Home > Search Results: Serra-Mir, Gabriel
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Results overview: Found 3 records in 0.02 seconds.
Articles, 2 records found
Research literature, 1 records found
Articles 2 records found  
1.
9 p, 3.7 MB Amyloid-beta peptide and tau protein crosstalk in Alzheimer's disease / Ramos Roda, Alejandro (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Serra-Mir, Gabriel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Montoliu-Gaya, Laia (University of Gothenburg) ; Tiessler, Lidia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Alzheimer's disease is a neurodegenerative disease that accounts for most of the 50-million dementia cases worldwide in 2018. A large amount of evidence supports the amyloid cascade hypothesis, which states that amyloid-beta accumulation triggers tau hyperphosphorylation and aggregation in form of neurofibrillary tangles, and these aggregates lead to inflammation, synaptic impairment, neuronal loss, and thus to cognitive decline and behavioral abnormalities. [...]
2022 - 10.4103/1673-5374.332127
Neural Regeneration Research, Vol. 17, Num. 8 (August 2022) , p. 1666-1674  
Detailed record - Creative Commons
2.
23 p, 12.1 MB Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice / Ramos Roda, Alejandro. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Montoliu Gaya, Laia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Serra-Mir, Gabriel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Alzheimer's disease (AD) is the most common dementia worldwide. According to the amyloid hypothesis,the early accumulation of the Aβ-peptide triggers tau phosphorylation,synaptic dysfunction, and eventually neuronal death leading to cognitive impairment, as well as behavioral and psychological symptoms of dementia. [...]
2020 - 10.3390/ijms21186630
International journal of molecular sciences, Vol. 21, Núm. 18 (September 2020) , art. 6630  
Detailed record - Creative Commons

Research literature 1 records found  
1.
7.0 MB Fragments d'anticòs com a model d'estudi de l'amiloïdosi de cadena lleugera i com agents terapèutics per a la malaltia d'Alzheimer / Serra Mir, Gabriel ; Villegas Hernández, Sandra, dir.
Els mecanismes de l'amiloidogènesi segueixen sent desconeguts. Les amiloïdosis són malalties incurables que solen acabar amb la vida dels pacients, i engloben un grup heterogeni de proteïnes. Les proteïnes amiloidogèniques agreguen formant dipòsits tant en els compartiments intracel·lulars com en els extracel·lulars, cosa que provoca la mort cel·lular i, posteriorment, el deteriorament dels teixits. [...]
Los mecanismos de la amiloidogénesis siguen siendo desconocidos. Las amiloidosis son enfermedades incurables que suelen acabar con la vida de los pacientes, y engloban a un grupo heterogéneo de proteínas. [...]
Mechanisms of amyloidogenesis remain poorly understood. Amyloidoses are incurable life-threatening diseases, which encompass a heterogeneous group of proteins. Amyloid proteins aggregate as deposits either intracellularly or extracellularly, leading to cell death and subsequently to tissue impairment. [...]
2022  
Detailed record - Creative Commons

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1 Serra-Mir, G.
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