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8 p, 490.0 KB Hypothalamic-specific manipulation of Fto , the ortholog of the human obesity gene FTO , affects food intake in rats / Tung, Yi-Chun Loraine (University of Cambridge. Metabolic Research Laboratories) ; Ayuso, Eduard (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Shan, Xiaoye (University of Cambridge. Metabolic Research Laboratories) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; O'Rahilly, Stephen (University of Cambridge. Metabolic Research Laboratories) ; Coll, Anthony P. (University of Cambridge. Metabolic Research Laboratories) ; Yeo, Gilles S. H. (University of Cambridge. Metabolic Research Laboratories)
Sequence variants in the first intron of FTO are strongly associated with human obesity and human carriers of the risk alleles show evidence for increased appetite and food intake. Mice globally lacking Fto display a complex phenotype characterised by both increased energy expenditure and increased food intake. [...]
2010 - 10.1371/journal.pone.0008771
PloS one, Vol. 5, Issue 1 (January 2010) , p. e8771  
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1 Yeo, Giles S. H.
1 Yeo, Gilles S. H.
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