Home > Search Results: Siedlecki-Wullich, Dolores
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Results overview: Found 5 records in 0.01 seconds.
Articles, 3 records found
Research literature, 2 records found
Articles 3 records found  
1.
25 p, 1.2 MB MicroRNAs as Early Biomarkers of Alzheimer's Disease : a synaptic perspective / Siedlecki-Wullich, Dolores (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Miñano Molina, Alfredo Jesús (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Rodríguez Álvarez, José (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Pathogenic processes underlying Alzheimer's disease (AD) affect synaptic function from initial asymptomatic stages, long time before the onset of cognitive decline and neurodegeneration. Therefore, reliable biomarkers enabling early AD diagnosis and prognosis are needed to maximize the time window for therapeutic interventions. [...]
2021 - 10.3390/cells10010113
Cells, Vol. 10, Num. 1 (January 2021) , art. 113  
Detailed record - Creative Commons
2.
19 p, 7.3 MB Proteasomal-Mediated Degradation of AKAP150 Accompanies AMPAR Endocytosis during cLTD / Cheng, Wenwen (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Siedlecki-Wullich, Dolores (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Català-Solsona, Judit (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Fábregas Ordóñez, Cristina (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Fadó, Rut (Universitat Internacional de Catalunya) ; Casals, Nuria (Universitat Internacional de Catalunya) ; Solé Piñol, Montserrat (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Unzeta López, Mercedes (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Saura Antolín, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Rodríguez Álvarez, José (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Miñano Molina, Alfredo Jesús (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The number and function of synaptic AMPA receptors (AMPARs) tightly regulates excitatory synaptic transmission. Current evidence suggests that AMPARs are inserted into the postsynaptic membrane during long-term potentiation (LTP) and are removed from the membrane during long-term depression (LTD). [...]
2020 - 10.1523/ENEURO.0218-19.2020
eNeuro, Vol. 7 (march 2020)  
Detailed record - Creative Commons
3.
11 p, 788.5 KB Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer's disease / Siedlecki-Wullich, Dolores (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Català-Solsona, Judit (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Fábregas Ordóñez, Cristina (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Hernández, Isabel (Institut Català de Neurociènces Aplicades) ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Boada, Mercè (Institut Català de Neurociènces Aplicades) ; Saura Antolín, Carlos (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Rodríguez Álvarez, José (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Miñano Molina, Alfredo Jesús (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Several evidences suggest that failure of synaptic function occurs at preclinical stages of Alzheimer's disease (AD) preceding neuronal loss and the classical AD pathological hallmarks. Nowadays, there is an urgent need to identify reliable biomarkers that could be obtained with non-invasive methods to improve AD diagnosis at early stages. [...]
2019 - 10.1186/s13195-019-0501-4
Alzheimer's research & therapy, Vol. 11 (may 2019)  
Detailed record - Creative Commons

Research literature 2 records found  
1.
175 p, 3.0 MB Analysis of miRNA expression in Alzheimer's disease : potential use as early biomarkers / Siedlecki Wullich, Dolores J. ; Rodríguez Álvarez, José, dir. ; Miñano Molina, Alfredo Jesús, dir. ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
La Enfermedad de Alzheimer (EA) es un desorden neurodegenerativo caracterizado por la pérdida temprana de sinapsis seguida por una degeneración progresiva y déficits de memoria que derivan en demencia. [...]
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by early loss of synapses followed by progressive neurodegeneration and memory deficits, eventually leading to dementia. To date, AD can only be clinically diagnosed in its later stages, when neurodegeneration has already spread to several brain areas, making it difficult for potential therapies to prevent its progression. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2019.  
Detailed record - Creative Commons
2.
4.9 MB miRNA expression analysis in AD human brain / Siedlecki Wullich, Dolores J. ; Miñano Molina, Alfredo Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Rodríguez Álvarez, José (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Full data of Affimetrix 4. 0 miRNA analysis from brain tissue (entorhinal cortex, hippocampus, prefrontal cortex and cerebellum) from healthy controls and AD subjects a different pathological stages (ADI-II, ADIII-IV, ADV-I).
Universitat Autònoma de Barcelona 2017 - 10.5565/ddd.uab.cat/196853  
Detailed record - Creative Commons

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1 Siedlecki-Wullich, D.
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