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1.
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5 p, 206.7 KB |
Characteristics of potentially inappropriate prescribing of drugs in elderly polypathological patients Características del uso inadecuado de medicamentos en pacientes pluripatológicos de edad avanzada
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Rivas-Cobas, Paula Carolina (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Ramírez-Duque, Nieves (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Gómez Hernández, Mercedes (Hospital San Juan de Dios del Aljarafe) ;
García, Juana (Hospital General Juan Ramón Jiménez) ;
Agustí Escasany, M. Antònia (Hospital Universitari Vall d'Hebron) ;
Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron) ;
Formiga, Francesc (Hospital Universitari de Bellvitge) ;
López-Soto, Alfonso (Hospital Clínic i Provincial de Barcelona) ;
Torres Bonafonte, Olga H (Institut d'Investigació Biomèdica Sant Pau) ;
San-José, Antonio (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
To analyse potentially inappropriate prescribing (PIP) in elderly polypathological patients (PP). Multicentre observational, prospective study of 672 patients aged 75 years and older hospitalised in Internal Medicine between April 2011 and March 2012. [...]
2017 -  10.1016/j.gaceta.2016.06.013
Gaceta sanitaria, Vol. 31 Núm. 4 (julio 2017) , p. 327-331
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2.
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14 p, 928.6 KB |
Incidence and characteristics of adverse drug reactions in a cohort of patients treated with PD-1/PD-L1 inhibitors in real-world practice
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Sabaté, Mònica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pérez, Eulàlia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia Doladé, Núria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Carreras Soler, Maria Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Farriols Danés, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Felip, Enriqueta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Braña, Irene (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Carles, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Morales-Barrera, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Muñoz Couselo, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Agustí Escasany, M. Antònia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Data related to adverse drug reactions (ADRs), specifically immune-related adverse events (irAEs), in long-term treatment with immunotherapy in real-world practice is scarce, as is general information regarding the management of ADRs. [...]
2022 - 10.3389/fmed.2022.891179
Frontiers in Medicine, Vol. 9 (august 2022)
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3.
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21 p, 5.9 MB |
Oxidative Stress in Structural Valve Deterioration : A Longitudinal Clinical Study
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Galiñanes, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Casós, Kelly (Hospital Universitari de Bellvitge) ;
Blasco-Lucas, Arnau (Hospital Universitari de Bellvitge) ;
Permanyer, Eduard (Centro Médico Teknon) ;
Máñez, Rafael (Hospital Universitari de Bellvitge) ;
Le Tourneau, Thierry (Université de Nantes) ;
Barquinero, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Schwartz, Simon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bottio, Tomaso (University Hospital of Padova (Pàdua, Itàlia)) ;
Roussel, Jean Christian (CHU de Nantes) ;
Fellah-Hebia, Imen (CHU de Nantes) ;
Sénage, Thomas (Université de Nantes) ;
Evangelista Masip, Arturo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Badano, Luigi P. (San Luca Hospital(Itàlia)) ;
Ruiz-Majoral, Alejandro (Hospital Universitari de Bellvitge) ;
Galli, Cesare (Avantea and Fondazione Avantea Onlus (Itàlia)) ;
Padler-Karavani, Vered (Tel Aviv University) ;
Soulillou, Jean-Paul (Centre Hospitalier Universitaire de Nantes) ;
Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron) ;
Cozzi, Emanuele (University Hospital of Padova (Pàdua, Itàlia)) ;
Costa, Cristina (Hospital Universitari de Bellvitge) ;
Universitat Autònoma de Barcelona
The cause of structural valve deterioration (SVD) is unclear. Therefore, we investigated oxidative stress markers in sera from patients with bioprosthetic heart valves (BHVs) and their association with SVD. [...]
2022 - 10.3390/biom12111606
Biomolecules, Vol. 12 (october 2022)
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4.
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7 p, 710.9 KB |
Indications related to antidepressant prescribing in the Nivel-PCD database and the SIDIAP database
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Camacho-Arteaga, Lina (Hospital Universitari Vall d'Hebron) ;
Gardarsdottir, Helga (Utrecht University. Division of Pharmacoepidemiology and Clinical Pharmacology) ;
Ibáñez, Luisa (Hospital Universitari Vall d'Hebron) ;
Souverein, Patrick (Utrecht University. Division of Pharmacoepidemiology and Clinical Pharmacology) ;
van Dijk, Liset (Netherlands Institute for Health Services Research (NIVEL)) ;
Hek, Karin (Netherlands Institute for Health Services Research (NIVEL)) ;
Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron) ;
Ballarín, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sabaté, Mònica (Hospital Universitari Vall d'Hebron)
Antidepressant drug consumption has increased, mainly in the elderly. This trend could be explained by the use for indications other than depression. We aimed to describe the indications related to antidepressant drug new users in two primary care settings.
2022 - 10.1016/j.jad.2022.02.001
Journal of affective disorders, Vol. 303 (04 2022) , p. 131
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5.
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9 p, 611.2 KB |
Adverse Reactions to Drugs of Special Interest in a Pediatric Oncohematology Service
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Amaro-Hosey, Kristopher (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Danés Carreras, Immaculada (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vendrell Bosch, Lourdes (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alonso, Laura (Vall d'Hebron Institut d'Oncologia) ;
Renedo-Miró, Berta (Hospital Universitari Vall d'Hebron) ;
Gros, Luis (Vall d'Hebron Institut d'Oncologia) ;
Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron) ;
Cereza García, Gloria (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Agustí Escasany, M. Antònia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Introduction: Drugs used in oncological diseases are frequently related to adverse drug reactions (ADR). Few studies have analyzed the toxicity of cancer treatments in children in real practice. Methods: An observational, longitudinal and prospective study has been carried out in an Oncohematology Service of a tertiary hospital. [...]
2021 - 10.3389/fphar.2021.670945
Frontiers in Pharmacology, Vol. 12 (may 2021)
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6.
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1.1 MB |
Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage : a multicenter case-control study
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Mallah, Narmeen (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Zapata-Cachafeiro, Maruxa (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Aguirre, Carmelo (Universidad del País Vasco) ;
Ibarra-García, Eguzkiñe (Hospital de Urduliz Alfredo Espinosa) ;
Palacios-Zabalza, Itziar (Hospital de Galdakao (Usansolo, Biscaia)) ;
Macías-García, Fernando (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Piñeiro-Lamas, María (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Ibáñez, Luisa (Hospital Universitari Vall d'Hebron) ;
Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron) ;
Vendrell Bosch, Lourdes (Hospital Universitari Vall d'Hebron) ;
Martin-Arias, Luis (Universidad de Valladolid) ;
Sáinz-Gil, María (Universidad de Valladolid) ;
Velasco-González, Verónica (Universidad de Valladolid) ;
Bacariza-Cortiñas, Manuel (Centro de Saúde de Vite) ;
Salgado, Angel (University of Santiago de Compostela) ;
Estany-Gestal, Ana (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Figueiras, Adolfo (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Universitat Autònoma de Barcelona
Interindividual genetic variations contribute to differences in patients' response to drugs as well as to the development of certain disorders. Patients who use non-steroidal anti-inflammatory drugs (NSAIDs) may develop serious gastrointestinal disorders, mainly upper gastrointestinal haemorrhage (UGIH). [...]
2022 - 10.1080/07853890.2021.2016940
Annals of Medicine, Vol. 54 (february 2022) , p. 379-392
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2 p, 208.5 KB |
Corrigendum : Influence of Polymorphisms Involved in Platelet Activation and Inflammatory Response on Aspirin-Related Upper Gastrointestinal Bleeding: A Case-Control Study
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Mallah, Narmeen (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Zapata-Cachafeiro, Maruxa (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Aguirre, Carmelo (Universidad del País Vasco) ;
Ibarra-García, Eguzkiñe (Hospital de Urduliz Alfredo Espinosa) ;
Palacios-Zabalza, Itziar (Hospital de Galdakao (Usansolo, Biscaia)) ;
Macías-García, Fernando (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Domínguez-Muñoz, J. Enrique (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Piñeiro-Lamas, María (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Ibáñez, Luisa (Hospital Universitari Vall d'Hebron) ;
Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron) ;
Vendrell Bosch, Lourdes (Hospital Universitari Vall d'Hebron) ;
Martin-Arias, Luis (Universidad de Valladolid) ;
Sáinz-Gil, María (Universidad de Valladolid) ;
Velasco-González, Verónica (Universidad de Valladolid) ;
Figueiras, Adolfo (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Universitat Autònoma de Barcelona
2020 - 10.3389/fphar.2020.01072
Frontiers in Pharmacology, Vol. 11 (july 2020)
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10 p, 372.3 KB |
Polymorphisms Involved in Platelet Activation and Inflammatory Response on Aspirin-Related Upper Gastrointestinal Bleeding : A Case-Control Study
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Mallah, Narmeen (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Zapata-Cachafeiro, Maruxa (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Aguirre, Carmelo (Universidad del País Vasco) ;
Ibarra-García, Eguzkiñe (Hospital de Urduliz Alfredo Espinosa) ;
Palacios-Zabalza, Itziar (Hospital de Galdakao (Usansolo, Biscaia)) ;
Macías-García, Fernando (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Domínguez-Muñoz, J. Enrique (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Piñeiro-Lamas, María (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Ibáñez, Luisa (Hospital Universitari Vall d'Hebron) ;
Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron) ;
Vendrell Bosch, Lourdes (Hospital Universitari Vall d'Hebron) ;
Martin-Arias, Luis (Universidad de Valladolid) ;
Sáinz-Gil, María (Universidad de Valladolid) ;
Velasco-González, Verónica (Universidad de Valladolid) ;
Figueiras, Adolfo (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Universitat Autònoma de Barcelona
Despite the wide benefits of aspirin and its cost-effectiveness, aspirin prescriptions have been reduced due to idiosyncratic responses in susceptible individuals. Low-dose aspirin and single-nucleotide polymorphisms (SNPs) are independently associated with increased risk of gastrointestinal hemorrhage; however, to-date, no studies investigated the SNP-aspirin interaction effect on upper gastrointestinal hemorrhage (UGIH). [...]
2020 - 10.3389/fphar.2020.00860
Frontiers in Pharmacology, Vol. 11 (june 2020)
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9.
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11 p, 1.8 MB |
Antidepressant use and stroke or mortality risk in the elderly
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Ön, Begüm Irmak (Institute for Medical Information Processing. Biometry and Epidemiology. LMU Munich) ;
Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron) ;
Berger, Úrsula (Institute for Medical Information Processing. Biometry and Epidemiology. LMU Munich) ;
Sabaté, Mònica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ballarín, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Maisterra Santos, Olga (Hospital Universitari Vall d'Hebron) ;
San-Jose, Antonio (Hospital Universitari Vall d'Hebron) ;
Ibáñez, Luisa (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Background and purpose: Current evidence on antidepressant-related stroke or mortality risk is inconsistent. Because the elderly have the highest exposure to antidepressants, the aim was to quantify their association with stroke and mortality risks in this vulnerable population. [...]
2021 - 10.1111/ene.15137
European Journal of Neurology, Vol. 29 (2021) , p. 469-477
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16 p, 1.2 MB |
Incidence of direct oral anticoagulant use in patients with nonvalvular atrial fibrillation and characteristics of users in 6 European countries (2008-2015) : A cross-national drug utilization study
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Ibáñez, Luisa (Universitat Autònoma de Barcelona) ;
Sabaté, Mònica (Universitat Autònoma de Barcelona) ;
Vidal Guitart, Xavier (Universitat Autònoma de Barcelona) ;
Ballarín, Elena (Hospital Universitari Vall d'Hebron) ;
Rottenkolber, Marietta (Klinikum der Universität München) ;
Schmiedl, Sven (Helios University Hospital Wuppertal) ;
Heeke, Andreas (AOK NORDWEST) ;
Huerta, Consuelo (Agencia Española de Medicamentos y Productos Sanitarios) ;
Martin Merino, Elisa (Agencia Española de Medicamentos y Productos Sanitarios) ;
Montero, Dolores (Agencia Española de Medicamentos y Productos Sanitarios) ;
Leon-Muñoz, Luz María (Agencia Española de Medicamentos y Productos Sanitarios) ;
Gasse, Christiane (Aarhus University) ;
Moore, Nicholas (INSERM CIC1401, Université de Bordeaux) ;
Droz, Cécile (INSERM CIC1401, Université de Bordeaux) ;
Lassalle, Régis (INSERM CIC1401, Université de Bordeaux) ;
Aakjær, Mia (University of Copenhagen) ;
Andersen, Morten (University of Copenhagen) ;
De Bruin, Marie Louise (University of Copenhagen) ;
Groenwold, Rolf (Leiden University Medical Center) ;
van den Ham, Hendrika A. (Universiteit Utrecht, David de Wiedgebouw) ;
Souverein, Patrick (Universiteit Utrecht, David de Wiedgebouw) ;
Klungel, Olaf (University Medical Center Utrecht) ;
Gardarsdottir, Helga (University of Iceland) ;
Universitat Autònoma de Barcelona ;
Hospital Universitari Vall d'Hebron
To estimate the incidence of direct oral anticoagulant drug (DOAC) use in patients with nonvalvular atrial fibrillation and to describe user and treatment characteristics in 8 European healthcare databases representing 6 European countries. [...]
2019 - 10.1111/bcp.14071
British Journal of Clinical Pharmacology, Vol. 85 (september 2019) , p. 2524-2539
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