22 p, 15.5 MB Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis / Manils, Joan (Universitat de Barcelona. Facultat de Medicina) ; Gómez, Diana (Universitat de Barcelona. Facultat de Medicina) ; Salla Martret, Mercè (Universitat de Barcelona. Facultat de Medicina) ; Fischer, Heinz (Medical University of Vienna (Àustria)) ; Fye, Jason M. (Wake Forest School of Medicine (Winston-Salem, Estats Units d'Amèrica)) ; Marzo, Elena (Universitat de Barcelona. Facultat de Medicina) ; Marruecos, Laura (Universitat de Barcelona. Facultat de Medicina) ; Serrano, Inma (Universitat de Barcelona. Facultat de Medicina) ; Salgado, Rocío (Hospital del Mar (Barcelona, Catalunya)) ; Rodrigo, Juan P. (Instituto Universitario de Oncología del Principado de Asturias (Oviedo)) ; García Pedrero,Juana M. (Instituto Universitario de Oncología del Principado de Asturias (Oviedo)) ; Serafin, Anna M. (Parc Científic de Barcelona) ; Cañas, Xavier (Parc Científic de Barcelona) ; Benito, Carmen (Universitat de Barcelona) ; Toll, Agustí (Hospital del Mar (Barcelona, Catalunya)) ; Forcales, Sònia Vanina (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Perrino, Fred W. (Wake Forest School of Medicine (Winston-Salem, Estats Units d'Amèrica)) ; Eckhart, Leopold (Medical University of Vienna (Àustria)) ; Soler, Concepció (Universitat de Barcelona. Facultat de Medicina)
TREX2 is a 3'-DNA exonuclease specifically expressed in keratinocytes. Here, we investigated the relevance and mechanisms of TREX2 in ultraviolet (UV)-induced skin carcinogenesis. TREX2 expression was up-regulated by chronic UV exposure whereas it was de-regulated or lost in human squamous cell carcinomas (SCCs). [...]
2015 - 10.18632/oncotarget.4296
Oncotarget, Vol. 6 Núm. 26 (2015)  

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1 Serafin, Anna
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