Twomey, B - Search Results - UAB Digital Repository of Documents

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Dynamic molecular analysis and clinical correlates of tumor evolution within a phase II trial of panitumumab-based therapy in metastatic colorectal cancer / Siena, S. (Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy) ; Sartore-Bianchi, A. (Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy) ; García-Carbonero, Rocío (Universidad Complutense de Madrid) ; Karthaus, M. (Department for Hematology and Oncology, Staedt Klinikum Neuperlach and Harlaching, Munich, Germany) ; Smith, D. (Bordeaux University Hospital (França)) ; Tabernero, Josep (Universitat Autònoma de Barcelona) ; Van Cutsem, E. (KU Leuven, Leuven, Belgium) ; Guan, X (Amgen Inc., Thousand Oaks, CA, USA) ; Boedigheimer, M. (Amgen Inc., Thousand Oaks, CA, USA) ; Ang, A. (Amgen Inc., Thousand Oaks, CA, USA) ; Twomey, B. (Amgen Inc., Thousand Oaks, CA, USA) ; Bach, B. A. (Amgen Inc., Thousand Oaks, CA, USA) ; Jung, A. S. (Amgen Inc., Thousand Oaks, CA, USA) ; Bardelli, Alberto (Department of Oncology, University of Torino, Candiolo, Italy)
Mutations in rat sarcoma (RAS) genes may be a mechanism of secondary resistance in epidermal growth factor receptor inhibitor-treated patients. Tumor-tissue biopsy testing has been the standard for evaluating mutational status; however, plasma testing of cell-free DNA has been shown to be a more sensitive method for detecting clonal evolution. [...]
2017 - DOI (Digital Object Identifier)

10.1093/annonc/mdx504
Annals of oncology, Vol. 29 (september 2017) , p. 119-126

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1	Twomey, B.

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