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16 p, 3.8 MB The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation / Serrano, Lourdes (Department of Genetics, the Human Genetics Institute of New Jersey. Rutgers University) ; Martínez-Redondo, Paloma (Institut d'Investigació Biomèdica de Bellvitge) ; Marazuela Duque, Anna (Institut d'Investigació Biomèdica de Bellvitge) ; Vazquez Prat, Berta Nieves (Department of Genetics, the Human Genetics Institute of New Jersey. Rutgers University) ; Dooley, Scott J. (Department of Genetics, the Human Genetics Institute of New Jersey. Rutgers University) ; Voigt, Philipp (Department of Biochemistry, New York University School of Medicine) ; Beck, David B. (Department of Biochemistry, New York University School of Medicine) ; Kane-Goldsmith, Noriko (Department of Genetics, the Human Genetics Institute of New Jersey. Rutgers University) ; Tong, Qiang (Children's Nutrition Research Center) ; Rabanal Prados, Rosa Ma. (Rosa Maria) (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Fondevila, Dolors (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Muñoz, Purificación (Institut d'Investigació Biomèdica de Bellvitge) ; Krüger, Marcus (Max Planck Institute for Heart and Lung Research. Department of Cardiac Development and Remodeling) ; Tischfield, Jay A. (Department of Genetics, the Human Genetics Institute of New Jersey. Rutgers University) ; Vaquero, Alejandro (Institut d'Investigació Biomèdica de Bellvitge)
The establishment of the epigenetic mark H4K20me1 (monomethylation of H4K20) by PR-Set7 during G2/M directly impacts S-phase progression and genome stability. However, the mechanisms involved in the regulation of this event are not well understood. [...]
2013 - 10.1101/gad.211342.112
Genes & Development, 2013  
Detailed record - Creative Commons

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