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16 p, 2.4 MB TYK2 Variants in B-Acute Lymphoblastic Leukaemia / Turrubiartes-Martínez, Edgar (Instituto de Investigación Hospital Universitario de la Princesa) ; Bodega-Mayor, Irene (Instituto de Investigación Hospital Universitario de la Princesa) ; Delgado-Wicke, Pablo (Instituto de Investigación Hospital Universitario de la Princesa) ; Molina-Jiménez, Francisca (Instituto de Investigación Hospital Universitario de la Princesa) ; Casique-Aguirre, Diana (Latin University of Mexico) ; González-Andrade, Martín (Universidad Nacional Autónoma de México) ; Rapado, Inmaculada (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ; Camós, Mireia (University Hospital Sant Joan de Déu) ; Díaz de Heredia, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Barragán, Eva (Hospital Universitari i Politècnic La Fe (València)) ; Ramírez, Manuel (Hospital Infantil Universitario Niño Jesús (Madrid)) ; Aguado, Beatriz (Instituto de Investigación Hospital Universitario de la Princesa) ; Figuera, Ángela (Instituto de Investigación Hospital Universitario de la Princesa) ; Martínez-López, Joaquín (Complutense University of Madrid) ; Fernández-Ruiz, Elena (Universidad Autónoma de Madrid) ; Universitat Autònoma de Barcelona
B-cell precursor acute lymphoblastic leukaemia (B-ALL) is a malignancy of lymphoid progenitor cells with altered genes including the Janus kinase (JAK) gene family. Among them, tyrosine kinase 2 (TYK2) is involved in signal transduction of cytokines such as interferon (IFN) α/β through IFN−α/β receptor alpha chain (IFNAR1). [...]
2020 - 10.3390/genes11121434
Genes, Vol. 11 (november 2020)  
Detailed record - Creative Commons

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