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13 p, 443.6 KB |
Opportunities for better use of collective action theory in research and governance for invasive species management
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Graham, Sonia (University of New South Wale. School of Social Sciences) ;
Metcalf, Alexander L. (Australian Centre for Cultural Environmental Research) ;
Gill, Nicholas (Australian Centre for Cultural Environmental Research) ;
Niemiec, Rebecca (Stanford University. Emmett Interdisciplinary Program in Environment and Resources) ;
Moreno, Carlo (The College of Wooster. Environmental Studies Program) ;
Bach, Thomas (The University of Melbourne. School of Geography) ;
Ikutegbe, Victoria (Australian Centre for Cultural Environmental Research) ;
Hallstrom, Lars (Alberta Centre for Sustainable Rural Communities,) ;
Ma, Zhao (Purdue University. Department of Forestry and Natural Resources) ;
Lubeck, Alice (Australian Centre for Cultural Environmental Research) ;
Universitat Autònoma de Barcelona.
Institut de Ciència i Tecnologia Ambientals
Controlling invasive species presents a public-good dilemma. Although environmental, social, and economic benefits of control accrue to society, costs are borne by only a few individuals and organizations. [...]
2018 -  10.1111/cobi.13266
Conservation biology, First published 11 Dec. 2018
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20 p, 2.2 MB |
Role of muscle IL-6 in gender-specific metabolism in mice
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Molinero Egea, María Amalia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Fernandez-Perez, Antonio (Universidad Autonoma de Madrid. Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades metabólicas asociadas CIBERDEM) ;
Mogas Barcons, Aina (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Giralt Carbonell, Mercedes (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Comes Orpinell, Gemma (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Fernandez Gayol, Olaya (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Vallejo, Mario (Universidad Autonoma de Madrid (CSIC-UAM). Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades metabólicas asociadas CIBERDEM.) ;
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Universitat Autònoma de Barcelona.
Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
The aim of the present work was to further explore the physiological roles of muscle-derived IL-6. Adult-floxed and conditional skeletal muscle IL-6 knock out male and female mice were used to study energy expenditure (indirect calorimetry at rest and during treadmill exercise, and body temperature cycle during the light phase) and energy intake (response to fast/ refeeding). [...]
2017 - 10.1371/journal.pone.0173675
PLoS ONE, Vol. 12, Núm. 3 (March 2017) , art. e173675
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18 p, 288.5 KB |
Translational research opportunities regarding homologous recombination in ovarian cancer
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Romeo Marín, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pardo, J.C. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Balibrea, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Quiroga, Vanesa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Román, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Solé, Francesc (Institut Germants Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Margelí, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mesía, Ricard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Homologous recombination (HR) is a DNA repair pathway that is deficient in 50% of high-grade serous ovarian carcinomas (HGSOC). Deficient HR (DHR) constitutes a therapeutic opportunity for these patients, thanks to poly (ADP-ribose) polymerases (PARP) inhibitors (PARPi; olaparib, niraparib, and rucaparib are already commercialized). [...]
2018 - 10.3390/ijms19103249
International Journal of Molecular Sciences, Vol. 19 Núm. 10 (19 2018) , p. 3249
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11 p, 1.1 MB |
Immune-mediated inflammatory diseases differently affect IGRAs' accuracy for latent tuberculosis infection diagnosis in clinical practice
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Latorre,Irene (Institut Germans Trias i Pujol. Servei de Microbiologia) ;
Mínguez, Sonia (Institut Germans Trias i Pujol. Servei de Reumatologia) ;
Carrascosa, José-Manuel (Institut Germans Trias i Pujol. Servei de Dermatologia) ;
Naves, Juan (Institut Germans Trias i Pujol. Servei de Digestiu) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Servei de Microbiologia) ;
Muriel, Beatriz (Institut Germans Trias i Pujol. Servei de Microbiologia) ;
Prat, Cristina (Institut Germans Trias i Pujol. Servei de Microbiologia) ;
García-García, Esther (Institut Germans Trias i Pujol. Servei de Microbiologia) ;
Casas, Irma (Institut Germans Trias i Pujol. Servei de Medicina Preventiva) ;
Domènech, Eugeni (Institut Germans Trias i Pujol. Servei de Digestiu) ;
Ferrándiz, Carlos (Institut Germans Trias i Pujol. Servei de Dermatologia) ;
Mateo, Lourdes (Institut Germans Trias i Pujol. Servei de Reumatologia) ;
Domínguez, Jose (Institut Germans Trias i Pujol. Servei de Microbiologia) ;
Universitat Autònoma de Barcelona
Background. Clinical accuracy of IGRAs remains unclear on patients with immune-mediated inflammatory diseases (IMIDs). Here, we assess the impact of immunosuppressants and IMIDs on QuantiFERON-TB Gold In-Tube (QFN-G-IT) and T-SPOT. [...]
2017 - 10.1371/journal.pone.0189202
Plos one, Vol. 12 Núm. 12 (december 2017) , p. 1-11
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5.
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515.0 KB |
GRECOS project (Genotyping Recurrence Risk of Stroke). The use of genetics to predict the vascular recurrence after stroke
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Fernández Cadenas, Israel (Hospital Vall d'Hebron. Departament de Neurologia) ;
Mendióroz, Maite (Hospital Vall d'Hebron. Departament de Neurologia) ;
Giralt, Dolors (Hospital Vall d'Hebron. Departament de Neurologia) ;
Nafria, Cristina (Hospital Vall d'Hebron. Departament de Neurologia) ;
Garcia, Elena (Fundació Docència i Recerca Mutua Terrassa) ;
Carrera, Caty (Hospital Vall d'Hebron Departament de Neurologia) ;
Gallego-Fabrega, Cristina (Fundació Docència i Recerca Mutua Terrassa) ;
Domingues-Montanari, Sophie (Hospital Vall d'Hebron. Departament de Neurologia) ;
Delgado, Pilar (Hospital Vall d'Hebron. Departament de Neurologia) ;
Ribó, Marc (Hospital Vall d'Hebron. Departament de Neurologia) ;
Castellanos, Mar (Hospital Universitari Dr. Josep Trueta. Departament de Neurologia) ;
Martínez, Sergi (Institut d'Investigació Biomèdica Sant Pau) ;
Freijo, Mari Mar (Hospital de Basurto. Departamento de Neurologia) ;
Jiménez-Conde, Jordi (Hospital del Mar. Departament de Neurologia) ;
Rubiera, Marta (Hospital Vall d'Hebron. Departament de Neurologia) ;
Alvarez Sabín, José (Hospital Vall d'Hebron. Departament de Neurologia) ;
Molina, Carlos A. (Hospital Vall d'Hebron. Departament de Neurologia) ;
Font, Maria Angels (Hospital de Bellvitge. Departament de Neurologia) ;
Grau Olivares, Marta (Hospital Universitari Sagrat Cor. Departament de Neurologia) ;
Palomeras, Ernest (Hospital de Mataró. Departament de Neurologia) ;
Perez de la Ossa, Natalia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martinez Zabaleta, Maite (Hospital Donostia. Departamento de Neurologia) ;
Masjuan, Jaime (Hospital Ramon y Cajal. Departamento de Neurologia) ;
Moniche, Francisco (Hospital Universitario Virgen del Rocío. Departamento de Neurologia) ;
Canovas, David (Corporació Sanitària Parc Taulí. Departament de Neurologia) ;
Piñana, Carlos (Hospital Universitario Virgen de las Nieves. Departamento de Neurologia) ;
Purroy, Francisco (Hospital Universitari Arnau de Vilanova. Departament de Neurologia) ;
Cocho, Dolores (Hospital de Granollers. Departament de Neurologia) ;
Navas, Inma (Hospital Mútua de Terrassa. Departament de Neurologia) ;
Tejero, Carlos (Hospital Clínico Universitario Lozano Blesa. Departamento de Neurologia) ;
Aymerich, Nuria (Hospital de Navarra. Departamento de Neurologia) ;
Cullell, Natalia (Fundació Docència i Recerca Mutua Terrassa) ;
Muiño, Elena (Fundació Docència i Recerca Mutua Terrassa) ;
Serena, Joaquín (Hospital Universitari Dr. Josep Trueta. Departament de Neurologia) ;
Rubio, Francisco (Hospital de Bellvitge. Departament de Neurologia) ;
Davalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Roquer, Jaume (Hospital del Mar. Departament de Neurologia) ;
Arenillas, Juan Francisco (Hospital Clínico Universitario de Valladolid. Departamento de Neurologia) ;
Martí Fábregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Keene, Keith (Center for Health Disparities. East Carolina University) ;
Chen, Wei-Min (Department of Public Health Sciences; Center for Public Health Genomics, University of Virginia) ;
Worrall, Bradford (Department of Neurology; Department of Public Health Sciences, University of Virginia) ;
Sale, Michele (Center for Public Health Genomics, University of Virginia) ;
Arboix, Adrià (Hospital Universitari Sagrat Cor. Departament de Neurologia) ;
Krupinski, Jerzy (Hospital Mútua de Terrassa. Departament de Neurologia) ;
Montaner, Joan (Hospital Vall d'Hebron. Departament de Neurologia) ;
GRECOSstudy group ;
Universitat Autònoma de Barcelona
Background and Purpose—Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack (TIA). Clinical scores do not predict the whole vascular recurrence risk, therefore we aimed to find genetic variants associated with recurrence that might improve the clinical predictive mode is in IS. [...]
2017 - 10.1161/STROKEAHA.116.014322
Stroke, Vol. 48 Núm. 5 (2017) , p. 1147-1153
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11 p, 899.4 KB |
H-FABP: A new biomarker to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury
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Lagerstedt,Linnéa (University of Geneva. Department of Human Protein Sciences) ;
Egea Guerrero, Juan José (Hospital Universitario Virgen del Rocío) ;
Bustamante, Alejandro (Vall d'Hebron Institut de Recerca) ;
Montaner, Joan (Vall d'Hebron Institut de Recerca) ;
Rodríguez Rodríguez, Ana (Hospital Universitario Virgen del Rocío) ;
El Rahal, Amir (Geneva University Hospitals. Department of Clinical Neurosciences.) ;
Turck, Natacha (University of Geneva. Department of Human Protein Sciences) ;
Quintana, Manuel (Hospital Universitario La Paz) ;
García Armengol, Roser (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prica, Carmen Melinda (Hospital de Tortosa Verge de la Cinta) ;
Andereggen, Elisabeth (Geneva University Hospitals. Emergency Center) ;
Rinaldi, Lara (Geneva University Hospitals. Department of Surgery) ;
Sarrafzadeh, Asita (University Hospital Heidelberg. Department of Neurosurgery) ;
Schaller, Karl (Geneva University Hospitals. Department of Clinical Neurosciences) ;
Sanchez, Jean-Charles (University of Geneva. Department of Human Protein Sciences) ;
Universitat Autònoma de Barcelona
The majority of patients with mild traumatic brain injury (mTBI) will have normal Glasgow coma scale (GCS) of 15. Furthermore, only 5%±8% of them will be CT-positive for an mTBI. Having a useful biomarker would help clinicians evaluate a patient's risk of developing intracranial lesions. [...]
2017 - 10.1371/journal.pone.0175572
Plos one, Vol. 12 Núm. 4 (2017) , p. 1-11
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11 p, 788.9 KB |
Poor phenotype-genotype association in a large series of patients with Type III Bartter syndrome
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García Castaño, Alejandro (Instituto de Investigación Sanitaria BioCruces Bizkaia) ;
Pérez de Nanclares, Gustavo (Instituto de Investigación Sanitaria BioCruces Bizkaia) ;
Madariaga, Leire (Universidad del País Vasco. Departamento de Pediatría) ;
Aguirre, Mireia (Hospital Universitario Cruces, Bizkaia) ;
Madrid, Álvaro (Hospital Universitari Vall d'Hebron) ;
Chocrón, Sara (Hospital Universitari Vall d'Hebron) ;
Nadal, Inmaculada (Hospital Virgen del Camino, Pamplona) ;
Navarro, Mercedes (Hospital Universitario La Paz, Madrid) ;
Lucas, Elena (Hospital de Manises, Valencia) ;
Fijo, Julia (Hospital Virgen del Rocio, Sevilla) ;
Espino, Mar (Hospital Universitario Fundación Alcorcón) ;
Espitaletta, Zilac (Hospital Universitario San Ignacio, Bogotá) ;
García Nieto, Víctor (Hospital Universitario Nuestra Señora de Candelaria, Tenerife) ;
Barajas de Frutos, David (Hospital Virgen de las Nieves, Granada) ;
Loza, Reyner (Hospital Cayetano Heredia, Lima) ;
Pintos, Guillem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Castaño, Luis (Instituto de Investigación Sanitaria BioCruces Bizkaia) ;
Grupo RenalTube ;
Ariceta, Gema (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Type III Bartter syndrome (BS) is an autosomal recessive renal tubule disorder caused by loss-of-function mutations in the CLCNKB gene, which encodes the chloride channel protein ClC-Kb. In this study, we carried out a complete clinical and genetic characterization in a cohort of 30 patients, one of the largest series described. [...]
2017 - 10.1371/journal.pone.0173581
Plos one, Vol. 12 Núm. 3 (2017) , p. 1-11
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13 p, 2.4 MB |
Apoptosis, Toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens
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Martínez, Isidoro (Centro Nacional de Microbiologia. Instituto de Salud Carlos III) ;
Oliveros, Juan C. (Centro Nacional de Biotecnologia) ;
Cuesta, Isabel (Centro Nacional de Microbiologia. Instituto de Salud Carlos III) ;
de la Barrera, Jorge (Centro Nacional de Microbiologia. Instituto de Salud Carlos III) ;
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Casals, Cristina (Universidad Complutense de Madrid. Departamento de Bioquímica y Biologia Molecular) ;
de Lorenzo, Alba (Universidad Complutense de Madrid. Departamento de Bioquímica y Biologia Molecular) ;
García, Ernesto (Centro de Investigaciones Biológicas) ;
García Fojeda, Belén (Universidad Complutense de Madrid. Departamento de Bioquímica y Biologia Molecular) ;
Garmendia, Junkal (Universidad Pública de Navarra. Instituto de Agrobiotecnologia) ;
González Nicolau, Mar (Fundación de Investigación Sanitaria de las Islas Baleares) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Menéndez, Margarita (Instituto de Química Física Rocasolano) ;
Moranta, David (Fundación de Investigación Sanitaria de las Islas Baleares) ;
Nieto, Amelia (Centro Nacional de Biotecnologia) ;
Ortín, Juan (Centro Nacional de Biotecnologia) ;
Pérez González, Alicia (Centro Nacional de Biotecnologia) ;
Prat, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ramos Sevillano, Elisa (Centro de Investigaciones Biológicas) ;
Regueiro, Verónica (Fundación de Investigación Sanitaria de las Islas Baleares) ;
Rodriguez Frandsen, Ariel (Centro Nacional de Biotecnologia) ;
Solís, Dolores (Instituto de Química Física Rocasolano) ;
Yuste, José (Centro de Investigaciones Biológicas) ;
Bengoechea, José A. (Fundación de Investigación Sanitaria de las Islas Baleares) ;
Melero, José A. (Centro Nacional de Microbiologia. Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. [...]
2017
Frontiers in microbiology, Vol. 8 (2017) , p. 1-13
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13 p, 1.6 MB |
Delivery is key: lessons learnt from developing splice-switching antisense therapies
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Godfrey, Caroline (University of Oxford. Department of Physiology, Anatomy and Genetics) ;
Desviat, Lourdes R (Centro de Biología Molecular Severo Ochoa UAM-CSIC) ;
Smedsrød, Bård (University of TromsØ. Department of Medical Biology) ;
Piétri-Rouxel, France (Institut de Myologie, Paris) ;
Denti, Michela A (Università di Trento. Centre for Integrative Biology) ;
Disterer, Petra (University College London. Centre for Amyloidosis and Acute Phase Proteins) ;
Lorain, Stéphanie (Institut de Myologie, Paris) ;
Nogales Gadea, Gisela (Institut Germans Trias i Pujol. Grup d'Investigació en Malalties Neuromuscular i Neuropediàtriques) ;
Sardone, Valentina (University College London) ;
Anwar, Rayan (Drug Discovery Informatics Lap, Qasemi-Research Center, Al-Qasemi Academic College) ;
EL Andaloussi, Samir (Karolinska Institute. Department of Laboratory Medicine) ;
Lehto, Taavi (University of Tartu. Institute of Technology) ;
Khoo, Bernard (University College London. Centre for Neuroendocrinology) ;
Brolin, Camilla (University of Copenhagen. Department of Cellular and Molecular Medicine) ;
van Roon-Mom, Willeke MC (Leiden University Medical Center. DEpartment of Human Genetics) ;
Goyenvalle, Aurélie (Université Versailles Saint Quentin) ;
Aartsma-Rus, Annemieke (Leiden University Medical Center. Department of Human Genetics) ;
Arechavala-Gomeza, Virginia (Neuromuscular Disorders Group. BioCruces Health Research Insitute, Bizkaia) ;
Universitat Autònoma de Barcelona
The use of splice-switching antisense therapy is highly promising, with a wealth of pre-clinical data and numerous clinical trials ongoing. Nevertheless, its potential to treat a variety of disorders has yet to be realized. [...]
2017 - 10.15252/emmm.201607199
EMBO Molecular Medicine, Vol. 9 Núm. 5 (2017) , p. 545-557
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22 p, 1.6 MB |
Primitive Neuroectodermal Tumors of the Female Genital Tract: A Morphologic, Immunohistochemical and Molecular Study of 19 Cases
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Chiang, Sarah (Department of Pathology, Memorial Sloan Kettering Cancer Center) ;
Snuderl, Matija (Department of Pathology, New York University Langone Medical Center,) ;
Kojiro-Sanada, Sakiko (Department of Pathology, Kurume University School of Medicine) ;
Quer Pi-Sunyer, Ariadna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Daya, Dean (Department of Pathology, McMaster University, Juravinski Hospital) ;
Hayashi, Tohru (Department of Pathology, Junwakai Memorial Hospital) ;
Bosincu, Luisanna (Department of Pathology, University of Sassar) ;
Ogawa, Fumihiro (Department of Diagnostic Pathology, Sainokuni Higashiomiya Medical Center) ;
Rosenberg, Andrew E. (Department of Pathology, Miller School of Medicine, University of Miami) ;
Horn, Lars-Christian (Division of Gynecologic, Breast and Perinatal Pathology, University Hospital Leipzig) ;
Wang, Lu (Department of Pathology, Memorial Sloan Kettering Cancer Center) ;
Iafrate, John (Department of Pathology, Massachusetts General Hospital and Harvard Medical School) ;
Oliva, Esther (Department of Pathology, Massachusetts General Hospital and Harvard Medical School) ;
Universitat Autònoma de Barcelona
Primary primitive neuroectodermal tumor (PNET) of the female genital tract is rare, and its proper classification remains unclear. The clinical, histologic, and immunophenotypic features as well as EWSR1 rearrangement status of 19 gynecologic PNETs, including 10 ovarian, 8 uterine, and 1 vulvar tumors, are herein reported. [...]
2017 - 10.1097/PAS.0000000000000831
American Journal Of Surgical Pathology, Vol. 41 Núm. 6 (772 2017) , p. 761
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