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7 p, 823.4 KB |
Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease
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Jost, Stefanie Theresa (University of Cologne. Faculty of Medicine and University Hospital Cologne. Department of Neurology) ;
Visser-Vandewalle, Veerle (University of Cologne. Faculty of Medicine and University Hospital Cologne. Department of Stereotaxy and Functional Neurosurgery) ;
Rizos, Alexandra Marianne (King's College London. Parkinson Foundation International Centre of Excellence) ;
Loehrer, Philipp Alexander (Department of Neurology. University Hospital Giessen and Marburg. Campus Marburg) ;
Silverdale, Monty (Department of Neurology and Neurosurgery. Salford Royal NHS Foundation Trust. Manchester Academic Health Science Centre. University of Manchester) ;
Evans, Julian (Department of Neurology and Neurosurgery. Salford Royal NHS Foundation Trust. Manchester Academic Health Science Centre. University of Manchester) ;
Samuel, Michael (King's College London. Parkinson Foundation International Centre of Excellence) ;
Petry-Schmelzer, Jan Niklas (University of Cologne. Faculty of Medicine and University Hospital Cologne. Department of Neurology) ;
Sauerbier, Anna (Institute of Psychiatry. Psychology and Neuroscience. King's College London) ;
Gronostay, Alexandra (University of Cologne. Faculty of Medicine and University Hospital Cologne. Department of Neurology) ;
Barbe, Michael T. (University of Cologne. Faculty of Medicine and University Hospital Cologne. Department of Neurology) ;
Fink, Gereon R. (Cognitive Neuroscience. Institute of Neuroscience and Medicine (INM-3). Research Centre Jülich) ;
Ashkan, Keyoumars (King's College London. Parkinson Foundation International Centre of Excellence) ;
Antonini, Angelo (Padova University. Department of Neurosciences (DNS)) ;
Martinez-Martin, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Chaudhuri, Kallol Ray (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Timmermann, Lars (University Hospital Giessen and Marburg) ;
Dafsari, Haidar S. (University of Cologne. Faculty of Medicine and University Hospital Cologne. Department of Neurology) ;
Bhidayasiri, Roongroj (Chulalongkorn Centre of Excellence for Parkinson's Disease & Related Disorders. Department of Medicine. Faculty of Medicine. Chulalongkorn University and King Chulalongkorn Memorial Hospital. Thai Red Cross Society) ;
Falup-Pecurariu, Cristian (Faculty of Medicine. Transilvania University of Brașov) ;
Jeon, Beomseok (Department of Neurology. Seoul National University College of Medicine) ;
Leta, Valentina (King's College London. Institute of Psychiatry. Psychology & Neuroscience) ;
Borghammer, Per (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Odin, Per (University of Lund. Faculty of Medicine) ;
Schrag, Anette (UCL Institute of Neurology (Regne Unit)) ;
Storch, Alexander (German Center for Neurodegenerative Diseases (DZNE). Research Site Dresden) ;
Rodríguez-Violante, Mayela (Movement Disorders Clinic. National Institute of Neurology and Neurosurgery) ;
Weintraub, Daniel (Parkinson's Disease and Mental Illness Research. Education and Clinical Centers. Philadelphia Veterans Affairs Medical Center) ;
Adler, Charles (The Parkinson's Disease and Movement Disorders Center. Department of Neurology. Mayo Clinic) ;
Barone, Paolo (Center for Neurodegenerative Diseases (CEMAND). Neuroscience Section. University of Salerno) ;
Brooks, David J. (Department of Nuclear Medicine and PET Centre. Aarhus University Hospital) ;
Brown, Richard (Department of Medicine. University of Birmingham Institute of Cardiovascular Sciences. City Hospital) ;
Cantillon, Marc (Reviva Pharmaceuticals. Inc) ;
Carroll, Camille (Faculty of Medicine and Dentistry. University of Plymouth) ;
Coelho, Miguel (FAS Center for Systems Biology. Harvard University) ;
Henriksen, Tove (Movement Disorder Clinic. University Hospital of Bispebjerg) ;
Hu, Michele (Nuffield Department of Clinical Neurosciences. University of Oxford) ;
Jenner, Peter (Neurodegenerative Diseases Research Group. Institute of Pharmaceutical Sciences. Faculty of Life Sciences and Medicine. King's College London) ;
Kramberger, Milica (Department of Neurology. University Medical Centre Ljubljana) ;
Kumar, Padma (Parkinson's Disease Service for the Older Person. Rankin Park Centre. John Hunter Hospital. HNELHD) ;
Kurtis, Monica M. (Functional Movement Disorders Unit. Movement Disorders Program. Neurology Department. Hospital Ruber Internacional) ;
Lewis, Simon (Brain and Mind Centre. University of Sydney) ;
Litvan, Irene (Department of Neurosciences Movement Disorders Center. University of California) ;
Lyons, Kelly (University of Kansas Medical Center) ;
Martino, Davide (Department of Clinical Neurosciences. University of Calgary & Hotchkiss Brain Institute) ;
Masellis, Mario (Hurvitz Brain Sciences Program. Sunnybrook Research Institute) ;
Mochizuki, Hideki (Department of Neurology. Osaka University Graduate School of Medicine) ;
Morley, James F. (Department of Neurology. University of Pennsylvania) ;
Nirenberg, Melissa (Department of Neurology. NYU School of Medicine) ;
Pagonabarraga Mora, Javier (Institut d'Investigació Biomèdica Sant Pau) ;
Panicker, Jalesh (Neurology. National Hospital for Neurology & Neurosurgery) ;
Pavese, Nicola (Newcastle Magnetic Resonance Centre & Positron Emission Tomography Centre. Newcastle University. Campus for Ageing & Vitality) ;
Pekkonen, Eero (Department of Neurology. Helsinki University Hospital. and Department of Neurological Sciences (Neurology). University of Helsinki) ;
Postuma, Ron (Research Institute of McGill University Health Centre) ;
Rosales, Raimon L. (Center for Neurodiagnostic and Therapeutic Services. Metropolitan Medical Center) ;
Schapira, Anthony (Department of Clinical Neurosciences. University College London (UCL) Institute of Neurology. Royal Free Campus. Rowland Hill Street) ;
Simuni, Tanya (Department of Neurology. Northwestern University. Feinberg School of Medicine) ;
Stocchi, Fabrizio (University and Institute for Research and Medical Care. IRCCS San Raffaele) ;
Subramanian, Indu (UCLA/West LA VA) ;
Tagliati, Michele (Cedars-Sinai Medical Center) ;
Tinazzi, Michele (Department of Neuroscience. Biomedicine. and Movement. University of Verona) ;
Toledo, Jon (Department of Neurology. Houston Methodist Hospital) ;
Tsuboi, Yoshio (Department of Neurology. Fukuoka University) ;
Walker, Richard (Northumbria Healthcare NHS Foundation Trust. North Tyneside General Hospital. Rake Lane)
To identify predictors of 36-month follow-up quality of life (QoL) outcome after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD). In this ongoing, prospective, multicenter international study (Cologne, Manchester, London) including 73 patients undergoing STN-DBS, we assessed the following scales preoperatively and at 6-month and 36-month follow-up: PD Questionnaire-8 (PDQ-8), NMSScale (NMSS), Scales for Outcomes in PD (SCOPA)-motor examination, -activities of daily living, and -complications, and levodopa equivalent daily dose (LEDD). [...]
2021 -  10.1038/s41531-021-00174-x
NPJ Parkinson's disease, Vol. 7 Núm. 1 (december 2021) , p. 48
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17 p, 1.5 MB |
A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA) : Rationale, Design, and Baseline Data
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Pagano, Gennaro (F Hoffmann-La Roche AG Research and Development Division) ;
Boess, Frank (Roche Pharma Research and Early Development) ;
Taylor, Kirsten I. (Faculty of Psychology. University of Basel) ;
Ricci, Benedicte (Roche Pharma Research and Early Development) ;
Mollenhauer, Brit ;
Poewe, Werner ;
Boulay, Anne ;
Anzures-Cabrera, Judith (Roche Products Ltd) ;
Vogt, Annamarie ;
Marchesi, Maddalena ;
Post, Anke ;
Nikolcheva, Tania ;
Kinney, Gene G. (Prothena Biosciences Inc. South San Francisco) ;
Zago, Wagner M. ;
Ness, Daniel K. ;
Svoboda, Hanno (F. Hoffmann-La Roche) ;
Britschgi, Markus ;
Ostrowitzki, Susanne ;
Simuni, Tanya ;
Marek, Kenneth (Institute for Neurodegenerative Disorders) ;
Koller, Martin ;
Sevigny, Jeff ;
Doody, Rachelle ;
Fontoura, Paulo ;
Umbricht, Daniel ;
Bonni, Azad ;
Altendorf, Claudia ;
Anandan, Chareyna ;
Andrews, Giulia ;
Ansquer, Solène ;
Arrouasse, Raphaele ;
Aslam, Sana ;
Azulay, Jean-Philippe ;
Baker, Jeanette ;
Balaguer Martinez, Ernest ;
Barbu, Shadi ;
Bardram, Kara ;
Bega, Danny ;
Bejr-kasem, Helena (Institut d'Investigació Biomèdica Sant Pau) ;
Benatru, Isabelle ;
Benchetrit, Eve ;
Bernhard, Felix ;
Besharat, Amir ;
Bette, Sagari ;
Bichon, Amelie ;
Billnitzer, Andrew ;
Blondeau, Sophie ;
Boraud, Thomas ;
Borngräber, Freiderike ;
Boyd, James ;
Brockmann, Kathrin ;
Brodsky, Matthew ;
Brown, Ethan ;
Bruecke, Christof ;
Calvas, Fabienne ;
Canelo, Monica ;
Carbone, Federico ;
Carroll, Claire ;
Casado Fernandez, Laura ;
Cassé-Perrot, Catherine ;
Castrioto, Anna ;
Catala, Helene ;
Chan, Justine ;
Cheriet, Samia ;
Ciabarra, Aanthony ;
Classen, Joseph ;
Coleman, Juliana ;
Coleman, Robert ;
Compta, Yaroslau ;
Corbillé, Anne-Gaëlle ;
Corvol, Jean-Christophe ;
Cosgaya, Marina ;
Dahodwala, Nabila ;
Damier, Philippe ;
David, Elodie ;
Davis, Thomas ;
Dean, Marissa ;
Debilly, Berengere ;
DeGiorgio, Janell ;
Deik, Andres ;
Delaby, Laure ;
Delfini, Marie-Helene ;
Derkinderen, Pascal ;
Derost, Philipp ;
de Toledo, María ;
Deuel, Lisa ;
Diaz-Hernandez, Ann Marie ;
Dietiker, Cameron ;
Dimenshteyn, Karina ;
Dotor, Julio ;
Durif, Franck ;
Ebentheuer, Jens ;
Eggert, Karla Maria ;
Eichau Madueño, Sara ;
Eickhoff, Claudia ;
Ellenbogen, Aaron ;
Ellmerer, Philipp ;
Esparragosa Vazquez, Inés ;
Eusebio, Alexandre ;
Ewert, Siobhan ;
Fang, John ;
Feigenbaum, Danielle ;
Fluchere, Frederique ;
Foubert-Samier, Alexandra ;
Fournier, Marie ;
Fradet, Anne ;
Fraix, Valerie ;
Frank, Samuel ;
Fries, Franca ;
Galitzky, Monique ;
Gallardo Pérez, Marisol ;
Moreno, Jose Manuel García ;
Gasca, Carmen ;
Gasser, Thomas ;
Gibbons, Joyce ;
Giordana, Caroline ;
González Martinez, Alicia ;
Goodman, Ira ;
Gorospe, Arantza ;
Goubeaud, Marie ;
Grabli, David ;
Graziella, Mangone ;
Grimaldi, Stephan ;
Gross, Jeffrey ;
Guimaraes-Costa, Raquel ;
Hartmann, Andreas ;
Hartmann, Christian ;
Hassell, Travis ;
Hauser, Robert ;
Hernandez, Antonio ;
Hernández-Vara, Jorge ;
Hoeglinger, Günter ;
Homedes, Christian ;
Horta, Andrea ;
Houeto, Jean-Luc ;
Huebl, Julius ;
Hui, Jennifer ;
Isaacson, Stuart ;
Jankovic, Joseph ;
Janzen, Annette ;
Jauregui, Junior ;
Jiao, Jocelyne ;
Martí Domenech, María José ;
Joseph, Xavier ;
Kadimi, Srinath ;
Kaminski, Pat ;
Kannenberg, Silja ;
Kassubek, Jan ;
Katz, Maya ;
Klos, Kevin ;
Klos, Shannon ;
Kobet, Christopher ;
Koebert, Jennifer ;
Krause, Patricia ;
Kuehn, Andrea ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Kumar, Rajeev ;
Kunz, Martin ;
Kurvits, Lille ;
Kwei, Kimberly ;
Laganiere, Simon ;
Laurens, Brice ;
Levin, Johannes ;
Levy, Oren ;
LeWitt, Peter ;
Cristóbal, Gurutz Linazasoro ;
Litvan, Irene ;
Lizarraga, Karlo ;
Longardner, Katherine ;
Lopez, Rocío ;
López Manzanares, Lydia ;
Lucas del Pozo, Sara ;
Luquín Pulido, María Rosario ;
Luthra, Nijee ;
Lyons, Kelly ;
Maass, Sylvia ;
Machetanz, Gerrit ;
Macías, Yolanda ;
Maltete, David ;
Manez Miro, Jorge Uriel ;
Mariani, Louise-Laure ;
Marin, Juan ;
Marini, Kathrin ;
Marques, Ana ;
Marti, Gloria ;
Martí Domenech, María José ;
Martinez, Saul ;
Meissner, Wassilios ;
Meoni, Sara ;
Mollenhauer, Brit ;
Martinez, Dunia Mon ;
Moon, Johnson ;
Moro, Elena ;
Morrison, Peter ;
Muehlberg, Christoph ;
Multani, Manpreet ;
Murphy, Christine ;
Nicholas, Anthony ;
Pahwa, Rajesh ;
Palasí Franco, Antoni ;
Pape, Heidi ;
Patel, Neepa ;
Patel, Prity ;
Peball, Marina ;
Peckham, Elizabeth ;
Peery, Terry ;
Perez, Rafael ;
Perez, Jesús ;
Petit, Alisa ;
Pinkhardt, Elmar ;
Poewe, Werner ;
Pomies, Elsa ;
Preterre, Cecile ;
Quinn, Joseph ;
Rascol, Olivier ;
Remy, Philippe ;
Richard, Irene ;
Roeben, Benjamin ;
Ruether, Emily ;
Rumpf, Jost-Julian ;
Russell, David ;
Salhi, Hayet ;
Samaniego-Toro, Daniela ;
Samier-Foubert, Alexandra ;
Sánchez, Antonio ;
Schmitt, Emmanuelle ;
Schnitzler, Alfons ;
Schorr, Oliver ;
Schwartzbard, Julie ;
Schweyer, Kerstin ;
Seppi, Klaus ;
Sergo, Victoria ;
Shill, Holly ;
Siderowf, Andrew ;
Simuni, Tanya ;
Spampinato, Umberto ;
Sriram, Ashok ;
Stover, Natividad ;
Tanner, Caroline ;
Tarakad, Arjun ;
Taylor, Carolyn ;
Thalamus, Claire ;
Toothaker, Thomas ;
Van Blercom, Nadege ;
Vanegas-Arrogave, Nora ;
Vela, Lydia ;
Vergnet, Sylvian ;
Vidal, Tiphaine ;
Vöglein, Jonathan ;
Walsh, Ryan ;
Waters, Cheryl ;
Wegscheider, Mirko ;
Weidinger, Endy ;
Weill, Caroline ;
Wenzel, Gregor ;
Witjas, Tatiana ;
Wurster, Isabel ;
Wright, Brenton ;
Zimmermann, Milan ;
Zuzuarregui, Rafael ;
Abt, Markus ;
Bamdadian, Atieh ;
Barata, Teresa ;
Barbet, Nicholas ;
Belli, Sara ;
Boess, Frank ;
Bonni, Azad ;
Borroni, Edilio ;
Boulay, Anne ;
Britschgi, Markus ;
Chague, Jerome ;
Cosson, Valerie ;
Czech, Christian ;
Deptula, Dennis ;
Diack, Cheikh ;
Doody, Rachelle ;
Dukart, Juergen ;
D'Urso, Giulia ;
Dziadek, Sebastian (F. Hoffmann-La Roche) ;
Eddleston, Hannah ;
Edgar, Chris ;
Essioux, Laurent ;
Farell, Morgan ;
Finch, Rebecca (Roche Products Ltd) ;
Fontoura, Paulo ;
Gruenbauer, Waltraud ;
Hahn, Andreas ;
Holiga, Stefan (F. Hoffmann-La Roche) ;
Honer, Michael ;
Jadidi, Shirin ;
Johnson-Wood, Kelly ;
Keller, Markus ;
Kilchenmann, Timothy ;
Koller, Martin ;
Kremer, Thomas ;
Kustermann, Thomas (F. Hoffmann-La Roche) ;
Landsdall, Claire ;
Lindemann, Michael (F. Hoffmann-La Roche) ;
Lipsmeier, Florian ;
Luzy, Cecile ;
Manchester, Marianne ;
Marchesi, Maddalena ;
Martenyi, Ferenc ;
Martin-Facklam, Meret ;
Mironova, Katerina ;
Monnet, Annabelle (F. Hoffmann-La Roche) ;
Moore, Emma ;
Ness, Daniel K. ;
Niggli, Markus ;
Nikolcheva, Tania (F. Hoffmann-La Roche) ;
Ostrowitzki, Susanne ;
Passmard, Benedicte ;
Poirier, Agnes ;
Post, Anke ;
Prasad, Megana ;
Pross, Nathalie (F. Hoffmann-La Roche) ;
Quock, Tiffany ;
Rose, Ellen ;
Sarry, Christoph ;
Schubert, Christine ;
Selkoe, Dennis ;
Sevigny, Jeff ;
Sink, Kaycee ;
Staunton, Hannah ;
Steven, Tim ;
Strasak, Alexander ;
Svoboda, Hanno ;
Tripuraneni, Radhika ;
Trundell, Dylan ;
Umbricht, Daniel ;
Verselis, Lynne ;
Vogt, Annamarie ;
Volkova-Volkmar, Ekaterina ;
Weber, Cornelia ;
Weber, Silke ;
Zago, Wagner (Prothena Biosciences Inc. (San Francisco))
Background: Currently available treatments for Parkinson's disease (PD) do not slow clinical progression nor target alpha-synuclein, a key protein associated with the disease. Objective: The study objective was to evaluate the efficacy and safety of prasinezumab, a humanized monoclonal antibody that binds aggregated alpha-synuclein, in individuals with early PD. [...]
2021 - 10.3389/fneur.2021.705407
Frontiers in neurology, Vol. 12 (january 2021) , p. 705407
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