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1.
13 p, 1.8 MB Replication study of plasma proteins relating to Alzheimer's pathology / Shi, Liu (University of Oxford. Department of Psychiatry) ; Winchester, Laura M. (University of Oxford. Department of Psychiatry) ; Westwood, Sarah (University of Oxford. Department of Psychiatry) ; Baird, Alison L (University of Oxford. Department of Psychiatry) ; Anand, Sneha N (University of Oxford. Department of Psychiatry) ; Buckley, Noel J. (University of Oxford. Department of Psychiatry) ; Hye, Abdul (Maurice Wohl Clinical Neuroscience. Institute of Psychiatry. Psychology and Neuroscience. Kings College London) ; Ashton, Nicholas J. (University of Gothenburg) ; Bos, Isabelle (Alzheimer Center. VU University Medical Center) ; Vos, Stephanie J.B. (Maastricht University. School for Mental Health and Neuroscience) ; Kate, Mara Ten (Amsterdam UMC. University Medical Center) ; Scheltens, Philip (Amsterdam UMC. University Medical Center) ; Teunissen, Charlotte E. (Amsterdam University Medical Centers (AUMC)) ; Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ; Gabel, Silvy (KU Leuven. Laboratory for Cognitive Neurology) ; Meersmans, Karen (KU Leuven. Laboratory for Cognitive Neurology) ; Engelborghs, Sebastiaan (Department of Neurology. UZ Brussel and Center for Neurociences (C4N). Vrije Universiteit Brussel) ; De Roeck, Ellen E (Department of Neurology and Memory Clinic. Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken) ; Sleegers, Kristel (University of Antwerp. Institute Born-Bunge) ; Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Blin, Olivier (AIX marseille university. INS. Ap-hm) ; Richardson, Jill C. (Neurosciences Therapeutic Area. GlaxoSmithKline R&D) ; Bordet, Régis (Inserm. University of Lille. CHU Lille) ; Molinuevo, José Luis (Barcelonaβeta Brain Research Center (BBRC)) ; Rami Gonzalez, Lorena (Barcelonaβeta Brain Research Center (BBRC)) ; Wallin, Anders (Institute of Neuroscience and Physiology. Sahlgrenska Academy at University of Gothenburg) ; Kettunen, Petronella (Institute of Neuroscience and Physiology. Sahlgrenska Academy at University of Gothenburg) ; Tsolaki, Magda (AHEPA University Hospital (Grècia)) ; Verhey, Frans (Maastricht University. School for Mental Health and Neuroscience) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ; Popp, Julius (Geriatric Psychiatry. Department of Mental Health and Psychiatry. Geneva University Hospitals) ; Peyratout, Gwendoline (Lausanne University Hospital) ; Martinez-Lage, Pablo (CITA-Alzheimer Foundation) ; Tainta, Mikel (CITA-Alzheimer Foundation) ; Johannsen, Peter (Danish Dementia Research Centre. Rigshospitalet. Copenhagen University Hospital) ; Freund-Levi, Yvonne (Karolinska Institutet Center for Alzheimer Research. Division of Clinical Geriatrics. School of Medical Sciences Örebro University and Department of Neurobiology. Caring Sciences and Society (NVS)) ; Frölich, Lutz (Department of Geriatric Psychiatry. Zentralinstitut für Seelische Gesundheit. University of Heidelberg) ; Dobricic, Valerija (Lübeck Interdisciplinary Platform for Genome Analytics. Institutes of Neurogenetics and Cardiogenetics. University of Lübeck) ; Legido-Quigley, Cristina (The Systems Medicine Group. Steno Diabetes Center) ; Barkhof, Frederik (UCL Institutes of Neurology and Healthcare Engineering) ; Andreasson, Ulf (Clinical Sahlgrenska University Hospital) ; Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ; Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ; Streffer, Johannes (UCB. Braine-l'Alleud. Belgium. formerly Janssen R&D. LLC Beerse) ; Lill, Christina M. (Ageing Epidemiology Research Unit. School of Public Health. Imperial College) ; Bertram, Lars (Department of Psychology. University of Oslo) ; Visser, Pieter Jelle (Alzheimer Center. VU University Medical Center) ; Kolb, Hartmuth C. (Janssen R&D) ; Narayan, Vaibhav A. (Janssen R&D) ; Lovestone, Simon (Janssen R&D) ; Nevado-Holgado, Alejo (Department of Psychiatry. University of Oxford)
Introduction: This study sought to discover and replicate plasma proteomic biomarkers relating to Alzheimer's disease (AD) including both the "ATN" (amyloid/tau/neurodegeneration) diagnostic framework and clinical diagnosis. [...]
2021 - 10.1002/alz.12322
Alzheimer's & Dementia, Vol. 17 Núm. 9 (september 2021) , p. 1452-1464  
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2.
16 p, 903.0 KB Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology / Shi, Liu (University of Oxford) ; Winchester, Laura M. (University of Oxford) ; Liu, Benjamine Y. (University of Oxford) ; Killick, Richard (Maurice Wohl Institute Clinical Neuroscience Institute) ; Ribe, Elena M. (University of Oxford) ; Westwood, Sarah (University of Oxford) ; Baird, Alison L. (University of Oxford) ; Buckley, Noel J. (University of Oxford) ; Hong, Shengjun (University of Lübeck) ; Dobricic, Valerija (University of Lübeck) ; Kilpert, Fabian (University of Lübeck) ; Franke, Andre (Christian-Albrechts-University of Kiel) ; Kiddle, Steven (King's College London) ; Sattlecker, Martina (King's College London) ; Dobson, Richard (University College London) ; Cuadrado, Antonio ("Victor Babes" National Institute of Pathology) ; Hye, Abdul (Maurice Wohl Institute Clinical Neuroscience Institute) ; Ashton, Nicholas J. (University of Gothenburg) ; Morgan, Angharad R. (Cardiff University) ; Bos, Isabelle (Amsterdam UMC. University Medical Center) ; Vos, Stephanie J. B. (Maastricht University) ; ten Kate, Mara (Amsterdam UMC. University Medical Center) ; Scheltens, Philip (Amsterdam UMC. University Medical Center) ; Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ; Gabel, Silvy (Laboratory for Cognitive Neurology) ; Meersmans, Karen (Laboratory for Cognitive Neurology) ; Engelborghs, Sebastiaan (Universitair Ziekenhuis Brussel-UZ Brussel. Department of Neurology) ; De Roeck, Ellen E. (University of Antwerp) ; Sleegers, Kristel (Center for Molecular Neurology) ; Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Blin, Olivier (Aix-Marseille Université) ; Richardson, Jill C. (GlaxoSmithKline R&D. Neurosciences Therapeutic Area) ; Bordet, Régis (University of Lille) ; Molinuevo, José Luis (Barcelonaβeta Brain Research Center (BBRC)) ; Rami Gonzalez, Lorena (Barcelonaβeta Brain Research Center (BBRC)) ; Wallin, Anders (Sahlgrenska University Hospital (Suècia)) ; Kettunen, Petronella (University of Oxford) ; Tsolaki, Magda (Aristotle University of Thessaloniki) ; Verhey, Frans (Maastricht University) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Popp, Julius (University of Geneva) ; Peyratout, Gwendoline (Lausanne University Hospital) ; Martinez-Lage, Pablo (CITA-Alzheimer Foundation (San Sebastian)) ; Tainta, Mikel (Organización Sanitaria Integrada Goierri) ; Johannsen, Peter (Copenhagen University Hospital) ; Teunissen, Charlotte E. (Amsterdam UMC. University Medical Center) ; Freund-Levi, Yvonne (Department of Psychiatry, Örebro Universitetssjukhus) ; Frölich, Lutz (University of Heidelberg) ; Legido-Quigley, Cristina (Steno Diabetes Center Copenhagen) ; Barkhof, Frederik (UCL Institutes of Neurology and Healthcare Engineering) ; Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ; Rasmussen, Katrine Laura (University of Copenhagen) ; Nordestgaard, Børge Grønne (Copenhagen University Hospital) ; Frikke-Schmidt, Ruth (University of Copenhagen) ; Nielsen, Sune Fallgaard (Copenhagen University Hospital) ; Soininen, Hilkka (University of Eastern Finland) ; Vellas, Bruno (Univeriste Paul Sabatier) ; Kloszewska, Iwona (Medical University of Lodz) ; Mecocci, Patrizia (University of Perugia (Itàlia)) ; Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ; Morgan, B. Paul (Cardiff University) ; Streffer, Johannes (UCB Pharma (Braine-l'Alleud, Bèlgica)) ; Visser, Pieter Jelle (Karolinska Institutet (Estocolm, Suècia)) ; Bertram, Lars (University of Oslo) ; Nevado-Holgado, Alejo (University of Oxford) ; Lovestone, Simon (University of Oxford) ; Universitat Autònoma de Barcelona
Previous studies suggest that Dickkopf-1 (DKK1), an inhibitor of Wnt signaling, plays a role in amyloid-induced toxicity and hence Alzheimer's disease (AD). However, the effect of DKK1 expression on protein expression, and whether such proteins are altered in disease, is unknown. [...]
2020 - 10.3233/JAD-200208
Journal of Alzheimer's disease, Vol. 77 (september 2020) , p. 1353-1368  
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