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Resultats globals: 4 registres trobats en 0.02 segons.
Articles, 4 registres trobats
Articles 4 registres trobats  
1.
15 p, 2.8 MB Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance / Grünberg, John R. (Sahlgrenska Academy at the University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Hoffmann, Jenny M. (Sahlgrenska Academy at the University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Hedjazifar, Shahram (Sahlgrenska Academy at the University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Nerstedt, Annika (Sahlgrenska Academy at the University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Jenndahl, Lachmi (Sahlgrenska Academy at the University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Elvin, Johannes (Sahlgrenska Academy at the University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Castellot, John (Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine) ; Wei, Lan (Massachusetts General Hospital (Boston)) ; Movérare-Skrtic, Sofia (Sahlgrenska Academy at the University of Gothenburg. Centre for Bone and Arthritis Research) ; Ohlsson, Claes (Sahlgrenska Academy at the University of Gothenburg. Centre for Bone and Arthritis Research) ; Holm, Louise Mannerås (Sahlgrenska Academy at the University of Gothenburg. The Wallenberg Laboratory) ; Bäckhed, Fredrik (University of Copenhagen. Novo Nordisk Foundation Center for Basic Metabolic Research) ; Syed, Ismail (Beth Israel Deaconess and Harvard Medical School) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG)) ; Saghatelian, Alan (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica)) ; Kahn, Barbara B. (Beth Israel Deaconess and Harvard Medical School) ; Hammarstedt, Ann (Sahlgrenska Academy at the University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Smith, Ulf (Sahlgrenska Academy at the University of Gothenburg. The Lundberg Laboratory for Diabetes Research)
WISP2 is a novel adipokine, most highly expressed in the adipose tissue and primarily in undifferentiated mesenchymal cells. As a secreted protein, it is an autocrine/paracrine activator of canonical WNT signaling and, as an intracellular protein, it helps to maintain precursor cells undifferentiated. [...]
2017 - 10.1038/srep43515
Scientific reports, Vol. 7 (02 2017)  
Registre complet - Creative Commons
2.
17 p, 2.0 MB Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver / Khatib Shahidi, Roxana (University of Gothenburg. Department of Molecular and Clinical Medicine) ; M. Hoffmann, Jenny (University of Gothenburg. Department of Molecular and Clinical Medicine) ; Hedjazifar, Shahram (University of Gothenburg. Department of Molecular and Clinical Medicine) ; Bonnet, Laurianne (University of Gothenburg. Department of Molecular and Clinical Medicine) ; K. Baboota, Ritesh (University of Gothenburg. Department of Molecular and Clinical Medicine) ; Heasman, Stephanie (BioPharmaceuticals R&D. Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism) ; Church, Christopher (BioPharmaceuticals R&D. Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism) ; Elias Puigdomenech, Ivet (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Boucher, Jeremie (BioPharmaceuticals R&D. Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism) ; Hammarstedt, Ann (University of Gothenburg. Department of Molecular and Clinical Medicine) ; Smith, Ulf (University of Gothenburg. Department of Molecular and Clinical Medicine)
Gremlin 1 (GREM1) is a secreted BMP2/4 inhibitor which regulates commitment and differentiation of human adipose precursor cells and prevents the browning effect of BMP4. GREM1 is an insulin antagonist and serum levels are high in type 2 diabetes (T2D). [...]
2021 - 10.1371/journal.pone.0247300
PloS one, Vol. 16 (february 2021)  
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3.
12 p, 1.4 MB BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice / Hoffmann, Jenny M. (University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Grünberg, John R. (University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Hammarstedt, Ann (University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Kroon, Tobias (BioPharmaceuticals. Bioscience Metabolism, Research and Early Development) ; Greiner, Thomas U. (University of Gothenburg. Department of Molecular and Clinical Medicine) ; Maurer, Stefanie (BioPharmaceuticals. Bioscience Metabolism, Research and Early Development) ; Elias Puigdomenech, Ivet (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Palsdottir, Vilborg (University of Gothenburg. Department of Physiology/Endocrinology) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG)) ; Boucher, Jeremie (University of Gothenburgç. Wallenberg Centre for Molecular and Translational Medicine) ; Hedjazifar, Shahram (University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Smith, Ulf (University of Gothenburg. The Lundberg Laboratory for Diabetes Research)
Bone morphogenetic protein 4 (BMP4) adeno-associated viral vectors of serotype 8 (AAV8) gene therapy targeting the liver prevents the development of obesity in initially lean mice by browning the large subcutaneous white adipose tissue (WAT) and enhancing energy expenditure. [...]
2019 - 10.1016/j.molmet.2019.11.016
Molecular metabolism, Vol. 32 (december 2019) , p. 15-26  
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4.
9 p, 1.2 MB Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone / Westhrin, Marita (Norwegian University of Science and Technology) ; Holien, Toril (St Olav's University Hospital) ; Zahoor, Muhammad (Norwegian University of Science and Technology) ; Moen, Siv Helen (Norwegian University of Science and Technology) ; Buene, Glenn (Norwegian University of Science and Technology) ; Størdal, Berit (Norwegian University of Science and Technology) ; Hella, Hanne (Norwegian University of Science and Technology) ; Yuan, Huipin (Kuros Biosciences) ; de Bruijn, Joost D. (Queen Mary University of London) ; Martens, Anton (University Medical Center. Cancer Center Amsterdam) ; Groen, Richard W. J. (University Medical Center. Cancer Center Amsterdam) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Smith, Ulf (Sahlgrenska University Hospital (Suècia)) ; Sponaas, Anne-Marit (Norwegian University of Science and Technology) ; Sundan, Anders (Norwegian University of Science and Technology) ; Standal, Therese (St Olav's University Hospital)
Multiple myeloma is characterized by accumulation of malignant plasma cells in the bone marrow. Most patients suffer from an osteolytic bone disease, caused by increased bone degradation and reduced bone formation. [...]
2019 - 10.1002/jbm4.10247
JBMR Plus, Vol. 4 (november 2019)  
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