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13 p, 787.1 KB |
Monoaminergic impairment in Down syndrome with Alzheimer's disease compared to early-onset Alzheimer's disease
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Dekker, Alain D. (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ;
Vermeiren, Yannick (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ;
Carmona-Iragui, Maria (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ;
Benejam, Bessy (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ;
Videla, Laura (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ;
Gelpi, Ellen (Neurological Tissue Bank—Biobanc, Hospital Clinic Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain) ;
Aerts, Tony (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ;
Van Dam, Debby (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ;
Fernández, Susana (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ;
Lleó Bisa, Alberto (Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain) ;
Videla, Sebastian (Faculty of Health and Life Sciences, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain) ;
Sieben, Anne (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ;
Martin, Jean-Jacques (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ;
De Deyn, Peter P. (Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium)
People with Down syndrome (DS) are at high risk for Alzheimer's disease (AD). Defects in monoamine neurotransmitter systems are implicated in DS and AD but have not been comprehensively studied in DS. [...]
2017 -  10.1016/j.dadm.2017.11.001
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 10 (november 2017) , p. 99-111
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14 p, 1.0 MB |
A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials
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Sola, Susana de (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Torre Fornell, Rafael de la (Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBERobn)) ;
Sánchez-Benavides, Gonzalo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Benejam, Bessy (Fundació Catalana Síndrome de Down) ;
Cuenca-Royo, Aida (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Hoyo, Laura del (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodríguez, Joan (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Catuara-Solarz, Silvina (Centre de Regulació Genòmica (Barcelona)) ;
Sánchez-Gutiérrez, Judit (Fundació Espai Salut (Barcelona)) ;
Dueñas-Espin, Ivan (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Hernandez, Gimena (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Peña-Casanova, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Langohr, Klaus (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Videla, Sebastián (Fundació Catalana Síndrome de Down) ;
Blehaut, Henry (Fondation Jérôme Lejeune (Paris, França)) ;
Farré Albaladejo, Magí (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Dierssen, Mara (Networking Center of Biomedical Research in Rare Diseases (CIBERER)) ;
TESDAD Study Group ;
Universitat Autònoma de Barcelona
Abstract: The recent prospect of pharmaceutical interventions for cognitive impairment of Down syndrome (DS) has boosted a number of clinical trials in this population. However, running the trials has raised some methodological challenges and questioned the prevailing methodology used to evaluate cognitive functioning of DS individuals. [...]
2015 - 10.3389/fpsyg.2015.00708
Frontiers in psychology, Vol. 6 Núm. 708 (June 2015)
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