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Resultats globals: 14 registres trobats en 0.01 segons.
Articles, 7 registres trobats
Documents de recerca, 7 registres trobats
Articles 7 registres trobats  
1.
11 p, 1.1 MB Acute psychological stress increases paracellular permeability and modulates immune activity in rectal mucosa of healthy volunteers / Gerdin, Linda (Surgical Clinic of Jönköping County) ; González Castro, Ana Maria (Hospital Universitari Vall d'Hebron) ; Ericson, Ann-Charlott (Linköping University) ; Persborn, Mats (Surgical Clinic of Jönköping County) ; Santos, Javier (Hospital Universitari Vall d'Hebron) ; Walter, Susanna A. (Linköping University) ; Keita, Åsa V. (Linköping University) ; Vicario Perez, Maria (Hospital Universitari Vall d'Hebron) ; Söderholm, Johan D. (Linköping University) ; Universitat Autònoma de Barcelona
Psychological stress and increased permeability are implicated as contributing factors in the initiation and worsening of gastrointestinal diseases. A link between stress and intestinal permeability has been shown in animal models as well as in human small intestine, but stress effects on the human colorectal mucosal barrier has not been reported. [...]
2022 - 10.1002/ueg2.12329
United European Gastroenterology Journal, Vol. 11 (october 2022) , p. 31-41  
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2.
14 p, 3.4 MB miR-16 and miR-103 impact 5-HT receptor signalling and correlate with symptom profile in irritable bowel syndrome / Wohlfarth, Carolin (University of Heidelberg) ; Schmitteckert, Stefanie (University of Heidelberg) ; Härtle, Janina D. (University of Heidelberg) ; Houghton, Lesley A. (Mayo Clinic) ; Dweep, Harsh (National Centre for Toxicological Research) ; Fortea, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Assadi, Ghazaleh (Karolinska Institutet (Estocolm, Suècia)) ; Braun, Alexander (University of Heidelberg) ; Mederer, Tanja (University of Heidelberg) ; Pöhner, Sarina (University of Heidelberg) ; Becker, Philip P. (University of Heidelberg) ; Fischer, Christine (University of Heidelberg) ; Granzow, Martin (University of Heidelberg) ; Mönnikes, Hubert (Martin-Luther-Hospital) ; Mayer, Emeran A. (University of California) ; Sayuk, Gregory (Washington University School of Medicine) ; Boeckxstaens, Guy (University Hospitals Leuven (Bèlgica)) ; Wouters, Mira M. (University Hospitals Leuven (Bèlgica)) ; Simrén, Magnus (University of Gothenburg) ; Lindberg, Greger (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Ohlsson, Bodil (Skåne University Hospital (Suècia)) ; Schmidt, Peter Thelin (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Dlugosz, Aldona (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Agreus, Lars (Karolinska Institutet (Estocolm, Suècia)) ; Andreasson, Anna (Stockholm University) ; D'Amato, Mauro (Biodonostia Osasun Ikerketako Institutura (País Basc)) ; Burwinkel, Barbara (University of Heidelberg) ; Bermejo, Justo Lorenzo (University of Heidelberg) ; Röth, Ralph (University of Heidelberg) ; Lasitschka, Felix (University of Heidelberg) ; Vicario Perez, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Metzger, Marco (Branch of the Fraunhofer Institute Interfacial Engineering and Biotechnology) ; Santos, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rappold, Gudrun A. (University of Heidelberg) ; Martinez, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Niesler, Beate (University of Heidelberg) ; Universitat Autònoma de Barcelona
2017 - 10.1038/s41598-017-13982-0
Scientific reports, Vol. 7 (october 2017)  
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3.
9 p, 1.6 MB Activation of Eosinophils and Mast Cells in Functional Dyspepsia : an Ultrastructural Evaluation / Vanheel, Hanne (KU Leuven) ; Vicario Perez, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Boesmans, Werend (Maastricht University Medical Center) ; Vanuytsel, Tim (KU Leuven) ; Salvo-Romero, Eloisa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Tack, Jan (KU Leuven. Translational Research Center for Gastrointestinal Disorders) ; Farré, Ricard (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Universitat Autònoma de Barcelona
We recently identified mucosal mast cell and eosinophil hyperplasia in association with a duodenal impaired barrier function in functional dyspepsia (FD). We aimed to further describe the implication of these immune cells by assessing their activation state at the ultrastructural level and by evaluating the association between impaired epithelial integrity and immune activation. [...]
2018 - 10.1038/s41598-018-23620-y
Scientific reports, Vol. 8 (march 2018)  
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4.
14 p, 7.4 MB Duodenal acidification induces gastric relaxation and alters epithelial barrier function by a mast cell independent mechanism / Vanheel, Hanne (KU Leuven) ; Vicario Perez, Maria (Nestlé Research) ; Beeckmans, Dorien (KU Leuven) ; Cocca, Silvia (Endoscopy Unit-Azienda Ospedaliero Universitaria di Modena) ; Wauters, Lucas (University Hospitals Leuven (Bèlgica)) ; Accarie, Alison (KU Leuven) ; Toth, Joran (KU Leuven) ; Rodewald, Hans-Reimer (German Cancer Research Center) ; De Hertogh, Gert (University Hospitals Leuven (Bèlgica)) ; Matteoli, Gianluca (KU Leuven) ; Boeckxstaens, Guy (KU Leuven) ; Tack, Jan (University Hospitals Leuven (Bèlgica)) ; Farre, Ricard (Instituto de Salud Carlos III) ; Vanuytsel, Tim (University Hospitals Leuven (Bèlgica)) ; Universitat Autònoma de Barcelona
Duodenal hyperpermeability and low-grade inflammation in functional dyspepsia is potentially related to duodenal acid exposure. We aimed to evaluate in healthy volunteers the involvement of mast cell activation on the duodenogastric reflex and epithelial integrity during duodenal acidification. [...]
2020 - 10.1038/s41598-020-74491-1
Scientific reports, Vol. 10 (october 2020)  
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5.
11 p, 484.9 KB Increased Colonic Epithelial Permeability and Mucosal Eosinophilia in Ulcerative Colitis in Remission Compared With Irritable Bowel Syndrome and Health / Katinios, Georgios (Linköping University) ; Casado Bedmar, María Teresa (Linköping University) ; Walter, Susanna A. (Linköping University) ; Vicario Perez, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; González Castro, Ana Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bednarska, Olga (Linköping University) ; Söderholm, Johan D. (Linköping University) ; Hjortswang, Henrik (Linköping University) ; Keita, Åsa V. (Linköping University) ; Universitat Autònoma de Barcelona
Barrier dysfunction is recognized as a pathogenic factor in ulcerative colitis (UC) and irritable bowel syndrome (IBS), but it is unclear to what extent the factors related to barrier dysfunction are disease-specific. [...]
2020 - 10.1093/ibd/izz328
Inflammatory Bowel Diseases, Vol. 26 (january 2020) , p. 974-984  
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6.
24 p, 1.4 MB Intestinal mucosal mast cells : key modulators of barrier function and homeostasis / Albert-Bayo, Mercé (Hospital Universitari Vall d'Hebron) ; Paracuellos, Irene (Hospital Universitari Vall d'Hebron) ; González Castro, Ana Maria (Hospital Universitari Vall d'Hebron) ; Rodríguez-Urrutia, Amanda (Universitat Autònoma de Barcelona) ; Rodríguez-Lagunas, María J. (Universitat de Barcelona) ; Alonso Cotoner, Carmen (Hospital Universitari Vall d'Hebron) ; Santos, Javier (Hospital Universitari Vall d'Hebron) ; Vicario Perez, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca)
The gastrointestinal tract harbours the largest opulation of mast cells in the body; this highly specialised leukocyte cell type is able to adapt its phenotype and function to the microenvironment in which it resides. [...]
2019 - 10.3390/cells8020135
Cells, Vol. 8 (2019) , p. 1-24  
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7.
11 p, 2.3 MB Decreased TESK1-mediated cofilin 1 phosphorylation in the jejunum of IBS-D patients may explain increased female predisposition to epithelial dysfunction / Rodiño-Janeiro, Bruno K. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martínez Martínez, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fortea, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lobo Álvarez, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pigrau Pastor, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nieto Ruiz, Adoración (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; González Castro, Ana Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Salvo Romero, Eloísa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Guagnozzi, Danila (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pardo-Camacho, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Iribarren, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Azpiroz Vidaur, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Alonso Cotoner, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Santos, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vicario Perez, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Disturbed intestinal epithelial barrier and mucosal micro-inflammation characterize irritable bowel syndrome (IBS). Despite intensive research demonstrating ovarian hormones modulation of IBS severity, there is still limited knowledge on the mechanisms underlying female predominance in this disorder. [...]
2018 - 10.1038/s41598-018-20540-9
Scientific reports, Vol. 8 (2018) , art. 2255  
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Documents de recerca 7 registres trobats  
1.
Differential phenotype of jejunal enteric glial cells in diarrhoea-predominant irritable bowel syndrome with and without bile acid diarrhoea. The impact of bile acids on the intestinal epithelial barrier and glial cell biology / Albert-Bayo, Mercé ; Azpiroz Vidaur, Fernando, dir. ; Vicario Pérez, Maria, dir. ; Lobo Álvarez, Beatriz, dir. ; Jimenez Farrerons, Marcel, dir.
La síndrome de l'intestí irritable(SII) és un trastorn gastrointestinal comú i crònic que presenta dolor abdominal recurrent i hàbits intestinals anormals. A causa del seu origen desconegut, el tractament actual es dirigeix a alleujar els símptomes predominants, la qual cosa sovint comporta un maneig ineficaç. [...]
El síndrome del intestino irritable(SII) es un trastorno gastrointestinal común y crónico que presenta dolor abdominal recurrente y hábitos intestinales anormales. Debido a su origen desconocido, el tratamiento actual se dirige a aliviar los síntomas predominantes, lo que a menudo conlleva un manejo ineficaz. [...]
Irritable bowel syndrome (IBS) is a common and chronic gastrointestinal disorder presenting recurrent abdominal pain and abnormal bowel habits. Due to its unknown origin, the current treatment is targeted to relieve the predominant symptoms, which often brings to an ineffective management. [...]
2023  
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2.
245 p, 9.6 MB Mecanismos citotóxicos y humorales implicados en la etiopatogénesis de la esofagitis eosinofílica / Fortea, Marina ; Vicario Pérez, María, dir. ; Azpiroz Vidaur, Fernando, dir. ; Bassols Teixidó, Anna Maria, dir.
La esofagitis eosinofílica (EEo) és una malaltia inflamatòria crònica de l'esòfag caracteritzada per disfunció esofàgica associada, principalment, a la presència d'eosinòfils intraepitelials. [...]
La esofagitis eosinofílica (EEo) es una enfermedad inflamatoria crónica del esófago caracterizada por disfunción esofágica asociada, principalmente, a la presencia de eosinófilos intraepiteliales. [...]
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus characterized by esophageal dysfunction and is associated with a dense infiltrate of intraepithelial eosinophils. EoE causes a considerable deterioration in the quality of life of patients, both children and adults, and epidemiological studies indicate a prevalence increase in the last years. [...]
2020  
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3.
224 p, 4.9 MB Intestinal mucosal humoral response and neuro-immune interaction as contributors to the pathophysiology of diarrhea-predominant Irritable Bowel Syndrome / Pardo-Camacho, Cristina ; Vicario Pérez, María, dir. ; Santos Vicente, Francisco Javier, dir. ; Bassols Teixidó, Anna Maria, dir.
La Síndrome de l'Intestí Irritable (SII) és un trastorn gastrointestinal crònic i prevalent que cursa amb alteracions a la motilitat intestinal i amb dolor abdominal. La SII constitueix un trastorn recurrent i potencialment incapacitant sense un marcador de diagnòstic específic i únicament hi ha disponibles tractaments pal·liatius. [...]
El Síndrome del Intestino Irritable (SII) es un trastorno gastrointestinal crónico y prevalente que cursa con alteraciones en la motilidad intestinal y dolor abdominal. Constituye un trastorno recurrente y potencialmente incapacitante para el cual no existe un marcador específico diagnóstico ni tratamientos especificos. [...]
Irritable Bowel Syndrome (IBS) is a chronic and prevalent gastrointestinal disorder which curses with intestinal motility alterations and abdominal pain. IBS constitutes a relapsing and potentially disabling disorder and, currently, there is no specific diagnosis biomarker and only palliative treatments are available. [...]
2020  
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4.
266 p, 6.0 MB Molecular mechanisms and effect of acute and psychosocial stress on the intestinal barrier function : implications on the irritable bowel syndrome / Pigrau Pastor, Marc ; Santos Vicente, Francisco Javier, dir. ; Vicario Perez, Maria, dir. ; Alonso Cotoner, Carmen, dir. ; Azpiroz Vidaur, Fernando, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
El estrés psicosocial es uno de los grandes problemas de salud en las sociedades modernas. En condiciones fisiológicas el estrés representa una amenaza para la homeostasis. En respuesta al estrés se genera una respuesta coordinada que implica a los sistemas autonómico, endocrino e inmunitario para mantener la estabilidad del medio. [...]
Psychosocial stress is becoming a huge health problem in modern societies in the last years. In physiological conditions, stress represents a threat to the internal homeostasis, and in response to stress a coordinated response involving autonomic, endocrine, and immune systems is generated to maintain stability. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2019.  
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5.
213 p, 6.5 MB Implicación del eosinófilo intestinal y producción del factor liberador de corticotropina en la fisiopatología del Síndrome del Intestino Irritable con predominio de diarrea / Salvo Romero, Eloísa ; Vicario Perez, Maria, dir. ; Santos Vicente, Francisco Javier, dir. ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
[Barcelona] : Universitat Autònoma de Barcelona, 2018.  
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6.
220 p, 2.2 MB El mastocito: célula clave en la microinflamación intestinal y en la regulación de la función barrera mediada por el estrés en el síndrome del intestino irritable con predominio de diarrea / Guilarte, Mar ; Santos Vicente, Francisco Javier, dir. ; Vicario Perez, Maria, dir. ; Bosch Gil, Josep Àngel, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
El Síndrome del Intestino Irritable (SII), clásicamente considerada una enfermedad del colon, es un trastorno altamente prevalente, con gran impacto en la calidad de vida y pocas opciones terapéuticas eficaces. [...]
Irritable Bowel Syndrome (IBS), classically considered a disease of the colon, is a highly prevalent disorder with significant impact on quality of life and few effective therapeutic options. Its etiology is unknown, but stress has been associated with the development and maintenance of IBS, based on the observation that affected patients suffer more chronic stress than the healthy population. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2014  
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7.
200 p, 3.0 MB Efecto de la administración oral del agente estabilizador del mastocito, cromoglicato disódico, sobre la evolución clínica y biológica en pacientes con síndrome del intestino irritable con predominio de diarrea / Lobo Álvarez, Beatriz ; Santos Vicente, Francisco Javier, dir. ; Vicario Perez, Maria, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
El Síndrome del Intestino Irritable (SII) es un trastorno funcional con elevada prevalencia en la sociedad que se caracteriza por la presencia de dolor o molestia abdominal asociada a cambios en el hábito deposicional. [...]
Irritable Bowel Syndrome (IBS) is a chronic functional bowel disorder characterized by abdominal pain or discomfort and altered bowel habit. Despite its high prevalence in western societies, there is no reliable biological marker and its diagnosis relies on symptom-based criteria. [...]
Bellaterra : Universitat Autònoma de Barcelona, 2013  
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