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15 p, 1.1 MB |
Impact of Intensive Glucose Control on Brain Health : Meta-Analysis of Cumulative Data from 16,584 Patients with Type 2 Diabetes Mellitus
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Tang, Xingyao (Capital Medical University. Beijing Tongren Hospital) ;
Cardoso, Marly A. (University of Sao Paulo. Department of Nutrition, School of Public Health) ;
Yang, Jinkui (Capital Medical University. Department of Endocrinology, Beijing Tongren Hospital) ;
Zhou, Jian-Bo (Capital Medical University. Department of Endocrinology, Beijing Tongren Hospital) ;
Simó Canonge, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina)
Despite growing evidence that type 2 diabetes is associated with dementia, the question of whether intensive glucose control can prevent or arrest cognitive decline remains unanswered. In the analysis reported here, we explored the effect of intensive glucose control versus standard care on brain health, including structural abnormalities of the brain (atrophy, white matter hyperintensities, lacunar infarction, and cerebral microbleeds), cognitive dysfunction, and risk of dementia. [...]
2021 -  10.1007/s13300-021-01009-x
Diabetes Therapy, Vol. 12 (february 2021) , p. 765-779
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18 p, 767.0 KB |
Neuroprotection as a Therapeutic Target for Diabetic Retinopathy
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Hernández, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dal Monte, Massimo (Interdepartmental Research Center Nutrafood "Nutraceuticals and Food for Health", University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy) ;
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Casini, Giovanni (Interdepartmental Research Center Nutrafood "Nutraceuticals and Food for Health", University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy) ;
Universitat Autònoma de Barcelona
Diabetic retinopathy (DR) is a multifactorial progressive disease of the retina and a leading cause of vision loss. DR has long been regarded as a vascular disorder, although neuronal death and visual impairment appear before vascular lesions, suggesting an important role played by neurodegeneration in DR and the appropriateness of neuroprotective strategies. [...]
2016 - 10.1155/2016/9508541
Journal of Diabetes Research, Vol. 2016 (march 2016)
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10 p, 661.4 KB |
Clinical Applicability of the Specific Risk Score of Dementia in Type 2 Diabetes in the Identification of Patients with Early Cognitive Impairment : results of the MOPEAD Study in Spain
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Ortiz-Zuñiga, Angel Michael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodriguez-Gómez, Octavio (Institut Català de Neurociènces Aplicades) ;
Hernández Pascual, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodrigo, Adrian (GMV Soluciones Globales Internet SAU. Valencia) ;
Jamilis, Laura (GMV Soluciones Globales Internet SAU. Valencia) ;
Campo, Laura (International Corporate Affairs, Alzheimer's Disease, Eli Lilly and Co. Italy) ;
Alegret, Montserrat (Universitat Internacional de Catalunya. Institut Català de Neurociènces Aplicades) ;
Boada, Mercè (Institut Català de Neurociènces Aplicades) ;
Ciudin, Andreea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Introduction: Although the Diabetes Specific Dementia Risk Score (DSDRS) was proposed for predicting risk of dementia at 10 years, its usefulness as a screening tool is unknown. For this purpose, the European consortium MOPEAD included the DSDRS within the specific strategy for screening of cognitive impairment in type 2 diabetes (T2D) patients attended in a third-level hospital. [...]
2020 - 10.3390/jcm9092726
Journal of clinical medicine, Vol. 9 Núm. 9 (2020) , p. 2726
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12 p, 1.1 MB |
Utility of insulin resistance in estimating cardiovascular risk in subjects with type 1 diabetes according to the scores of the Steno Type 1
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Cano, Albert (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Mazarico, Isabel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Astiarraga, Brenno (Hospital Universitari Joan XXIII de Tarragona) ;
González-Sastre, Montserrat (Universitat Autònoma de Barcelona. Departament de Cirurgia) ;
Martínez, Laia (Hospital Universitari Joan XXIII de Tarragona. Departament d'Endocrinologia i Nutrició) ;
Fernández-Veledo, Sonia (Hospital Universitari Joan XXIII de Tarragona. Departament d'Endocrinologia i Nutrició) ;
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vendrell, Joan (Hospital Universitari Joan XXIII de Tarragona) ;
González-Clemente, José Miguel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Llauradó Cabot, Gemma (Universitat Autònoma de Barcelona. Departament d'Endocrinologia i Nutrició) ;
Albert Fàbregas, Lara (Universitat Autònoma de Barcelona. Departament de Medicina)
Background: We sought to assess the potential of insulin resistance (IR) for estimating cardiovascular disease (CVD) risk in adults with type 1 diabetes (T1DM) according to the scores of the Steno Type 1 Risk Engine (ST1RE). [...]
2020 - 10.3390/jcm9072192
Journal of clinical medicine, Vol. 9 Núm. 7 (2020) , p. 2192
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11 p, 1.9 MB |
Neurodegeneration in diabetic retinopathy : does it really matter?
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Simó Canonge, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Stitt, Alan W. (Queen's University. Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences) ;
Gardner, Thomas W. (Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School) ;
Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol
The concept of diabetic retinopathy as a microvascular disease has evolved, in that it is now considered a more complex diabetic complication in which neurodegeneration plays a significant role. In this article we provide a critical overview of the role of microvascular abnormalities and neurodegeneration in the pathogenesis of diabetic retinopathy. [...]
2018 - 10.1007/s00125-018-4692-1
Diabetologia, Vol. 61 (july 2018) , p. 1902-1912
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11 p, 794.5 KB |
Arterial stiffness is highly correlated with the scores obtained from the Steno Type 1 Risk Engine in subjects with T1DM
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Llauradó, G. (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM). Instituto de Salud Carlos III) ;
Cano-Palomares, Albert. (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Albert Fàbregas, Lara (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Ballesta Purroy, Sílvia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Mazarico, Isabel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Luchtenberg, M.F. (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
González-Sastre, Montserrat (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Megía, A. (Hospital Universitari Joan XXIII de Tarragona) ;
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vendrell, J. (Hospital Universitari Joan XXIII de Tarragona) ;
González-Clemente, José-Miguel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Objectives Currently used risk scores for type 2 diabetes mellitus (T2DM) clearly underestimate cardiovascular risk in type 1 diabetes (T1DM). Hence, there is a need to develop novel and specific risk-estimation tools for this population. [...]
2019 - 10.1371/journal.pone.0220206
PloS one, Vol. 14 Núm. 9 (2019) , p. e0220206
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8 p, 1.2 MB |
Genetic testing to predict weight loss and diabetes remission and long-term sustainability after bariatric surgery : a pilot study
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Ciudin, Andreea (Hospital Universitari Vall d'Hebron) ;
Fidilio , Enzamaria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ortiz-Zuñiga, Angel Michael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pich, Sara (Hospital Universitari Joan XXIII de Tarragona) ;
Salas, Eduardo (Hospital Universitari Joan XXIII de Tarragona) ;
Mesa Manteca, Jordi (Hospital Universitari Vall d'Hebron) ;
Hernández Pascual, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Simó-Servat, Olga (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Lecube, Albert (Hospital Universitari Arnau de Vilanova) ;
Simó Canonge, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina)
Introduction: The aim of this pilot study was to assess genetic predisposition risk scores (GPS) in type 2 diabetic and non-diabetic patients in order to predict the better response to bariatric surgery (BS) in terms of either weight loss or diabetes remission. [...]
2019 - 10.3390/jcm8070964
Journal of clinical medicine, Vol. 8 (2019) , p. 1-8
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20 p, 8.4 MB |
New insights into the mechanisms of action of topical administration of GLP-1 in an experimental model of diabetic retinopathy
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Sampedro, Joel (CIBERDEM (Instituto de Salud Carlos III)) ;
Solà-Adell, Cristina (CIBERDEM (Instituto de Salud Carlos III)) ;
Turch, Mireia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Valeri, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Simó-Servat, Olga (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Lagunas, Carmen (Ferrer Advanced Biotherapeutics) ;
Simó Canonge, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Hernández Pascual, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bogdanov, Patricia (CIBERDEM (Instituto de Salud Carlos III)) ;
Ramos, Hugo (Hospital Universitari Vall d'Hebron. Institut de Recerca)
The main goals of this work were to assess whether the topical administration of glucagon-like peptide-1 (GLP-1) could revert the impairment of the neurovascular unit induced by long-term diabetes (24 weeks) in diabetic mice and to look into the underlying mechanisms. [...]
2019 - 10.3390/jcm8030339
Journal of clinical medicine, Vol. 8 (2019) , p. 1-20
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12 p, 1.0 MB |
Usefulness of eye fixation assessment for identifying type 2 diabetic subjects at risk of dementia
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Simó-Servat, Olga (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Ciudin, Andreea (Hospital Universitari Vall d'Hebron) ;
Ortiz-Zuñiga, Angel Michael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernández Pascual, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Simó Canonge, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina)
Type 2 diabetic (T2D) subjects have a significantly higher risk of developing mild cognitive impairment (MCI) and dementia than age-matched non-diabetic individuals. However, the accurate evaluation of cognitive status is based on complex neuropsychological tests, which makes their incorporation into the current standard of care for the T2D population infeasible. [...]
2019 - 10.3390/jcm8010059
Journal of clinical medicine, Vol. 8 (2019) , p. 1-12
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