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4 p, 972.8 KB |
Molecular portrait of high alpha-fetoprotein in hepatocellular carcinoma : implications for biomarker-driven clinical trials
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Montal, Robert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Andreu-Oller, Carmen (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Bassaganyas, Laia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Esteban-Fabró, Roger (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Moran, S (Institut d'Investigació Biomèdica de Bellvitge) ;
Montironi, Carla (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Moeini, Agrin (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pinyol, Roser (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Peix, Judit (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Cabellos, Laia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Villanueva, Augusto (Icahn School of Medicine at Mount Sinai) ;
Sia, Daniela (Icahn School of Medicine at Mount Sinai) ;
Mazzaferro, Vincenzo (University of Milan and Gastrointestinal Surgery and Liver Transplantation Unit. Fondazione IRCCS. Istituto Nazionale dei Tumori) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Llovet, Josep M. (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
The clinical utility of serum alpha-fetoprotein (AFP) in patients with hepatocellular carcinoma (HCC) is widely recognised. However, a clear understanding of the mechanisms of AFP overexpression and the molecular traits of patients with AFP-high tumours are not known. [...]
2019 -  10.1038/s41416-019-0513-7
British Journal of Cancer, Vol. 121 Núm. 4 (13 2019) , p. 340-343
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15 p, 1.7 MB |
Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications
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Carrillo-Reixach, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Torrens, L. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Simón-Coma, Marina (Institut Germans Trias i Pujol) ;
Royo, Laura (Institut Germans Trias i Pujol) ;
Domingo-Sàbat, Montse (Institut Germans Trias i Pujol) ;
Abril-Fornaguera, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Akers, N. (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica)) ;
Sala Llinas, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ragull, Sonia (Institut Germans Trias i Pujol) ;
Arnal, Magdalena (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Villalmanzo, Núria (Institut Germans Trias i Pujol) ;
Cairo, Stefano (Instituto di Ricerca Pediatrica. Corso Stati Uniti 4) ;
Villanueva, Alberto (Institut d'Investigació Biomèdica de Bellvitge) ;
Kappler, R. (Department of Pediatric Surgery. Dr. von Hauner Children's Hospital. Ludwig-Maximilians-University Munich) ;
Garrido-Pontnou, Marta (Hospital Universitari Vall d'Hebron) ;
Guerra, Laura (Hospital Universitario La Paz (Madrid)) ;
Sábado, Constantino (Hospital Universitari Vall d'Hebron) ;
Guillén, Gabriela (Hospital Universitari Vall d'Hebron) ;
Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Piñeyro, David (Institut Germans Trias i Pujol) ;
Vázquez-Vitali, María (Institut Germans Trias i Pujol) ;
Kuchuk, O. (Mount Sinai Liver Cancer Program. Divisions of Liver Diseases. Tisch Cancer Institute. Icahn School of Medicine at Mount Sinai) ;
Mateos, María Elena (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Ramírez, G. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Santamaría, María (Hospital Universitario La Paz (Madrid)) ;
Mozo, Y. (Hospital Universitario La Paz (Madrid)) ;
Soriano, Aroa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Grotzer, M. (Department of Pediatric Oncology. University Children's Hospital Zurich. University of Zurich) ;
Branchereau, S. (Bicêtre Hospital) ;
de Andoin, N. G. (Hospital Universitario de Donostia (Sant Sebastià, País Basc)) ;
López-Ibor, B. (Department of Pediatric Hematology and Oncology. HM Montepríncipe Hospital) ;
López-Almaraz, R. (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Salinas, J. A. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Torres, B. (Hospital Universitari i Politècnic La Fe (València)) ;
Hernández, Francisco (Hospital Universitario La Paz (Madrid)) ;
Uriz, J. J. (Hospital Universitario de Donostia (Sant Sebastià, País Basc)) ;
Fabre, M. (Department of Pathology. Hôpital Universitaire Necker-Enfants Malades. Assistance Publique-Hôpitaux de Paris. Université Paris Descartes) ;
Blanco, J. (Joan) (Joan) (Universitat de Vic - Universitat Central de Catalunya) ;
Paris, C. (Stem Cell Transplant Unit. Hospital Luis Calvo Mackenna) ;
Bajčiová, V. (Department of Pediatric Oncology. Childrens University Hospital Brno) ;
Laureys, G. (Ghent University Hospital. (Bèlgica)) ;
Masnou, Helena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Clos, Ariadna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Beléndez, Cristina (Hospital General Universitario Gregorio Marañón) ;
Guettier, C. (Bicêtre Hospital) ;
Sumoy, Lauro (Institut Germans Trias i Pujol) ;
Planas, Ramón (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jordà, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Nonell, Lara (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Czauderna, P. (Department of Surgery and Urology for Children and Adolescents. Medical University of Gdansk) ;
Morland, B. (Birmingham Women's Hospital) ;
Sia, D. (Mount Sinai Liver Cancer Program. Divisions of Liver Diseases. Tisch Cancer Institute. Icahn School of Medicine at Mount Sinai) ;
Losic, B. (Icahn Institute for Data Science and Genomic Technology (Nova York, Estats Units d'Amèrica)) ;
Buendia, M. A. (INSERM. UMR 1193. Paul-Brousse Hospital. Hepatobiliary Centre) ;
Sarrias, Maria-Rosa (Institut Germans Trias i Pujol) ;
Llovet, J. M. (Institució Catalana de Recerca i Estudis Avançats) ;
Armengol, Carolina (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Background & Aims: Hepatoblastoma (HB) is a rare disease. Nevertheless, it is the predominant pediatric liver cancer, with limited therapeutic options for patients with aggressive tumors. Herein, we aimed to uncover the mechanisms of HB pathobiology and to identify new biomarkers and therapeutic targets in a move towards precision medicine for patients with advanced HB. [...]
2020 - 10.1016/j.jhep.2020.03.025
Journal of Hepatology, Vol. 73 Núm. 2 (august 2020) , p. 328-341
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26 p, 7.8 MB |
An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents
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Moeini, Agrin (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Torrecilla, Sara (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Tovar, Victoria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Montironi, Carla (Icahn School of Medicine at Mount Sinai) ;
Andreu-Oller, Carmen (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Peix, Judit (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Higuera, Mónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pfister, Dominik (German Cancer Research Center Heidelberg (DKFZ)) ;
Ramadori, Pierluigi (German Cancer Research Center Heidelberg (DKFZ)) ;
Pinyol, Roser (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Solé, Manel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Heikenwälder, Mathias (German Cancer Research Center Heidelberg (DKFZ)) ;
Friedman, Scott L. (Icahn School of Medicine at Mount Sinai) ;
Sia, Daniela (Icahn School of Medicine at Mount Sinai) ;
Llovet, Josep M. (Institució Catalana de Recerca i Estudis Avançats)
Background & Aims: Cirrhosis and chronic inflammation precede development of hepatocellular carcinoma (HCC) in approximately 80% of cases. We investigated immune-related gene expression patterns in liver tissues surrounding early-stage HCCs and chemopreventive agents that might alter these patterns to prevent liver tumorigenesis. [...]
2019 - 10.1053/j.gastro.2019.07.028
Gastroenterology, Vol. 157 Núm. 5 (november 2019) , p. 1383-1397.e11
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