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18 p, 767.0 KB |
Neuroprotection as a Therapeutic Target for Diabetic Retinopathy
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Hernández, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dal Monte, Massimo (Interdepartmental Research Center Nutrafood "Nutraceuticals and Food for Health", University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy) ;
Simó, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Casini, Giovanni (Interdepartmental Research Center Nutrafood "Nutraceuticals and Food for Health", University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy) ;
Universitat Autònoma de Barcelona
Diabetic retinopathy (DR) is a multifactorial progressive disease of the retina and a leading cause of vision loss. DR has long been regarded as a vascular disorder, although neuronal death and visual impairment appear before vascular lesions, suggesting an important role played by neurodegeneration in DR and the appropriateness of neuroprotective strategies. [...]
2016 -  10.1155/2016/9508541
Journal of Diabetes Research, Vol. 2016 (march 2016)
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10 p, 661.4 KB |
Clinical Applicability of the Specific Risk Score of Dementia in Type 2 Diabetes in the Identification of Patients with Early Cognitive Impairment : results of the MOPEAD Study in Spain
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Ortiz-Zuñiga, Angel Michael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodriguez-Gómez, Octavio (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ;
Hernández Pascual, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodrigo, Adrian (GMV Soluciones Globales Internet SAU. Valencia) ;
Jamilis, Laura (GMV Soluciones Globales Internet SAU. Valencia) ;
Campo, Laura (International Corporate Affairs, Alzheimer's Disease, Eli Lilly and Co. Italy) ;
Alegret, Montserrat (Universitat Internacional de Catalunya. Institut Català de Neurociènces Aplicades) ;
Boada, Mercè (Universitat Internacional de Catalunya. Institut Català de Neurociències Aplicades) ;
Ciudin, Andreea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Simó, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Introduction: Although the Diabetes Specific Dementia Risk Score (DSDRS) was proposed for predicting risk of dementia at 10 years, its usefulness as a screening tool is unknown. For this purpose, the European consortium MOPEAD included the DSDRS within the specific strategy for screening of cognitive impairment in type 2 diabetes (T2D) patients attended in a third-level hospital. [...]
2020 - 10.3390/jcm9092726
Journal of clinical medicine, Vol. 9 Núm. 9 (2020) , p. 2726
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12 p, 1.1 MB |
Utility of insulin resistance in estimating cardiovascular risk in subjects with type 1 diabetes according to the scores of the Steno Type 1
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Cano, Albert (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Mazarico, Isabel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Astiarraga, Brenno (Hospital Universitari Joan XXIII de Tarragona. Department of Endocrinology and Nutrition) ;
González-Sastre, Montserrat (Universitat Autònoma de Barcelona. Departament de Cirurgia) ;
Martínez, Laia (Hospital Universitari Joan XXIII de Tarragona. Departament d'Endocrinologia i Nutrició) ;
Fernández-Veledo, Sonia (Hospital Universitari Joan XXIII de Tarragona. Departament d'Endocrinologia i Nutrició) ;
Simó, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Vendrell, Joan (Hospital Universitari de Tarragona Joan XXIII. Departament d'Endocrinologia i Nutrició) ;
González-Clemente, José Miguel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Llauradó Cabot, Gemma (Universitat Autònoma de Barcelona. Departament d'Endocrinologia i Nutrició) ;
Fàbregas, Lara Albert (Universitat Autònoma de Barcelona. Departament de Medicina)
Background: We sought to assess the potential of insulin resistance (IR) for estimating cardiovascular disease (CVD) risk in adults with type 1 diabetes (T1DM) according to the scores of the Steno Type 1 Risk Engine (ST1RE). [...]
2020 - 10.3390/jcm9072192
Journal of clinical medicine, Vol. 9 Núm. 7 (2020) , p. 2192
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11 p, 1.9 MB |
Neurodegeneration in diabetic retinopathy : does it really matter?
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Simó, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Stitt, Alan W. (Queen's University. Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences) ;
Gardner, Thomas W. (Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School)
The concept of diabetic retinopathy as a microvascular disease has evolved, in that it is now considered a more complex diabetic complication in which neurodegeneration plays a significant role. In this article we provide a critical overview of the role of microvascular abnormalities and neurodegeneration in the pathogenesis of diabetic retinopathy. [...]
2018 - 10.1007/s00125-018-4692-1
Diabetologia, Vol. 61 (july 2018) , p. 1902-1912
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8 p, 1.2 MB |
Genetic testing to predict weight loss and diabetes remission and long-term sustainability after bariatric surgery : a pilot study
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Ciudin, Andreea (Hospital Universitari Vall d'Hebron) ;
Fidilio , Enzamaria (Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona) ;
Ortiz-Zuñiga, Angel Michael (Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona) ;
Pich, Sara (Joan XXIII. Scientific Department) ;
Salas, Eduardo (Joan XXIII. Scientific Department) ;
Mesa Manteca, Jordi (Hospital Universitari Vall d'Hebron) ;
Hernández Pascual, Cristina (Vall d'Hebron Insitut de Recerca) ;
Simó-Servat, Olga (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Lecube, Albert (Hospital Universitari Arnau de Vilanova) ;
Simó, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina)
Introduction: The aim of this pilot study was to assess genetic predisposition risk scores (GPS) in type 2 diabetic and non-diabetic patients in order to predict the better response to bariatric surgery (BS) in terms of either weight loss or diabetes remission. [...]
2019 - 10.3390/jcm8070964
Journal of clinical medicine, Vol. 8 (2019) , p. 1-8
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20 p, 8.4 MB |
New insights into the mechanisms of action of topical administration of GLP-1 in an experimental model of diabetic retinopathy
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Sampedro, Joel (CIBERDEM (Instituto de Salud Carlos III)) ;
Solà-Adell, Cristina (CIBERDEM (Instituto de Salud Carlos III)) ;
Turch, Mireia (Vall d'Hebron Research Institute. Diabetes and Metabolism Research Unit) ;
Valeri, Marta (Vall d'Hebron Research Institute. Unit of High Technology) ;
Simó-Servat, Olga (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Lagunas, Carmen (Ferrer Advanced Biotherapeutics) ;
Simó, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Hernández Pascual, Cristina (Vall d'Hebron Insitut de Recerca) ;
Bogdanov, Patricia (CIBERDEM (Instituto de Salud Carlos III)) ;
Ramos, Hugo (Vall d'Hebron Insitut de Recerca)
The main goals of this work were to assess whether the topical administration of glucagon-like peptide-1 (GLP-1) could revert the impairment of the neurovascular unit induced by long-term diabetes (24 weeks) in diabetic mice and to look into the underlying mechanisms. [...]
2019 - 10.3390/jcm8030339
Journal of clinical medicine, Vol. 8 (2019) , p. 1-20
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12 p, 1.0 MB |
Usefulness of eye fixation assessment for identifying type 2 diabetic subjects at risk of dementia
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Simó-Servat, Olga (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Ciudin, Andreea (Hospital Universitari Vall d'Hebron) ;
Ortiz-Zuñiga, Angel Michael (Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona) ;
Hernández Pascual, Cristina (Vall d'Hebron Insitut de Recerca) ;
Simó, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina)
Type 2 diabetic (T2D) subjects have a significantly higher risk of developing mild cognitive impairment (MCI) and dementia than age-matched non-diabetic individuals. However, the accurate evaluation of cognitive status is based on complex neuropsychological tests, which makes their incorporation into the current standard of care for the T2D population infeasible. [...]
2019 - 10.3390/jcm8010059
Journal of clinical medicine, Vol. 8 (2019) , p. 1-12
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11 p, 1.3 MB |
Retinal microperimetry : a useful tool for detecting insulin resistance-related cognitive impairment in morbid obesity
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Ciudin, Andreea (Hospital Universitari Vall d'Hebron) ;
Ortiz-Zuñiga, Angel Michael (Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona) ;
Fidilio , Enzamaria (Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona) ;
Romero, Diana (Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona) ;
Sanchez, Marta (Department of Endocrinology, Vall d'Hebron University Hospital) ;
Comas, Marta (Department of Endocrinology, Vall d'Hebron University Hospital) ;
González López, Óscar (Department of Surgery. Vall d'Hebron University Hospital) ;
Vilallonga Puy, Ramon (Universitat Autònoma de Barcelona. Departament de Cirurgia) ;
Simó-Servat, Olga (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Hernández Pascual, Cristina (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Simó, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina)
Background: There is clear association between type 2 diabetes (T2D) and cognitive decline. Retinal microperimetry is a useful tool for detecting cognitive impairment in T2D. Morbid obesity (MO) has been associated with cognitive impairment. [...]
2019 - 10.3390/jcm8122181
Journal of clinical medicine, Vol. 8 (2019)
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15 p, 4.2 MB |
Effects of liposomal formulation of citicoline in experimental diabetes-induced retinal neurodegeneration
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Bogdanov, Patricia (CIBERDEM (Instituto de Salud Carlos III)) ;
Sampedro, Joel (CIBERDEM (Instituto de Salud Carlos III)) ;
Solà-Adell, Cristina (CIBERDEM (Instituto de Salud Carlos III)) ;
Simó-Servat, Olga (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Russo, Carla (R&D Department. Omikron Italia Srl) ;
Varela-Sende, Luisa (Clinical Research Department. OPKO Health Spain S.L) ;
Simó, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Hernández Pascual, Cristina (Universitat Autònoma de Barcelona. Departament de Medicina)
Diabetic retinopathy (DR) has been classically considered a microcirculatory disease of the retina. However, there is growing evidence to suggest that retinal neurodegeneration is also an early event in the pathogenesis of DR. [...]
2018 - 10.3390/ijms19082458
International journal of molecular sciences, Vol. 19 Núm. 8 (20 2018) , p. 2458
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