1.
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11 p, 4.3 MB |
Antigen-specific immunotherapy combined with a regenerative drug in the treatment of experimental type 1 diabetes
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Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Ampudia, Rosa Maria (Institut Germans Trias i Pujol) ;
Gomez-Muñoz, Laia (Institut Germans Trias i Pujol) ;
Pujol-Autonell, Irma (Institut Germans Trias i Pujol) ;
Aguilera, Eva (Institut Germans Trias i Pujol) ;
Risueño, Ruth M. (Josep Carreras Leukaemia Research Institute) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Vázquez, Federico (Institut Germans Trias i Pujol) ;
Vives-Pi, Marta (Institut Germans Trias i Pujol)
Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. To revert type 1 diabetes, the suppression of the autoimmune attack should be combined with a β-cell replacement strategy. [...]
2020 - 10.1038/s41598-020-76041-1
Scientific reports (Nature Publishing Group), Vol. 10 (2020) , art. 18927
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2.
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2 p, 318.1 KB |
Dendritic cells from paediatric patients with type 1 diabetes show altered phagocytosis capacity correlating with disease evolution
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Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ;
Murillo, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Bel, Joan (Hospital Universitari Germans Trias i Pujol. Servei de Pediatria) ;
Vives Pi, Marta (Institut Germans Trias i Pujol)
Autoimmunity against β-cells in type 1 diabetes (T1D) is prompted by defective immunological tolerance, an event in which dendritic cells (DCs) play a crucial role as orchestrators of the immune response. [...]
2019 - 10.1007/s00125-019-4946-6
Diabetologia, Vol. 62, supl. 1 (Set. 2019) , art. S224
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3.
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8 p, 1.3 MB |
Preclinical evaluation of antigen-specific nanotherapy based on phosphatidylserine-liposomes for type 1 diabetes
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Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ;
Ampudia, Rosa Maria (Institut Germans Trias i Pujol) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Bertran-Cobo, Cesc (Institut Germans Trias i Pujol) ;
Ehrenberg, Clara (Institut Germans Trias i Pujol) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Vives Pi, Marta (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of insulin-producing cells. Due to the ability of apoptotic cells clearance to induce tolerance, we previously generated liposomes rich in phophatidylserine (PS) -a feature of apoptotic cells- loaded with insulin peptides to mimic apoptotic beta-cells. [...]
2020 - 10.1080/21691401.2019.1699812
Artificial Cells, Nanomedicine and Biotechnology, Vol. 48, issue 1 (2020) , p. 77-83
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4.
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14 p, 2.6 MB |
Repurposed analog of GLP-1 ameliorates hyperglycemia in type 1 diabetic mice through pancreatic cell reprogramming
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Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ;
Rodríguez Fernández, Silvia (Institut Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Ampudia, Rosa Maria (Institut Germans Trias i Pujol) ;
Gomez-Muñoz, Laia (Institut Germans Trias i Pujol) ;
Pujol-Autonell, Irma (Institut Germans Trias i Pujol) ;
Aguilera, Eva (Institut Germans Trias i Pujol) ;
Coma, Mireia (Anaxomics Biotech SL) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
Vázquez, Federico (Institut Germans Trias i Pujol) ;
Verdaguer, Joan (Universitat de Lleida. Departament de Medicina Experimental) ;
Vives Pi, Marta (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. An ideal immunotherapy should combine the blockade of the autoimmune response with the recovery of functional target cell mass. [...]
2020 - 10.3389/fendo.2020.00258
Frontiers in Endocrinology, Vol. 11 (May 2020) , art. 258
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5.
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13 p, 1.5 MB |
Impaired Phagocytosis in Dendritic Cells From Pediatric Patients With Type 1 Diabetes Does Not Hamper Their Tolerogenic Potential
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Rodríguez Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Murillo, Marta (Hospital Germans Trias i Pujol) ;
Villalba Felipe, Adrián (Hospital Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
Gómez Muñoz, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Aguilera, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Vázquez, Federico (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bel, Joan (Hospital Germans Trias i Pujol) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Type 1 diabetes (T1D) is prompted by defective immunological tolerance, an event in which dendritic cells (DCs) are crucial as immune response orchestrators. In fact, they contribute to maintaining tolerance to self-antigens, but they can also prompt an immunogenic response against them, leading to autoimmunity. [...]
2019 - 10.3389/fimmu.2019.02811
Frontiers in immunology, Vol. 10 (November 2019) , art. 2811
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6.
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12 p, 2.5 MB |
Liposome-based immunotherapy against autoimmune diseases : Therapeutic effect on multiple sclerosis
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Pujol Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mansilla López, Maria José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
Navarro-Barriuso, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ampudia, Rosa Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rius, Aleix (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García Jimeno, Sonia (Institut Català de Nanociència i Nanotecnologia) ;
Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Based on the ability of apoptosis to induce immunological tolerance, liposomes were generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our aim was to validate the immunotherapy in other autoimmune disease: multiple sclerosis. [...]
2017 - 10.2217/nnm-2016-0410
Nanomedicine, Vol. 12, Issue 11 (June 2017) , p. 1231-1242
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7.
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8.
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15 p, 5.9 MB |
Prenatal administration of Betamethasone causes changes in the T cell receptor repertoire influencing Development of autoimmunity
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Gieras, Anna (University Medical Center Hamburg-Eppendorf. Department of Immunology) ;
Gehbauer, Christina (University Medical Center Hamburg-Eppendorf. Department of Immunology) ;
Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Engler, Jan Broder (Institute of Neuroimmunology and Multiple Sclerosis. Center for Molecular Neurobiology Hamburg) ;
Diepenbruck, Ines (University Medical Center Hamburg-Eppendorf. Department of Immunology) ;
Glau, Laura (University Medical Center Hamburg-Eppendorf. Department of Immunology) ;
Joosse, Simon A. (University Medical Center Hamburg-Eppendorf. Department of Tumor Biology) ;
Kersten, Nora (University Medical Center Hamburg-Eppendorf. Department of Immunology) ;
Klinge, Stefanie (University Medical Center Hamburg-Eppendorf. Department of Immunology) ;
Mittrücker, Hans-Willi (University Medical Center Hamburg-Eppendorf. Department of Immunology) ;
Friese, Manuel A. (Institute of Neuroimmunology and Multiple Sclerosis, Center for Molecular Neurobiology Hamburg) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tolosa, Eva (University Medical Center Hamburg-Eppendorf. Department of Immunology) ;
Universitat Autònoma de Barcelona
Prenatal glucocorticoids are routinely administered to pregnant women at risk of preterm delivery in order to improve survival of the newborn. However, in half of the cases, birth occurs outside the beneficial period for lung development. [...]
2017 - 10.3389/fimmu.2017.01505
Frontiers in immunology, Vol. 8 (november 2017) , p. 1-15
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9.
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17 p, 2.4 MB |
Phosphatidylserine-liposomes promote tolerogenic features on dendritic cells in human type 1 diabetes by apoptotic mimicry
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Rodriguez Fernandez, Silvia (Institut Germans Trias i Pujol) ;
Pujol Autonell, Irma (Institut Germans Trias i Pujol) ;
Brianso, Ferran (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
García Jimeno, Sonia (Institut Català de Nanociència i Nanotecnologia) ;
Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ;
Sanchez, Alex (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Aguilera, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vazquez, Federico (Hospital Universitari Germans Trias i Pujol. Servei d'Endocrinologia) ;
Verdaguer, Joan (Universitat de Lleida. Departament de Medicina Experimental) ;
Maspoch Comamala, Daniel (Institució Catalana de Recerca i Estudis Avançats) ;
Vives Pi, Marta (Institut Germans Trias i Pujol)
Type 1 diabetes (T1D) is a metabolic disease caused by the autoimmune destruction of insulin-producing β-cells. With its incidence increasing worldwide, to find a safe approach to permanently cease autoimmunity and allow β-cell recovery has become vital. [...]
2018 - 10.3389/fimmu.2018.00253
Frontiers in immunology, Vol. 9 (Feb. 2018) , art. 253
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10.
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8 p, 1.1 MB |
Expression of REG family genes in human inflammatory bowel diseases and its regulation
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Tsuchida, Chikatsugu (Saiseikai Nara Hospital, Japan) ;
Sakuramoto-Tsuchida, Sumiyo (Department of Biochemistry, Nara Medical University) ;
Taked, Maiko (Department of Laboratory Medicine and Pathology, National Hospital Organization Kinki-chuo Chest Medical Center) ;
Itaya-Hironaka, Asako (Department of Biochemistry, Nara Medical University) ;
Yamauchi, Akiyo (Department of Biochemistry, Nara Medical University) ;
Misu, Masayasu (Department of Biochemistry, Nara Medical University) ;
Shobatake, Ryogo (Department of Biochemistry, Nara Medical University) ;
Uchiyama, Tomoko (Department of Diagnostic Pathology, Nara Medical University) ;
Makino, Mai (Department of Biochemistry, Nara Medical University) ;
Pujol-Autonell, Irma (Institut Germans Trias i Pujol) ;
Vives Pi, Marta (Institut Germans Trias i Pujol) ;
Ohbayashi, Chiho (Department of Diagnostic Pathology, Nara Medical University) ;
Takasawa, Shin (Department of Biochemistry, Nara Medical University)
The pathophysiology of inflammatory bowel disease (IBD) reflects a balance between mucosal injury and reparative mechanisms. Some regenerating gene (Reg) family members have been reported to be expressed in Crohn's disease (CD) and ulcerative colitis (UC) and to be involved as proliferative mucosal factors in IBD. [...]
2017 - 10.1016/j.bbrep.2017.10.003
Biochemistry and Biophysics Reports, Vol. 12 (october 2017) , p. 198-205
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