Toivonen, J.M. - Search Results - UAB Digital Repository of Documents

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Chemotherapeutic agent 5-fluorouracil increases survival of SOD1 mouse model of ALS / Rando, Amaya (Instituto de Investigación Sanitaria Aragón. Centro de Investigación Biomédica de Aragón (CIBA)) ; De La Torre, M. (Instituto de Investigación Sanitaria Aragón. Centro de Investigación Biomédica de Aragón (CIBA)) ; Martínez-Muriana, Anna (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Zaragoza, Pilar (Instituto de Investigación Sanitaria Aragón. Centro de Investigación Biomédica de Aragón (CIBA)) ; Musaro, A. (Center for Life Nano Science@Sapienza. Istituto Italiano di Tecnologia) ; Hernández Estañol, Sara (Institut de Recerca Biomèdica de Lleida) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Toivonen, J. M. (Instituto de Investigación Sanitaria Aragón. Centro de Investigación Biomédica de Aragón (CIBA)) ; Osta, R. (Instituto de Investigación Sanitaria Aragón. Centro de Investigación Biomédica de Aragón (CIBA))
Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease with no cure. Currently there are only two ALS drugs approved by the FDA, both with a limited therapeutic effect. In the search for drug candidates for ALS, we studied the effect of known stem cell mobilizing agents (treatment) and antimetabolite 5-fluorouracil (5-FU) (anti-treatment) in SOD1G93A model of ALS. [...]
2019 - DOI (Digital Object Identifier)

10.1371/journal.pone.0210752
PloS one, Vol. 14 Núm. 1 (january 2019) , p. e0210752

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1	Toivonen, J. M.

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