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11 p, 571.9 KB Multiple genomic events altering Hominin SIGLEC biology and innate immunity predated the common ancestor of humans and archaic Hominins / Khan, Naazneen (University of California. Glycobiology Research and Training Center. Department of Medicine (USA)) ; de Manuel, Marc (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Peyregne, Stephane (Max Planck Institute for Evolutionary Anthropology. Department of Evolutionary Genetics) ; Do, Raymond (University of California. Glycobiology Research and Training Center. Department of Medicine (USA)) ; Prufer, Kay (Max Planck Institute for Evolutionary Anthropology. Department of Evolutionary Genetics) ; Marques-Bonet, Tomas, 1975- (Institut Català de Paleontologia Miquel Crusafont) ; Varki, Nissi (University of California. Glycobiology Research and Training Center. Department of Medicine (USA)) ; Gagneux, Pascal (University of California. Glycobiology Research and Training Center. Department of Medicine (USA)) ; Varki, Ajit (University of California. Glycobiology Research and Training Center. Department of Medicine (USA))
Human-specific pseudogenization of the CMAH gene eliminated the mammalian sialic acid (Sia) Neu5Gc (generating an excess of its precursor Neu5Ac), thus changing ubiquitous cell surface "self-associated molecular patterns" that modulate innate immunity via engagement of CD33-related-Siglec receptors. [...]
2020 - 10.1093/gbe/evaa125
Genome biology and evolution, Vol. 12, Issue 7 (July 2020) , p. 1040-1050  

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