Resultados globales: 7 registros encontrados en 0.01 segundos.
Artículos, Encontrados 7 registros
Artículos Encontrados 7 registros  
1.
A saturated map of common genetic variants associated with human height / Yengo, Loic (The University of Queensland) ; Vedantam, Sailaja (Program in Medical and Population Genetics. Broad Institute of MIT and Harvard) ; Marouli, Eirini (William Harvey Research Institute. Barts and the London School of Medicine and Dentistry. Queen Mary University of London) ; Sidorenko, Julia (Institute for Molecular Bioscience. The University of Queensland) ; Bartell, Eric (Harvard Medical School) ; Sakaue, Saori (Divisions of Genetics and Rheumatology. Brigham and Women's Hospital and Department of Medicine. Harvard Medical School) ; Graff, Marielisa (Gillings School of Global Public Health. University of North Carolina at Chapel Hill) ; Eliasen, Anders U. (Section for Bioinformatics. Department of Health Technology. Technical University of Denmark) ; Jiang, Yunxuan (23andMe) ; Raghavan, Sridharan (Division of Biomedical Informatics and Personalized Medicine) ; Miao, Jenkai (Broad Institute of MIT and Harvard) ; Arias, Joshua D. (National Cancer Institute) ; Graham, Sarah E. (University of Michigan) ; Mukamel, Ronen E. (Harvard Medical School) ; Spracklen, Cassandra N. (University of Massachusetts) ; Yin, Xianyong (University of Michigan School of Public Health) ; Chen, Shyh-Huei (Wake Forest School of Medicine) ; Ferreira, Teresa (University of Oxford) ; Highland, Heather H. (University of North Carolina at Chapel Hill) ; Ji, Yingjie (University of Exeter) ; Karaderi, Tugce (University of Oxford) ; Lin, Kuang (Nuffield University of Oxford) ; Lüll, Kreete (University of Tartu) ; Malden, Deborah (University of Oxford) ; Medina-Gomez, Carolina (University Medical Center Rotterdam) ; Machado, Moara (National Cancer Institute) ; Moore, Amy (RTI International) ; Rüeger, Sina (Swiss Institute of Bioinformatics) ; Sim, Xueling (National University of Singapore) ; Vrieze, Scott (University of Minnesota) ; Ahluwalia, Tarunveer Singh (University of Copenhagen) ; Akiyama, Masato (Kyushu University) ; Allison, Matthew A. (University of California (San Diego, Estats Units)) ; Álvarez, Marcus (David Geffen School of Medicine) ; Andersen, Mette korre (University of Copenhagen) ; Ani, Alireza (Isfahan University of Medical Sciences) ; Appadurai, Vivek (Copenhagen University Hospital) ; Arbeeva, Liubov (University of North Carolina) ; Bhaskar, Seema (CSIR-Centre for Cellular and Molecular Biology) ; Bielak, Lawrence F. (University of Michigan School of Public Health) ; Bollepalli, Sailalitha (University of Helsinki) ; Bonnycastle, Lori L. (National Institutes of Health) ; Bork-Jensen, Jette (University of Copenhagen) ; Bradfield, J.P. (Quantinuum Research) ; Bradford, Y. (University of Pennsylvania) ; Braund, P.S. (Glenfield Hospital) ; Brody, J.A. (University of Washington) ; Burgdorf, K.S. (Copenhagen University) ; Cade, B.E. (Brigham and Women's Hospital) ; Cai, H. (Vanderbilt University Medical Center) ; Cai, Q. (Vanderbilt University Medical Center) ; Campbell, A. (University of Edinburgh) ; Cañadas-Garre, M. (Queen's University of Belfast) ; Catamo, E. (Burlo Garofolo) ; Chai, J.F. (National University of Singapore and National University Health System) ; Chai, X. (National University of Singapore and National University Health System) ; Chang, L.C. (Academia Sinica) ; Chang, Y.C. (National Taiwan University Hospital) ; Chen, C.H. (Academia Sinica) ; Chesi, A. (Children's Hospital of Philadelphia) ; Choi, S.H. (Broad Institute of MIT and Harvard) ; Chung, R.H. (National Health Research Institutes) ; Cocca, M. (Burlo Garofolo) ; Concas, M.P. (Burlo Garofolo) ; Couture, C. (Université Laval) ; Cuellar-Partida, Gabriel (University of Queensland Diamantina Institute) ; Danning, R. (Brigham and Women's Hospital) ; Daw, E.W. (Washington University School of Medicine) ; Degenhard, F. (Christian-Albrechts University of Kiel) ; Delgado, G.E. (Heidelberg University) ; Delitala, A. (Università degli Studi di Sassari) ; Demirkan, A. (University of Surrey) ; Deng, X. (Boston University School of Public Health) ; Devineni, P. (VA Boston Healthcare System) ; Dietl, A. (University Hospital Regensburg) ; Dimitriou, M. (Harokopio University of Athens) ; Dimitrov, L. (Medical Center Boulevard) ; Dorajoo, R. (Duke-NUS Medical School) ; Ekici, A.B. (Friedrich-Alexander-Universität Erlangen-Nürnberg) ; Engmann, J.E. (University College London) ; Fairhurst-Hunter, Z. (University of Oxford) ; Farmaki, A.E. (Harokopio University of Athens) ; Faul, J.D. (University of Michigan) ; Fernandez-Lopez, J.C. (National Institute of Genomic Medicine) ; Forer, L. (Medical University of Innsbruck) ; Francescatto, M. (University of Trieste) ; Freitag-Wolf, S. (Kiel University) ; Fuchsberger, C. (Affiliated Institute of the University of Lübeck) ; Galesloot, T.E. (Radboud University Medical Center) ; Gao, Y. (University of Mississippi) ; Gao, Z. (Helmholtz Zentrum München Research Center for Environmental Health) ; Geller, F. (Statens Serum Institut) ; Giannakopoulou, O. (Queen Mary University of London) ; Giulianini, F. (Brigham and Women's Hospital) ; Gjesing, A.P. (University of Copenhagen) ; Goel, A. (University of Oxford) ; Gordon, S.D. (QIMR Berghofer Medical Research Institute) ; Gorski, M. (University of Regensburg) ; Grove, J. (Aarhus University) ; Guo, X. (Harbor-UCLA Medical Center) ; Gustafsson, S. (Uppsala University) ; Haessler, J. (Fred Hutchinson Cancer Research Center) ; Hansen, T.F. (Copenhagen University Hospital) ; Havulinna, A.S. (Finnish Institute for Health and Welfare) ; Haworth, S.J. (University of Bristol) ; He, J. (Vanderbilt University Medical Center) ; Heard-Costa, N. (Framingham Heart Study) ; Hebbar, P. (Dasman Diabetes Institute) ; Hindy, G. (Lund University) ; Ho, Y.L.A. (Veterans Affairs Boston Healthcare System) ; Hofer, E. (Medical University of Graz) ; Holliday, E. (University of Newcastle) ; Horn, K. (University of Leipzig) ; Hornsby, W.E. (University of Michigan) ; Hottenga, J.J. (Vrije Universiteit Amsterdam) ; Huang, H. (Chan School of Public Health) ; Huang, J. (Peking University) ; Huerta-Chagoya, A. (Instituto Nacional de Ciencias Médicas y Nutrición) ; Huffman, J.E. (Veterans Affairs Boston Healthcare System) ; Hung, Y.J. (Tri-Service General Hospital Songshan Branch) ; Huo, S. (Chinese Academy of Sciences) ; Hwang, M.Y. (National Institute of Health) ; Iha, H. (Otsuka Pharmaceutical Co.) ; Ikeda, D.D. (Otsuka Pharmaceutical Co.) ; Isono, M. (National Center for Global Health and Medicine) ; Jackson, A.U. (University of Michigan School of Public Health) ; Jäger, S. (German Center for Diabetes Research (DZD)) ; Jansen, I.E. (Vrije Universiteit Medical Center) ; Johansson, I. (Umeå University) ; Jonas, J.B. (Capital Medical University) ; Jonsson, A. (University of Copenhagen) ; Jørgensen, T. (University of Copenhagen) ; Kalafati, I.P. (Harokopio University of Athens) ; Kanai, M. (Osaka University Graduate School of Medicine) ; Kanoni, S. (Queen Mary University of London) ; Kårhus, L.L. (Copenhagen University Hospital) ; Kasturiratne, A. (University of Kelaniya) ; Katsuya, T. (Osaka University Graduate School of Medicine) ; Kawaguchi, T. (Kyoto University Graduate School of Medicine) ; Kember, R.L. (University of Pennsylvania) ; Kentistou, K.A. (University of Edinburgh) ; Kim, H.N. (Sungkyunkwan University) ; Kim, Y.J. (National Institute of Health) ; Kleber, M.E. (SYNLAB MVZ Humangenetik Mannheim) ; Knol, M.J. (University Medical Center Rotterdam) ; Kurbasic, A. (Lund University) ; Lauzon, M. (Harbor-UCLA Medical Center) ; Le, P. (University of Toronto at Mississauga) ; Lea, R. (Queensland University of Technology) ; Lee, J.Y. (Soonchunhyang Mirai Medical Center) ; Leonard, H.L. (Data Tecnica International) ; Li, S.A. (Leidos Biomedical Research) ; Li, X. (St Cloud State University) ; Liang, J. (Case Western Reserve University) ; Lin, H. (University of Massachusetts Chan Medical School) ; Lin, S.Y. (Taichung Veterans General Hospital) ; Liu, J. (Genome Institute of Singapore) ; Liu, X. (Statens Serum Institut) ; Lo, K.S. (Montreal Heart Institute) ; Long, J. (Vanderbilt University Medical Center) ; Lores-Motta, L. (Radboud University Nijmegen Medical Center) ; Luan, J. (University of Cambridge School of Clinical Medicine) ; Lyssenko, V. (Lund University Diabetes Centre) ; Lyytikäinen, L.P. (Tampere University Hospital) ; Mahajan, A. (RIKEN Center for Integrative Medical Sciences) ; Mamakou, V. (National and Kapodistrian University of Athens) ; Mangino, M. (Guy's and St Thomas' Foundation Trust) ; Manichaikul, A. (University of Virginia School of Medicine) ; Marten, J. (University of Edinburgh) ; Mattheisen, M. (University Hospital) ; Mavarani, L. (University Hospital Essen) ; McDaid, A.F. (Swiss Institute of Bioinformatics) ; Meidtner, K. (German Center for Diabetes Research) ; Melendez, T.L. (University of Michigan) ; Mercader, J.M. (Massachusetts General Hospital) ; Milaneschi, Y. (Amsterdam UMC and Vrije Universiteit) ; Miller, J.E. (University of Pennsylvania) ; Millwood, I.Y. (University of Oxford) ; Mishra, P.P. (Tampere University) ; Mitchell, R.E. (University of Bristol) ; Møllehave, L.T. (Copenhagen University Hospital) ; Morgan, A. (Burlo Garofolo) ; Mucha, S. (University of Lübeck) ; Munz, M. (University of Lübeck) ; Nakatochi, M. (Nagoya University Graduate School of Medicine) ; Nelson, C.P. (Glenfield Hospital) ; Nethander, M. (University of Gothenburg) ; Nho, C.W. (Gangneung Institute of Natural Products) ; Nielsen, A.A. (Lillebaelt Hospital) ; Nolte, I.M. (University Medical Center Groningen) ; Nongmaithem, S.S. (Wellcome Sanger Institute) ; Noordam, R. (Leiden University Medical Center) ; Ntalla, I. (Queen Mary University of London) ; Nutile, T. (Institute of Genetics and Biophysics A. Buzzati-Traverso) ; Pandit, A. (University of Michigan School of Public Health) ; Christofidou, P. (King's College London) ; Pärna, K. (University Medical Center Groningen) ; Pauper, M. (Radboud University Nijmegen Medical Center) ; Petersen, E.R.B. (Hospital of Southern Jutland) ; Petersen, L.V. (University of Aarhus) ; Pitkänen, N. (University of Turku) ; Polašek, O. (Algebra University College) ; Poveda, A. (Lund University) ; Preuss, M.H. (Icahn School of Medicine at Mount Sinai) ; Pyarajan, S. (VA Boston Healthcare System) ; Raffield, L.M. (University of North Carolina at Chapel Hill) ; Rakugi, H. (Osaka University Graduate School of Medicine) ; Ramirez, J. (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Rasheed, A. (Center for Non-Communicable Diseases) ; Raven, D. (University of Groningen) ; Rayner, N.W. (University of Oxford. Churchill Hospital) ; Riveros, C. (The University of Newcastle) ; Rohde, R. (University of North Carolina at Chapel Hill) ; Ruggiero, D. (IRCCS Neuromed) ; Ruotsalainen, S.E. (University of Helsinki) ; Ryan, K.A. (University of Maryland School of Medicine) ; Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ; Saxena, R. (Massachusetts General Hospital) ; Scholz, M. (University of Leipzig) ; Sendamarai, A. (VA Boston Healthcare System) ; Shen, B. (National Institutes of Health) ; Shi, J. (23andMe) ; Shin, J.H. (Hallym University) ; Sidore, C. (Consiglio Nazionale delle Ricerche (CNR)) ; Sitlani, C.M. (University of Washington) ; Slieker, R.C. (Amsterdam Cardiovascular Sciences) ; Smit, R.A.J. (Leiden University Medical Center) ; Smith, A.V. (Icelandic Heart Association) ; Smith, J.A. (University of Michigan) ; Smyth, L.J. (Queen's University of Belfast) ; Southam, L. (Wellcome Trust Sanger Institute (Regne Unit)) ; Steinthorsdottir, V. (deCODE Genetics/Amgen) ; Sun, L. (University of Chinese Academy of Sciences) ; Takeuchi, F. (National Center for Global Health and Medicine) ; Tallapragada, D.S.P. (University of Bergen) ; Taylor, K.D. (Harbor-UCLA Medical Center) ; Tayo, B.O. (Loyola University Chicago) ; Tcheandjieu, C. (Stanford University School of Medicine) ; Terzikhan, N. (University Medical Center Rotterdam) ; Tesolin, P. (University of Trieste) ; Teumer, A. (DZHK (German Centre for Cardiovascular Research)) ; Theusch, E. (University of California) ; Thompson, D.J. (University of Cambridge) ; Thorleifsson, G. (deCODE Genetics/Amgen) ; Timmers, P.R.H.J. (Western General Hospital) ; Trompet, S. (Leiden University Medical Center) ; Turman, C. (Chan School of Public Health) ; Vaccargiu, S. (Consiglio Nazionale delle Ricerche) ; van der Laan, S.W. (Utrecht University) ; van der Most, P.J. (University Medical Center Groningen) ; van Klinken, J.B. (University of Amsterdam) ; van Setten, J. (Utrecht University) ; Verma, S.S. (University of Pennsylvania) ; Verweij, N. (University Medical Center Groningen) ; Veturi, Y. (University of Pennsylvania) ; Wang, C.A. (The University of Newcastle) ; Wang, C. (Huazhong University of Science and Technology) ; Wang, L. (Washington University School of Medicine) ; Wang, Z. (Icahn School of Medicine at Mount Sinai) ; Warren, H.R. (Queen Mary University of London) ; Bin Wei, W. (Capital Medical University) ; Wickremasinghe, A.R. (University of Kelaniya) ; Wielscher, M. (Medical University of Vienna) ; Wiggins, K.L. (University of Washington) ; Winsvold, B.S. (Oslo University Hospital) ; Wong, A. (University College London) ; Wu, Y. (The University of Queensland) ; Wuttke, M. (University of Freiburg) ; Xia, R. (University of Texas Health Science Center at Houston) ; Xie, T. (University Medical Center Groningen) ; Yamamoto, K. (Kurume University School of Medicine) ; Yang, J. (Westlake Laboratory of Life Sciences and Biomedicine) ; Yao, J. (Harbor-UCLA Medical Center) ; Young, H. (University of Minnesota) ; Yousri, N.A. (Alexandria University) ; Yu, L. (Rush University Medical Center) ; Zeng, L. (Technical University Munich) ; Zhang, W. (Imperial College London) ; Zhang, X. (University of Pennsylvania) ; Zhao, J.H. (University of Cambridge) ; Zhao, W. (University of Michigan School of Public Health) ; Zhou, W. (Broad Institute of MIT and Harvard) ; Zimmermann, M.E. (University of Regensburg) ; Zoledziewska, M. (Consiglio Nazionale delle Ricerche) ; Adair, L.S. (University of North Carolina at Chapel Hill) ; Adams, H.H.H. (Universidad Adolfo Ibáñez) ; Aguilar-Salinas, C.A. (Escuela de Medicina y Ciencias de la Salud) ; Al-Mulla, F. (Dasman Diabetes Institute) ; Arnett, D.K. (University of Kentucky) ; Asselbergs, F.W. (University College London) ; Åsvold, B.O. (Trondheim University Hospital) ; Attia, J. (University of Newcastle) ; Banas, B. (University Hospital Regensburg) ; Bandinelli, S. (Azienda Toscana Centro) ; Bennett, D.A. (Rush University Medical Center) ; Bergler, T. (University Hospital Regensburg) ; Bharadwaj, D. (Jawaharlal Nehru University) ; Biino, G. (National Research Council of Italy) ; Bisgaard, H. (University of Copenhagen) ; Boerwinkle, E. (University of Texas Health Science Center at Houston) ; Böger, C.A. (KfH Kidney Center Traunstein) ; Bønnelykke, K. (University of Copenhagen) ; Boomsma, D.I. (Vrije Universiteit Amsterdam) ; Børglum, A.D. (Aarhus University) ; Borja, J.B. (University of San Carlos) ; Bouchard, C. (Pennington Biomedical Research Center) ; Bowden, D.W. (Medical Center Boulevard) ; Brandslund, I. (University of Southern Denmark) ; Brumpton, B. (Trondheim University Hospital) ; Buring, J.E. (Brigham and Women's Hospital) ; Caulfield, M.J. (Queen Mary University of London) ; Chambers, J.C. (Imperial College London) ; Chandak, G.R. (JSS (Deemed to be) University) ; Chanock, Stephen J. (National Cancer Institute) ; Chaturvedi, N. (University College London) ; Chen, Y.D.I. (Harbor-UCLA Medical Center) ; Chen, Z. (University of Oxford) ; Cheng, C.Y. (Duke-NUS Medical School) ; Christophersen, I.E. (Vestre Viken Hospital Trust) ; Ciullo, M. (IRCCS Neuromed) ; Cole, J.W. (Baltimore Veterans Affairs Medical Center) ; Collins, F.S. (National Institutes of Health) ; Cooper, R.S. (Loyola University Chicago) ; Cruz, M. (Instituto Mexicano del Seguro Social) ; Cucca, F. (Università degli Studi di Sassari) ; Cupples, L.A. (Framingham Heart Study) ; Cutler, M.J. (Intermountain Medical Center) ; Damrauer, S.M. (Crescenz VA Medical Center) ; Dantoft, T.M. (Copenhagen University Hospital - Bispebjerg and Frederiksberg) ; de Borst, G.J. (University of Utrecht) ; de Groot, L.C.P.G.M. (Department of Human Nutrition. Wageningen University) ; De Jager, P.L. (Columbia University Medical Center) ; de Kleijn, D.P.V. (University of Utrecht) ; Janaka de Silva, H. (University of Kelaniya) ; Dedoussis, G.V. (Harokopio University of Athens) ; den Hollander, A.I. (Radboud University Nijmegen Medical Center) ; Du, S. (University of North Carolina at Chapel Hill) ; Easton, D.F. (Department of Oncology. University of Cambridge) ; Elders, P.J.M. (Amsterdam UMC) ; Eliassen, A.H. (Chan School of Public Health) ; Ellinor, P.T. (Massachusetts General Hospital) ; Elmståhl, S. (Lund University) ; Erdmann, J. (University Heart Center Lübeck) ; Evans, M.K. (National Institutes of Health) ; Fatkin, D. (UNSW Sydney) ; Feenstra, B. (Statens Serum Institut) ; Feitosa, M.F. (Washington University School of Medicine) ; Ferrucci, L. (National Institutes of Health) ; Ford, I. (University of Glasgow) ; Fornage, M. (University of Texas Health Science Center at Houston) ; Franke, A. (Christian-Albrechts University of Kiel) ; Franks, P.W. (Umeå University) ; Freedman, B.I. (Medical Center Boulevard) ; Gasparini, P. (University of Trieste) ; Gieger, C. (German Center for Diabetes Research) ; Girotto, G. (University of Trieste) ; Goddard, M.E. (Precincts and Regions) ; Golightly, Y.M. (University of North Carolina at Chapel Hill) ; Gonzalez-Villalpando, C. (Centro de Estudios en Diabetes) ; Gordon-Larsen, P. (University of North Carolina at Chapel Hill) ; Grallert, H. (German Center for Diabetes Research) ; Grant, S.F.A. (Children's Hospital of Philadelphia) ; Grarup, N. (University of Copenhagen) ; Griffiths, L. (Queensland University of Technology) ; Gudnason, V. (University of Iceland) ; Haiman, C. (Keck School of Medicine of USC) ; Hakonarson, H. (Children's Hospital of Philadelphia) ; Hansen, T. (University of Copenhagen) ; Hartman, C.A. (University Medical Center Groningen) ; Hattersley, A.T. (University of Exeter Medical School) ; Hayward, C. (University of Edinburgh) ; Heckbert, S.R. (University of Washington) ; Heng, C.K. (National University Health System) ; Hengstenberg, C. (Medical University of Vienna) ; Hewitt, A.W. (University of Western Australia) ; Hishigaki, H. (Otsuka Pharmaceutical Co.) ; Hoyng, C.B. (Radboud University Nijmegen Medical Center) ; Huang, P.L. (Massachusetts General Hospital) ; Huang, W. (Shanghai Industrial Technology Institute) ; Hunt, S.C. (University of Utah) ; Hveem, K. (Norwegian University of Science and Technology) ; Hyppönen, E. (South Australian Health and Medical Research Institute) ; Iacono, W.G. (University of Minnesota) ; Ichihara, S. (Jichi Medical University School of Medicine) ; Ikram, M.A. (University Medical Center Rotterdam) ; Isasi, C.R. (Albert Einstein College of Medicine) ; Jackson, R.D. (Ohio State University) ; Jarvelin, M.R. (Brunel University London) ; Jin, Z.B. (Wenzhou Medical University) ; Jöckel, K.H. (University Hospital Essen) ; Joshi, P.K. (University of Edinburgh) ; Jousilahti, P. (Finnish Institute for Health and Welfare) ; Jukema, J.W. (Netherlands Heart Institute) ; Kähönen, M. (Tampere University) ; Kamatani, Y. (The University of Tokyo) ; Kang, K.D. (The Catholic University of Korea Incheon St. Mary's Hospital) ; Kaprio, J. (University of Helsinki) ; Kardia, S.L.R. (University of Michigan School of Public Health) ; Karpe, F. (Churchill Hospital) ; Kato, N. (National Center for Global Health and Medicine) ; Kee, F. (Queen's University of Belfast) ; Kessler, T. (German Centre for Cardiovascular Research) ; Khera, A.V. (Massachusetts General Hospital) ; Khor, C.C. (Genome Institute of Singapore) ; Kiemeney, L.A.L.M. (Radboud University Medical Center) ; Kim, B.J. (National Institute of Health) ; Kim, E.K. (Saevit Eye Hospital) ; Kim, H.L. (Ewha Womans University) ; Kirchhof, P. (Atrial Fibrillation NETwork) ; Kivimaki, M. (University College London) ; Koh, W.P. (National University of Singapore) ; Koistinen, H.A. (Minerva Foundation Institute for Medical Research) ; Kolovou, G.D. (Metropolitan Hospital) ; Kooner, J.S. (Imperial College London) ; Kooperberg, C. (Fred Hutchinson Cancer Research Center) ; Köttgen, A. (University of Freiburg) ; Kovacs, P. (University of Leipzig Medical Center) ; Kraaijeveld, A. (Utrecht University) ; Kraft, P. (Chan School of Public Health) ; Krauss, R.M. (University of California) ; Kumari, M. (University of Essex) ; Kutalik, Z. (Swiss Institute of Bioinformatics) ; Laakso, M. (Kuopio University Hospital) ; Lange, L.A. (University of Colorado at Denver) ; Langenberg, C. (Charité - Universitätsmedizin Berlin) ; Launer, L.J. (National Institutes of Health) ; Le Marchand, L. (University of Hawaii Cancer Center) ; Lee, H. (Ewha Womans University School of Medicine) ; Lee, N.R. (University of San Carlos) ; Lehtimäki, T. (Tampere University) ; Li, H. (University of Chinese Academy of Sciences) ; Li, L. (Peking University Center for Public Health) ; Lieb, W. (Kiel University) ; Lin, X. (University of Chinese Academy of Sciences) ; Lind, L. (Uppsala University) ; Linneberg, A. (University of Copenhagen) ; Liu, C.T. (Boston University School of Public Health) ; Liu, J. (Genome Institute of Singapore) ; Loeffler, M. (University of Leipzig) ; London, B. (University of Iowa Hospitals and Clinics) ; Lubitz, S.A. (Massachusetts General Hospital) ; Lye, S.J. (Sinai Health System) ; Mackey, D.A. (University of Western Australia) ; Mägi, R. (University of Tartu) ; Magnusson, P.K.E. (Karolinska Institutet) ; Marcus, G.M. (University of California) ; Vidal, P.M. (University of Lausanne) ; Martin, N.G. (QIMR Berghofer Medical Research Institute) ; März, W. (Medical University of Graz) ; Matsuda, F. (Kyoto University Graduate School of Medicine) ; McGarrah, R.W. (Duke University School of Medicine) ; McGue, M. (University of Minnesota) ; McKnight, A.J. (Queen's University of Belfast) ; Medland, S.E. (QIMR Berghofer Medical Research Institute) ; Mellström, D. (University of Gothenburg) ; Metspalu, A. (University of Tartu) ; Mitchell, B.D. (Baltimore Veterans Administration Medical Center) ; Mitchell, P. (University of Sydney) ; Mook-Kanamori, D.O. (Leiden University Medical Center) ; Morris, A.D. (University of Edinburgh) ; Mucci, L.A. (Chan School of Public Health) ; Munroe, P.B. (Queen Mary University of London) ; Nalls, M.A. (Data Tecnica International) ; Nazarian, S. (University of Pennsylvania) ; Nelson, A.E. (University of North Carolina at Chapel Hill) ; Neville, M.J. (Churchill Hospital) ; Newton-Cheh, C. (Massachusetts General Hospital) ; Nielsen, C.S. (Oslo University Hospital) ; Nöthen, M.M. (University Hospital Bonn) ; Ohlsson, C. (Sahlgrenska University Hospital) ; Oldehinkel, A.J. (University of Groningen) ; Orozco, L. (Instituto Nacional de Medicina Genómica) ; Pahkala, K. (University of Turku) ; Pajukanta, P. (David Geffen School of Medicine at UCLA) ; Palmer, C.N.A. (University of Dundee) ; Parra, E.J. (University of Toronto at Mississauga) ; Pattaro, C. (University of Lübeck) ; Pedersen, O. (University of Copenhagen) ; Pennell, C.E. (University of Newcastle) ; Penninx, B.W.J.H. (Amsterdam UMC and Vrije Universiteit) ; Perusse, L. (Université Laval) ; Peters, A. (IBE. LMU Munich) ; Peyser, P.A. (University of Michigan School of Public Health) ; Porteous, D.J. (University of Edinburgh) ; Posthuma, D. (Vrije Universiteit Amsterdam) ; Power, C. (UCL Great Ormond Street Hospital Institute of Child Health) ; Pramstaller, P.P. (University of Lübeck) ; Province, M.A. (Washington University School of Medicine) ; Qi, Q. (Albert Einstein College of Medicine) ; Qu, J. (Wenzhou Medical University) ; Rader, D.J. (University of Pennsylvania) ; Raitakari, O.T. (Turku University Hospital) ; Ralhan, S. (Dyanand Medical College) ; Rallidis, L.S. (University General Hospital Attikon) ; Rao, D.C. (Washington University School of Medicine) ; Redline, S. (Brigham and Women's Hospital) ; Reilly, D.F. (Genetics. Merck Sharp & Dohme) ; Reiner, A.P. (University of Washington) ; Rhee, S.Y. (Kyung Hee University School of Medicine) ; Ridker, P.M. (Brigham and Women's Hospital) ; Rienstra, M. (University Medical Center Groningen) ; Ripatti, S. (University of Helsinki) ; Ritchie, M.D. (University of Pennsylvania) ; Roden, D.M. (Vanderbilt University Medical Center) ; Rosendaal, F.R. (Leiden University Medical Center) ; Rotter, J.I. (Harbor-UCLA Medical Center) ; Rudan, I. (University of Edinburgh) ; Rutters, F. (Amsterdam Public Health Institute) ; Sabanayagam, C. (Duke-NUS Medical School) ; Saleheen, D. (Columbia University) ; Salomaa, V. (Finnish Institute for Health and Welfare) ; Samani, N.J. (Glenfield Hospital) ; Sanghera, D.K. (University of Oklahoma Health Sciences Center) ; Sattar, N. (University of Glasgow) ; Schmidt, B. (University Hospital Essen) ; Schmidt, H. (Medical University of Graz) ; Schmidt, R. (Medical University of Graz) ; Schulze, M.B. (University of Potsdam) ; Schunkert, H. (Technische Universität München) ; Scott, L.J. (University of Michigan School of Public Health) ; Scott, R.J. (University of Newcastle) ; Sever, P. (Imperial College London) ; Shiroma, E.J. (National Institutes of Health) ; Shoemaker, M.B. (Vanderbilt University Medical Center) ; Shu, X.O. (Vanderbilt University Medical Center) ; Simonsick, E.M. (National Institutes of Health) ; Sims, M. (University of Mississippi) ; Singh, J.R. (Central University of Punjab) ; Singleton, A. B. (National Institute on Aging) ; Sinner, M.F. (LMU Munich) ; Smith, J.G. (Lund University) ; Snieder, H. (University Medical Center Groningen) ; Spector, T.D. (King's College London) ; Stampfer, M.J. (Chan School of Public Health) ; Stark, K.J. (University of Regensburg) ; Strachan, D.P. (University of London) ; 't Hart, L.M. (Leiden University Medical Center) ; Tabara, Y. (Kyoto University Graduate School of Medicine) ; Tang, H. (Stanford University School of Medicine) ; Tardif, J.C. (Université de Montréal) ; Thanaraj, T.A. (Department of Genetics and Bioinformatics) ; Timpson, N.J. (University of Bristol) ; Tönjes, A. (University of Leipzig Medical Center) ; Tremblay, A. (Université Laval) ; Tuomi, T. (Folkhälsan Research Center) ; Tuomilehto, J. (King Abdulaziz University) ; Tusié-Luna, M.T. (Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán) ; Uitterlinden, A.G. (University Medical Center Rotterdam) ; van Dam, R.M. (The George Washington University) ; van der Harst, P. (University of Groningen) ; Van der Velde, N. (Amsterdam Public Health) ; van Duijn, C.M. (University Medical Center Rotterdam) ; van Schoor, N.M. (Amsterdam UMC) ; Vitart, V. (University of Edinburgh) ; Völker, U. (University Medicine Greifswald) ; Vollenweider, P. (University of Lausanne) ; Völzke, H. (DZHK (German Centre for Cardiovascular Research)) ; Wacher-Rodarte, N.H. (Centro Médico Nacional Siglo XXI) ; Walker, M. (Newcastle University) ; Wang, Y.X. (Capital Medical University) ; Wareham, N.J. (University of Cambridge School of Clinical Medicine) ; Watanabe, R.M. (Keck School of Medicine of USC) ; Watkins, Hugh (University of Oxford) ; Weir, D.R. (University of Michigan) ; Werge, T.M. (University of Copenhagen) ; Widen, E. (University of Helsinki) ; Wilkens, Lynne R. (University of Hawaii Cancer Center) ; Willemsen, Gonneke (Vrije Universiteit Amsterdam) ; Willett, Walter C. (Chan School of Public Health) ; Wilson, James F. (Western General Hospital) ; Wong, Tien-Yin (Duke-NUS Medical School) ; Woo, Jeong-Taek (Kyung Hee University School of Medicine) ; Wright, Alan F. (University of Edinburgh) ; Wu, Jer-Yuarn (China Medical University) ; Xu, Huichun (University of Maryland School of Medicine) ; Yajnik, Chittaranjan S. (King Edward Memorial Hospital and Research Centre) ; Yokota, Mitsuhiro (Kurume University School of Medicine (Kurume, Japó)) ; Yuan, Jian-Min (University of Pittsburgh) ; Zeggini, Eleftheria (Technical University of Munich) ; Zemel, Babette S. (University of Pennsylvania) ; Zheng, Wei (Vanderbilt University Medical Center) ; Zhu, Xiaofeng (Case Western Reserve University) ; Zmuda, Joseph M. (University of Pittsburgh) ; Zonderman, Alan B. (National Institutes of Health) ; Zwart, John-Anker (University of Oslo) ; Croteau-Chonka, Damien (Brigham and Women's Hospital) ; Vonk, Judith M. (University Medical Center Groningen) ; Le Marchand, Loic (University of Hawaii Cancer Center) ; Chasman, Daniel I. (Brigham and Women's Hospital) ; Cho, Yoon Shin (Hallym University (Chuncheon, Corea del Sud)) ; Heid, Iris M. (University of Regensburg) ; McCarthy, Mark I. (Genentech (South San Francisco, Estats Units)) ; Ng, Maggie C. Y. (Vanderbilt University Medical Center) ; O'Donnell, Christopher J. (Veterans Affairs Boston Healthcare System) ; Rivadeneira, Fernando (Erasmus Medical Center Rotterdam) ; Thorsteinsdottir, Unnur (University of Iceland) ; Sun, Yan V. (Atlanta VA Health Care System) ; Tai, E. Shyong (National University Health System (Singapur)) ; Boehnke, Michael (University of Michigan School of Public Health) ; Deloukas, Panos (King Abdulaziz University (Jeddah, Aràbia Saudita)) ; Justice, Anne E. (Department of Population Health Sciences Geisinger (Danville, Estats Units)) ; Lindgren, Cecilia M. (University of Oxford) ; Loos, Ruth J. F. (Icahn School of Medicine at Mount Sinai (New York, Estats Units)) ; Mohlke, Karen L. (University of North Carolina at Chapel Hill) ; North, Kari E. (University of North Carolina at Chapel Hill) ; Stefansson, Kari (University of Iceland) ; Walters, Robin G. (University of Oxford (Oxford, Regne Unit))) ; Winkler, Thomas W. (University of Regensburg (Regensburg, Alemanya)) ; Young, Kristin L. (University of North Carolina at Chapel Hill) ; Loh, Po-Ru (Harvard Medical School (Boston, Estats Units)) ; Yang, Jian (Westlake Laboratory of Life Sciences and Biomedicine (Hangzhou, Xina)) ; Esko, Tõnu (University of Tartu) ; Assimes, Themistocles (Stanford University School of Medicine) ; Auton, Adam (23andMe (Sunnyvale, Estats Units)) ; Abecasis, Goncalo R. (University of Michigan School of Public Health) ; Willer, Cristen J. (University of Michigan) ; Locke, Adam E. (Washington University School of Medicine) ; Berndt, Sonja I. (National Cancer Institute (Rocville, Estats Units)) ; Lettre, Guillaume (Université de Montréal) ; Frayling, Timothy M. (University of Exeter (Devon, Anglaterra)) ; Okada, Yukinori (The University of Tokyo) ; Wood, Andrew R. (University of Exeter) ; Visscher, PM. (University of Queensland) ; Hirschhorn, Joel N. (Harvard Medical School (Boston, Estats Units)) ; Universitat Autònoma de Barcelona
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes. [...]
2022 - 10.1038/s41586-022-05275-y
Nature, Vol. 610 Núm. 7933 (27 2022) , p. 704-712  
2.
19 p, 2.4 MB Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations / Temprano-Sagrera, Gerard (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; Sitlani, Collen M. (University of Washington) ; Bone, William P. (University of Pennsylvania) ; Martín Bórnez, Miguel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; Voight, Benjamin F. (University of Pennsylvania Perelman School of Medicine) ; Morrison, Alanna C. ; Damrauer, Scott M. ; de Vries, Paul S. ; Smith, Nicholas L. ; Sabater Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ; Dehghan, Abbas ; Heath, Adam S. ; Reiner, Alex P. ; Johnson, Andrew ; Richmond, Anne ; Peters, Annette ; van Hylckama Vlieg, Astrid ; McKnight, Barbara ; Psaty, Bruce M. ; Hayward, Caroline ; Ward-Caviness, Cavin ; O'Donnell, Cristopher ; Chasman, Daniel ; Strachan, David P. ; Tregouet, David A. ; Mook-Kanamori, Dennis ; Gill, Dipender ; Thibord, Florian ; Asselbergs, Folkert W. ; Leebeek, Frank W. G. ; Rosendaal, Frits R. ; Davies, Gail ; Homuth, Georg ; Temprano, Gerard ; Campbell, Harry ; Taylor, Herman A. ; Bressler, Jan ; Huffman, Jennifer E. ; Rotter, Jerome I. ; Yao, Jie ; Wilson, James F. ; Bis, Joshua C. ; Hahn, Julie M. ; Desch, Karl C. ; Wiggins, Kerri L. ; Raffield, Laura M. ; Bielak, Lawrence F. ; Yanek, Lisa R. ; Kleber, Marcus E. ; Mueller, Martina ; Kavousi, Maryam ; Mangino, Massimo ; Liu, Melissa ; Brown, Michael R. ; Conomos, Matthew P. ; Jhun, Min-A. ; Chen, Ming-Huei ; de Maat, Moniek P. M. ; Pankratz, Nathan ; Smith, Nicholas L. ; Peyser, Patricia A. ; Elliot, Paul ; Wei, Peng ; Wild, Philipp S. ; Morange, Pierre E. ; van der Harst, Pim ; Yang, Qiong ; Le, Ngoc-Quynh ; Marioni, Riccardo ; Li, Ruifang ; Damrauer, Scott M. ; Cox, Simon R. ; Trompet, Stella ; Felix, Stephan B. ; Völker, Uwe ; Tang, Weihong ; Koenig, Wolfgang ; Jukema, J. Wouter ; Guo, Xiuqing ; Lindstrom, Sara ; Wang, Lu ; Smith, Erin N. ; Gordon, William ; van Hylckama Vlieg, Astrid ; de Andrade, Mariza ; Brody, Jennifer A. ; Pattee, Jack W. ; Haessler, Jeffrey ; Brumpton, Ben M. ; Suchon, Pierre ; Chen, Ming-Huei ; Turman, Constance ; Germain, Marine ; Wiggins, Kerri L. ; MacDonald, James ; Braekkan, Sigrid K. ; Armasu, Sebastian M. ; Pankratz, Nathan ; Jackson, Rabecca D. ; Nielsen, Jonas B. ; Giulianini, Franco ; Puurunen, Marja K. ; Ibrahim, Manal ; Heckbert, Susan R. ; Bammler, Theo K. ; Frazer, Kelly A. ; McCauley, Bryan M. ; Taylor, Kent ; Pankow, James S. ; Reiner, Alexander P. ; Gabrielsen, Maiken E. ; Deleuze, Jean-François ; O'Donnell, Chris J. ; Kim, Jihye ; McKnight, Barbara ; Kraft, Peter ; Hansen, John-Bjarne ; Rosendaal, Frits R. ; Heit, John A. ; Psaty, Bruce M. ; Tang, Weihong ; Kooperberg, Charles ; Hveem, Kristian ; Ridker, Paul M. ; Morange, Pierre-Emmanuel ; Johnson, Andrew D. ; Kabrhel, Christopher ; Trégouët, David-Alexandre ; Smith, Nicholas L. ; Malik, Rainer ; Chauhan, Ganesh ; Traylor, Matthew ; Sargurupremraj, Muralidharan ; Okada, Yukinori ; Mishra, Aniket ; Rutten-Jacobs, Loes ; Giese, Anne-Katrin ; van der Laan, Sander W. ; Gretarsdottir, Solveig ; Anderson, Christopher D. ; Chong, Michael ; Adams, Hieab HH. ; Ago, Tetsuro ; Almgren, Peter ; Amouyel, Philippe ; Ay, Hakan ; Bartz, Traci M. ; Benavente, Oscar R. ; Bevan, Steve ; Boncoraglio, Giorgio B. ; Brown, Robert D. ; Butterworth, Aadam S. ; Carrera, Caty ; Carty, Cara L. ; Chen, Wei-Min ; Cole, John W. ; Correa, Adolfo ; Cotlarciuc, Ioanna ; Cruchaga, Carlos ; Danesh, John ; de Bakker, Paul I. W. ; DeStefano, Anita L. ; den Hoed, Marcel ; Duan, Qing ; Engelter, Stefan T. ; Falcone, Guido J. ; Gottesman, Rebecca F. ; Grewal, Raji P. ; Gudnason, Vilmundur ; Gustafsson, Stefan ; Haessler, Jeffrey ; Harris, Tamara B. ; Hassan, Ahamad ; Havulinna, Aki S. ; Heckbert, Susan R. ; Holliday, Elizabeth G. ; Howard, George ; Hsu, Fang-Chi ; Hyacinth, Hyacinth I. ; Arfan Ikram, M. ; Ingelsson, Erik ; Irvin, Marguerite R. ; Jian, Xueqiu ; Jiménez-Conde, Jordi ; Johnson, Julie A. ; Jukema, J. Wouter ; Kanai, Masahiro ; Keene, Keith L. ; Kissela, Brett M. ; Kleindorfer, Dawn O. ; Kooperberg, Charles ; Kubo, Michiaki ; Lange, Leslie A. ; Langefeld, Carl D. ; Langenberg, Claudia ; Launer, Lenore J. ; Lee, Jin-Moo ; Lemmens, Robin ; Leys, Didier ; Lewis, Cathryn M. ; Lin, Wei-Yu ; Lindgren, Arne G. ; Lorentzen, Erik ; Magnusson, Patrik K. ; Maguire, Jane ; Manichaikul, Ani ; McArdle, Patrick F. ; Meschia, James F. ; Mitchell, Braxton D. ; Mosley, Thomas H. ; Nalls, Michael A. ; Ninomiya, Toshiharu ; O'Donnell, Martin J. ; Psaty, Bruce M. ; Pulit, Sara L. ; Rannikmäe, Kristiina ; Reiner, Alexander P. ; Rexrode, Kathryn M. ; Rice, Kenneth ; Rich, Stephen S. ; Ridker, Paul M. ; Rost, Natalia S. ; Rothwell, Peter M. ; Rotter, Jerome I. ; Rundek, Tatjana ; Sacco, Ralph L. ; Sakaue, Saori ; Sale, Michele M. ; Salomaa, Veikko ; Sapkota, Bishwa R. ; Schmidt, Reinhold ; Schmidt, Carsten O. ; Schminke, Ulf ; Sharma, Pankaj ; Slowik, Agnieszka ; Sudlow, Cathie L. M. ; Tanislav, Christian ; Tatlisumak, Turgut ; Taylor, Kent D. ; Thijs, Vincent N. S. ; Thorleifsson, Gudmar ; Thorsteinsdottir, Unnur ; Tiedt, Steffen ; Trompet, Stella ; Tzourio, Christophe ; van Duijn, Cornelia M. ; Walters, Matthew ; Wareham, Nicholas J. ; Wassertheil-Smoller, Sylvia ; Wilson, James G. ; Wiggins, Kerri L. ; Yang, Qiong ; Yusuf, Salim ; Amin, Najaf ; Aparicio, Hugo S. ; Arnett, Donna K. ; Attia, John ; Beiser, Alexa S. ; Berr, Claudine ; Buring, Julie E. ; Bustamante, Mariana ; Caso, Valeria ; Cheng, Yu-Ching ; Hoan Choi, Seung ; Chowhan, Ayesha ; Cullell, Natalia ; Dartigues, Jean-François ; Delavaran, Hossein ; Delgado, Pilar ; Dörr, Marcus ; Engström, Gunnar ; Ford, Ian ; Gurpreet, Wander S. ; Hamsten, Anders ; Heitsch, Laura ; Hozawa, Aatsushi ; Ibanez, Laura ; Ilinca, Andrea ; Ingelsson, Martin ; Iwasaki, Motoki ; Jackson, Rebecca D. ; Jood, Katarina ; Jousilahti, Pekka ; Kaffashian, Sara ; Kalra, Lalit ; Kamouchi, Masahiro ; Kitazono, Takanari ; Kjartansson, Olafur ; Kloss, Manja ; Koudstaal, Peter J. ; Krupinski, Jerzy ; Labovitz, Daniel L. ; Laurie, Cathy C. ; Levi, Christhoper R. ; Li, Linxin ; Lind, Lars ; Lindgren, Cecilia M. ; Lioutas, Vasileios ; Mei Liu, Yong ; Lopez, Oscar L. ; Makoto, Hirata ; Martinez-Majander, Nicolas ; Matsuda, Koichi ; Minegishi, Naoko ; Montaner, Joan ; Morris, Andrew P. ; Muiño, Elena ; Müller-Nurasyid, Martina ; Norrving, Bo ; Ogishima, Soichi ; Parati, Eugenio A. ; Reddy Peddareddygari, Leema ; Pedersen, Nancy L. ; Pera, Joanna ; Perola, Markus ; Pezzini, Alessandro ; Pileggi, Silvana ; Rabionet, Raquel ; Riba-Llena, Iolanda ; Ribasés, Marta ; Romero, Jose R. ; Roquer, Jaume ; Rudd, Anthony G. ; Sarin, Antti-Pekka ; Sarju, Ralhan ; Sarnowski, Chloe ; Sasaki, Makoto ; Satizabal, Claudia L. ; Satoh, Mamoru ; Sattar, Naveed ; Sawada, Norie ; Sibolt, Gerli ; Sigurdsson, Ásgeir ; Smith, Albert ; Sobue, Kenji ; Soriano-Tárraga, Carolina ; Stanne, Tara ; Colin Stine, O. ; Stott, David J. ; Strauch, Konstantin ; Takai, Takako ; Tanaka, Hideo ; Tanno, Kozo ; Teumer, Alexander ; Tomppo, Liisa ; Torres-Aguila, Nuria P. ; Touze, Emmanuel ; Tsugane, Shoichiro ; Uitterlinden, Aandre G. ; Valdimarsson, Einar M. ; van der Lee, Sven J. ; Völzke, Henry ; Wakai, Kenji ; Weir, David ; Williams, Stephen R. ; Wolfe, Charles D.A. ; Wong, Quenna ; Xu, Huichun ; Yamaji, Taiki ; Sanghera, Dharambir K. ; Melander, Olle ; Jern, Christina ; Strbian, Daniel ; Fernandez-Cadenas, Israel ; Longstreth, W.T. ; Rolfs, Arndt ; Hata, Jun ; Woo, Daniel ; Rosand, Jonathan ; Pare, Guillaume ; Hopewell, Jemma C. ; Saleheen, Danish ; Stefansson, Kari ; Worrall, BradfordB. ; Kittner, Steven J. ; Seshadri, Sudha ; Fornage, Myriam ; Markus, Hugh S. ; Howson, Joana M. M. ; Kamatani, Yoichiro ; Debette, Stephanie ; Dichgans, Martin ; Universitat Autònoma de Barcelona
Multi-phenotype analysis of genetically correlated phenotypes can increase the statistical power to detect loci associated with multiple traits, leading to the discovery of novel loci. This is the first study to date to comprehensively analyze the shared genetic effects within different hemostatic traits, and between these and their associated disease outcomes. [...]
2022 - 10.1111/jth.15698
Journal of Thrombosis and Haemostasis, Vol. 20 Núm. 6 (01 2022) , p. 1331-1349  
3.
34 p, 16.2 MB Stroke genetics informs drug discovery and risk prediction across ancestries / Mishra, Aniket (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Malik, Rainer (University Hospital, LMU Munich. Institute for Stroke and Dementia Research (ISD)) ; Hachiya, Tsuyoshi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Jürgenson, Tuuli (University of Tartu. Institute of Mathematics and Statistics) ; Namba, Shinichi (Osaka University Graduate School of Medicine. Department of Statistical Genetics) ; Posner, Daniel C. (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Kamanu, Frederick K. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Koido, Masaru (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; Le Grand, Quentin (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Shi, Mingyang (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; He, Yunye (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; Georgakis, Marios K. (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ; Caro, Ilana (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Krebs, Kristi (University of Tartu. Estonian Genome Centre, Institute of Genomics) ; Liaw, Yi-Ching (Chung Shan Medical University. Department of Public Health and Institute of Public Health) ; Vaura, Felix C. (Finnish Institute for Health and Welfare. Department of Public Health and Welfare) ; Lin, Kuang (University of Oxford. Nuffield Department of Population Health) ; Winsvold, Bendik Slagsvold (Oslo University Hospital (Oslo, Noruega)) ; Srinivasasainagendra, Vinodh (University of Alabama at Birmingham. Department of Biostatistics, School of Public Health) ; Parodi, Livia (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ; Bae, Hee-Joon (Seoul National University Bundang Hospital, Seoul National University College of Medicine. Department of Neurology and Cerebrovascular Disease Center) ; Chauhan, Ganesh (Rajendra Institute of Medical Sciences) ; Chong, Michael R. (McMaster University. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine) ; Tomppo, Liisa (Helsinki University Hospital) ; Akinyemi, Rufus (University of Ibadan. Neuroscience and Ageing Research Unit Institute for Advanced Medical Research and Training, College of Medicine) ; Roshchupkin, Gennady V. (Erasmus MC University Medical Center Rotterdam. Department of Radiology and Nuclear Medicine) ; Habib, Naomi (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences) ; Jee, Yon Ho (Harvard T. H. Chan School of Public Health. Department of Epidemiology) ; Thomassen, Jesper Qvist (Copenhagen University Hospital-Rigshospitalet. Department of Clinical Biochemistry) ; Abedi, Vida (The Pennsylvania State University. Department of Public Health Sciences, College of Medicine) ; Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ; Nygaard, Marianne (Odense University Hospital (Dinamarca)) ; Leonard, Hampton L. (Data Tecnica International) ; Yang, Chaojie (University of Virginia. Department of Biochemistry and Molecular Genetics) ; Yonova-Doing, Ekaterina (Novo Nordisk Research Centre Oxford. Department of Genetics) ; Knol, Maria J. (Erasmus MC University Medical Center Rotterdam. Department of Epidemiology) ; Lewis, Adam J. (Vanderbilt University Medical Center. Department of Biomedical Informatics) ; Judy, Renae L. (University of Pennsylvania. Department of Surgery) ; Ago, Tetsuro (Kyushu University. Department of Medicine and Clinical Science, Graduate School of Medical Sciences) ; Amouyel, Philippe (Institut Pasteur de Lille) ; Armstrong, Nicole D. (University of Alabama at Birmingham. Department of Epidemiology) ; Bakker, Mark K. (University Medical Center Utrecht, University Utrecht. UMC Utrecht Brain Center, Department of Neurology and Neurosurgery) ; Bartz, Traci M. (University of Washington. Department of Biostatistics) ; Bennett, David A. (Rush University Medical Center. Rush Alzheimer's Disease Center) ; Bis, Joshua C (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ; Bordes, Constance (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Børte, Sigrid (Oslo University Hospital. Research and Communication Unit for Musculoskeletal Health (FORMI), Department of Research and Innovation, Division of Clinical Neuroscience) ; Cain, Anael (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences) ; Ridker, Paul M. (Harvard Medical School) ; Cho, Kelly (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Chen, Zhengming (University of Oxford. MRC Population Health Research Unit) ; Cruchaga, Carlos (Washington University School of Medicine. NeuroGenomics and Informatics Center) ; Cole, John W. (University of Maryland School of Medicine. Department of Neurology) ; De Jager, Philip L (Columbia University Medical Center. Center for Translational and Computational Neuroimmunology, Department of Neurology) ; de Cid, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Endres, Matthias (partner site Berlin. German Centre for Cardiovascular Research (DZHK)) ; Ferreira, Leslie E. (Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil) ; Geerlings, Mirjam I. (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ; Gasca, Natalie C. (University of Washington. Department of Biostatistics) ; Gudnason, Vilmundur (University of Iceland. Faculty of Medicine) ; Hata, Jun (Kyushu University. Department of Epidemiology and Public Health, Graduate School of Medical Sciences) ; He, Jing (Vanderbilt University Medical Center. Department of Biomedical Informatics) ; Heath, Alicia K. (Imperial College London. Department of Epidemiology and Biostatistics, School of Public Health) ; Ho, Yuk-Lam (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Havulinna, Aki S (FIMM-HiLIFE. Institute for Molecular Medicine Finland) ; Hopewell, Jemma C. (University of Oxford. Clinical Trial Service and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health) ; Hyacinth, Hyacinth I. (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ; Inouye, Michael (University of Cambridge. British Heart Foundation Centre of Research Excellence) ; Jacob, Mina A. (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ; Jeon, Christina E. (Los Angeles County Department of Public Health) ; Jern, Christina (Sahlgrenska University Hospital (Suècia)) ; Kamouchi, Masahiro (Kyushu University. Department of Health Care Administration and Management, Graduate School of Medical Sciences) ; Keene, Keith L. (East Carolina University. Department of Biology, Brody School of Medicine Center for Health Disparities) ; Kitazono, Takanari (Kyushu University. Department of Medicine and Clinical Science, Graduate School of Medical Sciences) ; Kittner, Steven J. (VA Maryland Health Care System. Department of Neurology and Geriatric Research and Education Clinical Center) ; Konuma, Takahiro (Osaka University Graduate School of Medicine. Department of Statistical Genetics) ; Kumar, Amit (Rajendra Institute of Medical Sciences) ; Lacaze, Paul (Monash University. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine) ; Launer, Lenore Joy (National Institute on Aging, NIH. Intramural Research Program) ; Lee, Keon-Joo (Korea University Guro Hospital. Department of Neurology) ; Lepik, Kaido (University Center for Primary Care and Public Health, Lausanne, Switzerland) ; Li, Jiang (Geisinger Health System. Department of Molecular and Functional Genomics, Weis Center for Research) ; Li, Liming (Peking University Health Science Center. Department of Epidemiology and Biostatistics, School of Public Health) ; Manichaikul, Ani (University of Virginia. Center for Public Health Genomics) ; Markus, Hugh S. (University of Cambridge. Stroke Research Group, Department of Clinical Neurosciences) ; Marston, Nicholas A. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Meitinger, Thomas (German Research Center for Environmental Health. Institute of Human Genetics, Helmholtz Zentrum München) ; Mitchell, Braxton D. (Baltimore Veterans Administration Medical Center. Geriatrics Research and Education Clinical Center) ; Montellano, Felipe A. (University Hospital Würzburg. Department of Neurology) ; Morisaki, Takayuki (The University of Tokyo. Division of Molecular Pathology, Institute of Medical Sciences) ; Mosley, Thomas H. (University of Mississippi Medical Center. The MIND Center) ; Nalls, Mike A. (Data Tecnica International) ; Nordestgaard, Børge G. (University of Copenhagen. Department of Clinical Medicine) ; O'Donnell, Martin J. (NUI Galway. College of Medicine Nursing and Health Science) ; Okada, Yukinori (Osaka University. Center for Infectious Disease Education and Research (CiDER)) ; Onland-Moret, N. Charlotte (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ; Ovbiagele, Bruce (University of California, San Francisco. Weill Institute for Neurosciences) ; Peters, Annette (German Centre for Cardiovascular Research (DZHK), partner site Munich) ; Psaty, Bruce M. (University of Washington. Department of Health Systems and Population Health) ; Rich, Stephen S. (University of Virginia. Center for Public Health Genomics) ; Rosand, Jonathan (Massachusetts General Hospital. McCance Center for Brain Health) ; Sabatine, Marc S. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Sacco, Ralph L. (Evelyn F. McKnight Brain Institute) ; Saleheen, Danish (Columbia University. Division of Cardiology, Department of Medicine) ; Sandset, Else Charlotte (The Norwegian Air Ambulance Foundation. Research and Development) ; Salomaa, Veikko (Finnish Institute for Health and Welfare. Department of Public Health and Welfare) ; Sargurupremraj, Muralidharan (University of Texas Health Sciences Center. Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ; Sasaki, Makoto (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Satizabal, Claudia L. (Framingham Heart Study) ; Schmidt, Carsten O. (University Medicine Greifswald, Institute for Community Medicine, SHIP/KEF) ; Shimizu, Atsushi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Smith, Nicholas L. (Seattle Epidemiologic Research and Information Center. Department of Veterans Affairs Office of Research and Development) ; Sloane, Kelly L. (University of Pennsylvania. Department of Neurology) ; Sutoh, Yoichi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Sun, Yan V. (Emory University Rollins School of Public Health. Department of Epidemiology) ; Tanno, Kozo (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Tiedt, Steffen (University Hospital, LMU Munich. Institute for Stroke and Dementia Research (ISD)) ; Tatlisumak, Turgut (Sahlgrenska University Hospital (Suècia)) ; Torres-Aguila, Nuria P.. (Institut d'Investigació Biomèdica Sant Pau) ; Tiwari, Hemant K. (University of Alabama at Birmingham. Department of Biostatistics, School of Public Health) ; Trégouët, David-Alexandre (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Trompet, Stella (Leiden University Medical Center. Department of Cardiology) ; Tuladhar, Anil Man (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ; Tybjærg-Hansen, Anne (University of Copenhagen. Department of Clinical Medicine) ; van Vugt, Marion (University Medical Center Utrecht, Utrecht University. Division Heart & Lungs, Department of Cardiology) ; Vibo, Riina (University of Tartu. Department of Neurology and Neurosurgery) ; Verma, Shefali S. (University of Pennsylvania. Department of Pathology and Laboratory Medicine) ; Wiggins, Kerri L. (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ; Wennberg, Patrik (Umeå University. Department of Public Health and Clinical Medicine) ; Woo, Daniel (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ; Wilson, Peter W. F. (Emory University School of Medicine. Department of Medicine, Division of Cardiovascular Disease) ; Xu, Huichun (University of Maryland School of Medicine. Department of Medicine) ; Yang, Qiong (Boston University School of Public Health. Department of Biostatistics) ; Yoon, Kyungheon (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ; Millwood, Iona Y. (University of Oxford. MRC Population Health Research Unit) ; Gieger, Christian (German Research Center for Environmental Health. Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München) ; Ninomiya, Toshiharu (Kyushu University. Department of Epidemiology and Public Health, Graduate School of Medical Sciences) ; Grabe, Hans J. (German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald) ; Jukema, J. Wouter (LUMC. Einthoven Laboratory for Experimental Vascular Medicine) ; Rissanen, Ina L. (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ; Strbian, Daniel (Helsinki University Hospital) ; Kim, Young Jin (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ; Chen, Pei-Hsin (Chung Shan Medical University. Department of Public Health and Institute of Public Health) ; Mayerhofer, Ernst (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ; Howson, Joanna M. M. (Novo Nordisk Research Centre Oxford. Department of Genetics) ; Irvin, Marguerite R. (University of Alabama at Birmingham. Department of Epidemiology) ; Adams, Hieab (Universidad Adolfo Ibáñez. Latin American Brain Health (BrainLat)) ; Wassertheil-Smoller, Sylvia (Albert Einstein College of Medicine. Department of Epidemiology and Population Health) ; Christensen, Kaare (Odense University Hospital (Dinamarca)) ; Ikram, M. Arfan (Erasmus MC University Medical Center Rotterdam. Department of Epidemiology) ; Rundek, Tatjana (Evelyn F. McKnight Brain Institute) ; Worrall, Bradford B. (University of Virginia. Department of Public Health Science) ; Lathrop, G. Mark (McGill Genome Centre) ; Riaz, Moeen (Monash University. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine) ; Simonsick, Eleanor M. (National Institute on Aging. Longitudinal Studies Section, Translational Gerontology Branch) ; Kõrv, Janika (University of Tartu. Department of Neurology and Neurosurgery) ; França, Paulo H. C. (Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil) ; Zand, Ramin (The Pennsylvania State University. Department of Neurology, College of Medicine) ; Prasad, Kameshwar (Rajendra Institute of Medical Sciences) ; Frikke-Schmidt, Ruth (University of Copenhagen. Department of Clinical Medicine) ; de Leeuw, Frank-Erik (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ; Liman, Thomas (Carl von Ossietzky University of Oldenburg. Klinik für Neurologie) ; Haeusler, Karl Georg (University Hospital Würzburg. Department of Neurology) ; Ruigrok, Ynte M. (University Medical Center Utrecht, University Utrecht. UMC Utrecht Brain Center, Department of Neurology and Neurosurgery) ; Heuschmann, Peter Ulrich (University Hospital Würzburg. Clinical Trial Center) ; Longstreth, W. T. (University of Washington. Department of Neurology) ; Jung, Keum Ji (Yonsei University. Institute for Health Promotion, Graduate School of Public Health) ; Bastarache, Lisa (Vanderbilt University Medical Center. Department of Biomedical Informatics) ; Paré, Guillaume (David Braley Cardiac, Vascular and Stroke Research Institute. Population Health Research Institute) ; Damrauer, Scott M. (Corporal Michael Crescenz VA Medical Center) ; Chasman, Daniel I. (Harvard Medical School) ; Rotter, Jerome I. (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics) ; Anderson, Christopher D. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Zwart, John-Anker (University of Oslo. Institute of Clinical Medicine, Faculty of Medicine) ; Niiranen, Teemu J. (Turku University Hospital. Division of Medicine) ; Fornage, Myriam (University of Texas Health Science Center at Houston. Human Genetics Center, School of Public Health) ; Liaw, Yung-Po (Chung Shan Medical University Hospital. Department of Medical Imaging) ; Seshadri, Sudha (Boston University School of Medicine. Department of Neurology) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Walters, Robin G. (University of Oxford. MRC Population Health Research Unit) ; Ruff, Christian T. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Owolabi, Mayowa O. (University of Ibadan. Department of Medicine) ; Huffman, Jennifer E. (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Milani, Lili (University of Tartu. Estonian Genome Centre, Institute of Genomics) ; Kamatani, Yoichiro (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; Dichgans, Martin (German Center for Neurodegenerative Diseases (DZNE)) ; Debette, Stéphanie (CHU de Bordeaux. Department of Neurology, Institute for Neurodegenerative Diseases) ; Universitat Autònoma de Barcelona
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry ,. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. [...]
2022 - 10.1038/s41586-022-05165-3
Nature, september 2022, p. 1-15  
4.
1 p, 647.1 KB Publisher Correction : Stroke genetics informs drug discovery and risk prediction across ancestries / Mishra, Aniket (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Malik, Rainer (University Hospital, LMU Munich. Institute for Stroke and Dementia Research (ISD)) ; Hachiya, Tsuyoshi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Jürgenson, Tuuli (University of Tartu. Institute of Mathematics and Statistics) ; Namba, Shinichi (Osaka University Graduate School of Medicine. Department of Statistical Genetics) ; Posner, Daniel C. (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Kamanu, Frederick K. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Koido, Masaru (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; Le Grand, Quentin (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Shi, Mingyang (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; He, Yunye (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; Georgakis, Marios K. (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ; Caro, Ilana (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Krebs, Kristi (University of Tartu. Estonian Genome Centre, Institute of Genomics) ; Liaw, Yi-Ching (Chung Shan Medical University. Department of Public Health and Institute of Public Health) ; Vaura, Felix C. (Finnish Institute for Health and Welfare. Department of Public Health and Welfare) ; Lin, Kuang (University of Oxford. Nuffield Department of Population Health) ; Winsvold, Bendik Slagsvold (Oslo University Hospital (Oslo, Noruega)) ; Srinivasasainagendra, Vinodh (University of Alabama at Birmingham. Department of Biostatistics, School of Public Health) ; Parodi, Livia (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ; Bae, Hee-Joon (Seoul National University Bundang Hospital, Seoul National University College of Medicine. Department of Neurology and Cerebrovascular Disease Center) ; Chauhan, Ganesh (Rajendra Institute of Medical Sciences) ; Chong, Michael R. (McMaster University. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine) ; Tomppo, Liisa (Helsinki University Hospital (Finlàndia)) ; Akinyemi, Rufus (University of Ibadan. Neuroscience and Ageing Research Unit Institute for Advanced Medical Research and Training, College of Medicine) ; Roshchupkin, Gennady V. (Erasmus MC University Medical Center Rotterdam. Department of Radiology and Nuclear Medicine) ; Habib, Naomi (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences) ; Jee, Yon Ho (Harvard T. H. Chan School of Public Health. Department of Epidemiology) ; Thomassen, Jesper Qvist (Copenhagen University Hospital-Rigshospitalet. Department of Clinical Biochemistry) ; Abedi, Vida (The Pennsylvania State University. Department of Public Health Sciences, College of Medicine) ; Cárcel-Márquez, Jara (Universitat Autònoma de Barcelona. Departament de Medicina) ; Nygaard, Marianne (Odense University Hospital (Dinamarca)) ; Leonard, Hampton L. (Data Tecnica International) ; Yang, Chaojie (University of Virginia. Department of Biochemistry and Molecular Genetics) ; Yonova-Doing, Ekaterina (Novo Nordisk Research Centre Oxford. Department of Genetics) ; Knol, Maria J. (Erasmus MC University Medical Center Rotterdam. Department of Epidemiology) ; Lewis, Adam J. (Vanderbilt University Medical Center. Department of Biomedical Informatics) ; Judy, Renae L. (University of Pennsylvania. Department of Surgery) ; Ago, Tetsuro (Kyushu University. Department of Medicine and Clinical Science, Graduate School of Medical Sciences) ; Amouyel, Philippe (Institut Pasteur de Lille) ; Armstrong, Nicole D. (University of Alabama at Birmingham. Department of Epidemiology) ; Bakker, Mark K. (University Medical Center Utrecht, University Utrecht. UMC Utrecht Brain Center, Department of Neurology and Neurosurgery) ; Bartz, Traci M. (University of Washington. Department of Biostatistics) ; Bennett, David A. (Rush University Medical Center. Rush Alzheimer's Disease Center) ; Bis, Joshua C. (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ; Bordes, Constance (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Børte, Sigrid (Oslo University Hospital. Research and Communication Unit for Musculoskeletal Health (FORMI), Department of Research and Innovation, Division of Clinical Neuroscience) ; Cain, Anael (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences) ; Ridker, Paul M. (Harvard Medical School) ; Cho, Kelly (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Chen, Zhengming (University of Oxford. MRC Population Health Research Unit) ; Cruchaga, Carlos (Washington University School of Medicine. NeuroGenomics and Informatics Center) ; Cole, John W. (University of Maryland School of Medicine. Department of Neurology) ; De Jager, Philip L (Columbia University Medical Center. Center for Translational and Computational Neuroimmunology, Department of Neurology) ; de Cid, Rafael (Institut Germans Trias i Pujol) ; Endres, Matthias (partner site Berlin. German Centre for Cardiovascular Research (DZHK)) ; Ferreira, Leslie E. (Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil) ; Geerlings, Mirjam I. (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ; Gasca, Natalie C. (University of Washington. Department of Biostatistics) ; Gudnason, Vilmundur (University of Iceland. Faculty of Medicine) ; Hata, Jun (Kyushu University. Department of Epidemiology and Public Health, Graduate School of Medical Sciences) ; He, Jing (Vanderbilt University Medical Center. Department of Biomedical Informatics) ; Heath, Alicia K. (Imperial College London. Department of Epidemiology and Biostatistics, School of Public Health) ; Ho, Yuk-Lam (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Havulinna, Aki S. (FIMM-HiLIFE. Institute for Molecular Medicine Finland) ; Hopewell, Jemma C. (University of Oxford. Clinical Trial Service and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health) ; Hyacinth, Hyacinth I. (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ; Inouye, Michael (University of Cambridge. British Heart Foundation Centre of Research Excellence) ; Jacob, Mina A. (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ; Jeon, Christina E. (Los Angeles County Department of Public Health) ; Jern, Christina (Sahlgrenska University Hospital (Suècia)) ; Kamouchi, Masahiro (Kyushu University. Department of Health Care Administration and Management, Graduate School of Medical Sciences) ; Keene, Keith L. (East Carolina University. Department of Biology, Brody School of Medicine Center for Health Disparities) ; Kitazono, Takanari (Kyushu University. Department of Medicine and Clinical Science, Graduate School of Medical Sciences) ; Kittner, Steven J. (VA Maryland Health Care System. Department of Neurology and Geriatric Research and Education Clinical Center) ; Konuma, Takahiro (Osaka University Graduate School of Medicine. Department of Statistical Genetics) ; Kumar, Amit (Rajendra Institute of Medical Sciences) ; Lacaze, Paul (Monash University. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine) ; Launer, Lenore Joy (National Institute on Aging, NIH. Intramural Research Program) ; Lee, Keon-Joo (Korea University Guro Hospital. Department of Neurology) ; Lepik, Kaido (University Center for Primary Care and Public Health, Lausanne, Switzerland) ; Li, Jiang (Geisinger Health System. Department of Molecular and Functional Genomics, Weis Center for Research) ; Li, Liming (Peking University Health Science Center. Department of Epidemiology and Biostatistics, School of Public Health) ; Manichaikul, Ani (University of Virginia. Center for Public Health Genomics) ; Markus, Hugh S. (University of Cambridge. Stroke Research Group, Department of Clinical Neurosciences) ; Marston, Nicholas A. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Meitinger, Thomas (German Research Center for Environmental Health. Institute of Human Genetics, Helmholtz Zentrum München) ; Mitchell, Braxton D. (Baltimore Veterans Administration Medical Center. Geriatrics Research and Education Clinical Center) ; Montellano, Felipe A. (University Hospital Würzburg. Department of Neurology) ; Morisaki, Takayuki (The University of Tokyo. Division of Molecular Pathology, Institute of Medical Sciences) ; Mosley, Thomas H. (University of Mississippi Medical Center. The MIND Center) ; Nalls, Mike A. (Data Tecnica International) ; Nordestgaard, Børge G. (University of Copenhagen. Department of Clinical Medicine) ; O'Donnell, Martin J. (NUI Galway. College of Medicine Nursing and Health Science) ; Okada, Yukinori (Osaka University. Center for Infectious Disease Education and Research (CiDER)) ; Onland-Moret, N. Charlotte (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ; Ovbiagele, Bruce (University of California, San Francisco. Weill Institute for Neurosciences) ; Peters, Annette (German Centre for Cardiovascular Research (DZHK), partner site Munich) ; Psaty, Bruce M. (University of Washington. Department of Health Systems and Population Health) ; Rich, Stephen S. (University of Virginia. Center for Public Health Genomics) ; Rosand, Jonathan (Massachusetts General Hospital. McCance Center for Brain Health) ; Sabatine, Marc S. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Sacco, Ralph L. (Evelyn F. McKnight Brain Institute) ; Saleheen, Danish (Columbia University. Division of Cardiology, Department of Medicine) ; Sandset, Else Charlotte (The Norwegian Air Ambulance Foundation. Research and Development) ; Salomaa, Veikko (Finnish Institute for Health and Welfare. Department of Public Health and Welfare) ; Sargurupremraj, Muralidharan (University of Texas Health Sciences Center. Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ; Sasaki, Makoto (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Satizabal, Claudia L. (Framingham Heart Study) ; Schmidt, Carsten O. (University Medicine Greifswald, Institute for Community Medicine, SHIP/KEF) ; Shimizu, Atsushi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Smith, Nicholas L. (Seattle Epidemiologic Research and Information Center. Department of Veterans Affairs Office of Research and Development) ; Sloane, Kelly L. (University of Pennsylvania. Department of Neurology) ; Sutoh, Yoichi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Sun, Yan V. (Emory University Rollins School of Public Health. Department of Epidemiology) ; Tanno, Kozo (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Tiedt, Steffen (University Hospital, LMU Munich. Institute for Stroke and Dementia Research (ISD)) ; Tatlisumak, Turgut (Sahlgrenska University Hospital (Suècia)) ; Torres-Aguila, Nuria P.. (Institut d'Investigació Biomèdica Sant Pau) ; Tiwari, Hemant K. (University of Alabama at Birmingham. Department of Biostatistics, School of Public Health) ; Trégouët, David-Alexandre (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Trompet, Stella (Leiden University Medical Center. Department of Cardiology) ; Tuladhar, Anil Man (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ; Tybjærg-Hansen, Anne (University of Copenhagen. Department of Clinical Medicine) ; van Vugt, Marion (University Medical Center Utrecht, Utrecht University. Division Heart & Lungs, Department of Cardiology) ; Vibo, Riina (University of Tartu. Department of Neurology and Neurosurgery) ; Verma, Shefali S. (University of Pennsylvania. Department of Pathology and Laboratory Medicine) ; Wiggins, Kerri L. (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ; Wennberg, Patrik (Umeå University. Department of Public Health and Clinical Medicine) ; Woo, Daniel (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ; Wilson, Peter W. F. (Emory University School of Medicine. Department of Medicine, Division of Cardiovascular Disease) ; Xu, Huichun (University of Maryland School of Medicine. Department of Medicine) ; Yang, Qiong (Boston University School of Public Health. Department of Biostatistics) ; Yoon, Kyungheon (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ; Millwood, Iona Y. (University of Oxford. MRC Population Health Research Unit) ; Gieger, Christian (German Research Center for Environmental Health. Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München) ; Ninomiya, Toshiharu (Kyushu University. Department of Epidemiology and Public Health, Graduate School of Medical Sciences) ; Grabe, Hans J. (German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald) ; Jukema, J. Wouter (LUMC. Einthoven Laboratory for Experimental Vascular Medicine) ; Rissanen, Ina L. (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ; Strbian, Daniel (Helsinki University Hospital (Finlàndia)) ; Kim, Young Jin (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ; Chen, Pei-Hsin (Chung Shan Medical University. Department of Public Health and Institute of Public Health) ; Mayerhofer, Ernst (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ; Howson, Joanna M. M. (Novo Nordisk Research Centre Oxford. Department of Genetics) ; Irvin, Marguerite R. (University of Alabama at Birmingham. Department of Epidemiology) ; Adams, Hieab (Universidad Adolfo Ibáñez) ; Wassertheil-Smoller, Sylvia (Albert Einstein College of Medicine. Department of Epidemiology and Population Health) ; Christensen, Kaare (Odense University Hospital (Dinamarca)) ; Ikram, M. Arfan (Erasmus MC University Medical Center Rotterdam. Department of Epidemiology) ; Rundek, Tatjana (Evelyn F. McKnight Brain Institute) ; Worrall, Bradford B. (University of Virginia. Department of Public Health Science) ; Lathrop, G. Mark (McGill Genome Centre) ; Riaz, Moeen (Monash University. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine) ; Simonsick, Eleanor M. (National Institute on Aging. Longitudinal Studies Section, Translational Gerontology Branch) ; Kõrv, Janika (University of Tartu. Department of Neurology and Neurosurgery) ; França, Paulo H. C. (Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil) ; Zand, Ramin (The Pennsylvania State University. Department of Neurology, College of Medicine) ; Prasad, Kameshwar (Rajendra Institute of Medical Sciences) ; Frikke-Schmidt, Ruth (University of Copenhagen. Department of Clinical Medicine) ; de Leeuw, Frank-Erik (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ; Liman, Thomas (Carl von Ossietzky University of Oldenburg. Klinik für Neurologie) ; Haeusler, Karl Georg (University Hospital Würzburg. Department of Neurology) ; Ruigrok, Ynte M. (University Medical Center Utrecht, University Utrecht. UMC Utrecht Brain Center, Department of Neurology and Neurosurgery) ; Heuschmann, Peter Ulrich (University Hospital Würzburg. Clinical Trial Center) ; Longstreth, W. T. (University of Washington. Department of Neurology) ; Jung, Keum Ji (Yonsei University. Institute for Health Promotion, Graduate School of Public Health) ; Bastarache, Lisa (Vanderbilt University Medical Center. Department of Biomedical Informatics) ; Paré, Guillaume (David Braley Cardiac, Vascular and Stroke Research Institute. Population Health Research Institute) ; Damrauer, Scott M. (Corporal Michael Crescenz VA Medical Center) ; Chasman, Daniel I. (Harvard Medical School) ; Rotter, Jerome I. (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics) ; Anderson, Christopher D. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Zwart, John-Anker (University of Oslo. Institute of Clinical Medicine, Faculty of Medicine) ; Niiranen, Teemu J. (Turku University Hospital. Division of Medicine) ; Fornage, Myriam (University of Texas Health Science Center at Houston. Human Genetics Center, School of Public Health) ; Liaw, Yung-Po (Chung Shan Medical University Hospital. Department of Medical Imaging) ; Seshadri, Sudha (Boston University School of Medicine. Department of Neurology) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Walters, Robin G. (University of Oxford. MRC Population Health Research Unit) ; Ruff, Christian T. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Owolabi, Mayowa O. (University of Ibadan. Department of Medicine) ; Huffman, Jennifer E. (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Milani, Lili (University of Tartu. Estonian Genome Centre, Institute of Genomics) ; Kamatani, Yoichiro (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; Dichgans, Martin (German Center for Neurodegenerative Diseases (DZNE)) ; Debette, Stéphanie (CHU de Bordeaux. Department of Neurology, Institute for Neurodegenerative Disease) ; Universitat Autònoma de Barcelona
2022 - 10.1038/s41586-022-05492-5
Nature, Vol. 612 (november 2022) , p. E7  
5.
17 p, 693.0 KB Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke / Jaworek, Thomas ; Xu, Huichun ; Gaynor, Brady ; Cole, John W. ; Rannikmae, Kristiina ; Stanne, Tara M. ; Tomppo, Liisa ; Abedi, Vida ; Amouyel, Philippe ; Armstrong, Nicole D. ; Attia, John ; Bell, Steven ; Benavente, Oscar R. ; Boncoraglio, Giorgio B. ; Butterworth, Adam ; Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ; Chen, Zhengming ; Chong, Michael ; Cruchaga, Carlos ; Cushman, Mary ; Danesh, John ; Debette, Stéphanie ; Duggan, David J. ; Durda, Jon Peter ; Engstrom, Gunnar ; Enzinger, Chris ; Faul, Jessica D. ; Fecteau, Natalie S. ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Gieger, Christian ; Giese, Anne-Katrin ; Grewal, Raji P. ; Grittner, Ulrike ; Havulinna, Aki S. ; Heitsch, Laura ; Hochberg, Marc C. ; Holliday, Elizabeth ; Hu, Jie ; Ilinca, Andreea ; Irvin, Marguerite R. ; Jackson, Rebecca D. ; Jacob, Mina A. ; Rabionet, Raquel ; Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Johnson, Julie A. ; Kamatani, Yoichiro ; Kardia, Sharon L.R. ; Koido, Masaru ; Kubo, Michiaki ; Lange, Leslie ; Lee, Jin-Moo ; Lemmens, Robin ; Levi, Christopher R. ; Li, Jiang ; Li, Liming ; Lin, Kuang ; Lopez, Haley ; Luke, Sothear ; Maguire, Jane ; McArdle, Patrick F. ; McDonough, Caitrin W. ; Meschia, James F. (Mayo Clinic (Jacksonville, Estats Units d'Amèrica)) ; Metso, Tiina ; Müller-Nurasyid, Martina ; Dichgans, Martin ; O'Donnell, Martin ; Peddareddygari, Leema R. ; Pera, Joanna ; Perry, James A. ; Peters, Annette ; Putaala, Jukka ; Ray, Debashree ; Rexrode, Kathryn ; Ribasés Haro, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rosand, Jonathan ; Rothwell, Peter M. ; Rundek, Tatjana ; Ryan, Kathleen A. ; Sacco, Ralph L. ; Salomaa, Veikko ; Sánchez-Mora, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Schmidt, Reinhold ; Sharma, Pankaj ; Slowik, Agnieszka ; Smith, Jennifer A. ; Smith, Nicholas L. ; Wassertheil-Smoller, Sylvia ; Söderholm, Martin ; Stine, O. Colin ; Strbian, Daniel ; Sudlow, Cathie L.M. ; Tatlisumak, Turgut ; Terao, Chikashi ; Thijs, Vincent ; Torres-Aguila, Nuria P.. ; Trégouët, David-Alexandre ; Tuladhar, Anil M. ; Veldink, Jan ; Walters, Robin G. ; Weir, David R. ; Woo, Daniel ; Worrall, Bradford B. ; Hong, Charles C. ; Ross, Owen A. ; Zand, Ramin ; de Leeuw, Frank-Erik ; Lindgren, Arne G. ; Paré, Guillaume ; Anderson, Christopher D. ; Markus, Hugh S. ; Jern, Christina ; Malik, Rainer ; Dichgans, Martin ; Mitchell, Braxton D. ; Kittner, Steven J. ; Universitat Autònoma de Barcelona
Current genome-wide association studies of ischemic stroke have focused primarily on late-onset disease. As a complement to these studies, we sought to identify the contribution of common genetic variants to risk of early-onset ischemic stroke. [...]
2022 - 10.1212/WNL.0000000000201006
Neurology, Vol. 99 (october 2022) , p. e1738-e1754  
6.
26 p, 1.4 MB The copy number variation and stroke (CaNVAS) risk and outcome study / Cole, John W. (University of Maryland School of Medicine) ; Adigun, Taiwo (University of Ibadan) ; Akinyemi, Rufus (University of Ibadan) ; Akpa, Onoja Matthew (University of Ibadan) ; Bell, Steven (Unversity of Cambridge) ; Chen, Bowang (National Center for Cardiovascular Diseases, Beijing) ; Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Lazcano, Uxue (Institut Hospital del Mar d'Investigacions Mèdiques) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Fornage, Myriam (University of Texas Health Science at Houston) ; Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ; Jern, Christina (University of Gothenburg) ; Krawczak, Michael (University of Kiel) ; Lindgren, Arne (Neurology, Lund University) ; Markus, Hugh S. (Unversity of Cambridge) ; Melander, Olle (Neurology, Lund University) ; Owolabi, Mayowa (University of Ibadan) ; Schlicht, Kristina (University of Kiel) ; Söderholm, Martin (Skåne University Hospital (Suècia)) ; Srinivasasainagendra, Vinodh (University of Alabama at Birmingham) ; Soriano Tárraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ; Stenman, Martin (Lund University) ; Tiwari, Hemant (University of Alabama at Birmingham) ; Corasaniti, Margaret (University of Maryland School of Medicine) ; Fecteau, Natalie (University of Maryland School of Medicine) ; Guizzardi, Beth (University of Maryland School of Medicine) ; Lopez, Haley (University of Maryland School of Medicine) ; Nguyen, Kevin (University of Maryland School of Medicine) ; Gaynor, Brady (University of Maryland School of Medicine) ; O'Connor, Timothy (University of Maryland School of Medicine) ; Stine, O. Colin (University of Maryland School of Medicine) ; Kittner, Steven J. (University of Maryland School of Medicine) ; McArdle, Patrick (University of Maryland School of Medicine) ; Mitchell, Braxton D. (University of Maryland School of Medicine) ; Xu, Huichun (University of Maryland School of Medicine) ; Grond-Ginsbach, Caspar (Heidelberg University) ; Universitat Autònoma de Barcelona
The role of copy number variation (CNV) variation in stroke susceptibility and outcome has yet to be explored. The Copy Number Variation and Stroke (CaNVAS) Risk and Outcome study addresses this knowledge gap. [...]
2021 - 10.1371/journal.pone.0248791
PloS one, Vol. 16 (april 2021)  
7.
13 p, 2.7 MB White matter hyperintensity quantification in large-scale clinical acute ischemic stroke cohorts - The MRI-GENIE study / Schirmer, Markus D. (Massachusetts General Hospital (Boston)) ; Dalca, Adrian Vasile (Massachusetts Institute of Technology) ; Sridharan, Ramesh (Massachusetts Institute of Technology) ; Giese, Anne-Katrin (Massachusetts General Hospital (Boston)) ; Donahue, Kathleen L. (Massachusetts General Hospital (Boston)) ; Nardin, Marco J. (Massachusetts General Hospital (Boston)) ; Mocking, Steven J. T. (Massachusetts General Hospital (Boston)) ; McIntosh, Elissa C. (Massachusetts General Hospital (Boston)) ; Frid, Petrea (Lund University) ; Wasselius, Johan (Lund University) ; Cole, John W. (University of Maryland School of Medicine) ; Holmegaard, Lukas (University of Gothenburg) ; Jern, Christina (University of Gothenburg) ; Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Lemmens, Robin (Leuven Research Institute for Neuroscience and Disease) ; Lindgren, Arne G. (Lund University) ; Meschia, James F. (Mayo Clinic (Jacksonville, Estats Units d'Amèrica)) ; Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ; Rundek, Tatjana (University of Miami. Miller School of Medicine) ; Sacco, Ralph L. (University of Miami. Miller School of Medicine) ; Schmidt, Reinhold (Medical University Graz) ; Sharma, Pankaj (Royal Holloway University of London) ; Slowik, Agnieszka (Jagiellonian University Medical College) ; Thijs, Vincent (Florey Institute of Neuroscience and Mental Health) ; Woo, Daniel (University of Cincinnati College of Medicine) ; Vagal, Achala (University of Cincinnati College of Medicine) ; Xu, Huichun (University of Maryland School of Medicine) ; Kittner, Steven J. (University of Maryland School of Medicine) ; McArdle, Patrick F. (University of Maryland School of Medicine) ; Mitchell, Braxton D. (University of Maryland School of Medicine) ; Rosand, Jonathan (Massachusetts General Hospital (Boston)) ; Worrall, Bradford B. (University of Virginia) ; Wu, Ona (Massachusetts General Hospital (Boston)) ; Golland, Polina (Massachusetts Institute of Technology) ; Rost, Natalia S. (Massachusetts General Hospital (Boston)) ; Universitat Autònoma de Barcelona
White matter hyperintensity (WMH) burden is a critically important cerebrovascular phenotype linked to prediction of diagnosis and prognosis of diseases, such as acute ischemic stroke (AIS). However, current approaches to its quantification on clinical MRI often rely on time intensive manual delineation of the disease on T2 fluid attenuated inverse recovery (FLAIR), which hinders high-throughput analyses such as genetic discovery. [...]
2019 - 10.1016/j.nicl.2019.101884
NeuroImage, Vol. 23 (may 2019)  

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