Resultados globales: 2 registros encontrados en 0.02 segundos.
Artículos, Encontrados 2 registros
Artículos Encontrados 2 registros  
1.
11 p, 927.9 KB A Multi-Arm Phase I Study of the PI3K/mTOR Inhibitors PF-04691502 and Gedatolisib (PF-05212384) plus Irinotecan or the MEK Inhibitor PD-0325901 in Advanced Cancer / Wainberg, Zev A. (David Geffen School of Medicina, UCLA (USA)) ; Alsina Maqueda, Maria (Institut d'Oncologia de la Vall Hebron (VHIO)) ; Soares, Heloisa P. (Moffitt Cancer Center (USA)) ; Braña, Irene (Princess Margaret Cancer Centre (Canada)) ; Britten, Carolyn D. (Medical University of South Carolina (USA)) ; Del Conte, Gianluca (IRCCS Ospedale San Raffaele(Italy)) ; Ezeh, Patrick (Pfizer Oncology (USA)) ; Houk, Brett (Pfizer Oncology (USA)) ; Kern, Kenneth A. (Pfizer Oncology (USA)) ; Leong, Stephen (University of Colorado (USA)) ; Pathan, Nuzhat (Pfizer Oncology, 10646 Science Center Drive, San Diego, CA 92121 USA) ; Pierce, Kristen J. (Pfizer Oncology (USA)) ; Siu, Lillian L. (Princess Margaret Cancer Centre (Canada)) ; Vermette, Jennifer (Pfizer Oncology (USA)) ; Tabernero Caturla, Josep (Institut d'Oncologia de la Vall Hebron (VHIO)) ; Universitat Autònoma de Barcelona
This phase I, four-arm, open-label study (NCT01347866) evaluated the PI3K/mTOR inhibitors PF-04691502 (arms A, B) and gedatolisib (PF-05212384; arms C, D) in combination with the MEK inhibitor PD-0325901 (arm A, D) or irinotecan (arm B, C) in patients with advanced solid tumors. [...]
2017 - 10.1007/s11523-017-0530-5
Targeted Oncology, Vol. 12, Issue 6 (December 2017) , p. 775-785  
2.
10 p, 426.6 KB A first-in-human phase I, dose-escalation, multicentre study of HSP990 administered orally in adult patients with advanced solid malignancies / Spreafico, A. (University of Toronto. Princess Margaret Cancer Centre. Division of Medical Oncology and Hematology (Canada)) ; Delord, J. P. (Institut Claudius Regaud (France)) ; Mattos Arruda, Leticia de (Hospital Universitari Vall d'Hebron) ; Berge, Y. (Institut Claudius Regaud (France)) ; Pérez Rodon, Jordi (Hospital Universitari Vall d'Hebron) ; Cottura, E. (Institut Claudius Regaud (France)) ; Bedard, P. L. (University of Toronto. Princess Margaret Cancer Centre. Division of Medical Oncology and Hematology (Canada)) ; Akimov, M. (Novartis Pharma AG (Switzerland)) ; Lu, H. (Novartis Pharmaceuticals Corp (USA)) ; Pain, S. (Novartis Pharmaceuticals Corp (USA)) ; Kaag, A. (Novartis Pharma AG (Switzerland)) ; Siu, L. L. (University of Toronto. Princess Margaret Cancer Centre. Division of Medical Oncology and Hematology (Canada)) ; Cortés Castán, Javier (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
Heat-shock protein 990 (HSP990) is a potent and selective synthetic small-molecule HSP90 inhibitor. The primary objectives of this phase I first-in-human study were to determine dose-limiting toxicities (DLTs), maximum-tolerated dose (MTD) and recommended phase II dose (RP2D). [...]
2015 - 10.1038/bjc.2014.653
British Journal of Cancer, Vol. 112 (February 2015) , p. 650-659  

Vea también: autores con nombres similares
1 Siu, L. L.
1 Siu, Lillian L.
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