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1.
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12 p, 1.1 MB |
A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype
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Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ;
Lledós, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
Llucià-Carol, Laia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Sobrino, Tomás (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Campos, Francisco (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Castillo, José (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Freijo, Marimar (Biocruces-Bizkaia Health Research Institute. Department of Neurology) ;
Arenillas, Juan F (Hospital Universitario de Valladolid) ;
Obach, Víctor (Hospital Clínic i Provincial de Barcelona) ;
Álvarez Sabín, José (Hospital Universitari Vall d'Hebron) ;
Molina, Carlos A. (Hospital Universitari Vall d'Hebron) ;
Ribó, Marc (Hospital Universitari Vall d'Hebron) ;
Jiménez-Conde, Jordi (Hospital del Mar (Barcelona, Catalunya)) ;
Roquer, Jaume (Hospital del Mar (Barcelona, Catalunya)) ;
Muñoz-Narbona, Lucia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
López-Cancio, Elena (Hospital Central de Asturias (HUCA)) ;
Millán, Mònica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Diaz-Navarro, Rosa (Institut d’Investigació Sanitària Illes Balears) ;
Vives-Bauza, Cristòfol (Institut d’Investigació Sanitària Illes Balears) ;
Serrano-Heras, Gemma (Complejo Hospitalario Universitario de Albacete) ;
Segura, Tomás (Complejo Hospitalario Universitario de Albacete) ;
Ibañez, Laura (Washington University School of Medicine. Department of Psychiatry) ;
Heitsch, Laura (Washington University School of Medicine. Department of Neurology) ;
Delgado, Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dhar, Rajat (Washington University School of Medicine. Department of Neurology.) ;
Krupinski, Jerzy (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Delgado Mederos, Raquel (Institut d'Investigació Biomèdica Sant Pau) ;
Prats-Sánchez, Luis Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Camps-Renom, Pol (Institut d'Investigació Biomèdica Sant Pau) ;
Blay, Natalia (Institut Germans Trias i Pujol) ;
Sumoy, Lauro (Institut Germans Trias i Pujol) ;
de Cid, Rafael (Institut Germans Trias i Pujol) ;
Montaner, Joan (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Cruchaga, Carlos (Washington University in St. Louis. Neurogenomics and Informatics Center.) ;
Lee, Jim-Moo (Washington University School of Medicine. Department of Neurology.) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Background: Occult atrial fibrillation (AF) is one of the major causes of embolic stroke of undetermined source (ESUS). Knowing the underlying etiology of an ESUS will reduce stroke recurrence and/or unnecessary use of anticoagulants. [...]
2022 -  10.3389/fcvm.2022.940696
Frontiers in Cardiovascular Medicine, Vol. 9 (august 2022) , p. 940696
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12 p, 990.9 KB |
Cold stress protein RBM3 responds to hypothermia and is associated with good stroke outcome
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Ávila-Gómez, Paulo (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Vieites-Prado, Alba (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Dopico-López, Antonio (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Bashir, Saima (Hospital Universitari de Girona Doctor Josep Trueta) ;
Fernández-Susavila, Héctor (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Gubern, Carme (Hospital Universitari de Girona Doctor Josep Trueta) ;
Pérez-Mato, María (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Correa-Paz, Clara (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Iglesias-Rey, Ramón (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Sobrino, Tomás (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Bustamante, Alejandro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Wellmann, Sven (University of Regensburg) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Serena, Joaquín (Hospital Universitari de Girona Doctor Josep Trueta) ;
Castillo, José (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Hervella, Pablo (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Campos, Francisco (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Universitat Autònoma de Barcelona
RNA-binding motif protein 3 is a molecular marker of hypothermia that has proved neuroprotective in neurodegenerative disease models. However, its relationship to the well-recognized therapeutic effect of hypothermia in ischaemic stroke had not been studied. [...]
2020 - 10.1093/braincomms/fcaa078
Brain Communications, Vol. 2 (june 2020)
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3.
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15 p, 1.7 MB |
Article targeting pro-oxidant iron with deferoxamine as a treatment for ischemic stroke : safety and optimal dose selection in a randomized clinical trial
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Millán, Mónica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
de la Ossa Pérez, Natàlia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Reverté, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Costa, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Giner, Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Silva, Yolanda (Hospital Universitari de Girona Doctor Josep Trueta) ;
Sobrino, Tomás (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Rodríguez-Yáñez, Manuel (Hospital Clínico Universitario. Departamento de Neurología) ;
Nombela, Florentino (Hospital Universitario de la Princesa (Madrid)) ;
Campos, Francisco (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Serena, Joaquín (Hospital Universitari de Girona Doctor Josep Trueta) ;
Vivancos, José (Hospital Universitario de la Princesa (Madrid)) ;
Martí-Sistac, Octavi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Cortés, Jordi (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gasull Dalmau, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
A role of iron as a target to prevent stroke-induced neurodegeneration has been recently revisited due to new evidence showing that ferroptosis inhibitors are protective in experimental ischemic stroke and might be therapeutic in other neurodegenerative brain pathologies. [...]
2021 - 10.3390/antiox10081270
Antioxidants, Vol. 10, p. 1270
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11 p, 1.2 MB |
Association of High Serum Levels of Growth Factors with Good Outcome in Ischemic Stroke : a Multicenter Study
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Sobrino, Tomás (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Rodríguez-Yáñez, Manuel (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Campos, Francisco (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Iglesias-Rey, Ramón (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Millán, Mónica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
de la Ossa Pérez, Natàlia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Delgado Mederos, Raquel (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-Domeño, Alejandro (Institut d'Investigació Biomèdica Sant Pau) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Castellanos, María del Mar (Complejo Hospitalario Universitario de A Coruña) ;
Serena, Joaquín (Hospital Universitari de Girona Doctor Josep Trueta) ;
Lago, Aida (Hospital Universitari i Politècnic La Fe (València)) ;
Díez-Tejedor, Exuperio (Universidad Autónoma de Madrid) ;
Castillo, José (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Universitat Autònoma de Barcelona
The main objective of this research work was to study the association of serum levels of growth factors (GF) and SDF-1α with the functional outcome and reduction of lesion volume in ischemic stroke patients. [...]
2019 - 10.1007/s12975-019-00747-2
Translational Stroke Research, Vol. 11 (november 2019) , p. 653-663
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5.
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16 p, 2.9 MB |
In Vivo Theranostics at the Peri-Infarct Region in Cerebral Ischemia
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Agulla, Jesús (Universidade de Santiago de Compostela) ;
Brea, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Campos, Francisco (Universidade de Santiago de Compostela) ;
Sobrino, Tomás (Universidade de Santiago de Compostela) ;
Argibay, Bárbara (Universidade de Santiago de Compostela) ;
Al-Soufi, Wajih (Universidade de Santiago de Compostela) ;
Blanco, Miguel (Universidade de Santiago de Compostela) ;
Castillo, José (Universidade de Santiago de Compostela) ;
Ramos-Cabrer, Pedro (Universidade de Santiago de Compostela)
The use of theranostics in neurosciences has been rare to date because of the limitations imposed on the free delivery of substances to the brain by the blood-brain barrier. Here we report the development of a theranostic system for the treatment of stroke, a leading cause of death and disability in developed countries. [...]
2013 - 10.7150/thno.7088
Theranostics, Vol. 4 (december 2013) , p. 90-105
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8 p, 333.4 KB |
Biological signatures of brain damage associated with high serum ferritin levels in patients with acute ischemic stroke and thrombolytic treatment
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Millán, Mònica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sobrino, Tomás ;
Arenillas, Juan F.. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez-Yáñez, Manuel ;
García, María ;
Nombela, Florentino ;
Castellanos, María del Mar ;
Pérez de la Ossa, Natalia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cuadras, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Background and purpose : Increased body iron stores have been related to greater oxidative stress and brain injury in clinical and experimental cerebral ischemia and reperfusion. We aimed to investigate the biological signatures of excitotoxicity, inflammation and blood brain barrier disruption potentially associated with high serum ferritin levels-related damage in acute stroke patients treated with i. [...]
2008 - 10.1155/2008/380356
Disease markers, Vol. 25 (12 2008) , p. 181-188
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11 p, 1.4 MB |
Study of protein expresion in peri-infarct tissue after cerebral ischemia
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Brea, David (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Agulla, Jesús (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Staes, An (Ghent University) ;
Gevaert, Kris (Ghent University) ;
Campos, Francisco (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Sobrino, Tomás (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Blanco, Miguel (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Castillo, José (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Ramos-Cabrer, Pedro (Instituto de Investigación Sanitaria de Santiago (IDIS))
In this work, we report our study of protein expression in rat peri-infarct tissue, 48 h after the induction of permanent focal cerebral ischemia. Two proteomic approaches, gel electrophoresis with mass spectrometry and combined fractional diagonal chromatography (COFRADIC), were performed using tissue samples from the periphery of the induced cerebral ischemic lesions, using tissue from the contra-lateral hemisphere as a control. [...]
2015 - 10.1038/srep12030
Scientific reports, Vol. 5 (2015) , article 12030
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