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Articles, 2 records found
Articles 2 records found  
1.
12 p, 2.5 MB Cancer network activity associated with therapeutic response and synergism / Serra-Musach, Jordi (Institut Català d'Oncologia (ICO)) ; Mateo, Francesca (Institut Català d'Oncologia (ICO)) ; Capdevila-Busquets, Eva (Institut de Recerca Biomèdica (IRB Barcelona)) ; de Garibay, Gorka Ruiz (Institut Català d'Oncologia (ICO)) ; Zhang, Xiaohu (National Institutes of Health. Medical Center Dr. Rockville. National Center for Advancing Translational Sciences (NCATS)) ; Guha, Raj (National Institutes of Health. Medical Center Dr. Rockville. National Center for Advancing Translational Sciences (NCATS)) ; Thomas, Craig J. (National Institutes of Health. Medical Center Dr. Rockville. National Center for Advancing Translational Sciences (NCATS)) ; Grueso, Judit (Institut d'Oncologia de la Vall Hebron (VHIO)) ; Villanueva, Alberto (Institut Català d'Oncologia (ICO).) ; Jaeger, Samira (Institut de Recerca Biomèdica (IRB Barcelona)) ; Heyn, Holger (Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)) ; Vizoso, Miguel (Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)) ; Pérez, Hector (Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)) ; Cordero, Alex (Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)) ; Gonzalez-Suarez, Eva (Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)) ; Esteller, Manel (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ; Moreno-Bueno, Gema (Universidad Autónoma de Madrid. Departamento de Bioquímica) ; Tjärnberg, Andreas (Linköping University. Departament of Clinical and Experimental Medicine) ; Lázaro, Conxi (Institut Català d'Oncologia (ICO)) ; Serra, Violeta (Institut d'Oncologia de la Vall Hebron (VHIO)) ; Arribas, Joaquín V. (Vicente) (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Benson, Mikael (Linköping University. Department of Clinical and Experimental Medicine) ; Gustafsson, Mika (Linköping University. Department of Clinical and Experimental Medicine) ; Ferrer, Marc (National Institutes of Health. Medical Center Dr. Rockville. National Center for Advancing Translational Sciences (NCATS)) ; Aloy, Patrick (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ; Pujana, Miquel Àngel (Institut Català d'Oncologia (ICO))
Cancer patients often show no or only modest benefit from a given therapy. This major problem in oncology is generally attributed to the lack of specific predictive biomarkers, yet a global measure of cancer cell activity may support a comprehensive mechanistic understanding of therapy efficacy. [...]
2016 - 10.1186/s13073-016-0340-x
Genome Medicine, Vol. 8 (August 2016) , ART. 88  
2.
14 p, 6.9 MB Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer / Hergueta-Redondo, Marta (Biochemistry Department, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), IdiPAZ, Madrid, Spain) ; Sarrio, David (Biochemistry Department, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), IdiPAZ, Madrid, Spain) ; Molina-Crespo, Ángela (Biochemistry Department, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), IdiPAZ, Madrid, Spain) ; Vicario, Rocío (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bernadó-Morales, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martínez, Lidia (Biochemistry Department, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), IdiPAZ, Madrid, Spain) ; Rojo-Sebastián, Alejandro (Pathology Department, MD Anderson Cancer Center, Madrid, Spain) ; Serra-Musach, Jordi (Breast Cancer and Systems Biology Unit, ProCURE, Catalan Institute of Oncology, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain) ; Mota, Alba (Translational Research Laboratory, MD Anderson Internacional Foundation, Madrid, Spain) ; Martínez-Ramírez, Ángel (Cytogenetics Department, MD Anderson Cancer Center, Madrid, Spain) ; Castilla, Maria Ángeles (Pathology Department, Hospital Universitario Virgen del Rocío, Sevilla, Spain) ; González-Martin, Antonio (Oncology Department, MD Anderson Cancer Center, Madrid, Spain) ; Pernas, Sonia (Breast Cancer and Systems Biology Unit, ProCURE, Catalan Institute of Oncology, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain) ; Cano, Amparo (Biochemistry Department, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), IdiPAZ, Madrid, Spain) ; Cortes, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nuciforo, Paolo G. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Peg, Vicente (Hospital Universitari Vall d'Hebron) ; Palacios, José (Pathology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain) ; Pujana, Miguel Ángel (Breast Cancer and Systems Biology Unit, ProCURE, Catalan Institute of Oncology, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain) ; Arribas, Joaquín (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Moreno-Bueno, Gema (Translational Research Laboratory, MD Anderson Internacional Foundation, Madrid, Spain) ; Universitat Autònoma de Barcelona
Around, 30-40% of HER2-positive breast cancers do not show substantial clinical benefit from the targeted therapy and, thus, the mechanisms underlying resistance remain partially unknown. Interestingly, ERBB2 is frequently co-amplified and co-expressed with neighbour genes that may play a relevant role in this cancer subtype. [...]
2016 - 10.18632/oncotarget.10787
Oncotarget, Vol. 7 (july 2016) , p. 56295-56308  

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1 Serra-Musach, J
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