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14 p, 221.9 KB |
The Use of Antihypertensive Medication and the Risk of Breast Cancer in a Case-Control Study in a Spanish Population : The MCC-Spain Study
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Gomez-Acebo, Ines (Universidad de Cantabria) ;
Dierssen-Sotos, Trinidad (Universidad de Cantabria) ;
Palazuelos, Camilo (Universidad de Cantabria) ;
Pérez-Gómez, Beatriz (Cancer Epidemiology Research Group (Madrid)) ;
Lope, Virginia (Cancer Epidemiology Research Group (Madrid)) ;
Tusquets, Ignasi (Universitat Autònoma de Barcelona) ;
Alonso, M. Henar (Institut d'Investigació Biomèdica de Bellvitge) ;
Moreno Aguado, Víctor (Institut d'Investigació Biomèdica de Bellvitge) ;
Amiano, Pilar (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Molina de la Torre, Antonio José (Universidad de León) ;
Barricarte, Aurelio (Instituto de Investigación Sanitaria de Navarra) ;
Tardón, Adonina (Universidad de Oviedo) ;
Camacho, Antonio (Universidad de Huelva) ;
Peiro-Perez, Rosana (Fundación FISABIO- Salud Pública (València)) ;
Marcos-Gragera, Rafael (Institut Català d'Oncologia) ;
Muñoz, Montse (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Michelena-Echeveste, Maria Jesus (Onkologikoa- Oncology Institute Gipuzkoa) ;
Ortega Valin, Luis (Universidad de León) ;
Guevara, Marcela (Instituto de Investigación Sanitaria de Navarra) ;
Castaño-Vinyals, Gemma (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Aragonés, Nuria (Cancer Epidemiology Research Group, Oncology and Hematology Area (Madrid)) ;
Kogevinas, M (Universitat Pompeu Fabra) ;
Pollán, Marina (Cancer Epidemiology Research Group (Madrid)) ;
Llorca, Javier (Universidad de Cantabria)
The evidence on the relationship between breast cancer and different types of antihypertensive drugs taken for at least 5 years is limited and inconsistent. Furthermore, the debate has recently been fueled again with new data reporting an increased risk of breast cancer among women with a long history of use of antihypertensive drugs compared with nonusers. [...]
2016 -  10.1371/journal.pone.0159672
PloS one, Vol. 11 (august 2016)
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8 p, 1.9 MB |
Validating a breast cancer score in Spanish women. The MCC-Spain study
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Dierssen-Sotos, Trinidad (Universidad de Cantabria) ;
Gomez-Acebo, Ines (Universidad de Cantabria) ;
Palazuelos, Camilo (Universidad de Cantabria) ;
Fernández-Navarro, Pablo (IIS Puerta de Hierro) ;
Altzibar, Jone M. (Delegación Territorial de Salud y Consumo de Bizkaia) ;
González-Donquiles, Carmen (Universidad de León) ;
Ardanaz, Eva (Instituto de Investigación Sanitaria de Navarra) ;
Bustamante, Mariona (Universitat Pompeu Fabra) ;
Alonso-Molero, Jessica (Universidad de Cantabria) ;
Vidal, Carmen (Institut Català d'Oncologia) ;
Bayo-Calero, Juan (Universidad de Huelva) ;
Tardón, Adonina (Universidad de Oviedo) ;
Salas, Dolores (Agencia Valenciana de Salud) ;
Marcos-Gragera, Rafael (Institut Català d'Oncologia) ;
Morros, Rosa (Universitat de Barcelona. Departament de Ciències Clíniques) ;
Rodriguez-Cundin, Paz (Instituto de Investigación Sanitaria Valdecilla (Cantàbria)) ;
Vinyals, Gemma Castaño (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Ederra, María (Instituto de Investigación Sanitaria de Navarra) ;
Vilorio-Marqués, Laura (Universidad de León) ;
Amiano, Pilar (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Pérez-Gómez, Beatriz (IIS Puerta de Hierro) ;
Aragonés, Nuria (IIS Puerta de Hierro) ;
Kogevinas, M (School of Public Health (Grècia)) ;
Pollán, Marina (IIS Puerta de Hierro) ;
Llorca, Javier (Universidad de Cantabria) ;
Universitat Autònoma de Barcelona
A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. [...]
2018 - 10.1038/s41598-018-20832-0
Scientific reports, Vol. 8 (february 2018)
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18 p, 6.6 MB |
A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer
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López de Maturana, Evangelina (Centro de Investigación Biomédica en Red de Cáncer) ;
Rodríguez, Juan Antonio (Centre de Regulació Genòmica) ;
Alonso, Lola (Centro de Investigación Biomédica en Red de Cáncer) ;
Lao, Oscar (Centre de Regulació Genòmica) ;
Molina-Montes, Esther (Centro de Investigación Biomédica en Red de Cáncer) ;
Martín-Antoniano, Isabel Adoración (Centro de Investigación Biomédica en Red de Cáncer) ;
Gómez-Rubio, Paulina (Centro de Investigación Biomédica en Red de Cáncer) ;
Lawlor, Rita (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics) ;
Carrato, Alfredo (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Hidalgo, Manuel (Weill Cornell Medicine) ;
Iglesias, Mar (Parc de Salut MAR de Barcelona) ;
Molero, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Löhr, Matthias (Gastrocentrum, Karolinska Institutet and University Hospital) ;
Michalski, Christopher (Martin-Luther-University Halle-WittenberHalle (Saale). Department of Visceral, Vascular and Endocrine Surgery) ;
Perea, José (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
O'Rorke, Michael (The University of Iowa. College of Public Health) ;
Barberà, Victor Manuel (Hospital General Universitario de Elche) ;
Tardón, Adonina (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Farré, Antoni (Institut d'Investigació Biomèdica Sant Pau) ;
Muñoz-Bellvís, Luís (Instituto de Investigación Biomédica de Salamanca) ;
Crnogorac-Jurcevic, Tanja (Queen Mary University of London. Barts Cancer Institute, Centre for Molecular Oncology) ;
Domínguez-Muñoz, Enrique (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Gress, Thomas (University Hospital of Giessen and Marburg (Alemanya)) ;
Greenhalf, William (University of Liverpool. Department of Molecular and Clinical Cancer Medicine) ;
Sharp, Linda (Newcastle University, Institute of Health & Society) ;
Arnes, Luís (Columbia University Medical Center. Department of Systems Biology) ;
Cecchini, Lluís (Parc de Salut MAR de Barcelona) ;
Balsells, Joaquim (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Costello, Eithne (University of Liverpool. Department of Molecular and Clinical Cancer Medicine) ;
Ilzarbe, Lucas (Parc de Salut MAR de Barcelona) ;
Kleeff, Jörg (Martin-Luther-University Halle-WittenberHalle (Saale). Department of Visceral, Vascular and Endocrine Surgery) ;
Kong, Bo (Technical University of Munich. Department of Surgery) ;
Márquez, Mirari (Centro de Investigación Biomédica en Red de Cáncer) ;
Mora Brugués, Josefina (Institut d'Investigació Biomèdica Sant Pau) ;
O'Driscoll, Damian (University College Cork. National Cancer Registry Ireland and HRB Clinical Research Facility) ;
Scarpa, Aldo (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics) ;
Ye, Weimin (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
Yu, Jingru (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
García-Closas, Montserrat (Centro Nacional de Investigaciones Oncológicas) ;
Kogevinas, M.. (Hospital del Mar (Barcelona, Catalunya)) ;
Rothman, Nathaniel (Centro Nacional de Investigaciones Oncológicas) ;
Silverman, Debra T. (Centro Nacional de Investigaciones Oncológicas) ;
Albanes, Demetrius (Centro Nacional de Investigaciones Oncológicas) ;
Arslan, Alan A. (New York University School of Medicine. Department of Population Health) ;
Beane-Freeman, Laura (Centro Nacional de Investigaciones Oncológicas) ;
Bracci, Paige M. (University of California. Department of Epidemiology and Biostatistics) ;
Brennan, Paul (International Agency for Research on Cancer (IARC)) ;
Bueno-de-Mesquita, Bas (National Institute for Public Health and the Environment (RIVM). Deparment for Determinants of Chronic Diseases (DCD)) ;
Buring, Julie (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Canzian, Federico (German Cancer Research Center (DKFZ. Genomic Epidemiology Group) ;
Du, Margaret (Memorial Sloan Kettering Cancer Center) ;
Gallinger, Steven (Sinai Health System. Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute) ;
Gaziano, J. Michael (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Goodman, Phyllis J. (SWOG Statistical Center, Fred Hutchinson Cancer Research Center) ;
Gunter, Marc (International Agency for Research on Cancer (IARC)) ;
LeMarchand, Loic (University of Hawaii Cancer Center. Cancer Epidemiology Program) ;
Li, Donghui (University of Texas MD Anderson Cancer Center) ;
Neale, Rachael E. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia). Population Health Department) ;
Peters, Ulrika (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ;
Petersen, Gloria M. (Mayo Clinic College of Medicine. Department of Health Sciences Research) ;
Risch, Harvey A. (Yale School of Public Health. Department of Chronic Disease Epidemiology) ;
Sánchez, Maria José (Universidad de Granada) ;
Shu, Xiao-Ou (Vanderbilt University School of Medicine. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center) ;
Thornquist, Mark D. (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ;
Visvanathan, Kala (Mayo Clinic College of Medicine. Department of Health Sciences Research) ;
Zheng, Wei (Vanderbilt University School of Medicine. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center) ;
Chanock, Stephen (Centro Nacional de Investigaciones Oncológicas) ;
Easton, Douglas F (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Wolpin, Brian M. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Stolzenberg-Solomon, Rachael Z. (Centro Nacional de Investigaciones Oncológicas) ;
Klein, Alison P. (Johns Hopkins School of Medicine. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center) ;
Amundadottir, Laufey T. (National Cancer Institute (Bethesda, Estats Units d'Amèrica)) ;
Marti-Renom, Marc A. (Universitat Pompeu Fabra. Centre de Regulació Genòmica (CRG-UPF)) ;
Real, Francisco X (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Malats, Núria (Centro de Investigación Biomédica en Red de Cáncer)
Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4. [...]
2021 - 10.1186/s13073-020-00816-4
Genome Medicine, Vol. 13 (february 2021)
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