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1.
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20 p, 4.1 MB |
High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER + breast cancer
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Palafox, Marta (Hospital Universitari Vall d'Hebron) ;
Monserrat, Laia (Hospital Universitari Vall d'Hebron) ;
Bellet Ezquerra, Meritxell (Hospital Universitari Vall d'Hebron) ;
Villacampa Javierre, Guillermo (Hospital Universitari Vall d'Hebron) ;
Gonzalez-Perez, Abel (Universitat Pompeu Fabra) ;
Oliveira, Mafalda (Hospital Universitari Vall d'Hebron) ;
Brasó-Maristany, Fara (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ibrahimi, Nusaibah (University Paris-Saclay) ;
Kannan, Srinivasaraghavan (Bioinformatics Institute (A*STAR)) ;
Mina, Leonardo (Medica Scientia Innovation Research (MedSIR)) ;
Herrera-Abreu, Maria Teresa (The Breast Cancer Now Research Centre) ;
Òdena, Andreu (Hospital Universitari Vall d'Hebron) ;
Sánchez-Guixé, Mònica (Hospital Universitari Vall d'Hebron) ;
Capelán, Marta (Hospital Universitari Vall d'Hebron) ;
Azaro, Analía (Hospital Universitari Vall d'Hebron) ;
Bruna, Alejandra (The Institute of Cancer Research (Londres)) ;
Rodríguez, Olga (Hospital Universitari Vall d'Hebron) ;
Guzmán, Marta (Hospital Universitari Vall d'Hebron) ;
Grueso, Judit (Hospital Universitari Vall d'Hebron) ;
Viaplana, Cristina (Hospital Universitari Vall d'Hebron) ;
Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ;
Su, Faye (Novartis Pharmaceuticals) ;
Lin, Kui (Genentech, Inc., South San Francisco) ;
Clarke, Robert B. (Manchester Breast Centre) ;
Caldas, Carlos (Cancer Research UK) ;
Arribas, Joaquín V (Hospital Universitari Vall d'Hebron) ;
Michiels, Stefan (University Paris-Saclay) ;
García-Sanz, Alicia (Medica Scientia Innovation Research (MedSIR)) ;
Turner, Nicholas C. (The Breast Cancer Now Research Centre) ;
Prat, Aleix (Hospital Clínic i Provincial de Barcelona) ;
Nuciforo, Paolo (Hospital Universitari Vall d'Hebron) ;
Dienstmann, Rodrigo (Hospital Universitari Vall d'Hebron) ;
Verma, Chandra S. (National University of Singapore) ;
Lopez-Bigas, Nuria (Institució Catalana de Recerca i Estudis Avançats) ;
Scaltriti, Maurizio (Memorial Sloan-Kettering Cancer Center (Nova York, Estats Units d'Amèrica)) ;
Arnedos, Monica (Inserm Unit U981 (França)) ;
Saura, Cristina (Hospital Universitari Vall d'Hebron) ;
Serra, Violeta (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
CDK4/6 inhibitors combined with endocrine therapy have demonstrated higher antitumor activity than endocrine therapy alone for the treatment of advanced estrogen receptor-positive breast cancer. Some of these tumors are de novo resistant to CDK4/6 inhibitors and others develop acquired resistance. [...]
2022 -  10.1038/s41467-022-32828-6
Nature communications, Vol. 13 (september 2022)
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2.
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21 p, 11.5 MB |
MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding
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Massó Vallés, Daniel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Beaulieu, Marie-Eve (Hospital Universitari Vall d'Hebron) ;
Jauset González, Toni (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Giuntini, Fabio (Vall d'Hebron Institut d'Oncologia) ;
Zacarías-Fluck, Mariano F (Vall d'Hebron Institut d'Oncologia) ;
Foradada Felip, Laia (Hospital Universitari Vall d'Hebron) ;
Martínez-Martín, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Serrano, Erika (Vall d'Hebron Institut d'Oncologia) ;
Martín-Fernández, Génesis (Vall d'Hebron Institut d'Oncologia) ;
Casacuberta-Serra, Sílvia (Hospital Universitari Vall d'Hebron) ;
Castillo Cano, Virginia (Hospital Universitari Vall d'Hebron) ;
Kaur, Jastrinjan (Vall d'Hebron Institut d'Oncologia) ;
López-Estévez, Sergio (Hospital Universitari Vall d'Hebron) ;
Morcillo, Miguel Ángel (Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (Espanya)) ;
Alzrigat, Mohammad (Karolinska Institutet (Suècia). Department of Microbiology, Tumor and Cell Biology) ;
Mahmoud, Loay (Karolinska Institutet (Suècia). Department of Microbiology, Tumor and Cell Biology) ;
Luque-García, Antonio (Vall d'Hebron Institut d'Oncologia) ;
Escorihuela, Marta (Vall d'Hebron Institut d'Oncologia) ;
Guzman, Marta (Vall d'Hebron Institut d'Oncologia) ;
Arribas, Joaquín V (Institució Catalana de Recerca i Estudis Avançats) ;
Serra, Violeta (Vall d'Hebron Institut d'Oncologia) ;
Larsson, Lars-Gunnar (Karolinska Institutet (Suècia). Department of Microbiology, Tumor and Cell Biology) ;
Whitfield, Jonathan R. (Vall d'Hebron Institut d'Oncologia) ;
Soucek, Laura (Institució Catalana de Recerca i Estudis Avançats)
While MYC role in metastasis has been long controversial, this manuscript demonstrates that MYC inhibition by either transgenic expression or pharmacologic use of the recombinantly produced Omomyc miniprotein exerts antitumor and antimetastatic activity in breast cancer models in vitro and in vivo, suggesting its clinical applicability.
2022 - 10.1158/2767-9764.CRC-21-0103
Cancer Research Communications, Vol. 2 (february 2022) , p. 110-130
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3.
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19 p, 3.3 MB |
Analysis of matched primary and recurrent BRCA1/2 mutation-associated tumors identifies recurrence-specific drivers
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Shah, Jennifer B. (University of Pennsylvania) ;
Pueschl, Dana (University of Pennsylvania) ;
Wubbenhorst, Bradley (University of Pennsylvania) ;
Fan, Mengyao (University of Pennsylvania) ;
Pluta, John (University of Pennsylvania) ;
D'Andrea, Kurt (University of Pennsylvania) ;
Hubert, Anna P. (University of Pennsylvania) ;
Shilan, Jake S. (University of Pennsylvania) ;
Zhou, Wenting (University of Pennsylvania) ;
Kraya, Adam A. (University of Pennsylvania) ;
Llop Guevara, Alba (Vall d'Hebron Institut d'Oncologia) ;
Ruan, Catherine (University of Pennsylvania. Perelman School of Medicine) ;
Serra, Violeta (Vall d'Hebron Institut d'Oncologia) ;
Balmaña Gelpí, Judith (Vall d'Hebron Institut d'Oncologia) ;
Feldman, Michael (University of Pennsylvania) ;
Morin, Pat J. (University of Pennsylvania) ;
Nayak, Anupma (University of Pennsylvania) ;
Maxwell, Kara N. (University of Pennsylvania) ;
Domchek, Susan M. (University of Pennsylvania) ;
Nathanson, Katherine L. (University of Pennsylvania) ;
Universitat Autònoma de Barcelona
Recurrence is a major cause of death among BRCA1/2 mutation carriers with breast (BrCa) and ovarian cancers (OvCa). Herein we perform multi-omic sequencing on 67 paired primary and recurrent BrCa and OvCa from 27 BRCA1/2 mutation carriers to identify potential recurrence-specific drivers. [...]
2022 - 10.1038/s41467-022-34523-y
Nature communications, Vol. 13 (november 2022)
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4.
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1 p, 526.7 KB |
Author Correction : High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER + breast cancer
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Palafox, Marta (Vall d'Hebron Institut d'Oncologia) ;
Monserrat, Laia (Vall d'Hebron Institut d'Oncologia) ;
Bellet Ezquerra, Meritxell (Hospital Universitari Vall d'Hebron) ;
Villacampa Javierre, Guillermo (Vall d'Hebron Institut d'Oncologia) ;
Gonzalez-Perez, Abel (Universitat Pompeu Fabra) ;
Oliveira, Mafalda (Hospital Universitari Vall d'Hebron) ;
Brasó-Maristany, Fara (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ibrahimi, Nusaibah (University Paris-Saclay. Oncostat U1018, Inserm) ;
Kannan, Srinivasaraghavan (Bioinformatics Institute (A*STAR)) ;
Mina, Leonardo (Medica Scientia Innovation Research (MedSIR)) ;
Herrera-Abreu, Maria Teresa (The Breast Cancer Now Research Centre) ;
Òdena, Andreu (Vall d'Hebron Institut d'Oncologia) ;
Sánchez-Guixé, Mònica (Vall d'Hebron Institut d'Oncologia) ;
Capelán, Marta (Hospital Universitari Vall d'Hebron) ;
Azaro, Analía (Hospital Universitari Vall d'Hebron) ;
Bruna, Alejandra (The Institute of Cancer Research. Preclinical Modelling of Pediatric Cancer Evolution Group) ;
Rodríguez, Olga (Vall d'Hebron Institut d'Oncologia) ;
Guzmán, Marta (Vall d'Hebron Institut d'Oncologia) ;
Grueso, Judit (Vall d'Hebron Institut d'Oncologia) ;
Viaplana, Cristina (Vall d'Hebron Institut d'Oncologia) ;
Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Su, Faye (Novartis Pharmaceuticals) ;
Lin, Kui (Genentech, Inc., South San Francisco) ;
Clarke, Robert B. (Manchester Breast Centre) ;
Caldas, Carlos (Cancer Research UK) ;
Arribas, Joaquín V (Institució Catalana de Recerca i Estudis Avançats) ;
Michiels, Stefan (University Paris-Saclay) ;
García-Sanz, Alicia (Medica Scientia Innovation Research (MedSIR)) ;
Turner, Nicholas C. (The Breast Cancer Now Research Centre) ;
Prat, Aleix (IOB Institute of Oncology (Barcelona, Catalunya)) ;
Nuciforo, Paolo (Vall d'Hebron Institut d'Oncologia) ;
Dienstmann, Rodrigo (Vall d'Hebron Institut d'Oncologia) ;
Verma, Chandra S. (National University of Singapore. Department of Biological Sciences) ;
Lopez-Bigas, Nuria (Institució Catalana de Recerca i Estudis Avançats) ;
Scaltriti, Maurizio (Memorial Sloan-Kettering Cancer Center. Departments of Pathology and Human Oncology and Pathogenesis Program) ;
Arnedos, Monica (Inserm Unit U981) ;
Saura, Cristina (Hospital Universitari Vall d'Hebron) ;
Serra, Violeta (Vall d'Hebron Institut d'Oncologia)
2022 - 10.1038/s41467-022-34580-3
Nature communications, Vol. 13 (november 2022)
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5.
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16 p, 1.2 MB |
A RAD51 assay feasible in routine tumor samples calls inhibitor response beyond BRCA mutation
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Castroviejo-Bermejo, Marta (Vall d'Hebron Institut d'Oncologia) ;
Cruz Zambrano, Cristina (Universitat Autònoma de Barcelona) ;
Llop-Guevara, Alba (Vall d'Hebron Institut d'Oncologia) ;
Gutiérrez-Enríquez, Sara (Vall d'Hebron Institut d'Oncologia) ;
Ducy, Mandy (CHUL. Genomics Center) ;
Ibrahim, Yasir Hussein (Vall d'Hebron Institut d'Oncologia) ;
Gris-Oliver, Albert (Vall d'Hebron Institut d'Oncologia) ;
Pellegrino, Benedetta (University Hospital of Parma) ;
Bruna, Alejandra (University of Cambridge) ;
Guzmán, Marta (Vall d'Hebron Institut d'Oncologia) ;
Rodríguez, Olga (Vall d'Hebron Institut d'Oncologia) ;
Grueso, Judit (Vall d'Hebron Institut d'Oncologia) ;
Bonache, Sandra (Vall d'Hebron Institut d'Oncologia) ;
Moles-Fernández, Alejandro (Vall d'Hebron Institut d'Oncologia) ;
Villacampa Javierre, Guillermo (Vall d'Hebron Institut d'Oncologia) ;
Viaplana, Cristina (Vall d'Hebron Institut d'Oncologia) ;
Gómez, Patricia (Vall d'Hebron Institut d'Oncologia) ;
Vidal, Marc (Vall d'Hebron Institut d'Oncologia) ;
Peg, Vicente (Instituto de Salud Carlos III) ;
Serres-Créixams, Xavier (Hospital Universitari Vall d'Hebron) ;
Dellaire, Graham (Dalhousie University) ;
Simard, Jacques (CHUL. Genomics Center) ;
Nuciforo, Paolo (Vall d'Hebron Institut d'Oncologia) ;
Rubio, Isabel T. (Hospital Universitari Vall d'Hebron) ;
Dientsmann, Rodrigo (Vall d'Hebron Institut d'Oncologia) ;
Barrett, J. Carl (AstraZeneca) ;
Caldas, Carlos (Cancer Research UK (CRUK) Cambridge Cancer Centre) ;
Baselga Torres, Josep 1959-2021 (Memorial Sloan Kettering Cancer Center) ;
Saura, Cristina (Vall d'Hebron Institut d'Oncologia) ;
Cortés, Javier (Vall d'Hebron Institut d'Oncologia) ;
Déas, Olivier (XenTech) ;
Jonkers, Jos (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Masson, Jean-Yves (Laval University Cancer Research Center) ;
Cairo, Stefano (XenTech) ;
Judde, Jean-Gabriel (XenTech) ;
O'Connor, Mark J.. (AstraZeneca) ;
Diez, Orland (Vall d'Hebron Institut d'Oncologia) ;
Balmaña Gelpí, Judith (Vall d'Hebron Institut d'Oncologia) ;
Serra, Violeta (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
Poly(-ribose) polymerase () inhibitors (i) are effective in cancers with defective homologous recombination repair (), including 1/2-related cancers. A test to identify additional -deficient tumors will help to extend their use in new indications. [...]
2018 - 10.15252/emmm.201809172
EMBO Molecular Medicine, Vol. 10 (october 2018)
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6.
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10 p, 1.3 MB |
Coamplification of miR-4728 protects HER2 -amplified breast cancers from targeted therapy
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Floros, Konstantinos V. (Philips Institute for Oral Health Research) ;
Lochmann, Timothy L. (Philips Institute for Oral Health Research) ;
Hu, Bin (Virginia Commonwealth University School of Medicine) ;
Monterrubio, Carles (Memorial Sloan Kettering Cancer Center) ;
Hughes, Mark T. (Philips Institute for Oral Health Research) ;
Wells, Jason D. (Norris Cotton Cancer Center) ;
Bernadó Morales, Cristina (Vall d'Hebron Institut d'Oncologia) ;
Ghotra, Maninderjit S. (Philips Institute for Oral Health Research) ;
Costa, Carlotta (Massachusetts General Hospital (Boston)) ;
Souers, Andrew J. (AbbVie Inc) ;
Boikos, Sosipatros A. (Virginia Commonwealth University) ;
Leverson, Joel D. (AbbVie Inc) ;
Tan, Ming (University of South Alabama) ;
Serra, Violeta (Vall d'Hebron Institut d'Oncologia) ;
Koblinski, Jennifer E. (Virginia Commonwealth University School of Medicine) ;
Arribas, Joaquín V (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Prat, Aleix (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Paré Brunet, Laia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Miller, Todd W. (Norris Cotton Cancer Center) ;
Dozmorov, Mikhail G. (Virginia Commonwealth University) ;
Harada, Hisashi (Philips Institute for Oral Health Research) ;
Windle, Brad E. (Philips Institute for Oral Health Research) ;
Scaltriti, Maurizio (Memorial Sloan Kettering Cancer Center) ;
Faber, Anthony C. (Philips Institute for Oral Health Research)
In HER2 -amplified breast cancers, HER2 inhibitors have been very successful as adjuvant therapy but not as monotherapy. Here, we demonstrate that coamplification of a HER2 intronic miRNA causes intrinsic resistance to HER2 inhibitors by indirectly down-regulating the pro-apoptotic NOXA. [...]
2018 - 10.1073/pnas.1717820115
Proceedings of the National Academy of Sciences of the United States of America, Vol. 115 (february 2018) , p. E2594-E2603
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7.
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13 p, 2.0 MB |
Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer
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Garrido-Castro, Ana (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Saura, Cristina (SOLTI Breast Cancer Research Group, Barcelona) ;
Barroso-Sousa, Romualdo (Present Address: Hospital Sírio-Libanês, Brasilia, Brazil) ;
Guo, Hao (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica). Department of Data Sciences) ;
Ciruelos, Eva (Hospital Universitario 12 de Octubre (Madrid)) ;
Bermejo, Begoña (Centro de Investigación Biomédica en Red de Cáncer) ;
Gavilá, Joaquin (Fundació Institut Valencià d'Oncologia) ;
Serra, Violeta (Vall d'Hebron Institut d'Oncologia) ;
Prat, Aleix (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Paré Brunet, Laia (SOLTI Breast Cancer Research Group) ;
Céliz, Pamela (SOLTI Breast Cancer Research Group) ;
Villagrasa, Patricia (SOLTI Breast Cancer Research Group) ;
Li, Yisheng (The University of Texas MD Anderson Cancer Center. Department of Biostatistics, Division of Basic Sciences) ;
Savoie, Jennifer (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Xu, Zhan (Northern Arizona University. School of Communication) ;
Arteaga, Carlos L. (UT Southwestern Medical Center. Harold C. Simmons Comprehensive Cancer Center) ;
Krop, Ian E. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Solit, David B. (Memorial Sloan Kettering Cancer Center) ;
Mills, Gordon B. (The University of Texas MD Anderson Cancer Center. Present Address: Division of Basic Science Research, Department of Systems Biology) ;
Cantley, Lewis C. (Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College) ;
Winer, Eric P. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Lin, Nancy U. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Rodon, Jordi (The University of Texas MD Anderson Cancer Center. Present Address: Department of Investigational Cancer Therapeutics) ;
Universitat Autònoma de Barcelona
Treatment options for triple-negative breast cancer remain limited. Activation of the PI3K pathway via loss of PTEN and/or INPP4B is common. Buparlisib is an orally bioavailable, pan-class I PI3K inhibitor. [...]
2020 - 10.1186/s13058-020-01354-y
Breast cancer research, Vol. 22 (november 2020)
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8.
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23 p, 4.1 MB |
Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns
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Mateo, Lidia (Institute for Research in Biomedicine (IRB Barcelona)) ;
Duran-Frigola, Miquel (Institute for Research in Biomedicine (IRB Barcelona)) ;
Gris-Oliver, Albert (Vall d'Hebron Institut d'Oncologia) ;
Palafox, Marta (Vall d'Hebron Institut d'Oncologia) ;
Scaltriti, Maurizio (Memorial Sloan Kettering Cancer Center) ;
Razavi, Pedram (Memorial Sloan Kettering Cancer Center) ;
Chandarlapaty, Sarat (Memorial Sloan Kettering Cancer Center) ;
Arribas, Joaquín V (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Bellet Ezquerra, Meritxell (Vall d'Hebron Institut d'Oncologia) ;
Serra, Violeta (Vall d'Hebron Institut d'Oncologia) ;
Aloy, Patrick (Institució Catalana de Recerca i Estudis Avançats)
Identification of actionable genomic vulnerabilities is key to precision oncology. Utilizing a large-scale drug screening in patient-derived xenografts, we uncover driver gene alteration connections, derive driver co-occurrence (DCO) networks, and relate these to drug sensitivity. [...]
2020 - 10.1186/s13073-020-00774-x
Genome Medicine, Vol. 12 (september 2020)
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9.
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4 p, 1018.1 KB |
Activity of HSP90 Inhibiton in a Metastatic Lung Cancer Patient With a Germline BRCA1 Mutation
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Cedrés, Susana (Hospital Universitari Vall d'Hebron) ;
Felip, Enriqueta (Universitat Autònoma de Barcelona) ;
Cruz, Cristina (Hospital Universitari Vall d'Hebron) ;
Martinez de Castro, Ana (Hospital Universitari Vall d'Hebron) ;
Pardo Aranda, Nuria (Universitat Autònoma de Barcelona) ;
Navarro, Alejandro (Universitat Autònoma de Barcelona) ;
Martinez-Marti, Alex (Universitat Autònoma de Barcelona) ;
Remon, Jordin (Vall d'Hebron Institut d'Oncologia) ;
Zeron-Medina, Jorge (Hospital Universitari Vall d'Hebron) ;
Balmaña Gelpí, Judith (Universitat Autònoma de Barcelona) ;
Llop-Guevara, Alba (Experimental Therapeutic Group) ;
Miquel, Josep M. (Vall d'Hebron Institut d'Oncologia) ;
Sansano, Irene (Pathology Department) ;
Nuciforo, Paolo (Molecular Oncology Group) ;
Mancuso, Francesco M (Cancer Genomic Group) ;
Serra, Violeta (Experimental Therapeutic Group) ;
Vivancos, Ana (Cancer Genomic Group)
Heat shock proteins (HSPs) are molecular chaperones that maintain proteins in their correct conformation to ensure stability and protect carcinoma cells from apoptosis. HSP90 inhibitors (HSP90i) block multiple targets simultaneously, and despite responses in a selected population, no HSP90i have yet been approved. [...]
2018 - 10.1093/jnci/djy012
Journal of the National Cancer Institute, Vol. 110 (february 2018) , p. 914-917
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10.
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8 p, 473.7 KB |
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer
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Cruz, C. (Vall d'Hebron Institut d'Oncologia) ;
Castroviejo-Bermejo, Marta (Experimental Therapeutics Group) ;
Gutiérrez-Enríquez, Sara (Oncogenetics Group) ;
Llop-Guevara, A. (Experimental Therapeutics Group) ;
Ibrahim, Y. H. (Experimental Therapeutics Group) ;
Gris-Oliver, Albert. (Experimental Therapeutics Group) ;
Bonache, Sandra (Oncogenetics Group) ;
Morancho, Beatriz (Vall d'Hebron Institut d'Oncologia) ;
Bruna, Alejandra (Cancer Research UK Cambridge Institute. University of Cambridge) ;
Rueda, O. M. (Cancer Research UK Cambridge Institute. University of Cambridge) ;
Lai, Z. (AstraZeneca (USA)) ;
Polanska, U. M. (Cancer Research UK. Cambridge Institute) ;
Jones, G. N. (Cancer Research UK. Cambridge Institute) ;
Kristel, P. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
de Bustos, L. (Experimental Therapeutics Group) ;
Guzmán, Marta (Experimental Therapeutics Group) ;
Rodríguez, O. (Experimental Therapeutics Group) ;
Grueso, Judit (Experimental Therapeutics Group) ;
Montalban, G. (Oncogenetics Group) ;
Caratù, Ginevra (Cancer Genomics Group) ;
Mancuso, Francesco M (Cancer Genomics Group) ;
Fasani, R. (Vall d'Hebron Institut d'Oncologia) ;
Jiménez, J. (Vall d'Hebron Institut d'Oncologia) ;
Howat, W. J. (Cancer Research UK. Cambridge Institute) ;
Dougherty, B. (AstraZeneca (USA)) ;
Vivancos, A. (Cancer Genomics Group) ;
Nuciforo, Paolo (Vall d'Hebron Institut d'Oncologia) ;
Serres-Créixams, X. (Department of Radiology) ;
Rubio Rodríguez, Isabel Teresa (Hospital Universitari Vall d'Hebron) ;
Oaknin, Ana (Vall d'Hebron Institut d'Oncologia) ;
Cadogan, E. (Cancer Research UK. Cambridge Institute) ;
Barrett, J. Carl (AstraZeneca (USA)) ;
Caldas, Carlos (NIHR Cambridge Biomedical Research Centre (Regne Unit)) ;
Baselga Torres, Josep, 1959-2021, (Memorial Sloan Kettering Cancer Center) ;
Saura, Cristina (Vall d'Hebron Institut d'Oncologia) ;
Cortés, Javier (Vall d'Hebron Institut d'Oncologia) ;
Arribas, Joaquín V. (Vicente) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Jonkers, Jos (Cancer Genomics Group) ;
Diez, Orland (Hospital Universitari Vall d'Hebron) ;
O'Connor, M. J. (Oncology Innovative Medicine and Early Development Biotech Unit. AstraZeneca (UK)) ;
Balmaña Gelpí, Judith (Vall d'Hebron Institut d'Oncologia) ;
Serra, Violeta (Vall d'Hebron Institut d'Oncologia)
BRCA1 and BRCA2 (BRCA1/2) -deficient tumors display impaired homologous recombination repair (HRR) and enhanced sensitivity to DNA damaging agents or to poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi). [...]
2018 - 10.1093/annonc/mdy099
Annals of oncology, Vol. 29, Issue 5 (May 2018) , p. 1203-1210
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