Resultats globals: 3 registres trobats en 0.02 segons.
Articles, 3 registres trobats
Articles 3 registres trobats  
1.
25 p, 24.0 MB AAV9-mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic K-Ras-induced lung cancer / Muñoz-Lorente, Miguel A. (Centro Nacional de Investigaciones Oncológicas) ; Martínez, Paula (Centro Nacional de Investigaciones Oncológicas) ; Tejera, Águeda (Centro Nacional de Investigaciones Oncológicas) ; Whittemore, Kurt (Centro Nacional de Investigaciones Oncológicas) ; Moisés-Silva, Ana Carolina (Centro Nacional de Investigaciones Oncológicas) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Blasco, María A. (Centro Nacional de Investigaciones Oncológicas)
Short and dysfunctional telomeres are sufficient to induce a persistent DNA damage response at chromosome ends, which leads to the induction of senescence and/or apoptosis and to various age-related conditions, including a group of diseases known as "telomere syndromes", which are provoked by extremely short telomeres owing to germline mutations in telomere genes. [...]
2018 - 10.1371/journal.pgen.1007562
PLoS Genetics, Vol. 14 (august 2018)  
2.
33 p, 9.6 MB Telomerase gene therapy ameliorates the effects of neurodegeneration associated to short telomeres in mice / Whittemore, Kurt (Centro Nacional de Investigaciones Oncológicas) ; Derevyanko, Aksinya (Centro Nacional de Investigaciones Oncológicas) ; Martínez, Paula (Centro Nacional de Investigaciones Oncológicas) ; Serrano, Rosa (Centro Nacional de Investigaciones Oncológicas) ; Pumarola, Martí 1825-1896 (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Blasco, María A. (Centro Nacional de Investigaciones Oncológicas)
Neurodegenerative diseases associated with old age such as Alzheimer's disease present major problems for society, and they currently have no cure. The telomere protective caps at the ends of chromosomes shorten with age, and when they become critically short, they can induce a persistent DNA damage response at chromosome ends, triggering secondary cellular responses such as cell death and cellular senescence. [...]
2019 - 10.18632/aging.101982
Aging (Albany NY), Vol. 11 (may 2019) , p. 2916-2948  
3.
16 p, 2.7 MB Gene therapy with the 1 telomere gene rescues decreased 1 levels with aging and prolongs mouse health span / Derevyanko, Aksinya (Centro Nacional de Investigaciones Oncológicas) ; Whittemore, Kurt (Centro Nacional de Investigaciones Oncológicas) ; Schneider, Ralph P. (Centro Nacional de Investigaciones Oncológicas) ; Jiménez, Verónica (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Bosch, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Blasco, María A. (Centro Nacional de Investigaciones Oncológicas)
The shelterin complex protects telomeres by preventing them from being degraded and recognized as double-strand breaks. 1 is an essential component of shelterin, with important roles in telomere protection and telomere replication. [...]
2017 - 10.1111/acel.12677
Aging Cell, Vol. 16 (september 2017) , p. 1353-1368  

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