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13 p, 2.3 MB A Transgenic Model Reveals the Role of Klotho in Pancreatic Cancer Development and Paves the Way for New Klotho-Based Therapy / Rubinstein, Tammi Arbel (Institute of Oncology, Tel Aviv Sourasky Medical Center) ; Reuveni, Inbal (Institute of Oncology, Tel Aviv Sourasky Medical Center) ; Hesin, Arkadi (Institute of Oncology, Tel Aviv Sourasky Medical Center) ; Klein-Goldberg, Anat (Institute of Oncology, Tel Aviv Sourasky Medical Center) ; Olauson, Hannes (Karolinska Institutet (Estocolm, Suècia)) ; Larsson, Tobias E. (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Abraham, Carmela R. (Boston University School of Medicine. Department of Biochemistry) ; Zeldich, Ella (Boston University School of Medicine. Department of Biochemistry) ; Bosch i Merino, Assumpció (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Chillón Rodríguez, Miguel (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Hollander, Kenneth Samuel (Institute of Oncology, Tel Aviv Sourasky Medical Center) ; Shabtay-Orbach, Ayelet (Institute of Oncology, Tel Aviv Sourasky Medical Center) ; Vainer, Gilad W. (Pathology Institute, Tel Aviv Sourasky Medical Center) ; Wolf, Ido (Institute of Oncology, Tel Aviv Sourasky Medical Center) ; Rubinek, Tami (Institute of Oncology, Tel Aviv Sourasky Medical Center)
Klotho is an anti-aging transmembrane protein, which can be shed and can function as a hormone. Accumulating data indicate that klotho is a tumor suppressor in a wide array of malignancies, and designate the subdomain KL1 as the active region of the protein towards this activity. [...]
2021 - 10.3390/cancers13246297
Cancers, Vol. 13 Núm. 24 (2021) , p. 6297  

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