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10 p, 1.6 MB Cells alter their tRNA abundance to selectively regulate protein synthesis during stress conditions / Torrent Burgas, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Chalancon, Guilhem (Medical Research Council. Laboratory of Molecular Biology) ; Sánchez de Groot, Natalia (Medical Research Council. Laboratory of Molecular Biology) ; Wuster, Arthur (Medical Research Council. Laboratory of Molecular Biology) ; Babu, Madam M. (Medical Research Council. Laboratory of Molecular Biology)
Decoding the information in mRNA during protein synthesis relies on tRNA adaptors, the abundance of which can affect the decoding rate and translation efficiency. To determine whether cells alter tRNA abundance to selectively regulate protein expression, we quantified changes in the abundance of individual tRNAs at different time points in response to diverse stress conditions in Saccharomyces cerevisiae. [...]
2018 - 10.1126/scisignal.aat6409
Science Signaling, Vol. 11, Issue 546 (September 2018) , art. eaat6409  
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