Vázquez-Villa, Henar - Search Results - UAB Digital Repository of Documents

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Articles, 2 records found

Articles	2 records found

19 p, 6.9 MB

Novel antagonist of the type 2 lysophosphatidic acid receptor (LPA), UCM-14216, ameliorates spinal cord injury in mice / Khiar-Fernández, Nora (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Zian, Debora (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Vázquez-Villa, Henar (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Martínez, R. Fernando (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Escobar-Peña, Andrea (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Foronda-Sainz, Román (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Ray, Manisha (Sanford Burnham Prebys Medical Discovery Institute) ; Puigdomenech Poch, Maria (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Cincilla, Giovanni (Molomics) ; Sánchez-Martínez, Melchor (Burua Scientific) ; Kihara, Yasuyuki (Sanford Burnham Prebys Medical Discovery Institute) ; Chun, Jerold (Sanford Burnham Prebys Medical Discovery Institute) ; López Vales, Rubén (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; López-Rodríguez, María L. (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Ortega-Gutiérrez, Silvia (Universidad Complutense de Madrid. Departamento de Química Orgánica)
Spinal cord injuries (SCIs) irreversibly disrupt spinal connectivity, leading to permanent neurological disabilities. Current medical treatments for reducing the secondary damage that follows the initial injury are limited to surgical decompression and anti-inflammatory drugs, so there is a pressing need for new therapeutic strategies. [...]
2022 - DOI (Digital Object Identifier)

10.1021/acs.jmedchem.2c00046
Journal of Medicinal Chemistry, Vol. 65, issue 16 (August 2022) , p. 10956-10974

Detailed record -

10 p, 1.2 MB

A new serotonin 5-HT6 receptor antagonist with procognitive activity : importance of a halogen bond interaction to stabilize the binding / González-Vera, Juan A. (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Medina, Rocio A. (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Martín-Fontecha, Mar (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Gonzalez, Angel (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; De La Fuente, Tania (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Vázquez-Villa, Henar (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; García-Cárceles, Javier (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Botta, Joaquín (University of East Anglia. School of Pharmacy (Norwich, Regene Unit)) ; McCormick, Peter J. (University of East Anglia. School of Pharmacy (Norwich, Regene Unit)) ; Benhamú, Bellinda (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Pardo Carrasco, Leonardo (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; López-Rodríguez, Maria L. (Universidad Complutense de Madrid. Departamento de Química Orgánica)
Serotonin 5-HT6 receptor has been proposed as a promising therapeutic target for cognition enhancement though the development of new antagonists is still needed to validate these molecules as a drug class for the treatment of Alzheimer's disease and other pathologies associated with memory deficiency. [...]
2017 - DOI (Digital Object Identifier)

10.1038/srep41293
Scientific reports, Vol. 7 (2017) , art. 41293

Detailed record -

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