Resultats globals: 2 registres trobats en 0.03 segons.
Articles, 2 registres trobats
Articles 2 registres trobats  
1.
14 p, 2.4 MB Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects / Baquero, Juan Miguel (Centro Nacional de Investigaciones Oncológicas) ; Benítez-Buelga, Carlos (Karolinska Institutet (Estocolm, Suècia)) ; Rajagopal, Varshni (Karolinska Institutet (Estocolm, Suècia)) ; Zhenjun, Zhao (Karolinska Institutet (Estocolm, Suècia)) ; Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Müller, Sarah (Karolinska Institutet (Estocolm, Suècia)) ; Hanna, Bishoy M. F. (Karolinska Institutet (Estocolm, Suècia)) ; Loseva, Olga (Karolinska Institutet (Estocolm, Suècia)) ; Wallner, Olov (Karolinska Institutet (Estocolm, Suècia)) ; Michel, Maurice (Karolinska Institutet (Estocolm, Suècia)) ; Rodriguez-Perales, Sandra (Grupo de Citogenética Molecular. Programa de Genética del Cáncer Humano. Centro Nacional de Investigaciones Oncológicas de España (Madrid)) ; Gad, Helge (The University of Sheffield) ; Visnes, Torkild (SINTEF Industry (Noruega)) ; Helleday, Thomas (The University of Sheffield) ; Benitez, Javier (Centro Nacional de Investigaciones Oncológicas) ; Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ; Universitat Autònoma de Barcelona
The most common oxidative DNA lesion is 8-oxoguanine which is mainly recognized and excised by the 8-oxoG DNA glycosylase 1 (OGG1), initiating the base excision repair (BER) pathway. Telomeres are particularly sensitive to oxidative stress (OS) which disrupts telomere homeostasis triggering genome instability. [...]
2021 - 10.1038/s41598-021-82917-7
Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 3490  
2.
18 p, 4.0 MB Targeting OGG1 arrests cancer cell proliferation by inducing replication stress / Visnes, T. (Sintef Industry. Department of Biotechnology and Nanomedicine) ; Benítez-Buelga, Carlos (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Cázares-Körner, A. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Sanjiv, K. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Hanna, Bishoy (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Mortusewicz, O. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Rajagopal, Veera M (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Albers, J. J. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Hagey, D. W. (Karolinska Institutet (Estocolm, Suècia). Department of Laboratory Medicine) ; Bekkhus, T. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Eshtad, S. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Baquero, Juan Miguel (Centro Nacional de Investigaciones Oncológicas) ; Masuyer, G. (University of Bath. Department of Pharmacy and Pharmacology) ; Wallner, O. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Müller, S. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Pham, T. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Göktürk, C. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Rasti, A. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Suman, S. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Sarno, A. (Sintef Ocean. Department of Environment and New Resources) ; Wiita, E. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Homan, E. J. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Karsten, S. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Marimuthu, K. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Michel, M. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Koolmeister, T. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Scobie, M. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Loseva, O. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Almlöf, I. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Unterlass, J. E. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Pettke, A. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Boström, J. (Karolinska Institutet (Estocolm, Suècia). Department of Laboratory Medicine) ; Pandey, M. (University of Sheffield. Weston Park Cancer Centre) ; Gad, H. (University of Sheffield. Weston Park Cancer Centre) ; Herr, P. (University of Sheffield. Weston Park Cancer Centre) ; Jemth, A. S. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; El Andaloussi, S. (Karolinska Institutet (Estocolm, Suècia). Department of Laboratory Medicine) ; Kalderén, C. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Rodriguez-Perales, Sandra (Centro Nacional de Investigaciones Oncológicas) ; Benítez, J. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Krokan, H. E. (Research and Innovation in Central Norway) ; Altun, M. (Karolinska Institutet (Estocolm, Suècia). Department of Laboratory Medicine) ; Stenmark, P. (Lund University. Department of Experimental Medical Science.) ; Berglund, U. W. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ; Helleday, Thomas (University of Sheffield.Weston Park Cancer Centre) ; Universitat Autònoma de Barcelona
Altered oncogene expression in cancer cells causes loss of redox homeostasis resulting in oxidative DNA damage, e. g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER). PARP1 coordinates BER and relies on the upstream 8-oxoguanine-DNA glycosylase (OGG1) to recognise and excise 8-oxoG. [...]
2021 - 10.1093/nar/gkaa1048
Nucleic acids research, Vol. 48 Núm. 21 (february 2021) , p. 12234-12251  

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