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16 p, 2.6 MB Reduced level of docosahexaenoic acid shifts GPCR neuroreceptors to less ordered membrane regions / Javanainen, Matti (Czech Academy of Sciences. Institute of Organic Chemistry and Biochemistry) ; Enkavi, Giray (Department of Physics. University of Helsinki) ; Guixà González, Ramon (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Kulig, Waldemar (Department of Physics. University of Helsinki) ; Martinez-Seara, Hector (Czech Academy of Sciences. Institute of Organic Chemistry and Biochemistry) ; Levental, Ilya (Department of Integrated Biology and Pharmacology. McGovern Medical School. University of Texas Health Science Center at Houston) ; Vattulainen, Ilpo (MEMPHYS - Center for Biomembrane Physics)
G protein-coupled receptors (GPCRs) control cellular signaling and responses. Many of these GPCRs are modulated by cholesterol and polyunsaturated fatty acids (PUFAs) which have been shown to co-exist with saturated lipids in ordered membrane domains. [...]
2019 - 10.1371/journal.pcbi.1007033
PLoS computational biology, Vol. 15 Núm. 5 (may 2019) , p. e1007033  
Detailed record - Creative Commons

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