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Articles, 21 records found
Research literature, 8 records found
Course materials, 2 records found
Articles 21 records found  1 - 10nextend  jump to record:
1.
7 p, 176.2 KB Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients : an expert taskforce review / García-Foncillas, J (Hospital Universitario Fundación Jiménez Díaz) ; Alba, E (Hospital Universitario Regional Virgen de la Victoria, IBIMA, Málaga) ; Aranda, E (Hospital Reina Sofía, Cordoba) ; Díaz Rubio, E (Universidad Complutense de Madrid. Hospital Clínico San Carlos) ; López López, R (Hospital Clínico Universitario (Santiago de Compostela)) ; Tabernero Caturla, Josep (Universitat Autònoma de Barcelona) ; Vivancos, A (Vall d'Hebron Institut d'Oncologia)
The importance of mutation identification for advanced colorectal cancer treatment with anti-epidermal growth factor receptor agents is well established. However, due to delays in turnaround time, low-quality tissue samples, and/or lack of standardization of testing methods a significant proportion of patients are being treated without the information that Kirsten rat sarcoma and neuroblastoma rat sarcoma (RAS) testing can provide. [...]
2017 - 10.1093/annonc/mdx501
Annals of Oncology, Vol. 28 (september 2017) , p. 2943-2949  
2.
8 p, 196.5 KB Comparison between MRI and pathology in the assessment of tumour regression grade in rectal cancer / Sclafani, Francesco (Department of Medicine, The Royal Marsden NHS Foundation Trust) ; Brown, Gina (Department of Radiology, The Royal Marsden NHS Foundation Trust) ; Cunningham, David (Department of Medicine, The Royal Marsden NHS Foundation Trust) ; Wotherspoon, Andrew (Department of Histopathology, The Royal Marsden NHS Foundation Trust) ; Mendes, Larissa Sena Teixeira (Department of Histopathology, The Royal Marsden NHS Foundation Trust) ; Balyasnikova, Svetlana (Department of Radiology, The Royal Marsden NHS Foundation Trust) ; Evans, Jessica (Department of Radiology, The Royal Marsden NHS Foundation Trust) ; Peckitt, Clare (Clinical Research & Development, The Royal Marsden NHS Foundation Trust) ; Begum, Ruwaida (Department of Medicine, The Royal Marsden NHS Foundation Trust) ; Tait, Diana (Department of Medicine, The Royal Marsden NHS Foundation Trust) ; Tabernero Caturla, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ; Glimelius, Bengt (Department of Immunology, Genetics and Pathology, Section of Experimental and Clinical Oncology, University of Uppsala) ; Roselló, Susana (Department of Haematology and Medical Oncology, Biomedical Research Institute INCLIVA, University of Valencia) ; Thomas, Janet (Department of Medicine, The Royal Marsden NHS Foundation Trust) ; Oates, Jacqui (Department of Medicine, The Royal Marsden NHS Foundation Trust) ; Chau, Ian (Department of Medicine, The Royal Marsden NHS Foundation Trust)
Limited data exist regarding the correlation between MRI tumour regression grade (mrTRG) and pathological TRG (pTRG) in rectal cancer. mrTRG and pTRG were compared in rectal cancer patients from two phase II trials (EXPERT and EXPERT-C). [...]
2017 - 10.1038/bjc.2017.320
British Journal of Cancer, Vol. 117 (09 2017) , p. 1478-1485  
3.
8 p, 2.4 MB Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations / Tamborero, David (Institut d'Investigació Mèdica Hospital del Mar (IMIM)) ; Rubio-Perez, Carlota (Institut d'Investigació Mèdica Hospital del Mar (IMIM)) ; Deu-Pons, Jordi (Institut d'Investigació Mèdica Hospital del Mar (IMIM)) ; Schroeder, Michael P. (Charité-Universitätsmedizin (Germany)) ; Vivancos, Ana (Vall d'Hebron Institut d'Oncologia) ; Rovira, Ana (Institut d'Investigació Mèdica Hospital del Mar (IMIM)- CIBERONC) ; Tusquets, Ignasi (Institut d'Investigació Mèdica Hospital del Mar (IMIM)) ; Albanell, Joan (Institut d'Investigació Mèdica Hospital del Mar (IMIM)) ; Rodón Ahnert, Jordi (Vall d'Hebron Institut d'Oncologia) ; Tabernero Caturla, Josep (Vall d'Hebron Institut d'Oncologia) ; de Torres, Carmen (Institut de Recerca Pediàtrica. Hospital Sant Joan de Déu) ; Dienstmann, Rodrigo (Vall d'Hebron Institut d'Oncologia) ; Gonzalez-Perez, Abel (Institut d'Investigació Mèdica Hospital del Mar (IMIM)) ; Lopez-Bigas, Nuria (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ; Universitat Autònoma de Barcelona
While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck. Here we present the Cancer Genome Interpreter, a versatile platform that automates the interpretation of newly sequenced cancer genomes, annotating the potential of alterations detected in tumors to act as drivers and their possible effect on treatment response. [...]
2018 - 10.1186/s13073-018-0531-8
Genome Medicine, Vol. 10 (March 2018) , art. 25  
4.
11 p, 388.8 KB Meta-analysis of individual patient safety data from six randomized, placebo-controlled trials with the antiangiogenic VEGFR2-binding monoclonal antibody ramucirumab / Arnold, D (Instituto CUF de Oncologia (I.C.O.), Lisboa) ; Fuchs, C S (Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA) ; Tabernero Caturla, Josep (Universitat Autònoma de Barcelona) ; Ohtsu, A (Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan) ; Zhu, A X (Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, USA) ; Garon, E B (Hematology Oncology, David Geffen School of Medicine at UCLA Translational Research in Oncology-US Network, Santa Monica, USA) ; Mackey, J R (Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Canada) ; Paz Ares, L (Hospital Universitario Doce de Octubre. Departamento de Oncologia Médica) ; Baron, A D (Division of Hematology Oncology, California Pacific Medical Center, San Francisco, USA) ; Okusaka, T (Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan) ; Yoshino, T (Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan) ; Yoon, H H (Division of Medical Oncology, Mayo Clinic, Rochester, USA) ; Das, M (Oncology, Eli Lilly and Company, Indianapolis, USA) ; Ferry, D (Oncology, Eli Lilly and Company, Bridgewater, USA) ; Zhang, Y (Oncology, Eli Lilly and Company, Bridgewater, USA) ; Lin, Y (Oncology, Eli Lilly and Company, Indianapolis, USA) ; Binder, P (Oncology, Eli Lilly and Company, Bridgewater, USA) ; Sashegyi, A (Oncology, Eli Lilly and Company, Indianapolis, USA) ; Chau, I (Department of Medicine, Royal Marsden Hospital, Sutton, UK)
Ramucirumab, the human immunoglobulin G1 monoclonal antibody receptor antagonist of vascular endothelial growth factor receptor 2, has been approved for treating gastric/gastroesophageal junction, non-small-cell lung, and metastatic colorectal cancers. [...]
2017 - 10.1093/annonc/mdx514
Annals of Oncology, Vol. 28 (september 2017) , p. 2932-2942  
5.
7 p, 242.6 KB Primary tumor sidedness has an impact on prognosis and treatment outcome in metastatic colorectal cancer : results from two randomized first-line panitumumab studies / Boeckx, N. (Center of Medical Genetics, University of Antwerp and Antwerp University Hospital) ; Koukakis, R. (Biostatistics, Amgen Ltd) ; Op de Beeck, K. (Center of Medical Genetics, University of Antwerp and Antwerp University Hospital) ; Rolfo, C. (Department of Oncology, Antwerp University Hospital, Edegem) ; Van Camp, G. (Center of Medical Genetics, University of Antwerp and Antwerp University Hospital) ; Siena, S. (Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano) ; Tabernero Caturla, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ; Douillard, J.-Y. (Medical Oncology, Institut de Cancérologie de l'Ouest (ICO) René Gauducheau, Nantes, France) ; André, T. (Department of Medical Oncology, Hôpital Saint Antoine; Sorbonne Universités, UMPC Paris 06 and GERCOR, Paris, France) ; Peeters, M. (Department of Oncology, Antwerp University Hospital, Edegem)
Previous studies have reported the prognostic impact of primary tumor sidedness in metastatic colorectal cancer (mCRC) and its influence on cetuximab efficacy. The present retrospective analysis of two panitumumab trials investigated a possible association between tumor sidedness and treatment efficacy in first-line mCRC patients with RAS wild-type (WT) primary tumors. [...]
2017 - 10.1093/annonc/mdx119
Annals of Oncology, Vol. 28 (april 2017) , p. 1862-1868  
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8 p, 357.7 KB Concordance of blood- and tumor-based detection of RAS mutations to guide anti-EGFR therapy in metastatic colorectal cancer / Grasselli, J (Institut Català d'Oncologia) ; Élez Fernández, Mª Elena (Universitat Autònoma de Barcelona) ; Caratù, G (Vall d'Hebron Institut d'Oncologia) ; Matito, J (Vall d'Hebron Institut d'Oncologia) ; Santos, C (Institut Català d'Oncologia) ; Macarulla Mercadé, Teresa (Universitat Autònoma de Barcelona. Hospital Universitari de la Vall d'Hebron) ; Vidal, J (Hospital del Mar. Departament d'Oncologia) ; Garcia, M (Institut Català d'Oncologia) ; Viéitez, J M (Hospital Universitario de Asturias. Departamento de Oncologia Médica) ; Paéz, D (Institut d'Investigació Biomèdica Sant Pau) ; Falcó, E (Hospital Universitari Son Llatzer. Departament d'Oncologia Mèdica) ; Lopez Lopez, C (Hospital Universitario Marqués de Valdecilla. Departamento de Oncología Médica) ; Aranda, E (Hospital Universitario Reina Sofía (Córdoba). Departamento de Oncología Médica) ; Jones, F (Sysmex Inostics, Mundelein, USA) ; Sikri, V (Sysmex Inostics, Mundelein, USA) ; Nuciforo, Paolo (Vall d'Hebron Institut d'Oncologia) ; Fasani, R (Vall d'Hebron Institut d'Oncologia) ; Tabernero Caturla, Josep (Universitat Autònoma de Barcelona) ; Montagut, C (Hospital del Mar. Departament d'Oncologia) ; Azuara, D (Institut Català d'Oncologia) ; Dienstmann, Rodrigo (Vall d'Hebron Institut d'Oncologia) ; Salazar, R (Institut Català d'Oncologia) ; Vivancos, A (Vall d'Hebron Institut d'Oncologia)
Circulating tumor DNA (ctDNA) is a potential source for tumor genome analysis. We explored the concordance between the mutational status of RAS in tumor tissue and ctDNA in metastatic colorectal cancer (mCRC) patients to establish eligibility for anti-epidermal growth factor receptor (EGFR) therapy. [...]
2017 - 10.1093/annonc/mdx112
Annals of Oncology, Vol. 28 (march 2017) , p. 1294-1301  
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10 p, 1016.0 KB Global cancer control : responding to the growing burden, rising costs and inequalities in access / Prager, Gerald W (Medical University of Vienna) ; Braga, Sofia (Instituto CUF Oncologia) ; Bystricky, Branislav (Faculty Hospital Trencin) ; Qvortrup, Camilla (Odense University Hospital. Department of Oncology) ; Criscitiello, Carmen (Istituto Europeo di Oncologia) ; Esin, Ece (Ankara Oncology Education and Research Hospital) ; Sonke, Gabe S (Netherlands Cancer Institute) ; Argilés Martínez, Guillem (Vall d'Hebron Institut d'Oncologia) ; Frenel, Jean-Sebastian (Institut de Cancerologie de l'Ouest Saint-Herblain) ; Karamouzis, Michalis (National and Kapodistrian University of Athens) ; Strijbos, Michiel (AZ KLINA Hospitals) ; Yazici, Ozan (Ankara Numune Education and Research Hospital) ; Bossi, Paolo (Fondazione IRCCS Istituto Nazionale Tumori Milano) ; Banerjee, Susana (Royal Marsden Hospital NHS Foundation Trust) ; Troiani, Teresa (Università degli Studi della Campania Luigi Vanvitelli) ; Eniu, Alexandru (Cancer Institute "Ion Chiricuta") ; Ciardiello, Fortunato (Università degli Studi della Campania Luigi Vanvitelli) ; Tabernero Caturla, Josep (Universitat Autònoma de Barcelona.Departament de Medicina) ; Zielinski, Christoph C (Medical University Vienna, General Hospital, and Vienna Cancer Center) ; Casali, Paolo G (Istituto Nazionale Tumori) ; Cardoso, Fatima (Champalimaud Clinical Center) ; Douillard, Jean-Yves (European Society for Medical Oncology) ; Jezdic, Svetlana (European Society for Medical Oncology) ; McGregor, Keith (European Society for Medical Oncology) ; Bricalli, Gracemarie (European Society for Medical Oncology) ; Vyas, Malvika (European Society for Medical Oncology) ; Ilbawi, André (Disability, Violence and Injury Prevention (NVI), World Health Organization)
The cancer burden is rising globally, exerting significant strain on populations and health systems at all income levels. In May 2017, world governments made a commitment to further invest in cancer control as a public health priority, passing the World Health Assembly Resolution 70. [...]
2018 - 10.1136/esmoopen-2017-000285
ESMO Open, Vol. 3 (february 2018)  
8.
7 p, 770.6 KB Proxies of quality of life in metastatic colorectal cancer : analyses in the RECOURSE trial / Van Cutsem, Eric (University Hospitals Leuven and KU Leuven) ; Falcone, Alfredo (Azienda Ospedaliero-Universitaria Pisana) ; García Carbonero, Rocio (Hospital Universitario 12 de Octubre/i+12) ; Komatsu, Yoshito (Hokkaido University Hospital) ; Pastorino, Alessandro (IRCCS AOU San Martino IST) ; Peeters, Marc (Antwerp University Hospital) ; Shimada, Yasuhiro (National Cancer Center Hospital) ; Yamazaki, Kentaro (Shizuoka Cancer Center) ; Yoshino, Takayuki (National Cancer Center Hospital East) ; Zaniboni, Alberto (Fondazione Poliambulanza) ; Amellal, Nadia (Institut de Recherches Servier) ; Kanehisa, Akira (Institut de Recherches Servier) ; Winkler, Robert (Taiho Oncology) ; Makris, Lukas (Taiho Oncology) ; Mayer, Robert J (Dana-Farber Cancer Institute) ; Ohtsu, Atsushi (National Cancer Center Hospital East) ; Tabernero Caturla, Josep (Universitat Autònoma de Barcelona. Deaprtament de Medicina)
In the pivotal phase III, randomised, double-blind, placebo-controlled RECOURSE study, treatment with trifluridine/tipiracil was well tolerated and associated with prolonged progression-free and overall survival in patients with metastatic colorectal cancer (mCRC). [...]
2017 - 10.1136/esmoopen-2017-000261
ESMO Open, Vol. 2 (november 2017)  
9.
11 p, 927.9 KB A Multi-Arm Phase I Study of the PI3K/mTOR Inhibitors PF-04691502 and Gedatolisib (PF-05212384) plus Irinotecan or the MEK Inhibitor PD-0325901 in Advanced Cancer / Wainberg, Zev A. (David Geffen School of Medicina, UCLA (USA)) ; Alsina Maqueda, Maria (Institut d'Oncologia de la Vall Hebron (VHIO)) ; Soares, Heloisa P. (Moffitt Cancer Center (USA)) ; Braña, Irene (Princess Margaret Cancer Centre (Canada)) ; Britten, Carolyn D. (Medical University of South Carolina (USA)) ; Del Conte, Gianluca (IRCCS Ospedale San Raffaele(Italy)) ; Ezeh, Patrick (Pfizer Oncology (USA)) ; Houk, Brett (Pfizer Oncology (USA)) ; Kern, Kenneth A. (Pfizer Oncology (USA)) ; Leong, Stephen (University of Colorado (USA)) ; Pathan, Nuzhat (Pfizer Oncology, 10646 Science Center Drive, San Diego, CA 92121 USA) ; Pierce, Kristen J. (Pfizer Oncology (USA)) ; Siu, Lillian L. (Princess Margaret Cancer Centre (Canada)) ; Vermette, Jennifer (Pfizer Oncology (USA)) ; Tabernero Caturla, Josep (Institut d'Oncologia de la Vall Hebron (VHIO)) ; Universitat Autònoma de Barcelona
This phase I, four-arm, open-label study (NCT01347866) evaluated the PI3K/mTOR inhibitors PF-04691502 (arms A, B) and gedatolisib (PF-05212384; arms C, D) in combination with the MEK inhibitor PD-0325901 (arm A, D) or irinotecan (arm B, C) in patients with advanced solid tumors. [...]
2017 - 10.1007/s11523-017-0530-5
Targeted Oncology, Vol. 12, Issue 6 (December 2017) , p. 775-785  
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39 p, 4.7 MB mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer / Zabala Letona, Amaia (CIBERONC) ; Arruabarrena Aristorena, Amaia (CIC bioGUNE) ; Martín Martín, Natalia (CIBERONC) ; Fernández Ruiz, Sonia (CIBERONC) ; Sutherland, James D. (CIC bioGUNE) ; Clasquin, Michelle (AGIOS Pharmaceuticals) ; Tomás Cortázar, Julen (CIC bioGUNE) ; Jiménez, José (Hospital Universitari Vall d'Hebron) ; Torres Ramírez, Inés Ma. de (Hospital Universitari Vall d'Hebron) ; Quang, Phong (AGIOS Pharmaceuticals) ; Ximénez Embun, Pilar (Spanish National Cancer Research Centre) ; Bago, Ruzica (MRC Protein Phosphorylation and Ubiquitylation Unit) ; Ugalde Olano, Aitziber (Basurto University Hospital) ; Loizaga Iriarte, Ana (Basurto University Hospital) ; Lacasa Viscasillas, Isabel (Basurto University Hospital) ; Unda, Miguel (Basurto University Hospital) ; Torrano, Verónica (CIBERONC) ; Cabrera, Diana (CIC bioGUNE) ; van Liempd, Sebastiaan M. (CIC bioGUNE) ; Cendon, Ylenia (Universidad Autónoma de Madrid) ; Castro, Elena (Spanish National Cancer Research Centre) ; Murray, Stuart (AGIOS Pharmaceuticals) ; Revandkar, Ajinkya (University of Lausanne) ; Alimonti, Andrea (University of Lausanne) ; Zhang, Yinan (Harvard School of Public Health) ; Barnett, Amelia (AGIOS Pharmaceuticals) ; Lein, Gina (AGIOS Pharmaceuticals) ; Pirman, David (AGIOS Pharmaceuticals) ; Cortázar, Ana R. (CIC bioGUNE) ; Arreal, Leire (CIC bioGUNE) ; Prudkin, Ludmila (Hospital Universitari Vall d'Hebron) ; Astobiza, Ianire (CIC bioGUNE) ; Valcárcel Jiménez, Lorea (CIC bioGUNE) ; Zúñiga García, Patricia (CIC bioGUNE) ; Fernández Domínguez, Itziar (CIC bioGUNE) ; Piva, Marco (CIC bioGUNE) ; Caro Maldonado, Alfredo (CIC bioGUNE) ; Sánchez Mosquera, Pilar (CIC bioGUNE) ; Castillo Martín, Mireia (Fundação Champalimaud) ; Serra, Violeta (Hospital Universitari Vall d'Hebron) ; Beraza, Naiara (CIC bioGUNE) ; Gentilella, Antonio (Catalan Institute of Oncology) ; Thomas, George (Catalan Institute of Oncology) ; Azkargorta, Mikel (Carlos III Networked Proteomics Platform) ; Elortza, Felix (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Farràs, Rosa (Centro de Investigación Príncipe Felipe) ; Olmos, David (Hospitales Universitarios Virgen de la Victoria y Regional de Málaga) ; Efeyan, Alejo (Spanish National Cancer Research Centre) ; Anguita, Juan (Ikerbasque) ; Muñoz, Javier (Carlos III Networked Proteomics Platform) ; Falcón Pérez, Juan M. (Ikerbasque) ; Barrio, Rosa (CIC bioGUNE) ; Macarulla Mercadé, Teresa (Hospital Universitari Vall d'Hebron) ; Mato, José M. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Martínez Chantar, Maria L. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Cordon Cardo, Carlos (Icahn School of Medicine at Mount Sinai) ; Aransay, Ana M. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Marks, Kevin (AGIOS Pharmaceuticals) ; Baselga Torres, Josep, 1959-, (Memorial Sloan-Kettering Cancer Center) ; Tabernero Caturla, Josep (Hospital Universitari Vall d'Hebron) ; Nuciforo, Paolo (Hospital Universitari Vall d'Hebron) ; Manning, Brendan D. (Harvard School of Public Health) ; Marjon, Katya (AGIOS Pharmaceuticals) ; Carracedo, Arkaitz (University of the Basque Country) ; Universitat Autònoma de Barcelona
Activation of the PTEN-PI3K-mTORC1 pathway consolidates metabolic programs that sustain cancer cell growth and proliferation,. Here we show that mTORC1 regulates polyamine dynamics, a metabolic route that is essential for oncogenicity. [...]
2017 - 10.1038/nature22964
Nature, Vol. 547 (July 2017) , p. 109-113  

Articles : 21 records found   1 - 10nextend  jump to record:
Research literature 8 records found  
1.
124 p, 2.7 MB Caracterización molecular de los tumores de vías biliares avanzados e identificación de biomarcadores potenciales predictivos de respuesta a nuevas dianas terapéuticas / Saurí Nadal, Tamara, autor. ; Tabernero Caturla, Josep, supervisor acadèmic. ; Macarulla, Teresa, supervisor acadèmic. ; Selva O'Callaghan, Albert, supervisor acadèmic. ; Universitat Autònoma de Barcelona. Departament de Medicina.
Antecedentes: El cáncer de vía biliar (CVB) tiene un mal pronóstico y el beneficio del tratamiento con quimioterapia sistémica es modesto. En esta Tesis Doctoral se efectúa un estudio genómico de los CVB; se analiza la presencia de alteraciones moleculares clínicamente relevantes (AGCR) y se definen las alteraciones moleculares en función de la localización del tumor en el árbol biliar. [...]
Background: Biliary tract cancer (BTC) has a poor prognosis and treatment with systemic chemotherapy provides a modest benefit. In the present Doctoral Thesis, it is proposed whether genomic comprehensive profiling (GCP) of the BTC would reveal clinically relevant genomic alterations (CRGA), which may be different depending on the tumor location in the biliary tree. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2019.  
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123 p, 1.8 MB Análisis de RAS en plasma en cáncer colorrectal metastásico: impacto de la fracción mutante alélica en pronóstico / Sanz García, Enrique, autor. ; Tabernero Caturla, Josep, supervisor acadèmic. ; Élez Fernández, María Elena, supervisor acadèmic. ; Universitat Autònoma de Barcelona. Departament de Medicina.
Introducción: A pesar de los importantes avances en el tratamiento del cáncer de colon metastásico (mCRC), la supervivencia sigue siendo corta. Existen diversos factores pronósticos y predictivos que se han de tener en cuenta, entre ellos la mutación del oncogén RAS presente en más del 40% de tumores. [...]
Introduction: Despite recent major advances in metastatic colorrectal cancer (mCRC), survival is still poor. There are different prognostic and predictive factors to be taken into account, among them, RAS mutation which is observed in 40% of all tumors. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2019.  
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84 p, 8.1 MB Anticancer targeted agent combination / Braña García, Irene, autor. ; Pham, Nhu-An, supervisor acadèmic. ; Tabernero Caturla, Josep, supervisor acadèmic. ; Giralt López de Sagredo, Jorge Luis, supervisor acadèmic. ; Universitat Autònoma de Barcelona. Departament de Medicina.
Las toxicidades limitantes de dosis fuero una neutropenia febril grado 4 (en el brazo de docetaxel) y una neutropenia grado 3 en el brazo de gemcitabina. La combinación de carlumab no tuvo un impacto El cáncer es una enfermedad altamente frecuente y con alta mortalidad. [...]
Cancer is a highly frequent disease associated to high mortality. Drug development in Oncology has shown to be inefficient, having one of the lowest success rate of drugs entering in phase I trials that finally achieves marketed authorization. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2017.  
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155 p, 5.3 MB Caracterización molecular del cáncer gástrico HER2 positivo; mecanismos de resistencia al tratamiento con anticuerpos monoclonales dirigidos / Alsina Maqueda, Maria, autor ; Tabernero Caturla, Josep, supervisor acadèmic ; Giralt López de Sagredo, Jorge Luis, supervisor acadèmic ; Universitat Autònoma de Barcelona. Departament de Medicina
El cáncer gástrico (CG) y de la unión gastro-esofágica (CUGE) representa un problema a nivel mundial; si bien es la 5ª causa más frecuente de cáncer, se sitúa la 3ª como causa de muerte por cáncer. [...]
Gastric cancer (GC) and gastro-esophageal junction cancer (GEJC) is a worldwide problem; although it is the 5th most common cause of cancer, it remains the 3rd cause of death from cancer. The prognosis of patients with metastatic GC is very poor, with 5 year survival rates of less than 5%. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  
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119 p, 1.2 MB Tipificació molecular de tumors neuroendocrins gastroenteropancreàtics. Desenvolupament de noves teràpies i búsqueda de nous biomarcadors / Capdevila i Castillón, Jaume ; Tabernero Caturla, Josep, dir. ; Giralt López de Sagredo, Jorge Luis, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
El coneixement de la biologia molecular responsable de la carcinogènesi de les neoplàsies neuroendocrines segueix essent limitada avui en dia. Aquest fet, ha limitat la identificació de biomarcadors pronòstics i predictius i el desenvolupament de teràpies dirigies en aquesta població de pacients. [...]
The knowledge of the molecular biology of the neuroendocrine tumors carcinogenesis is still limited today. This fact has limited predictive and prognostic biomarker identification and the development of therapies aimed at this population of patients. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  
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84 p, 798.0 KB Análisis molecular en tumores de páncreas avanzados para identificar biomarcadores predictivos de respuesta a nuevas drogas biológicas / Macarulla Mercadé, Teresa ; Tabernero Caturla, Josep, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
Pancreatic cancer presented a dismal prognosis. During the last years an efford has been done in order to improve the results of the chemotherapy in this tumor, however, the overall survival in these patients is less than twelve months. [...]
El cáncer de páncreas es una enfermedad con un pronostico infausto en el momento actual. Durante los últimos años se ha realizado un esfuerzo para intentar mejorar el tratamiento oncológico de este tumor, no obstante, la supervivencia de los pacientes con un cáncer de páncreas avanzado no llega a los doce meses de vida como media. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2015  
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46 p, 812.1 KB Nuevas terapias en cáncer colorrectal metastásico refractario: papel de los fármacos que interfieren en la vía de met e integrinas / Élez Fernández, Mª Elena ; Tabernero Caturla, Josep, dir. ; Selva O'Callaghan, Albert ; Universitat Autònoma de Barcelona. Departament de Medicina
Pendent.
[Barcelona] : Universitat Autònoma de Barcelona, 2015  
8.
96 p, 1.0 MB Aportación de los estudios farmacodinámicos en el desarrollo de tratamientos dirigidos contra dianas moleculares de cascadas de señalización proliferativas / Tabernero Caturla, Josep ; Baselga Torres, Josep, 1959- , dir. (Vall d'Hebron Hospitals) ; Universitat Autònoma de Barcelona. Departament de Medicina
Esta tesis doctoral se ha realizado por compendio de publicaciones de dos estudios fase I desarrollados en el servicio de Oncología del Hospital Vall d'Hebron, de la Universitat Autònoma de Barcelona, en Barcelona, España. [...]
This doctoral thesis has been written on the basis of two publications of two phase I studies developed at the Medical Oncology Department at the Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain. [...]

Bellaterra : Universitat Autònoma de Barcelona, 2013  

Course materials 2 records found  
1.
8 p, 100.4 KB Oncologia Mèdica [103617] / Barnadas Molins, Agusti ; Seguí Palmer, Miquel Angel ; Balaña Quintero, Carme ; Tabernero Caturla, Josep Maria ; Universitat Autònoma de Barcelona. Facultat de Medicina
L'Oncologia Mèdica és una especialitat mèdica que s'ocupa del diagnòstic, tractament i atenció integral dels pacients que pateixen un càncer. Les malalties oncològiques representen ser la segona causa de mort en els països occidentals i tenir un coneixement de les mateixes ha de permetre als futurs graduats en medicina tenir competència en l'atenció d'aquests malalts englobant aspectes d'orientació diagnòstica i terapèutica, identificació de les complicacions derivades del tractament, el control dels símptomes en la malaltia avançada, l'atenció al malalt terminal i alhora alguns aspectes sobre la prevenció. [...]
La Oncología Médica es una especialidad médica que se ocupa del diagnóstico, tratamiento y atención integral de los pacientes que sufren un cáncer. Las enfermedades oncológicas representan la segunda causa de muerte en los países occidentales y tener un conocimiento de las mismas tiene que permitir a los futuros graduados en medicina tener competencia en la atención de estos enfermos englobando aspectos de orientación diagnóstica y terapéutica, identificación de las complicaciones derivadas del tratamiento, el control de los síntomas en la enfermedad adelantada y al mismo tiempo algunos aspectos sobre la prevención. [...]

2018-19
Grau en Medicina [1192]
2 documents
2.
7 p, 98.7 KB Oncologia Mèdica [103617] / Barnadas Molins, Agusti ; Seguí Palmer, Miquel Angel ; Balaña Quintero, Carme ; Tabernero Caturla, Josep Maria ; Universitat Autònoma de Barcelona. Facultat de Medicina
L'Oncologia Mèdica és una especialitat mèdica que s'ocupa del diagnòstic, tractament i atenció integral dels pacients que pateixen un càncer. Les malalties oncològiques representen ser la segona causa de mort en els països occidentals i tenir un coneixement de les mateixes ha de permetre als futurs graduats en medicina tenir competència en l'atenció d'aquests malalts englobant aspectes d'orientació diagnòstica i terapèutica, identificació de les complicacions derivades del tractament, el control dels símptomes en la malaltia avançada, l'atenció al malalt terminal i alhora alguns aspectes sobre la prevenció. [...]
La Oncología Médica es una especialidad médica que se ocupa del diagnóstico, tratamiento y atención integral de los pacientes que sufren un cáncer. Las enfermedades oncológicas representan la segunda causa de muerte en los países occidentales y tener un conocimiento de las mismas tiene que permitir a los futuros graduados en medicina tener competencia en la atención de estos enfermos englobando aspectos de orientación diagnóstica y terapéutica, identificación de las complicaciones derivadas del tratamiento, el control de los síntomas en la enfermedad adelantada y al mismo tiempo algunos aspectos sobre la prevención. [...]

2017-18
Grau en Medicina [1192]
2 documents

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