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Resultados globales: 6 registros encontrados en 0.03 segundos.
Artículos, Encontrados 6 registros
Artículos Encontrados 6 registros  
1.
17 p, 7.9 MB Defect-free graphene enhances enzyme delivery to fibroblasts derived from patients with lysosomal storage disorders / Chen, Yingxian (University of Manchester. Nanomedicine Lab) ; Taufiq, Tooba (The University of Manchester) ; Zeng, Niting (University of Manchester. Department of Chemistry) ; Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ; Karakasidi, Angeliki (University of Manchester. Nanomedicine Lab) ; Church, Heather (Manchester Centre for Genomic Medicine) ; Jovanovic, Ana (Salford Royal NHS Foundation Trust) ; Jones, Simon A. (Manchester Centre for Genomic Medicine) ; Panigrahi, Adyasha (University of Manchester. Department of Chemistry) ; Larrosa, Igor (University of Manchester. Department of Chemistry) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ; Casiraghi, Cinzia (University of Manchester. Department of Chemistry) ; Vranic, Sandra (University of Manchester. Nanomedicine Lab)
Enzyme replacement therapy shows remarkable clinical improvement in treating lysosomal storage disorders. However, this therapeutic approach is hampered by limitations in the delivery of the enzyme to cells and tissues. [...]
2023 - 10.1039/d2nr04971f
Nanoscale, Vol. 15, Issue 21 (June 2023) , p. 9348-9364  
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2.
11 p, 9.3 MB Effects of lateral size, thickness, and stabilizer concentration on the cytotoxicity of defect-free graphene nanosheets : implications for biological applications / Hu, Chen-Xia (University of Manchester. Department of Chemistry) ; Read, Oliver (University of Manchester. Department of Chemistry) ; Shin, Yuyoung (University of Manchester. Department of Chemistry) ; Chen, Yingxian (University of Manchester. Nanomedicine Lab) ; Wang, Jingjing (University of Manchester. Department of Chemistry) ; Boyes, Matthew (University of Manchester. Department of Chemistry) ; Zeng, Niting (University of Manchester. Department of Chemistry) ; Panigrahi, Adyasha (University of Manchester. Department of Chemistry) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ; Larrosa, Igor (University of Manchester. Department of Chemistry) ; Vranic, Sandra (University of Manchester. Nanomedicine Lab) ; Casiraghi, Cinzia (University of Manchester. Department of Chemistry)
In this work, we apply liquid cascade centrifugation to highly concentrated graphene dispersions produced by liquid-phase exfoliation in water with an insoluble bis-pyrene stabilizer to obtain fractions containing nanosheets with different lateral size distributions. [...]
2022 - 10.1021/acsanm.2c02403
ACS applied nano materials, Vol. 5, issue 9 (Sep. 2022) , p. 12626-12636  
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3.
12 p, 3.7 MB Stable, concentrated, biocompatible, and defect-free graphene dispersions with positive charge / Shin, Yuyoung (University of Manchester. Department of Chemistry) ; Vranic, Sandra (University of Manchester. Nanomedicine Lab) ; Just-Baringo, Xavier (University of Manchester. Department of Chemistry) ; Gali, Sai Manoj (Institut Català de Nanociència i Nanotecnologia) ; Kisby, Thomas (University of Manchester. National Graphene Institute) ; Chen, Yingxian (University of Manchester. Nanomedicine Lab) ; Gkoutzidou, Alexandra (University of Manchester. Department of Materials) ; Prestat, Eric (SciTech Daresbury Campus. SuperSTEM Laboratory) ; Beljonne, David (Institut Català de Nanociència i Nanotecnologia) ; Larrosa, Igor (University of Manchester. Department of Chemistry) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ; Casiraghi, Cinzia (University of Manchester. Department of Chemistry)
The outstanding properties of graphene offer high potential for biomedical applications. In this framework, positively charged nanomaterials show better interactions with the biological environment, hence there is strong interest in the production of positively charged graphene nanosheets. [...]
2020 - 10.1039/d0nr02689a
Nanoscale, Vol. 12, Issue 23 (June 2020) , p. 12383-12394  
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4.
8 p, 4.7 MB Nitric oxide-dependent biodegradation of graphene oxide reduces inflammation in the gastrointestinal tract / Peng, Guotao (Karolinska Institutet (Estocolm, Suècia). Institute of Environmental Medicine) ; Montenegro, Marcelo F. (Karolinska Institutet (Estocolm, Suècia). Department of Physiology and Pharmacology) ; Ntola, Chifundo N. M. (University of Manchester. National Graphene Institute) ; Vranic, Sandra (University of Manchester. National Graphene Institute) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ; Vogt, Carmen (Kungl. Tekniska högskolan (Estocolm (Suècia)) ; Toprak, Muhammet S. (Kungl. Tekniska högskolan (Estocolm (Suècia)) ; Duan, Tianbo (Uppsala University. Department of Engineering Sciences) ; Leifer, Klaus (Uppsala University. Department of Engineering Sciences) ; Bräutigam, Lars (Karolinska Institutet (Estocolm, Suècia)) ; Lundberg, Jon O. (Karolinska Institutet (Estocolm, Suècia). Department of Physiology and Pharmacology) ; Fadeel, Bengt (Karolinska Institutet (Estocolm, Suècia). Institute of Environmental Medicine)
Understanding the biological fate of graphene-based materials such as graphene oxide (GO) is crucial to assess adverse effects following intentional or inadvertent exposure. Here we provide first evidence of biodegradation of GO in the gastrointestinal tract using zebrafish as a model. [...]
2020 - 10.1039/d0nr03675g
Nanoscale, Vol. 12, Issue 32 (August 2020) , p. 16730-16737  
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5.
15 p, 2.5 MB Deep tissue translocation of graphene oxide sheets in human glioblastoma 3D spheroids and an orthotopic xenograft model / de Lázaro, Irene (University of Manchester. Nanomedicine Lab) ; Sharp, Paul (University of Manchester. Nanomedicine Lab.) ; Gurcan, Cansu (Ankara University. Department of Biomedical Engineering) ; Ceylan, Ahmed (Ankara University. Faculty of Veterinary Medicine. Department of Histology Embryology) ; Stylianou, Maria (University of Manchester. Nanomedicine Lab.) ; Kisby, Thomas (University of Manchester. Nanomedicine Lab.) ; Chen, Yingxian (University of Manchester. Nanomedicine Lab.) ; Vranic, Sandra (University of Manchester. Nanomedicine Lab.) ; Barr, Katharine (University of Manchester. Nanomedicine Lab.) ; Taheri, Hadiseh (Ankara University. Department of Biomedical Engineering) ; Ozen, Asuman (Ankara University. Faculty of Veterinary Medicine. Department of Histology Embryology) ; Bussy, Cyrill (University of Manchester. Nanomedicine Lab.) ; Yilmazer, Acelya (Ankara University. Department of Biomedical Engineering) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
Its anatomical localization, a highly heterogeneous and drug-resistant tumor cell population and a "cold" immune microenvironment, all challenge the treatment of glioblastoma. Nanoscale drug delivery systems, including graphene oxide (GO) flakes, may circumvent some of these issues bypassing biological barriers, delivering multiple cargoes to impact several pathways simultaneously, or targeting the immune compartment. [...]
2021 - 10.1002/adtp.202000109
Advanced Therapeutics, Vol. 4, issue 1 (Jan. 2021) , art. 2000109  
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6.
43 p, 1.6 MB Non-cytotoxic carbon nanocapsules synthesized via one-pot filling and end-closing of multi-walled carbon nanotubes / Martincic, Markus (Institut de Ciència de Materials de Barcelona) ; Vranic, Sandra (The University of Manchester) ; Pach, Elzbieta (Institut Català de Nanociència i Nanotecnologia) ; Sandoval, Stefania (Institut de Ciència de Materials de Barcelona) ; Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ; Kostarelos, Kostas (The University of Manchester) ; Tobias, Gerard (Institut de Ciència de Materials de Barcelona)
Filled carbon nanotubes (CNTs) find application in a variety of fields that expand from sensors to supercapacitors going through targeted therapies. Bulk filling of CNTs in general results in samples that contain a large amount of non-encapsulated material external to the CNTs. [...]
2019 - 10.1016/j.carbon.2018.10.006
Carbon, Vol. 141 (January 2019) , p. 782-793  
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