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34 p, 16.2 MB |
Stroke genetics informs drug discovery and risk prediction across ancestries
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Mishra, Aniket (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Malik, Rainer (University Hospital, LMU Munich. Institute for Stroke and Dementia Research (ISD)) ;
Hachiya, Tsuyoshi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Jürgenson, Tuuli (University of Tartu. Institute of Mathematics and Statistics) ;
Namba, Shinichi (Osaka University Graduate School of Medicine. Department of Statistical Genetics) ;
Posner, Daniel C. (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ;
Kamanu, Frederick K. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ;
Koido, Masaru (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ;
Le Grand, Quentin (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Shi, Mingyang (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ;
He, Yunye (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ;
Georgakis, Marios K. (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ;
Caro, Ilana (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Krebs, Kristi (University of Tartu. Estonian Genome Centre, Institute of Genomics) ;
Liaw, Yi-Ching (Chung Shan Medical University. Department of Public Health and Institute of Public Health) ;
Vaura, Felix C. (Finnish Institute for Health and Welfare. Department of Public Health and Welfare) ;
Lin, Kuang (University of Oxford. Nuffield Department of Population Health) ;
Winsvold, Bendik Slagsvold (Oslo University Hospital (Oslo, Noruega)) ;
Srinivasasainagendra, Vinodh (University of Alabama at Birmingham. Department of Biostatistics, School of Public Health) ;
Parodi, Livia (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ;
Bae, Hee-Joon (Seoul National University Bundang Hospital, Seoul National University College of Medicine. Department of Neurology and Cerebrovascular Disease Center) ;
Chauhan, Ganesh (Rajendra Institute of Medical Sciences) ;
Chong, Michael R. (McMaster University. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine) ;
Tomppo, Liisa (Helsinki University Hospital) ;
Akinyemi, Rufus (University of Ibadan. Neuroscience and Ageing Research Unit Institute for Advanced Medical Research and Training, College of Medicine) ;
Roshchupkin, Gennady V. (Erasmus MC University Medical Center Rotterdam. Department of Radiology and Nuclear Medicine) ;
Habib, Naomi (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences) ;
Jee, Yon Ho (Harvard T. H. Chan School of Public Health. Department of Epidemiology) ;
Thomassen, Jesper Qvist (Copenhagen University Hospital-Rigshospitalet. Department of Clinical Biochemistry) ;
Abedi, Vida (The Pennsylvania State University. Department of Public Health Sciences, College of Medicine) ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Nygaard, Marianne (Odense University Hospital (Dinamarca)) ;
Leonard, Hampton L. (Data Tecnica International) ;
Yang, Chaojie (University of Virginia. Department of Biochemistry and Molecular Genetics) ;
Yonova-Doing, Ekaterina (Novo Nordisk Research Centre Oxford. Department of Genetics) ;
Knol, Maria J. (Erasmus MC University Medical Center Rotterdam. Department of Epidemiology) ;
Lewis, Adam J. (Vanderbilt University Medical Center. Department of Biomedical Informatics) ;
Judy, Renae L. (University of Pennsylvania. Department of Surgery) ;
Ago, Tetsuro (Kyushu University. Department of Medicine and Clinical Science, Graduate School of Medical Sciences) ;
Amouyel, Philippe (Institut Pasteur de Lille) ;
Armstrong, Nicole D. (University of Alabama at Birmingham. Department of Epidemiology) ;
Bakker, Mark K. (University Medical Center Utrecht, University Utrecht. UMC Utrecht Brain Center, Department of Neurology and Neurosurgery) ;
Bartz, Traci M. (University of Washington. Department of Biostatistics) ;
Bennett, David A. (Rush University Medical Center. Rush Alzheimer's Disease Center) ;
Bis, Joshua C (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ;
Bordes, Constance (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Børte, Sigrid (Oslo University Hospital. Research and Communication Unit for Musculoskeletal Health (FORMI), Department of Research and Innovation, Division of Clinical Neuroscience) ;
Cain, Anael (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences) ;
Ridker, Paul M. (Harvard Medical School) ;
Cho, Kelly (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ;
Chen, Zhengming (University of Oxford. MRC Population Health Research Unit) ;
Cruchaga, Carlos (Washington University School of Medicine. NeuroGenomics and Informatics Center) ;
Cole, John W. (University of Maryland School of Medicine. Department of Neurology) ;
De Jager, Philip L (Columbia University Medical Center. Center for Translational and Computational Neuroimmunology, Department of Neurology) ;
de Cid, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Endres, Matthias (partner site Berlin. German Centre for Cardiovascular Research (DZHK)) ;
Ferreira, Leslie E. (Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil) ;
Geerlings, Mirjam I. (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ;
Gasca, Natalie C. (University of Washington. Department of Biostatistics) ;
Gudnason, Vilmundur (University of Iceland. Faculty of Medicine) ;
Hata, Jun (Kyushu University. Department of Epidemiology and Public Health, Graduate School of Medical Sciences) ;
He, Jing (Vanderbilt University Medical Center. Department of Biomedical Informatics) ;
Heath, Alicia K. (Imperial College London. Department of Epidemiology and Biostatistics, School of Public Health) ;
Ho, Yuk-Lam (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ;
Havulinna, Aki S (FIMM-HiLIFE. Institute for Molecular Medicine Finland) ;
Hopewell, Jemma C. (University of Oxford. Clinical Trial Service and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health) ;
Hyacinth, Hyacinth I. (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ;
Inouye, Michael (University of Cambridge. British Heart Foundation Centre of Research Excellence) ;
Jacob, Mina A. (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ;
Jeon, Christina E. (Los Angeles County Department of Public Health) ;
Jern, Christina (Sahlgrenska University Hospital (Suècia)) ;
Kamouchi, Masahiro (Kyushu University. Department of Health Care Administration and Management, Graduate School of Medical Sciences) ;
Keene, Keith L. (East Carolina University. Department of Biology, Brody School of Medicine Center for Health Disparities) ;
Kitazono, Takanari (Kyushu University. Department of Medicine and Clinical Science, Graduate School of Medical Sciences) ;
Kittner, Steven J. (VA Maryland Health Care System. Department of Neurology and Geriatric Research and Education Clinical Center) ;
Konuma, Takahiro (Osaka University Graduate School of Medicine. Department of Statistical Genetics) ;
Kumar, Amit (Rajendra Institute of Medical Sciences) ;
Lacaze, Paul (Monash University. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine) ;
Launer, Lenore Joy (National Institute on Aging, NIH. Intramural Research Program) ;
Lee, Keon-Joo (Korea University Guro Hospital. Department of Neurology) ;
Lepik, Kaido (University Center for Primary Care and Public Health, Lausanne, Switzerland) ;
Li, Jiang (Geisinger Health System. Department of Molecular and Functional Genomics, Weis Center for Research) ;
Li, Liming (Peking University Health Science Center. Department of Epidemiology and Biostatistics, School of Public Health) ;
Manichaikul, Ani (University of Virginia. Center for Public Health Genomics) ;
Markus, Hugh S. (University of Cambridge. Stroke Research Group, Department of Clinical Neurosciences) ;
Marston, Nicholas A. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ;
Meitinger, Thomas (German Research Center for Environmental Health. Institute of Human Genetics, Helmholtz Zentrum München) ;
Mitchell, Braxton D. (Baltimore Veterans Administration Medical Center. Geriatrics Research and Education Clinical Center) ;
Montellano, Felipe A. (University Hospital Würzburg. Department of Neurology) ;
Morisaki, Takayuki (The University of Tokyo. Division of Molecular Pathology, Institute of Medical Sciences) ;
Mosley, Thomas H. (University of Mississippi Medical Center. The MIND Center) ;
Nalls, Mike A. (Data Tecnica International) ;
Nordestgaard, Børge G. (University of Copenhagen. Department of Clinical Medicine) ;
O'Donnell, Martin J. (NUI Galway. College of Medicine Nursing and Health Science) ;
Okada, Yukinori (Osaka University. Center for Infectious Disease Education and Research (CiDER)) ;
Onland-Moret, N. Charlotte (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ;
Ovbiagele, Bruce (University of California, San Francisco. Weill Institute for Neurosciences) ;
Peters, Annette (German Centre for Cardiovascular Research (DZHK), partner site Munich) ;
Psaty, Bruce M. (University of Washington. Department of Health Systems and Population Health) ;
Rich, Stephen S. (University of Virginia. Center for Public Health Genomics) ;
Rosand, Jonathan (Massachusetts General Hospital. McCance Center for Brain Health) ;
Sabatine, Marc S. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ;
Sacco, Ralph L. (Evelyn F. McKnight Brain Institute) ;
Saleheen, Danish (Columbia University. Division of Cardiology, Department of Medicine) ;
Sandset, Else Charlotte (The Norwegian Air Ambulance Foundation. Research and Development) ;
Salomaa, Veikko (Finnish Institute for Health and Welfare. Department of Public Health and Welfare) ;
Sargurupremraj, Muralidharan (University of Texas Health Sciences Center. Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ;
Sasaki, Makoto (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Satizabal, Claudia L. (Framingham Heart Study) ;
Schmidt, Carsten O. (University Medicine Greifswald, Institute for Community Medicine, SHIP/KEF) ;
Shimizu, Atsushi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Smith, Nicholas L. (Seattle Epidemiologic Research and Information Center. Department of Veterans Affairs Office of Research and Development) ;
Sloane, Kelly L. (University of Pennsylvania. Department of Neurology) ;
Sutoh, Yoichi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Sun, Yan V. (Emory University Rollins School of Public Health. Department of Epidemiology) ;
Tanno, Kozo (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Tiedt, Steffen (University Hospital, LMU Munich. Institute for Stroke and Dementia Research (ISD)) ;
Tatlisumak, Turgut (Sahlgrenska University Hospital (Suècia)) ;
Torres-Aguila, Nuria P.. (Institut d'Investigació Biomèdica Sant Pau) ;
Tiwari, Hemant K. (University of Alabama at Birmingham. Department of Biostatistics, School of Public Health) ;
Trégouët, David-Alexandre (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Trompet, Stella (Leiden University Medical Center. Department of Cardiology) ;
Tuladhar, Anil Man (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ;
Tybjærg-Hansen, Anne (University of Copenhagen. Department of Clinical Medicine) ;
van Vugt, Marion (University Medical Center Utrecht, Utrecht University. Division Heart & Lungs, Department of Cardiology) ;
Vibo, Riina (University of Tartu. Department of Neurology and Neurosurgery) ;
Verma, Shefali S. (University of Pennsylvania. Department of Pathology and Laboratory Medicine) ;
Wiggins, Kerri L. (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ;
Wennberg, Patrik (Umeå University. Department of Public Health and Clinical Medicine) ;
Woo, Daniel (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ;
Wilson, Peter W. F. (Emory University School of Medicine. Department of Medicine, Division of Cardiovascular Disease) ;
Xu, Huichun (University of Maryland School of Medicine. Department of Medicine) ;
Yang, Qiong (Boston University School of Public Health. Department of Biostatistics) ;
Yoon, Kyungheon (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ;
Millwood, Iona Y. (University of Oxford. MRC Population Health Research Unit) ;
Gieger, Christian (German Research Center for Environmental Health. Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München) ;
Ninomiya, Toshiharu (Kyushu University. Department of Epidemiology and Public Health, Graduate School of Medical Sciences) ;
Grabe, Hans J. (German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald) ;
Jukema, J. Wouter (LUMC. Einthoven Laboratory for Experimental Vascular Medicine) ;
Rissanen, Ina L. (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ;
Strbian, Daniel (Helsinki University Hospital) ;
Kim, Young Jin (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ;
Chen, Pei-Hsin (Chung Shan Medical University. Department of Public Health and Institute of Public Health) ;
Mayerhofer, Ernst (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ;
Howson, Joanna M. M. (Novo Nordisk Research Centre Oxford. Department of Genetics) ;
Irvin, Marguerite R. (University of Alabama at Birmingham. Department of Epidemiology) ;
Adams, Hieab (Universidad Adolfo Ibáñez. Latin American Brain Health (BrainLat)) ;
Wassertheil-Smoller, Sylvia (Albert Einstein College of Medicine. Department of Epidemiology and Population Health) ;
Christensen, Kaare (Odense University Hospital (Dinamarca)) ;
Ikram, M. Arfan (Erasmus MC University Medical Center Rotterdam. Department of Epidemiology) ;
Rundek, Tatjana (Evelyn F. McKnight Brain Institute) ;
Worrall, Bradford B. (University of Virginia. Department of Public Health Science) ;
Lathrop, G. Mark (McGill Genome Centre) ;
Riaz, Moeen (Monash University. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine) ;
Simonsick, Eleanor M. (National Institute on Aging. Longitudinal Studies Section, Translational Gerontology Branch) ;
Kõrv, Janika (University of Tartu. Department of Neurology and Neurosurgery) ;
França, Paulo H. C. (Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil) ;
Zand, Ramin (The Pennsylvania State University. Department of Neurology, College of Medicine) ;
Prasad, Kameshwar (Rajendra Institute of Medical Sciences) ;
Frikke-Schmidt, Ruth (University of Copenhagen. Department of Clinical Medicine) ;
de Leeuw, Frank-Erik (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ;
Liman, Thomas (Carl von Ossietzky University of Oldenburg. Klinik für Neurologie) ;
Haeusler, Karl Georg (University Hospital Würzburg. Department of Neurology) ;
Ruigrok, Ynte M. (University Medical Center Utrecht, University Utrecht. UMC Utrecht Brain Center, Department of Neurology and Neurosurgery) ;
Heuschmann, Peter Ulrich (University Hospital Würzburg. Clinical Trial Center) ;
Longstreth, W. T. (University of Washington. Department of Neurology) ;
Jung, Keum Ji (Yonsei University. Institute for Health Promotion, Graduate School of Public Health) ;
Bastarache, Lisa (Vanderbilt University Medical Center. Department of Biomedical Informatics) ;
Paré, Guillaume (David Braley Cardiac, Vascular and Stroke Research Institute. Population Health Research Institute) ;
Damrauer, Scott M. (Corporal Michael Crescenz VA Medical Center) ;
Chasman, Daniel I. (Harvard Medical School) ;
Rotter, Jerome I. (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics) ;
Anderson, Christopher D. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Zwart, John-Anker (University of Oslo. Institute of Clinical Medicine, Faculty of Medicine) ;
Niiranen, Teemu J. (Turku University Hospital. Division of Medicine) ;
Fornage, Myriam (University of Texas Health Science Center at Houston. Human Genetics Center, School of Public Health) ;
Liaw, Yung-Po (Chung Shan Medical University Hospital. Department of Medical Imaging) ;
Seshadri, Sudha (Boston University School of Medicine. Department of Neurology) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Walters, Robin G. (University of Oxford. MRC Population Health Research Unit) ;
Ruff, Christian T. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ;
Owolabi, Mayowa O. (University of Ibadan. Department of Medicine) ;
Huffman, Jennifer E. (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ;
Milani, Lili (University of Tartu. Estonian Genome Centre, Institute of Genomics) ;
Kamatani, Yoichiro (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ;
Dichgans, Martin (German Center for Neurodegenerative Diseases (DZNE)) ;
Debette, Stéphanie (CHU de Bordeaux. Department of Neurology, Institute for Neurodegenerative Diseases) ;
Universitat Autònoma de Barcelona
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry ,. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. [...]
2022 - 10.1038/s41586-022-05165-3
Nature, september 2022, p. 1-15
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Publisher Correction : Stroke genetics informs drug discovery and risk prediction across ancestries
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Mishra, Aniket (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Malik, Rainer (University Hospital, LMU Munich. Institute for Stroke and Dementia Research (ISD)) ;
Hachiya, Tsuyoshi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Jürgenson, Tuuli (University of Tartu. Institute of Mathematics and Statistics) ;
Namba, Shinichi (Osaka University Graduate School of Medicine. Department of Statistical Genetics) ;
Posner, Daniel C. (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ;
Kamanu, Frederick K. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ;
Koido, Masaru (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ;
Le Grand, Quentin (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Shi, Mingyang (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ;
He, Yunye (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ;
Georgakis, Marios K. (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ;
Caro, Ilana (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Krebs, Kristi (University of Tartu. Estonian Genome Centre, Institute of Genomics) ;
Liaw, Yi-Ching (Chung Shan Medical University. Department of Public Health and Institute of Public Health) ;
Vaura, Felix C. (Finnish Institute for Health and Welfare. Department of Public Health and Welfare) ;
Lin, Kuang (University of Oxford. Nuffield Department of Population Health) ;
Winsvold, Bendik Slagsvold (Oslo University Hospital (Oslo, Noruega)) ;
Srinivasasainagendra, Vinodh (University of Alabama at Birmingham. Department of Biostatistics, School of Public Health) ;
Parodi, Livia (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ;
Bae, Hee-Joon (Seoul National University Bundang Hospital, Seoul National University College of Medicine. Department of Neurology and Cerebrovascular Disease Center) ;
Chauhan, Ganesh (Rajendra Institute of Medical Sciences) ;
Chong, Michael R. (McMaster University. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine) ;
Tomppo, Liisa (Helsinki University Hospital (Finlàndia)) ;
Akinyemi, Rufus (University of Ibadan. Neuroscience and Ageing Research Unit Institute for Advanced Medical Research and Training, College of Medicine) ;
Roshchupkin, Gennady V. (Erasmus MC University Medical Center Rotterdam. Department of Radiology and Nuclear Medicine) ;
Habib, Naomi (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences) ;
Jee, Yon Ho (Harvard T. H. Chan School of Public Health. Department of Epidemiology) ;
Thomassen, Jesper Qvist (Copenhagen University Hospital-Rigshospitalet. Department of Clinical Biochemistry) ;
Abedi, Vida (The Pennsylvania State University. Department of Public Health Sciences, College of Medicine) ;
Cárcel-Márquez, Jara (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Nygaard, Marianne (Odense University Hospital (Dinamarca)) ;
Leonard, Hampton L. (Data Tecnica International) ;
Yang, Chaojie (University of Virginia. Department of Biochemistry and Molecular Genetics) ;
Yonova-Doing, Ekaterina (Novo Nordisk Research Centre Oxford. Department of Genetics) ;
Knol, Maria J. (Erasmus MC University Medical Center Rotterdam. Department of Epidemiology) ;
Lewis, Adam J. (Vanderbilt University Medical Center. Department of Biomedical Informatics) ;
Judy, Renae L. (University of Pennsylvania. Department of Surgery) ;
Ago, Tetsuro (Kyushu University. Department of Medicine and Clinical Science, Graduate School of Medical Sciences) ;
Amouyel, Philippe (Institut Pasteur de Lille) ;
Armstrong, Nicole D. (University of Alabama at Birmingham. Department of Epidemiology) ;
Bakker, Mark K. (University Medical Center Utrecht, University Utrecht. UMC Utrecht Brain Center, Department of Neurology and Neurosurgery) ;
Bartz, Traci M. (University of Washington. Department of Biostatistics) ;
Bennett, David A. (Rush University Medical Center. Rush Alzheimer's Disease Center) ;
Bis, Joshua C. (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ;
Bordes, Constance (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Børte, Sigrid (Oslo University Hospital. Research and Communication Unit for Musculoskeletal Health (FORMI), Department of Research and Innovation, Division of Clinical Neuroscience) ;
Cain, Anael (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences) ;
Ridker, Paul M. (Harvard Medical School) ;
Cho, Kelly (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ;
Chen, Zhengming (University of Oxford. MRC Population Health Research Unit) ;
Cruchaga, Carlos (Washington University School of Medicine. NeuroGenomics and Informatics Center) ;
Cole, John W. (University of Maryland School of Medicine. Department of Neurology) ;
De Jager, Philip L (Columbia University Medical Center. Center for Translational and Computational Neuroimmunology, Department of Neurology) ;
de Cid, Rafael (Institut Germans Trias i Pujol) ;
Endres, Matthias (partner site Berlin. German Centre for Cardiovascular Research (DZHK)) ;
Ferreira, Leslie E. (Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil) ;
Geerlings, Mirjam I. (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ;
Gasca, Natalie C. (University of Washington. Department of Biostatistics) ;
Gudnason, Vilmundur (University of Iceland. Faculty of Medicine) ;
Hata, Jun (Kyushu University. Department of Epidemiology and Public Health, Graduate School of Medical Sciences) ;
He, Jing (Vanderbilt University Medical Center. Department of Biomedical Informatics) ;
Heath, Alicia K. (Imperial College London. Department of Epidemiology and Biostatistics, School of Public Health) ;
Ho, Yuk-Lam (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ;
Havulinna, Aki S. (FIMM-HiLIFE. Institute for Molecular Medicine Finland) ;
Hopewell, Jemma C. (University of Oxford. Clinical Trial Service and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health) ;
Hyacinth, Hyacinth I. (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ;
Inouye, Michael (University of Cambridge. British Heart Foundation Centre of Research Excellence) ;
Jacob, Mina A. (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ;
Jeon, Christina E. (Los Angeles County Department of Public Health) ;
Jern, Christina (Sahlgrenska University Hospital (Suècia)) ;
Kamouchi, Masahiro (Kyushu University. Department of Health Care Administration and Management, Graduate School of Medical Sciences) ;
Keene, Keith L. (East Carolina University. Department of Biology, Brody School of Medicine Center for Health Disparities) ;
Kitazono, Takanari (Kyushu University. Department of Medicine and Clinical Science, Graduate School of Medical Sciences) ;
Kittner, Steven J. (VA Maryland Health Care System. Department of Neurology and Geriatric Research and Education Clinical Center) ;
Konuma, Takahiro (Osaka University Graduate School of Medicine. Department of Statistical Genetics) ;
Kumar, Amit (Rajendra Institute of Medical Sciences) ;
Lacaze, Paul (Monash University. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine) ;
Launer, Lenore Joy (National Institute on Aging, NIH. Intramural Research Program) ;
Lee, Keon-Joo (Korea University Guro Hospital. Department of Neurology) ;
Lepik, Kaido (University Center for Primary Care and Public Health, Lausanne, Switzerland) ;
Li, Jiang (Geisinger Health System. Department of Molecular and Functional Genomics, Weis Center for Research) ;
Li, Liming (Peking University Health Science Center. Department of Epidemiology and Biostatistics, School of Public Health) ;
Manichaikul, Ani (University of Virginia. Center for Public Health Genomics) ;
Markus, Hugh S. (University of Cambridge. Stroke Research Group, Department of Clinical Neurosciences) ;
Marston, Nicholas A. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ;
Meitinger, Thomas (German Research Center for Environmental Health. Institute of Human Genetics, Helmholtz Zentrum München) ;
Mitchell, Braxton D. (Baltimore Veterans Administration Medical Center. Geriatrics Research and Education Clinical Center) ;
Montellano, Felipe A. (University Hospital Würzburg. Department of Neurology) ;
Morisaki, Takayuki (The University of Tokyo. Division of Molecular Pathology, Institute of Medical Sciences) ;
Mosley, Thomas H. (University of Mississippi Medical Center. The MIND Center) ;
Nalls, Mike A. (Data Tecnica International) ;
Nordestgaard, Børge G. (University of Copenhagen. Department of Clinical Medicine) ;
O'Donnell, Martin J. (NUI Galway. College of Medicine Nursing and Health Science) ;
Okada, Yukinori (Osaka University. Center for Infectious Disease Education and Research (CiDER)) ;
Onland-Moret, N. Charlotte (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ;
Ovbiagele, Bruce (University of California, San Francisco. Weill Institute for Neurosciences) ;
Peters, Annette (German Centre for Cardiovascular Research (DZHK), partner site Munich) ;
Psaty, Bruce M. (University of Washington. Department of Health Systems and Population Health) ;
Rich, Stephen S. (University of Virginia. Center for Public Health Genomics) ;
Rosand, Jonathan (Massachusetts General Hospital. McCance Center for Brain Health) ;
Sabatine, Marc S. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ;
Sacco, Ralph L. (Evelyn F. McKnight Brain Institute) ;
Saleheen, Danish (Columbia University. Division of Cardiology, Department of Medicine) ;
Sandset, Else Charlotte (The Norwegian Air Ambulance Foundation. Research and Development) ;
Salomaa, Veikko (Finnish Institute for Health and Welfare. Department of Public Health and Welfare) ;
Sargurupremraj, Muralidharan (University of Texas Health Sciences Center. Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ;
Sasaki, Makoto (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Satizabal, Claudia L. (Framingham Heart Study) ;
Schmidt, Carsten O. (University Medicine Greifswald, Institute for Community Medicine, SHIP/KEF) ;
Shimizu, Atsushi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Smith, Nicholas L. (Seattle Epidemiologic Research and Information Center. Department of Veterans Affairs Office of Research and Development) ;
Sloane, Kelly L. (University of Pennsylvania. Department of Neurology) ;
Sutoh, Yoichi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Sun, Yan V. (Emory University Rollins School of Public Health. Department of Epidemiology) ;
Tanno, Kozo (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Tiedt, Steffen (University Hospital, LMU Munich. Institute for Stroke and Dementia Research (ISD)) ;
Tatlisumak, Turgut (Sahlgrenska University Hospital (Suècia)) ;
Torres-Aguila, Nuria P.. (Institut d'Investigació Biomèdica Sant Pau) ;
Tiwari, Hemant K. (University of Alabama at Birmingham. Department of Biostatistics, School of Public Health) ;
Trégouët, David-Alexandre (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Trompet, Stella (Leiden University Medical Center. Department of Cardiology) ;
Tuladhar, Anil Man (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ;
Tybjærg-Hansen, Anne (University of Copenhagen. Department of Clinical Medicine) ;
van Vugt, Marion (University Medical Center Utrecht, Utrecht University. Division Heart & Lungs, Department of Cardiology) ;
Vibo, Riina (University of Tartu. Department of Neurology and Neurosurgery) ;
Verma, Shefali S. (University of Pennsylvania. Department of Pathology and Laboratory Medicine) ;
Wiggins, Kerri L. (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ;
Wennberg, Patrik (Umeå University. Department of Public Health and Clinical Medicine) ;
Woo, Daniel (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ;
Wilson, Peter W. F. (Emory University School of Medicine. Department of Medicine, Division of Cardiovascular Disease) ;
Xu, Huichun (University of Maryland School of Medicine. Department of Medicine) ;
Yang, Qiong (Boston University School of Public Health. Department of Biostatistics) ;
Yoon, Kyungheon (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ;
Millwood, Iona Y. (University of Oxford. MRC Population Health Research Unit) ;
Gieger, Christian (German Research Center for Environmental Health. Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München) ;
Ninomiya, Toshiharu (Kyushu University. Department of Epidemiology and Public Health, Graduate School of Medical Sciences) ;
Grabe, Hans J. (German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald) ;
Jukema, J. Wouter (LUMC. Einthoven Laboratory for Experimental Vascular Medicine) ;
Rissanen, Ina L. (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ;
Strbian, Daniel (Helsinki University Hospital (Finlàndia)) ;
Kim, Young Jin (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ;
Chen, Pei-Hsin (Chung Shan Medical University. Department of Public Health and Institute of Public Health) ;
Mayerhofer, Ernst (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ;
Howson, Joanna M. M. (Novo Nordisk Research Centre Oxford. Department of Genetics) ;
Irvin, Marguerite R. (University of Alabama at Birmingham. Department of Epidemiology) ;
Adams, Hieab (Universidad Adolfo Ibáñez) ;
Wassertheil-Smoller, Sylvia (Albert Einstein College of Medicine. Department of Epidemiology and Population Health) ;
Christensen, Kaare (Odense University Hospital (Dinamarca)) ;
Ikram, M. Arfan (Erasmus MC University Medical Center Rotterdam. Department of Epidemiology) ;
Rundek, Tatjana (Evelyn F. McKnight Brain Institute) ;
Worrall, Bradford B. (University of Virginia. Department of Public Health Science) ;
Lathrop, G. Mark (McGill Genome Centre) ;
Riaz, Moeen (Monash University. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine) ;
Simonsick, Eleanor M. (National Institute on Aging. Longitudinal Studies Section, Translational Gerontology Branch) ;
Kõrv, Janika (University of Tartu. Department of Neurology and Neurosurgery) ;
França, Paulo H. C. (Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil) ;
Zand, Ramin (The Pennsylvania State University. Department of Neurology, College of Medicine) ;
Prasad, Kameshwar (Rajendra Institute of Medical Sciences) ;
Frikke-Schmidt, Ruth (University of Copenhagen. Department of Clinical Medicine) ;
de Leeuw, Frank-Erik (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ;
Liman, Thomas (Carl von Ossietzky University of Oldenburg. Klinik für Neurologie) ;
Haeusler, Karl Georg (University Hospital Würzburg. Department of Neurology) ;
Ruigrok, Ynte M. (University Medical Center Utrecht, University Utrecht. UMC Utrecht Brain Center, Department of Neurology and Neurosurgery) ;
Heuschmann, Peter Ulrich (University Hospital Würzburg. Clinical Trial Center) ;
Longstreth, W. T. (University of Washington. Department of Neurology) ;
Jung, Keum Ji (Yonsei University. Institute for Health Promotion, Graduate School of Public Health) ;
Bastarache, Lisa (Vanderbilt University Medical Center. Department of Biomedical Informatics) ;
Paré, Guillaume (David Braley Cardiac, Vascular and Stroke Research Institute. Population Health Research Institute) ;
Damrauer, Scott M. (Corporal Michael Crescenz VA Medical Center) ;
Chasman, Daniel I. (Harvard Medical School) ;
Rotter, Jerome I. (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics) ;
Anderson, Christopher D. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Zwart, John-Anker (University of Oslo. Institute of Clinical Medicine, Faculty of Medicine) ;
Niiranen, Teemu J. (Turku University Hospital. Division of Medicine) ;
Fornage, Myriam (University of Texas Health Science Center at Houston. Human Genetics Center, School of Public Health) ;
Liaw, Yung-Po (Chung Shan Medical University Hospital. Department of Medical Imaging) ;
Seshadri, Sudha (Boston University School of Medicine. Department of Neurology) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Walters, Robin G. (University of Oxford. MRC Population Health Research Unit) ;
Ruff, Christian T. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ;
Owolabi, Mayowa O. (University of Ibadan. Department of Medicine) ;
Huffman, Jennifer E. (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ;
Milani, Lili (University of Tartu. Estonian Genome Centre, Institute of Genomics) ;
Kamatani, Yoichiro (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ;
Dichgans, Martin (German Center for Neurodegenerative Diseases (DZNE)) ;
Debette, Stéphanie (CHU de Bordeaux. Department of Neurology, Institute for Neurodegenerative Disease) ;
Universitat Autònoma de Barcelona
2022 - 10.1038/s41586-022-05492-5
Nature, Vol. 612 (november 2022) , p. E7
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3.
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17 p, 693.0 KB |
Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke
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Jaworek, Thomas ;
Xu, Huichun ;
Gaynor, Brady ;
Cole, John W. ;
Rannikmae, Kristiina ;
Stanne, Tara M. ;
Tomppo, Liisa ;
Abedi, Vida ;
Amouyel, Philippe ;
Armstrong, Nicole D. ;
Attia, John ;
Bell, Steven ;
Benavente, Oscar R. ;
Boncoraglio, Giorgio B. ;
Butterworth, Adam ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Chen, Zhengming ;
Chong, Michael ;
Cruchaga, Carlos ;
Cushman, Mary ;
Danesh, John ;
Debette, Stéphanie ;
Duggan, David J. ;
Durda, Jon Peter ;
Engstrom, Gunnar ;
Enzinger, Chris ;
Faul, Jessica D. ;
Fecteau, Natalie S. ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Gieger, Christian ;
Giese, Anne-Katrin ;
Grewal, Raji P. ;
Grittner, Ulrike ;
Havulinna, Aki S. ;
Heitsch, Laura ;
Hochberg, Marc C. ;
Holliday, Elizabeth ;
Hu, Jie ;
Ilinca, Andreea ;
Irvin, Marguerite R. ;
Jackson, Rebecca D. ;
Jacob, Mina A. ;
Rabionet, Raquel ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Johnson, Julie A. ;
Kamatani, Yoichiro ;
Kardia, Sharon L.R. ;
Koido, Masaru ;
Kubo, Michiaki ;
Lange, Leslie ;
Lee, Jin-Moo ;
Lemmens, Robin ;
Levi, Christopher R. ;
Li, Jiang ;
Li, Liming ;
Lin, Kuang ;
Lopez, Haley ;
Luke, Sothear ;
Maguire, Jane ;
McArdle, Patrick F. ;
McDonough, Caitrin W. ;
Meschia, James F. (Mayo Clinic (Jacksonville, Estats Units d'Amèrica)) ;
Metso, Tiina ;
Müller-Nurasyid, Martina ;
Dichgans, Martin ;
O'Donnell, Martin ;
Peddareddygari, Leema R. ;
Pera, Joanna ;
Perry, James A. ;
Peters, Annette ;
Putaala, Jukka ;
Ray, Debashree ;
Rexrode, Kathryn ;
Ribasés Haro, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rosand, Jonathan ;
Rothwell, Peter M. ;
Rundek, Tatjana ;
Ryan, Kathleen A. ;
Sacco, Ralph L. ;
Salomaa, Veikko ;
Sánchez-Mora, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Schmidt, Reinhold ;
Sharma, Pankaj ;
Slowik, Agnieszka ;
Smith, Jennifer A. ;
Smith, Nicholas L. ;
Wassertheil-Smoller, Sylvia ;
Söderholm, Martin ;
Stine, O. Colin ;
Strbian, Daniel ;
Sudlow, Cathie L.M. ;
Tatlisumak, Turgut ;
Terao, Chikashi ;
Thijs, Vincent ;
Torres-Aguila, Nuria P.. ;
Trégouët, David-Alexandre ;
Tuladhar, Anil M. ;
Veldink, Jan ;
Walters, Robin G. ;
Weir, David R. ;
Woo, Daniel ;
Worrall, Bradford B. ;
Hong, Charles C. ;
Ross, Owen A. ;
Zand, Ramin ;
de Leeuw, Frank-Erik ;
Lindgren, Arne G. ;
Paré, Guillaume ;
Anderson, Christopher D. ;
Markus, Hugh S. ;
Jern, Christina ;
Malik, Rainer ;
Dichgans, Martin ;
Mitchell, Braxton D. ;
Kittner, Steven J. ;
Universitat Autònoma de Barcelona
Current genome-wide association studies of ischemic stroke have focused primarily on late-onset disease. As a complement to these studies, we sought to identify the contribution of common genetic variants to risk of early-onset ischemic stroke. [...]
2022 - 10.1212/WNL.0000000000201006
Neurology, Vol. 99 (october 2022) , p. e1738-e1754
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4.
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11 p, 1.9 MB |
Genetic basis of lacunar stroke : a pooled analysis of individual patient data and genome-wide association studies
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Traylor, Matthew (Clinical Pharmacology and The Barts Heart Centre and NIHR Barts Biomedical Research Centre, Barts Health NHS Trust, William Harvey Research Institute, Queen Mary University of London, London, UK) ;
Persyn, Elodie (King's College London) ;
Tomppo, Liisa (Helsinki University Hospital (Finlàndia)) ;
Klasson, Sofia (Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden) ;
Abedi, Vida (Department of Molecular and Functional Genomics, Weis Center for Research, Geisinger Health System, Danville, PA, USA) ;
Bakker, Mark K. (Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands) ;
Torres, Nuria (Institut d'Investigació Biomèdica Sant Pau) ;
Li, Linxin (University of Oxford. Nuffield Department of Clinical Neuroscience) ;
Bell, Steven (Unversity of Cambridge) ;
Rutten-Jacobs, Loes (Product Development Personalized Health Care, F Hoffmann-La Roche, Basel, Switzerland) ;
Tozer, Daniel J. (Clinical Neurosciences, University of Cambridge, Cambridge, UK) ;
Griessenauer, Christoph J. (Institute of Neurointervention, Paracelsus Medical University, Salzburg, Austria) ;
Zhang, Yanfei (Genomic Medicine Institute, Geisinger Health System, Danville, PA, USA) ;
Pedersen, Annie (Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden) ;
Sharma, Pankaj (Institute of Cardiovascular Research, Royal Holloway University of London, London, UK) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rundek, Tatjana (University of Miami. Miller School of Medicine) ;
Grewal, Raji P. (Neuroscience Institute, Saint Francis Medical Center, School of Health and Medical Sciences, Seton Hall University, South Orange, NJ, USA) ;
Lindgren, Arne (Lund University (Lund, Suècia)) ;
Meschia, James F. (Mayo Clinic (Jacksonville, Estats Units d'Amèrica)) ;
Salomaa, Veikko (Finnish Institute for Health and Welfare (Helsinki, Finlàndia)) ;
Havulinna, Aki S (Institute for Molecular Medicine Finland (FIMM HiLIFE), Helsinki, Finland) ;
Kourkoulis, Christina (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Crawford, Katherine (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Marini, Sandro (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Mitchell, Braxton D. (Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA) ;
Kittner, Steven J. (Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA) ;
Rosand, Jonathan (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Dichgans, Martin (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ;
Jern, Christina (Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden) ;
Strbian, Daniel (Helsinki University Hospital (Finlàndia)) ;
Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Zand, Ramin (Neuroscience Institute, Geisinger Health System, Danville, PA, USA) ;
Ruigrok, Ynte (Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands) ;
Rost, Natalia (Massachusetts General Hospital (Boston)) ;
Lemmens, Robin (University Hospitals Leuven (Bèlgica)) ;
Rothwell, Peter M. (University of Oxford. Nuffield Department of Clinical Neuroscience) ;
Anderson, Christopher D. (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Wardlaw, Joanna (Centre for Clinical Brain Sciences, UK Dementia Research Institute and Row Fogo Centre for Research into the Ageing Brain, University of Edinburgh, Edinburgh, UK) ;
Lewis, Cathryn M. (King's College London. Social, Genetic, and Developmental Psychiatry Centre) ;
Markus, Hugh S. (Clinical Neurosciences, University of Cambridge, Cambridge, UK) ;
Universitat Autònoma de Barcelona
The genetic basis of lacunar stroke is poorly understood, with a single locus on 16q24 identified to date. We sought to identify novel associations and provide mechanistic insights into the disease. [...]
2021 - 10.1016/S1474-4422(21)00031-4
The Lancet neurology, Vol. 20 (may 2021) , p. 351-361
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