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14 p, 1.5 MB |
Effects of Albumin Treatment on Systemic and Portal Hemodynamics and Systemic Inflammation in Patients With Decompensated Cirrhosis
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Fernández, Javier (Hospital Clínic i Provincial de Barcelona) ;
Clària, J (Hospital Clínic i Provincial de Barcelona) ;
Amorós, Alex (Grifols) ;
Aguilar, Ferran (Grifols) ;
Castro, Miriam (Hospital Clínic i Provincial de Barcelona) ;
Casulleras, Mireia (Hospital Clínic i Provincial de Barcelona) ;
Acevedo, Juan (Derriford Hospital) ;
Duran, Marta (Hospital Clínic i Provincial de Barcelona) ;
Nuñez, Laura (Grifols) ;
Costa, Montserrat (Grifols) ;
Torres, Mireia (Grifols) ;
Horrillo, Raquel (Grifols) ;
Ruiz-del-Árbol, Luis (Hospital Universitario Ramón y Cajal (Madrid)) ;
Villanueva, Càndid (Institut d'Investigació Biomèdica Sant Pau) ;
Prado, Veronica (Hospital Clínic i Provincial de Barcelona) ;
Arteaga, Mireya (Hospital Clínic i Provincial de Barcelona) ;
Trebicka, Jonel (University Hospital of Bonn) ;
Angeli, Paolo (University of Padova) ;
Merli, Manuela (Sapienza University of Rome) ;
Alessandria, Carlo (San Giovanni Battista Hospital) ;
Aagaard, Niels Kristian (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Soriano, German (Institut d'Investigació Biomèdica Sant Pau) ;
Durand, Francois (Hopital Beaujon) ;
Gerbes, Alexander L. (LMU Munich) ;
Gustot, Thierry (Erasme Hospital (ULB)) ;
Welzel, Tania M. (Goethe University) ;
Salerno, Francesco (Policlinico IRCCS San Donato) ;
Bañares, Rafael (Hospital General Universitario Gregorio Marañón) ;
Vargas Blasco, Víctor (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Albillos, Agustín (Hospital Universitario Ramón y Cajal (Madrid)) ;
Silva, Anibal (Hospital Clínic i Provincial de Barcelona) ;
Morales Ruiz, Manuel (Hospital Clínic i Provincial de Barcelona) ;
García-Pagán, JC. (Hospital Clínic i Provincial de Barcelona) ;
Pavesi, Marco (Grifols) ;
Jalan, Rajiv (Royal Free Hospital) ;
Bernardi, Mauro (University of Bologna) ;
Moreau, Richard (Université Paris Diderot-Paris 7) ;
Páez, Antonio (Grifols) ;
Arroyo, Vicente (Grifols) ;
Universitat Autònoma de Barcelona
We investigated the effect of albumin treatment (20% solution) on hypoalbuminemia, cardiocirculatory dysfunction, portal hypertension, and systemic inflammation in patients with decompensated cirrhosis with and without bacterial infections. [...]
2019 -  10.1053/j.gastro.2019.03.021
Gastroenterology, Vol. 157 Núm. 1 (july 2019) , p. 149-162
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14 p, 1.0 MB |
The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology
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Trebicka, Jonel (JW Goethe University Hospital) ;
Fernández, Javier (Hospital Clínic i Provincial de Barcelona) ;
Papp, Maria (University of Debrecen) ;
Caraceni, Paolo (University of Bologna) ;
Laleman, Wim (University of Leuven) ;
Gambino, Carmine (University of Padova) ;
Giovo, Ilaria (University of Torino) ;
Uschner, Frank Erhard (JW Goethe University Hospital) ;
Jiménez, Cesar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mookerjee, Rajeshwar Prosad (UCL Royal Free Hospital) ;
Gustot, Thierry (Universite Libre de Bruxelles) ;
Albillos, Agustín (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Bañares, Rafael (Universidad Complutense de Madrid) ;
Janicko, Martin (Pavol Jozef Safarik University in Kosice) ;
Steib, Christian (University Hospital Munich) ;
Reiberger, Thomas (Medical University of Vienna) ;
Acevedo, Juan (University Hospitals Plymouth NHS Trust (Regne Unit)) ;
Gatti, Pietro (Internal Medicine PO Ostuni. ASL Brindisi) ;
Bernal, William (King's College Hospital NHS Foundation Trust) ;
Zeuzem, Stefan (JW Goethe University Hospital) ;
Zipprich, Alexander (University Hospital Halle-Wittenberg) ;
Piano, Salvatore (University of Padova) ;
Berg, Thomas (Leipzig University) ;
Bruns, Tony (Aachen University Hospital) ;
Bendtsen, Flemming (Hvidovre University Hospital) ;
Coenraad, Minneke (Leiden University Medical Center) ;
Merli, Manuela (Universitá Sapienza Roma) ;
Stauber, Rudolf (Medical University of Graz) ;
Zoller, Heinz (Medical University of Innsbruck) ;
Presa Ramos, José (CHTMAD Vila Real) ;
Solé, Cristina (Hospital Clínic i Provincial de Barcelona) ;
Soriano, German (Institut d'Investigació Biomèdica Sant Pau) ;
De Gottardi, Andrea (Universita della Svizzera Italiana) ;
Gronbaek, Henning (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Saliba, Faouzi (AP-HP Hôpital Paul Brousse) ;
Trautwein, Christian (Aachen University Hospital) ;
Özdogan, Osman Cavit (Marmara University) ;
Francque, Sven (University Hospital Antwerp) ;
Ryder, Stephen David (University of Nottingham) ;
Nahon, Pierre (AP-HP. Hôpital Jean Verdier) ;
Romero-Gómez, Manuel (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Van Vlierberghe, Hans (Universitair Ziekenhuis Gent) ;
Francoz, Claire (Université de Paris) ;
Manns, Michael (Hannover Medical School) ;
García López, Elisabet (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Tufoni, Manuel (University of Bologna) ;
Amoros, Alex (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Pavesi, Marco (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Sanchez, Cristina (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Curto, Anna (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Pitarch, Carla (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Putignano, Antonella (Universite Libre de Bruxelles) ;
Moreno, Esau (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Shawcross, Debbie (King's College Hospital NHS Foundation Trust) ;
Aguilar, Ferran (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Clària, J (Hospital Clínic i Provincial de Barcelona) ;
Ponzo, Paola (University of Torino) ;
Jansen, Christian (University Hospital Bonn (Bonn, Alemanya)) ;
Vitalis, Zsuzsanna (University of Debrecen) ;
Zaccherini, Giacomo (University of Bologna) ;
Balogh, Boglarka (University of Debrecen) ;
Vargas Blasco, Víctor (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montagnese, Sara (University of Padova) ;
Alessandria, Carlo (University of Torino) ;
Bernardi, Mauro (University of Bologna) ;
Ginès, Pere (Hospital Clínic i Provincial de Barcelona) ;
Jalan, Rajiv (UCL Medical School. Royal Free Hospital) ;
Moreau, Richard (Université de Paris) ;
Angeli, Paolo (University of Padova) ;
Arroyo, Vicente (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Maschmeier, Miriam (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Semela, David (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Elkrief, Laure (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Elsharkawy, Ahmed (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Tornai, Tamás (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Tornai, Istvan (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Altorjay, Istvan (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Antognoli, Agnese (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Baldassarre, Maurizio (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Gagliardi, Martina (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Bertoli, Eleonora (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Mareso, Sara (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Brocca, Alessandra (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Campion, Daniela (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Saracco, Giorgio Maria (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Rizzo, Martina (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Lehmann, Jennifer (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Pohlmann, Alessandra (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Praktiknjo, Michael (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Schierwagen, Robert (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Solà, Elsa (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Amari, Nesrine (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Rodriguez, Miguel (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Nevens, Frederik (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Clemente, Ana (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Jarcuska, Peter (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Gerbes, Alexander L. (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Mandorfer, Mattias (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Welsch, Christoph (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Ciraci, Emanuela (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Patel, Vish (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Ripoll, Cristina (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Herber, Adam (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Horn, Paul (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Danielsen, Karen Vagner (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Gluud, Lise Lotte (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Schaapman, Jelte (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Riggio, Oliviero (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Rainer, Florian (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Moritz, Jörg Tobiasch (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Mesquita, Mónica (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Alvarado-Tapias, Edilmar (Institut d'Investigació Biomèdica Sant Pau) ;
Akpata, Osagie (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Lykke Eriksen, Peter (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Samuel, Didier (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Tresson, Sylvie (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Strnad, Pavel (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Amathieu, Roland (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Simón-Talero, Macarena (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Smits, Francois (PREDICT STUDY group of the EASL-CLIF Consortium) ;
van den Ende, Natalie (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Martinez, Javier (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Garcia, Rita (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Markwardt, Daniel (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Rupprechter, Harald (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Engelmann, Cornelius (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Universitat Autònoma de Barcelona
Acute decompensation (AD) of cirrhosis is defined as the acute development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination thereof, requiring hospitalization. [...]
2020 - 10.1016/j.jhep.2020.06.013
Journal of Hepatology, Vol. 73 Núm. 4 (october 2020) , p. 842-854
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12 p, 780.3 KB |
PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
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Trebicka, Jonel (Department of Internal Medicine I. Goethe University Frankfurt) ;
Fernández, Javier (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Papp, Maria (University of Debrecen. Faculty of Medicine. Institute of Medicine. Department of Gastroenterology) ;
Caraceni, Paolo (University of Bologna) ;
Laleman, Wim (University of Leuven) ;
Gambino, Carmine (University of Padova) ;
Giovo, Ilaria (A.O.U. Città della Salute e della Scienza Torino) ;
Uschner, Frank Erhard (Department of Internal Medicine I. Goethe University Frankfurt) ;
Jansen, Christian (Department of Internal Medicine I. University Hospital Bonn) ;
Jimenez, Cesar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mookerjee, Rajeshwar Prosad (UCL Medical School. Royal Free Hospital) ;
Gustot, Thierry (C.U.B. Erasme) ;
Albillos, Agustín (Hospital Universitario Ramón y Cajal (Madrid)) ;
Bañares, Rafael (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Jarcuska, Peter (Pavol Jozef Safarik University in Kosice) ;
Steib, Christian (Department of Medicine II. Liver Centre Munich. University Hospital. LMU) ;
Reiberger, Thomas (Medical University of Vienna) ;
Acevedo, Juan (University Hospitals Plymouth NHS Trust (Regne Unit)) ;
Gatti, Pietro (Internal Medicine PO Ostuni) ;
Shawcross, Debbie (King's College Hospital NHS Foundation Trust) ;
Zeuzem, Stefan (Department of Internal Medicine I. Goethe University Frankfurt) ;
Zipprich, Alexander (University Hospital Halle-Wittenberg) ;
Piano, Salvatore (University of Padova) ;
Berg, Thomas (Division of Hepatology. Department of Medicine II. Leipzig University. Medical Center) ;
Bruns, Tony (Aachen University Hospital) ;
Danielsen, Karen Vagner (University of Copenhagen) ;
Coenraad, Minneke (Leiden University Medical Center) ;
Merli, Manuela (Universitá Sapienza Roma) ;
Stauber, Rudolf (Medical University of Graz) ;
Zoller, Heinz (Medical University of Innsbruck) ;
Presa Ramos, José (CHTMAD Vila Real-Blueclinical) ;
Solé, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Soriano, German (Institut d'Investigació Biomèdica Sant Pau) ;
De Gottardi, Andrea (University Clinic of Visceral Surgery and Medicine-Inselspital. Bern and Ente Ospedaliero Cantonale. Universita della Svizzera Italiana) ;
Gronbaek, Henning (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Saliba, Faouzi (AP-HP Hôpital Paul Brousse. Centre Hépato-Biliaire. Universite Paris Saclay. INSERM Unit 1193) ;
Trautwein, Christian (Aachen University Hospital) ;
Kani, Haluk Tarik (Marmara University) ;
Francque, Sven (University Hospital Antwerp) ;
Ryder, Stephen David (NIHR Biomedical Research Centre at Nottingham University Hospitals NHS Trust and the University of Nottingham) ;
Nahon, Pierre (Inserm. UMR-1162. "Génomique fonctionnelle des tumeurs solides") ;
Romero-Gomez, Manuel (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Van Vlierberghe, Hans (Universitair Ziekenhuis Gent) ;
Francoz, Claire (Inserm. Université de Paris. Centre de Recherche sur L'Inflammation) ;
Manns, Michael (Hannover Medical School) ;
Garcia-Lopez, Elisabet (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Tufoni, Manuel (University of Bologna) ;
Amoros, Alex (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Pavesi, Marco (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Sanchez, Cristina (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Praktiknjo, Michael (Department of Internal Medicine I. University Hospital Bonn) ;
Curto, Anna (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Pitarch, Carla (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Putignano, Antonella (C.U.B. Erasme) ;
Moreno, Esau (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Bernal, William (King's College Hospital NHS Foundation Trust) ;
Aguilar, Ferran (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Clària, J (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ponzo, Paola (A.O.U. Città della Salute e della Scienza Torino) ;
Vitalis, Zsuzsanna (University of Debrecen. Faculty of Medicine. Institute of Medicine. Department of Gastroenterology) ;
Zaccherini, Giacomo (University of Bologna) ;
Balogh, Boglarka (University of Debrecen. Faculty of Medicine. Institute of Medicine. Department of Gastroenterology) ;
Gerbes, Alexander L (Department of Medicine II. Liver Centre Munich. University Hospital. LMU) ;
Vargas, Victor (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alessandria, Carlo (A.O.U. Città della Salute e della Scienza Torino) ;
Bernardi, Mauro (University of Bologna) ;
Ginès, Pere (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Moreau, Richard (Inserm. Université de Paris. Centre de Recherche sur L'Inflammation) ;
Angeli, Paolo (University of Padova) ;
Jalan, Rajiv (UCL Medical School. Royal Free Hospital) ;
Arroyo, Vicente (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Maschmeier, Miriam (Munster University Hospital) ;
Semela, David (University of Basel-St Gall Cantonal Hospital) ;
Elkrief, Laure (Hôpitaux Universitaires de Genève) ;
Elsharkawy, Ahmed (University of Birmingham) ;
Tornai, Tamas (University of Birmingham) ;
Tornai, Istvan (University of Debrecen. Faculty of Medicine. Institute of Medicine. Department of Gastroenterology) ;
Altorjay, Istvan (University of Debrecen. Faculty of Medicine. Institute of Medicine. Department of Gastroenterology) ;
Antognoli, Agnese (University of Bologna) ;
Baldassarre, Maurizio (University of Bologna) ;
Gagliardi, Martina (University of Bologna) ;
Bertoli, Eleonora (University of Padova) ;
Mareso, Sara (University of Padova) ;
Brocca, Alessandra (University of Padova) ;
Campion, Daniela (A.O.U. Città della Salute e della Scienza Torino) ;
Saracco, Giorgio Maria (A.O.U. Città della Salute e della Scienza Torino) ;
Rizzo, Martina (A.O.U. Città della Salute e della Scienza Torino) ;
Lehmann, Jennifer (University Hospital Bonn (Bonn, Alemanya)) ;
Pohlmann, Alessandra (University Hospital Bonn (Bonn, Alemanya)) ;
Brol, Maximilian Joseph (University Hospital Bonn (Bonn, Alemanya)) ;
Chang, Johannes (University Hospital Bonn (Bonn, Alemanya)) ;
Schierwagen, Robert (Department of Internal Medicine I. Goethe University Frankfurt) ;
Solà, Elsa (Hospital Clínic i Provincial de Barcelona) ;
Amari, Nesrine (C.U.B. Erasme) ;
Rodriguez, Miguel (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Nevens, Frederik (Department of Gastroenterology and Hepatology. Section of Liver and Biliopancreatic disorders. University of Leuven) ;
Clemente, Ana (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Janicko, Martin (Pavol Jozef Safarik University in Kosice) ;
Markwardt, Daniel (Department of Medicine II. Liver Centre Munich. University Hospital. LMU) ;
Mandorfer, Mattias (Medical University of Vienna) ;
Welsch, Christoph (Department of Internal Medicine I. Goethe University Frankfurt) ;
Welzel, Tanja M. (Department of Internal Medicine I. Goethe University Frankfurt) ;
Ciraci, Emanuela (Internal Medicine PO Ostuni) ;
Patel, Vish (King's College Hospital NHS Foundation Trust) ;
Ripoll, Cristina (University Hospital Halle-Wittenberg) ;
Herber, Aadam (Division of Hepatology. Department of Medicine II. Leipzig University. Medical Center) ;
Horn, Paul (Jena University Hospital (Alemanya)) ;
Bendtsen, Flemming (Gastrounit. Medical Section. Hvidovre Hospital and Department of Clinical Medicine. University of Copenhagen) ;
Gluud, Lise Lotte (Gastrounit. Medical Section. Hvidovre Hospital and Department of Clinical Medicine. University of Copenhagen) ;
Schaapman, Jelte (Leiden University Medical Center) ;
Riggio, Oliviero (Universitá Sapienza Roma) ;
Rainer, Florian (Medical University of Graz) ;
Moritz, Jörg Tobiasch (Medical University of Innsbruck) ;
Mesquita, M. (CHTMAD Vila Real-Blueclinical) ;
Alvarado-Tapias, Edilmar (Institut d'Investigació Biomèdica Sant Pau) ;
Akpata, Osagie (UCL Medical School. Royal Free Hospital) ;
Aamann, Luise (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Samuel, Didier (AP-HP Hôpital Paul Brousse. Centre Hépato-Biliaire. Universite Paris Saclay. INSERM Unit 1193) ;
Tresson, Sylvie (AP-HP Hôpital Paul Brousse. Centre Hépato-Biliaire. Universite Paris Saclay. INSERM Unit 1193) ;
Strnad, Pavel (Aachen University Hospital) ;
Amathieu, Roland (Inserm. UMR-1162. "Génomique fonctionnelle des tumeurs solides") ;
Simón-Talero, Macarena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Smits, Francois (C.U.B. Erasme) ;
van den Ende, Natalie (Department of Gastroenterology and Hepatology. Section of Liver and Biliopancreatic disorders. University of Leuven) ;
Martinez, Javier (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Garcia, Rita (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Rupprechter, Harald (Medical University of Vienna) ;
Engelmann, Cornelius (Division of Hepatology. Department of Medicine II. Leipzig University. Medical Center) ;
Özdogan, Osman Cavit (Marmara University) ;
Universitat Autònoma de Barcelona
Background & Aims: Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading to both of these AD phenotypes. [...]
2021 - 10.1016/j.jhep.2020.11.019
Journal of Hepatology, Vol. 74 Núm. 5 (may 2021) , p. 1097-1108
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10 p, 1.1 MB |
Risk of infections in patients with NAFLD and Type 2 Diabetes under treatment with SGLT2 inhibitors and relationship with liver outcomes : A retrospective case-control study
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Bañares, Juan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Manzano-Nuñez, Ramiro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Prió, Alba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rivera-Esteban, Jesús (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Camps-Relats, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Villarejo, Ana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz-Ortega, Lourdes (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pons, Mònica (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Ciudin, Andreea (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Salcedo, Maria-Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vargas, Víctor (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Genescà Ferrer, Joan (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Pericàs, Juan M. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in developed countries, with its incidence growing parallel to the epidemics of obesity and type 2 diabetes mellitus (T2DM). [...]
2022 - 10.3389/fendo.2022.945626
Frontiers in Endocrinology, Vol. 13 (august 2022)
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10 p, 389.9 KB |
A phase II study of human allogeneic liver-derived progenitor cell therapy for acute-on-chronic liver failure and acute decompensation
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Nevens, Frederik (University Hospitals Leuven (Bèlgica)) ;
Gustot, Thierry (C.U.B. Erasme Hospital) ;
Laterre, Pierre-François (Cliniques Universitaires Saint-Luc) ;
Lasser, Luc L. (CHU Brugmann) ;
Haralampiev, Lyudmil E. (Multiprofile Hospital for Active Treatment (MEDICA), Ruse) ;
Vargas, Victor (Hospital Universitari Vall d'Hebron) ;
Lyubomirova, Desislava (University Multiprofile Hospital for Active Treatment "Georgi Stranski") ;
Albillos, Agustín (Hospital Universitario Ramón y Cajal (Madrid)) ;
Najimi, Mustapha (Institute of Experimental and Clinical Research, Brussels) ;
Michel, Sébastien (Promethera Biosciences, Mont-Saint-Guibert) ;
Stoykov, Ivaylo (Promethera Biosciences, Mont-Saint-Guibert) ;
Gordillo, Noelia (Promethera Biosciences, Mont-Saint-Guibert) ;
Vainilovich, Yelena (Promethera Biosciences, Mont-Saint-Guibert) ;
Barthel, Virginie (Promethera Biosciences, Mont-Saint-Guibert) ;
Clerget-Chossat, Nathalie (Promethera Biosciences, Mont-Saint-Guibert) ;
Sokal, Etienne M. (Cliniques Universitaires Saint-Luc, UCLouvain, Pediatric Hepatology & Gastroenterology Unit) ;
Universitat Autònoma de Barcelona
Human allogeneic liver-derived progenitor cells (HALPC, HepaStem®; Promethera Biosciences, Mont-Saint-Guibert, Belgium) are an advanced therapy medicinal product that could potentially alleviate systemic inflammation and ameliorate liver function in patients with acute-on-chronic liver failure (ACLF) or acute decompensation of cirrhosis (AD). [...]
2021 - 10.1016/j.jhepr.2021.100291
JHEP Reports, Vol. 3 (april 2021)
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14 p, 383.4 KB |
The Use of Rifaximin in Patients With Cirrhosis
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Caraceni, Paolo (University Hospital S. Orsola-Malpighi di Bologna) ;
Vargas, Victor (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Solà, Elsa (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Alessandria, Carlo (University of Torino) ;
de Wit, Koos (Amsterdam UMC. University Medical Center) ;
Trebicka, Jonel (EF-CLIF (Barcelona)) ;
Angeli, Paolo (University Hospital of Padova (Pàdua, Itàlia)) ;
Mookerjee, Rajeshwar P. (University College London) ;
Durand, François (Hospital Beaujon) ;
Pose, Elisa (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Krag, Aleksander (University of Southern Denmark) ;
Bajaj, Jasmohan S. (Virginia Commonwealth University Medical Center) ;
Beuers, Ulrich (Amsterdam UMC. University Medical Center) ;
Ginès, Pere (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Universitat Autònoma de Barcelona
Rifaximin is an oral nonsystemic antibiotic with minimal gastrointestinal absorption and broad-spectrum antibacterial activity covering both gram-positive and gram-negative organisms. Rifaximin is currently used worldwide in patients with cirrhosis for preventing recurrent HE because its efficacy and safety have been proven by large randomized clinical trials. [...]
2021 - 10.1002/hep.31708
Hepatology, Vol. 74 (june 2021) , p. 1660-1673
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7.
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9 p, 3.9 MB |
Hepatocellular carcinoma with tumor thrombus extends to the right atrium and portal vein : a case report
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Gomez-Puerto, Diego (Hospital Universitari Vall d'Hebron) ;
Mirallas, Oriol (Hospital Universitari Vall d'Hebron) ;
Vidal-González, Judit (Hospital Universitari Vall d'Hebron) ;
Vargas Blasco, Víctor (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Hepatocellular carcinoma (HCC) is the most important primary malignant liver disease. A large proportion of patients with advanced HCC have macrovascular invasion. HCC tends to infiltrate vascular structures, particularly the portal vein and its branches, and more rarely, the hepatic veins. [...]
2020 - 10.4254/wjh.v12.i11.1128
World Journal of Hepatology, Vol. 12 (november 2020) , p. 1128-1135
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8.
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3 p, 481.9 KB |
La "candidalisina", una de les exotoxines del fong Candida albicans, contribueix a la malaltia hepàtica associada a l'alcohol
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Vargas Blasco, Víctor (Hospital Universitari Vall d'Hebron)
En les formes greus de malaltia hepàtica alcohòlica, a banda de la ingesta d'alcohol, hi ha altres factors que contribueixen al dany hepàtic. L'alteració de la microbiota intestinal n'és un. En l'estudi següent s'exposa la relació entre la presència del fong Candida albicans a l'intestí i d'una de les seves toxines, la candidalisina, com a factor afavoridor de la lesió hepàtica en l'hepatitis alcohòlica. [...]
En las formas graves de enfermedad hepática alcohólica, además de la ingesta de alcohol, existen otros factores que contribuyen al daño hepático. La alteración de la microbiota intestinal es uno de ellos. [...]
2020
UAB divulga, Setembre 2020
2 documentos
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9 p, 500.5 KB |
Reduction and stabilization of bilirubin with obeticholic acid treatment in patients with primary biliary cholangitis
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Parés, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Shiffman, Mitchell (Bon Secours Mercy Health) ;
Vargas, Victor (Hospital Universitari Vall d'Hebron) ;
Invernizzi, Pietro (University of Milano-Bicocca) ;
Malecha, Elizabeth S. (Intercept Pharmaceuticals) ;
Liberman, Alexander (Intercept Pharmaceuticals) ;
MacConell, Leigh (Intercept Pharmaceuticals) ;
Hirschfield, Gideon (University of Toronto)
Total bilirubin is a predictor of survival in primary biliary cholangitis, with the main elevated component being direct bilirubin. The purpose of this post hoc analysis was to assess the efficacy and safety of obeticholic acid across quartiles of varying baseline levels of direct bilirubin in the phase 3, randomized, placebo-controlled Primary Biliary Cholangitis Obeticholic Acid International Study of Efficacy. [...]
2020 - 10.1111/liv.14429
Liver International, Vol. 40 (march 2020) , p. 1121-1129
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