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18 p, 3.7 MB |
The KMT2A recombinome of acute leukemias in 2023
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Meyer, Claus (DCAL/Institute of Pharm. Biology. Goethe-University(Alemanya)) ;
Larghero, Patrizia (DCAL/Institute of Pharm. Biology. Goethe-University (Alemanya)) ;
Lopes, BA. (DCAL/Institute of Pharm. Biology. Goethe-University (Alemanya)) ;
Burmeister, Thomas (Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany) ;
Gröger, Daniela (Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin (Alemanya)) ;
Sutton, Rosemary (Molecular Diagnostics. Children's Cancer Institute. Lowy Cancer Research Centre. UNSW (Sidney, Austràlia)) ;
Venn, Nicola C. (Molecular Diagnostics. Children's Cancer Institute. Lowy Cancer Research Centre. UNSW (Sidney, Austràlia)) ;
Cazzaniga, Giovanni (University of Milano-Bicocca/Fondazione Tettamanti (Itàlia)) ;
Corral Abascal, Lilia (University of Milano-Bicocca/Fondazione Tettamanti (Itàlia)) ;
Tsaur, Grigory А. (Research Institute of Medical Cell Technologies (Ekaterinburg, Rússia)) ;
Fechina, Larisa G. (Research Institute of Medical Cell Technologies (Ekaterinburg, Rússia)) ;
Emerenciano, Mariana (Instituto Nacional de Câncer (INCA)(Rio de Janeiro, Brasil)) ;
Pombo-de-Oliveira, Maria S. (Instituto Nacional de Câncer (INCA)(Rio de Janeiro, Brasil)) ;
Lund-Aho, Tiina (Laboratory of Clinical Genetics, Fimlab Laboratories (Tampere, Finlàndia)) ;
Lundán, Tuija (University of Turku and Turku University Hospital (Turku, Finlàndia)) ;
Montonen, M. (University of Turku and Turku University Hospital (Turku, Finlàndia)) ;
Juvonen, Vesa (University of Turku and Turku University Hospital (Turku, Finlàndia)) ;
Zuna, Jan (Charles University and University Hospital Motol (Praga, República Txeca)) ;
Trka, Jan M. (Charles University and University Hospital Motol (Praga, República Txeca)) ;
Ballerini, Paola (Pierre et Marie Curie University (París, França)) ;
Lapillonne, Hélène (Pierre et Marie Curie University (París, França)) ;
Van der Velden, Vincent (University Medical Center Rotterdam (Països Baixos)) ;
Sonneveld, Edwin (Princess Máxima Center for Pediatric Oncology (Utrecht, Països Baixos)) ;
Delabesse, Éric C. M. (Institut Universitaire du Cancer de Toulouse (França)) ;
Capela de Matos, Roberto (National Cancer Institute (INCA) (Rio de Janeiro, Brasil)) ;
Silva, Maria Luiza (National Cancer Institute (INCA) (Rio de Janeiro, Brasil)) ;
Bomken, Simon (Newcastle University, Newcastle upon Tyne (Regne Unit)) ;
Katsibardi, Katerina (National and Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital (Atenes, Grècia)) ;
Keernik, Maria (Tartu University Hospital (Tartu, Estònia)) ;
Grardel, Nathalie (University Hospital Claude Huriez) ;
Mason, J. (Newcastle University and the Great North Children's West Midlands Regional Genetics Laboratory (Regne Unit)) ;
Price, Richard (Newcastle University and the Great North Children's West Midlands Regional Genetics Laboratory (Regne Unit)) ;
Kim, J. (DCAL/Institute of Pharm. Biology. Goethe-University (Alemanya)) ;
Eckert, Cornelia (Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin (Alemanya)) ;
Lo Nigro, Luca (Centro di Riferimento Regionale di Ematologia ed Oncologia Pediatrica, Azienda Policlinico "G. Rodolico" (Catània, Itàlia)) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Menéndez Bujan, Pablo (Centro di Riferimento Regionale di Ematologia ed Oncologia Pediatrica, Azienda Policlinico "G. Rodolico" (Catània, Itàlia)) ;
Zur Stadt, Udo (University Medical Center Hamburg-Eppendorf (Hamburg, Alemanya)) ;
Gameiro, Paula (Instituto Português de Oncologia, Departament of Hematology (Lisboa, Portugal)) ;
Sedek, Łukasz (Medical University of Silesia (Zabrze, Polònia)) ;
Szczepanski, Tomasz (Medical University of Silesia (Zabrze, Polònia)) ;
Bidet, A. (Laboratoire d'Hématologie Biologique, CHU Bordeaux (França)) ;
Marcu, Victoria (Hematology Laboratory, Sheba Medical Center, Tel-Hashomer, Israel) ;
Shichrur, Keren (Schneider Children's Medical Center of Israel, Petah Tikva, Israel) ;
Izraeli, Shai (Tel Aviv University, Tel Aviv, Israel) ;
Madsen, Hans Ole (Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark) ;
Schäfer, Beat (University Children's Hospital Zurich (Zúric, Suïssa)) ;
Kubetzko, Susanne (University Children's Hospital Zurich (Zúric, Suïssa)) ;
Kim, Rathana (Université Paris Cité (França)) ;
Clappier, Emmanuelle (Université Paris Cité (França)) ;
Trautmann, Heiko (University Hospital Schleswig-Holstein (Kiel, Alemanya)) ;
Brüggemann, Monika (University Hospital Schleswig-Holstein (Kiel, Alemanya)) ;
Archer, Paul (Bristol Genetics Laboratory, North Bristol NHS Trust (Bristol, Regne Unit)) ;
Hancock, Jeremy P. (Bristol Genetics Laboratory, North Bristol NHS Trust (Bristol, Regne Unit)) ;
Alten, Julia (University Hospital Schleswig-Holstein (Kiel, Alemanya)) ;
Möricke, Anja (University Hospital Schleswig-Holstein (Kiel, Alemanya)) ;
Stanulla, Martin (Department of Pediatrics, MHH (Hanover, Alemanya)) ;
Lentes, Jana (Medical School Hannover (Alemanya)) ;
Bergmann, Anke K. (Medical School Hannover (Alemanya)) ;
Strehl, Sabine (St. Anna Children's Cancer Research Institute (CCRI) (Vienna, Àustria)) ;
Köhrer, Stefan (St. Anna Children's Cancer Research Institute (CCRI) (Vienna, Àustria)) ;
Nebral, Karin (St. Anna Children's Cancer Research Institute (CCRI) (Vienna, Àustria)) ;
Dworzak, Michael Norbert (St. Anna Children's Cancer Research Institute (CCRI) (Vienna, Àustria)) ;
Haas, Oskar A. (St. Anna Children's Cancer Research Institute (CCRI) (Vienna, Àustria)) ;
Arfeuille, Chloe (Hopital Robert Debré (París, França)) ;
Caye Eude, Aurélie (Hopital Robert Debré (París, França)) ;
Cavé, Hélène (Hopital Robert Debré (París, França)) ;
Marschalek, Rolf (Goethe-University (Alemanya))
Chromosomal rearrangements of the human KMT2A/MLL gene are associated with de novo as well as therapy-induced infant, pediatric, and adult acute leukemias. Here, we present the data obtained from 3401 acute leukemia patients that have been analyzed between 2003 and 2022. [...]
2023 -  10.1038/s41375-023-01877-1
Leukemia, Vol. 37 Núm. 5 (may 2023) , p. 988-1005
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19 p, 4.7 MB |
Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer
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Hermanova, Ivana (Basque Research and Technology Alliance (BRTA)) ;
Zúñiga-García, Patricia (Basque Research and Technology Alliance (BRTA)) ;
Caro-Maldonado, Alfredo (Basque Research and Technology Alliance (BRTA)) ;
Fernandez-Ruiz, Sonia (Centro de Investigación Biomédica en Red de Cáncer) ;
Salvador, Fernando (Institut de Recerca Biomèdica) ;
Martín-Martín, Natalia (Centro de Investigación Biomédica en Red de Cáncer) ;
Zabala-Letona, Amaia (Centro de Investigación Biomédica en Red de Cáncer) ;
Nuñez-Olle, Marc (Institut de Recerca Biomèdica) ;
Torrano, Verónica (Universidad del País Vasco. Departamento de Bioquímica y Biología Molecular) ;
Camacho, Laura (Universidad del País Vasco. Departamento de Bioquímica y Biología Molecular) ;
Lizcano de Vega, José Miguel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Talamillo, Ana (Basque Research and Technology Alliance (BRTA)) ;
Carreira, Suzanne (The Institute of Cancer Research (London, Regne Unit)) ;
Gurel, Bora (The Institute of Cancer Research (London, Regne Unit)) ;
Cortazar, Ana Rosa (Centro de Investigación Biomédica en Red de Cáncer) ;
Guiu, Marc (Institut de Recerca Biomèdica) ;
López, Jose I. (Universidad del País Vasco) ;
Martinez-Romero, Anabel (Institut d'Investigació Biomèdica de Bellvitge) ;
Astobiza, Ianire (Centro de Investigación Biomédica en Red de Cáncer) ;
Valcarcel-Jimenez, Lorea (Basque Research and Technology Alliance (BRTA)) ;
Lorente, Mar (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular) ;
Arruabarrena-Aristorena, Amaia (Basque Research and Technology Alliance (BRTA)) ;
Velasco, Guillermo (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Gomez Muñoz, Antonio (Universidad del País Vasco. Departamento de Bioquímica y Biología Molecular) ;
Suárez-Cabrera, Cristian (Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (Espanya)) ;
Lodewijk, Iris (Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (Espanya)) ;
Flores, Juana M. (Universidad Complutense de Madrid. Departamento de Medicina y Cirugía Animal) ;
Sutherland, James D. (Basque Research and Technology Alliance (BRTA)) ;
Barrio, Rosa (Basque Research and Technology Alliance (BRTA)) ;
de Bono, Johann S. (The Royal Marsden National Health Service Foundation Trust (London, Regne Unit)) ;
Paramio, Jesús M. (Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (Espanya)) ;
Trka, Jan (Charles University (Praga, República Txeca). Department of Paediatric Haematology/Oncology) ;
Graupera, Mariona (Institut d'Investigació Biomèdica de Bellvitge) ;
Gomis, Roger R.. (Institució Catalana de Recerca i Estudis Avançats) ;
Carracedo, Arkaitz (Ikerbasque, Basque Foundation for Science (Bilbao, País Basc))
This study unravels an unprecedented murine model of lethal metastatic prostate cancer, based on the combined deletion of Pten and Lkb1. Importantly, minimal activity of LKB1 is sufficient to hamper prostate cancer cell aggressiveness, thus redefining the relationship between gene dosage and tumor suppression. [...]
2020 - 10.1084/jem.20191787
The journal of experimental medicine, Vol. 217 (march 2020)
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