Results overview: Found 2 records in 0.02 seconds.
Articles, 1 records found
Research literature, 1 records found
Articles 1 records found  
1.
18 p, 1.8 MB Targeting protein kinase CK2 : evaluationg CX-4945 potential for GL261 glioblastoma therapy in immunocompetent mice / Ferrer-Font, Laura (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Villamañán de Santiago, Lucía (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Arias-Ramos, Nuria (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Vilardell Vilà, Jordi (Università degli studi di Padova. Dipartimento di Scienze Biomediche) ; Plana i Coll, Maria (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ruzzene, Maria (Università degli studi di Padova. Dipartimento di Scienze Biomediche) ; Pinna, Lorenzo A. (Università degli studi di Padova. Dipartimento di Scienze Biomediche) ; Itarte, Emili (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Arús i Caraltó, Carles (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Candiota Silveira, Ana Paula (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Glioblastoma (GBM) causes poor survival in patients even with aggressive treatment. Temozolomide (TMZ) is the standard chemotherapeutic choice for GBM treatment but resistance always ensues. Protein kinase CK2 (CK2) contributes to tumour development and proliferation in cancer, and it is overexpressed in human GBM. [...]
2017 - 10.3390/ph10010024
Pharmaceuticals, Vol. 10 Núm. 1 (2017) , p. art 24
2 documents

Research literature 1 records found  
1.
Unraveling CK2 inhibition and temozolomide contribution to therapy response in preclinical GL261 glioblastoma: immune system implications and magnetic resonance based nosological imaging. / Villamañán de Santiago, Lucía, autor. ; Candiota Silveira, Ana Paula, supervisor acadèmic. ; Plana i Coll, Maria, supervisor acadèmic. ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
El glioblastoma (GB) es el tumor primario más común en adultos. Debido a su mal prognóstico, es urgente encontrar mejoras en su tratamiento. El objetivo de esta tesis es estudiar el efecto de inhibidores de CK2 y del agente alquilante Temozolamida (TMZ) a la respuesta a terapia en el modelo de GB preclínico GL261 utilizando tanto métodos in vitro (línea celular GL261) como in vivo (ratones GL261 con tumores). [...]
Glioblastoma is the most common primary brain tumor in adults with a very poor prognosis, for which urgent improvements in treatment are needed. The aim of this thesis was to unravel the contribution of the CK2 inhibitors and the alkylating agent Temozolomide (TMZ) to therapy response in the preclinical glioblastoma (GB) murine model GL261 using in vitro (GL261 cell line) and in vivo (GL261 tumor bearing mice) approaches. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2019.  

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