Home > Search Results: Sonenberg, Nahum
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Articles, 2 records found
Articles 2 records found  
1.
22 p, 4.8 MB Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T : A Rationale for Novel Therapeutic Approaches / Martínez, Alba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sesé, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ; Robichaud, Nathaniel (McGill University) ; Sonenberg, Nahum (McGill University) ; Aasen, Trond (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
Phosphorylation of the eukaryotic translation initiation factor eIF4E is associated with malignant progression and poor cancer prognosis. Accordingly, here we have analyzed the association between eIF4E phosphorylation and cellular resistance to oxidative stress, starvation, and DNA-damaging agents in vitro. [...]
2015 - 10.1371/journal.pone.0123352
PloS one, Vol. 10 (april 2015)  
Detailed record - Creative Commons
2.
12 p, 4.3 MB Beyond molecular tumor heterogeneity : protein synthesis takes control / Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Castellvi, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hümmer, Stefan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Peg, Vicente (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pelletier, Jerry (Montreal, QC Canada) ; Sonenberg, Nahum (Montreal, QC Canada) ; Universitat Autònoma de Barcelona
One of the daunting challenges facing modern medicine lies in the understanding and treatment of tumor heterogeneity. Most tumors show intra-tumor heterogeneity at both genomic and proteomic levels, with marked impacts on the responses of therapeutic targets. [...]
2018 - 10.1038/s41388-018-0152-0
Oncogene, Vol. 37 (february 2018) , p. 2490-2501  
Detailed record - Creative Commons

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