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20 p, 1.6 MB |
Autophagic- and Lysosomal-Related Biomarkers for Parkinson's Disease : Lights and Shadows
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Xicoy, Helena (Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Neuroscience, Faculty of Science, 6525 GA Nijmegen, The Netherlands) ;
Peñuelas, Núria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vila Bover, Miquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Laguna, Ariadna (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Parkinson's disease (PD) is a neurodegenerative disorder that currently affects 1% of the population over the age of 60 years, for which no disease-modifying treatments exist. This lack of effective treatments is related to the advanced stage of neurodegeneration existing at the time of diagnosis. [...]
2019 -  10.3390/cells8111317
Cells, Vol. 8 (october 2019)
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2.
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23 p, 4.3 MB |
Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice
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Larramona-Arcas, Raquel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
González-Arias, Candela (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Perea, Gertrudis (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Gutiérrez, Antonia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)) ;
Vitorica, Javier (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
García-Barrera, Tamara (Universidad de Huelva. Departamento de Química, Facultad de Ciencias Experimentales) ;
Gómez-Ariza, José Luis (Universidad de Huelva. Departamento de Química, Facultad de Ciencias Experimentales) ;
Pascua-Maestro, Raquel (Instituto de Biología y Genética Molecular, Universidad de Valladolid-CSIC. Departamento de Bioquímica y Biología Molecular y Fisiología) ;
Ganfornina, María Dolores (Instituto de Biología y Genética Molecular, Universidad de Valladolid-CSIC. Departamento de Bioquímica y Biología Molecular y Fisiología) ;
Kara, Eleanna (Present Address: Institute of Neuropathology, University Hospital of Zurich) ;
Hudry, Eloise (Alzheimer's Disease Research Laboratory, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School) ;
Martinez-Vicente, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vila Bover, Miquel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Galea, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Masgrau Juanola, Roser (Universitat Autònoma de Barcelona. Institut de Neurociències)
The apolipoprotein E (APOE) gene exists in three isoforms in humans: APOE2, APOE3 and APOE4. APOE4 causes structural and functional alterations in normal brains, and is the strongest genetic risk factor of the sporadic form of Alzheimer's disease (LOAD). [...]
2020 - 10.1186/s13024-020-00382-8
Molecular neurodegeneration, Vol. 15 (june 2020)
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3.
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12 p, 2.1 MB |
Neuromelanin, aging, and neuronal vulnerability in Parkinson's disease
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Vila Bover, Miquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Neuromelanin, a dark brown intracellular pigment, has long been associated with Parkinson's disease (PD). In PD, neuromelanin-containing neurons preferentially degenerate, tell-tale neuropathological inclusions form in close association with this pigment, and neuroinflammation is restricted to neuromelanin-containing areas. [...]
2019 - 10.1002/mds.27776
Movement Disorders, Vol. 34 Núm. 10 (january 2019) , p. 1440-1451
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4.
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20 p, 8.2 MB |
The small GTPase RAC1/CED-10 is essential in maintaining dopaminergic neuron function and survival against α-synuclein-induced toxicity
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Kim, Hanna (University of Alabama. Department of Biological Sciences) ;
Calatayud, Carles (Institut d'Investigació Biomèdica de Bellvitge) ;
Guha, Sanjib (Buck Institute for Age Research) ;
Fernández Carasa, Irene (Universitat de Barcelona. Institut de Biomedicina) ;
Berkowitz, Laura (University of Alabama. Department of Biological Sciences) ;
Carballo-Carbajal, Iria (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ezquerra, Mario (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Fernández Santiago, Rubén (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Kapahi, Pankaj (Buck Institute for Age Research) ;
Raya, Ángel (Institució Catalana de Recerca i Estudis Avançats) ;
Miranda Vizuete, Antonio (Instituto de Biomedicina de Sevilla (IBiS)) ;
Lizcano de Vega, José Miguel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Vila Bover, Miquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Caldwell, Kim A. (University of Alabama. Department of Biological Sciences) ;
Caldwell, Guy A. (University of Alabama. Department of Biological Sciences) ;
Consiglio, Antonella (Università degli Studi di Brescia. Dipartimento di Medicina Molecolare e Traslazionale) ;
Dalfo Capella, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Parkinson's disease is associated with intracellular α-synuclein accumulation and ventral midbrain dopaminergic neuronal death in the Substantia Nigra of brain patients. The Rho GTPase pathway, mainly linking surface receptors to the organization of the actin and microtubule cytoskeletons, has been suggested to participate to Parkinson's disease pathogenesis. [...]
2018 - 10.1007/s12035-018-0881-7
Molecular neurobiology, Vol. 55, issue 9 (Sep. 2018) , p. 7533-7552
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5.
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25 p, 2.6 MB |
Mitochondrial Quality Control in Neurodegenerative Diseases : Focus on Parkinson's Disease and Huntington's Disease
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Franco-Iborra, Sandra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vila Bover, Miquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Perier, Celine (Hospital Universitari Vall d'Hebron. Institut de Recerca)
In recent years, several important advances have been made in our understanding of the pathways that lead to cell dysfunction and death in Parkinson's disease (PD) and Huntington's disease (HD). Despite distinct clinical and pathological features, these two neurodegenerative diseases share critical processes, such as the presence of misfolded and/or aggregated proteins, oxidative stress, and mitochondrial anomalies. [...]
2018 - 10.3389/fnins.2018.00342
Frontiers in Neuroscience, Vol. 12 (May 2018) , art. 342
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6.
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14 p, 17.9 MB |
Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons
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Urrea, Laura (Universitat de Barcelona) ;
Segura-Feliu, Miriam (Universitat de Barcelona) ;
Masuda-Suzukake, Masami (Metropolitan Institute of Medical Science (Setagaya-ku, Tokyo)) ;
Hervera Abad, Arnau (Universitat de Barcelona) ;
Pedraz, Lucas (Institute for Bioengineering of Catalonia (IBEC)) ;
García Aznar, José Manuel (Universidad de Zaragoza) ;
Vila Bover, Miquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Samitier, Josep (Universitat de Barcelona) ;
Torrents, Eduard (Institute for Bioengineering of Catalonia (IBEC)) ;
Ferrer, Isidro (Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)) ;
Gavín, Rosalina (Universitat de Barcelona) ;
Hagesawa, Masato (Metropolitan Institute of Medical Science (Setagaya-ku, Tokyo)) ;
del Río, José Antonio (Universitat de Barcelona) ;
Universitat Autònoma de Barcelona
The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of β-amyloid. Their interaction is mandatory for neurotoxic effects of βamyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of α-synuclein. [...]
2017 - 10.1007/s12035-017-0451-4
Molecular neurobiology, Vol. 55 (february 2017) , p. 1847-1860
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7.
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9 p, 2.0 MB |
Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson's disease patients
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Recasens, Ariadna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Carballo-Carbajal, Iria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Parent, Annabelle (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bové, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gelpi, Ellen (Vienna, Austria) ;
Tolosa, Eduardo (Barcelona, Spain) ;
Vila Bover, Miquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The online version of this article (10. 1186/s40478-018-0509-1) contains supplementary material, which is available to authorized users.
2018 - 10.1186/s40478-018-0509-1
Acta neuropathologica communications, Vol. 6 (february 2018)
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8.
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13 p, 3.4 MB |
Functional Rescue of Dopaminergic Neuron Loss in Parkinson's Disease Mice After Transplantation of Hematopoietic Stem and Progenitor Cells
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Altarche-Xifro, Wassim (Universitat Pompeu Fabra) ;
di Vicino, Umberto (Universitat Pompeu Fabra) ;
Muñoz-Martin, Maria Isabel (Universitat Pompeu Fabra) ;
Bortolozzi, Analía (Department of Neurochemistry and Neuropharmacology, IIBB-CSIC (Consejo Superior de Investigaciones Científicas), Barcelona, Spain) ;
Bové, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vila Bover, Miquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cosma, Maria Pia (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ;
Universitat Autònoma de Barcelona
Parkinson's disease is a common neurodegenerative disorder, which is due to the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and for which no definitive cure is currently available. [...]
2016 - 10.1016/j.ebiom.2016.04.016
EBioMedicine, Vol. 8 (april 2016) , p. 83-95
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9.
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18 p, 2.2 MB |
Aberrant epigenome in -derived dopaminergic neurons from Parkinson's disease patients
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Fernández-Santiago, Rubén (Universitat de Barcelona) ;
Carballo-Carbajal, Iria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castellano, Giancarlo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Torrent, Roger (Universitat de Barcelona. Institut de Biomedicina) ;
Richaud, Yvonne (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Sánchez-Danés, Adriana (Universitat de Barcelona. Institut de Biomedicina) ;
Vilarrasa-Blasi, Roser (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Sánchez-Pla, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mosquera, José Luis (Universitat de Barcelona) ;
Soriano, Jordi (Universitat de Barcelona) ;
López-Barneo, José (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Canals, Josep M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Alberch i Vié, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Raya, Ángel (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ;
Vila Bover, Miquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Consiglio, Antonella (University of Brescia and National Institute of Neuroscience) ;
Martín-Subero, José I (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ezquerra, Mario (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Tolosa, Eduardo (Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)) ;
Universitat Autònoma de Barcelona
The epigenomic landscape of Parkinson's disease () remains unknown. We performed a genomewide methylation and a transcriptome studies in induced pluripotent stem cell ()-derived dopaminergic neurons (n) generated by cell reprogramming of somatic skin cells from patients with monogenic 2-associated (L2) or sporadic (), and healthy subjects. [...]
2015 - 10.15252/emmm.201505439
EMBO Molecular Medicine, Vol. 7, Núm. 12 (October 2015) , p. 1529-1546
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