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7 p, 474.6 KB Pharmacokinetic variability and exposures of fluconazole, anidulafungin, and caspofungin in intensive care unit patients : Data from multinational Defining Antibiotic Levels in Intensive care unit (DALI) patients Study / Sinnollareddy, Mahipal G. (The Queen Elizabeth Hospital. Basil Hetzel Institute for Translational Health Research) ; Roberts, Jason A. (Royal Brisbane and Women's Hospital) ; Lipman, Jeffrey (Royal Brisbane and Women's Hospital) ; Akova, Murat (Hacettepe University, Ankara) ; Bassetti, Matteo (Azienda Ospedaliera Universitaria Santa Maria della Misericordia) ; De Waele, Jan J. (Universitair Ziekenhuis Gent) ; Kaukonen, Kirsi-Maija (Helsinki University Central Hospital) ; Koulenti, Despoina (University General Hospital Attikon (Haidari, Grècia)) ; Martin, Claude (AzuRea Group, Antibes, France) ; Montravers, Philippe (Centre Hospitalier Universitaire Bichat-Claude Bernard) ; Rello, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rhodes, Andrew (St George's Healthcare NHS Trust and St George's University of London) ; Starr, Therese (Royal Brisbane and Women's Hospital) ; Wallis, Steven C. (The University of Queensland) ; Dimopoulos, George (University General Hospital Attikon (Haidari, Grècia)) ; Universitat Autònoma de Barcelona
The objective of the study was to describe the pharmacokinetics (PK) of fluconazole, anidulafungin, and caspofungin in critically ill patients and to compare with previously published data. We also sought to determine whether contemporary fluconazole doses achieved PK/pharmacodynamic (PD; PK/PD) targets in this cohort of intensive care unit patients. [...]
2015 - 10.1186/s13054-015-0758-3
Critical Care, Vol. 19 (february 2015)  
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