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Aggregation-prone peptides modulate activity of bovine interferon gamma released from naturally occurring protein nanoparticles
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Carratalá, José Vicente (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Cano Garrido, Olivia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez, Julieta María (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Membrado, Cristina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pérez, Eudald (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Arís i Giralt, Anna (Institut de Recerca i Tecnologia Agroalimentàries) ;
García Fruitós, Elena (Institut de Recerca i Tecnologia Agroalimentàries) ;
Ferrer Miralles, Neus (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Efficient protocols for the production of recombinant proteins are indispensable for the development of the biopharmaceutical sector. Accumulation of recombinant proteins in naturally-occurring protein aggregates is detrimental to biopharmaceutical development. [...]
2020 -  10.1016/j.nbt.2020.02.001
New Biotechnolgy, Vol. 57 (July 2020) , p. 11-19
2 documents
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13 p, 6.0 MB |
Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models
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Álamo, Patricia (Institut d'Investigació Biomèdica Sant Pau) ;
Gallardo, Alberto (CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN)) ;
Pavón Ribas, Miguel Ángel (Institut d'Investigació Biomèdica Sant Pau) ;
Casanova Rigat, Isolda (Institut d'Investigació Biomèdica Sant Pau) ;
Trias, Manuel (Institut d'Investigació Biomèdica Sant Pau) ;
Mangues, Maria Antonia (Institut d'Investigació Biomèdica Sant Pau) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mangues, Ramon (Institut d'Investigació Biomèdica Sant Pau) ;
Céspedes, Maria Virtudes (Institut d'Investigació Biomèdica Sant Pau)
Mouse colorectal cancer (CRC) models generated by orthotopic microinjection of human CRC cell lines reproduce the pattern of lymphatic, haematological and transcoelomic spread but generate low metastatic efficiency. [...]
2014 - 10.1242/dmm.013995
Disease Models & Mechanisms, Vol. 7, Núm. 3 (march 2014) , p. 387-396
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17 p, 4.4 MB |
Complex Particulate Biomaterials as Immunostimulant-Delivery Platforms
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Torrealba, Debora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Seras-Franzoso, Joaquín (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mamat, Uwe (Forschungszentrum Borstel. Division of Structural Biochemistry, Priority Area Asthma & Allergy) ;
Wilke, Kathleen (Forschungszentrum Borstel. Division of Structural Biochemistry, Priority Area Asthma & Allergy) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Roher Armentia, Nerea (Universitat Autònoma de Barcelona. Departament de Biologia, de Fisiologia i d'Immunologia) ;
García Fruitós, Elena (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The control of infectious diseases is a major current challenge in intensive aquaculture. Most commercial vaccines are based on live attenuated or inactivated pathogens that are usually combined with adjuvants, oil emulsions being as the most widely used for vaccination in aquaculture. [...]
2016 - 10.1371/journal.pone.0164073
PloS one, Vol. 11 Issue 10 (Octubre 2016) , p. 1-17, art. e0164073
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12 p, 4.0 MB |
Protein nanoparticles Made of recombinant Viral antigens : a Promising Biomaterial for Oral Delivery of Fish Prophylactics
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Thwaite, Rosemary (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Jie, Ji (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Torrealba, Debora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Coll, Julio (Instituto Nacional Investigaciones y Tecnologías Agrarias y Alimentarias (INIA), Departamento de Biotecnología) ;
Sabés Xamaní, Manuel, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Roher, Nerea (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
In the search for an eminently practical strategy to develop immunostimulants and vaccines for farmed fish, we have devised recombinant viral antigens presented as "nanopellets" (NPs). These are inclusion bodies of fish viral antigenic proteins produced in Escherichia coli. [...]
2018 - 10.3389/fimmu.2018.01652
Frontiers in immunology, Vol. 9 p. 1652 (2018)
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7 p, 1.2 MB |
Recombinant pharmaceuticals from microbial cells : a 2015 update
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Sanchez-Garcia, Laura (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Martín, Lucas (Universitat Autònoma de Barcelona. Technology Transfer Office) ;
Mangues, Ramon (Institut d'Investigacions Biomèdiques Sant Pau) ;
Ferrer Miralles, Neus (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vázquez Gómez, Esther (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Diabetes, growth or clotting disorders are among the spectrum of human diseases related to protein absence or malfunction. Since these pathologies cannot be yet regularly treated by gene therapy, the administration of functional proteins produced ex vivo is required. [...]
2016 - 10.1186/s12934-016-0437-3
Microbial cell factories, Vol. 15, Issue 33 (February 2016)
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1 p, 682.3 KB |
Erratum to : Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins
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Mamat, Uwe (Leibniz-Center for Medicine and Biosciences. Division of Structural Biochemistry) ;
Wilke, Kathleen (Leibniz-Center for Medicine and Biosciences. Division of Structural Biochemistry) ;
Bramhill, David (Bramhill Biological Consulting. East Moonstone Drive) ;
Schromm, Andra Beate (Leibniz-Center for Medicine and Biosciences. Division of Structural Biochemistry) ;
Lindner, Buko (Leibniz-Center for Medicine and Biosciences. Division of Structural Biochemistry) ;
Kohl, Thomas Andreas (Leibniz-Center for Medicine and Biosciences. Division of Structural Biochemistry) ;
Corchero, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Villaverde Corrales, Antonio (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ;
Schaffer, Lana (The Scripps Research Institute. NGS and Microarray Core Facility) ;
Head, Steven Robert (The Scripps Research Institute. NGS and Microarray Core Facility) ;
Souvignier, Chad (Research Corporation Technologies (Tucson)) ;
Meredith, Timothy Charles (Pennsylvania State University. Department of Biochemistry and Molecular Biology) ;
Woodard, Ronald Wesley (University of Michigan. Department of Medicinal Chemistry)
2015 - 10.1186/s12934-015-0265-x
Microbial cell factories, Vol. 14, Issue 57 (2015)
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5 p, 470.7 KB |
Packaging protein drugs as bacterial inclusion bodies for therapeutic applications
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Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
García Fruitós, Elena (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Rinas, Ursula (Helmholtz-Zentrum für Infektionsforschung) ;
Seras-Franzoso, Joaquín (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Kosoy, Ana (Janus Development SL) ;
Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Institut de Biotecnologia i de Biomedicina
A growing number of insights on the biology of bacterial inclusion bodies (IBs) have revealed intriguing utilities of these protein particles. Since they combine mechanical stability and protein functionality, IBs have been already exploited in biocatalysis and explored for bottom-up topographical modification in tissue engineering. [...]
2012 - 10.1186/1475-2859-11-76
Microbial cell factories, Vol. 11 (June 2012) , art. 76
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5 p, 243.9 KB |
Biological activities of histidine-rich peptides; merging biotechnology and nanomedicine
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Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Kumar, Pradeep (CSIR-Institute of Genomics and Integrative Biology) ;
Cedano Rodríguez, Juan Antonio (Universidad de la República (Uruguay).) ;
Gupta, Kailash C (CSIR-Indian Institute of Toxicology Research) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Histidine-rich peptides are commonly used in recombinant protein production as purification tags, allowing the one-step affinity separation of the His-tagged proteins from the extracellular media or cell extracts. [...]
2011 - 10.1186/1475-2859-10-101
Microbial cell factories, Vol. 10 (2011) , art. 101
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7 p, 370.3 KB |
Co-production of GroELS discriminates between intrinsic and thermally-induced recombinant protein aggregation during substrate quality control
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Platas, Gemma (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Rodríguez-Carmona, Escarlata (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
García Fruitós, Elena (CIBER de Bioingeniería, Biomateriales y Nanomedicina) ;
Cano Garrido, Olivia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villaverde Corrales, Antonio (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Genètica i Microbiologia.
The effects and effectiveness of the chaperone pair GroELS on the yield and quality of recombinant polypeptides produced in Escherichia coli are matter of controversy, as the reported activities of this complex are not always consistent and eventually indicate undesired side effects. [...]
2011 - 10.1186/1475-2859-10-79
Microbial cell factories, Vol. 10 (October 2011) , art. 79
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