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12 p, 2.3 MB |
The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia
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Gröschel, Matthias I. (University Medical Center Groningen. Department of Pulmonary Diseases & Tuberculosis) ;
Meehan, Conor J. (University of Bradford. School of Chemistry and Bioscience) ;
Barilar, Ivan (Research Center Borstel. Molecular and Experimental Mycobacteriology) ;
Diricks, Margo (BioMérieux) ;
Gonzaga, Aitor (Leibniz Institute DSMZ. German Collection of Microorganisms and Cell Cultures) ;
Steglich, Matthias (Leibniz Institute DSMZ. German Collection of Microorganisms and Cell Cultures) ;
Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Scherer, Isabell-Christin (University Hospital Schleswig-Holstein. Department of Infectious Diseases and Microbiology) ;
Mamat, Uwe (Cellular Microbiology, Research Center Borstel) ;
Luz, Christian F. (University Medical Center Groningen. Department of Medical Microbiology and Infection Prevention) ;
De Bruyne, Katrien (bioMérieux, Applied Maths NV) ;
Utpatel, Christian (Research Center Borstel. Molecular and Experimental Mycobacteriology) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Kampmeier, Stefanie (University Hospital of Münster (Alemanya)) ;
Rahman, Nurdyana Abdul (Singapore General Hospital. Department of Microbiology) ;
Kresken, Michael (Rheinische Fachhochschule Köln gGmbH) ;
van der Werf, Tjip S. (University Medical Center Groningen. Department of Pulmonary Diseases & Tuberculosis) ;
Alio, Ifey (University of Hamburg. Department of Microbiology and Biotechnology) ;
Streit, Wolfgang R. (University of Hamburg. Department of Microbiology and Biotechnology) ;
Zhou, Kai (Jinan University. Second Clinical Medical College) ;
Schwartz, Thomas (Karlsruhe Institute of Technology) ;
Rossen, John W. A. (University Medical Center Groningen. Department of Medical Microbiology and Infection Prevention) ;
Farhat, Maha R. (Massachusetts General Hospital (Boston)) ;
Schaible, Ulrich E. (Leibniz Research Alliance Infections'21) ;
Nübel, Ulrich (Technical University. Braunschweig Integrated Center of Systems Biology) ;
Rupp, Jan (German Center for Infection Research) ;
Steinmann, Joerg (Paracelsus Medical Private University) ;
Niemann, Stefan (Leibniz Research Alliance Infections'21) ;
Kohl, Thomas A. (German Center for Infection Research)
Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. [...]
2020 -  10.1038/s41467-020-15123-0
Nature communications, Vol. 11 (April 2020) , art. 2044
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2.
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16 p, 3.0 MB |
The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm
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Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Díaz-Lobo, Mireia (Institut de Recerca Biomèdica) ;
Costenaro, Lionel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mayo, Adrià (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ferrer-Navarro, Mario (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vilaseca, Marta (Institut de Recerca Biomèdica) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
In Pseudomonas aeruginosa, Ttg2D is the soluble periplasmic phospholipid-binding component of an ABC transport system thought to be involved in maintaining the asymmetry of the outer membrane. Here we use the crystallographic structure of Ttg2D at 2. [...]
2021 - 10.1038/s42003-021-01968-8
Communications Biology, Vol. 4 (April 2021) , art. 448
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3.
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2 p, 435.3 KB |
Un nou mecanisme cel·lular reforça la resistència intrínseca als antibiòtics de Pseudomonas aeruginosa
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Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Investigadors de la UAB, en col·laboració amb l'IRB Barcelona, han determinat la funció de la proteïna d'unió a substrat Ttg2D de Pseudomonas aeruginosa per mantenir l'asimetria dels fosfolípids entre les capes de la membrana interna i externa. [...]
Investigadores de la UAB, en colaboración con el IRB Barcelona, han determinado la función de la proteína de unión a sustrato Ttg2D de Pseudomonas aeruginosa para mantener la asimetría de los fosfolípidos entre las capas de la membrana interna y externa. [...]
UAB researchers in collaboration with researchers at IRB Barcelona elucidate the function of the Pseudomonas aeruginosa substrate-binding protein Ttg2D in maintaining phospholipid asymmetry between the outer and inner membrane layers. [...]
2021
UAB divulga, Maig 2021
3 documentos
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4.
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21 p, 4.1 MB |
Phenotypic and transcriptomic analyses of seven clinical Stenotrophomonas maltophilia isolates identify a small set of shared and commonly regulated genes involved in the biofilm lifestyle
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Alio, Ifey (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Gudzuhn, Mirja (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Pérez García, Pablo (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Danso, Dominik (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Schoelmerich, Marie Charlotte (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Mamat, Uwe (Research Center Borstel. Priority Area Infections. Molecular and Experimental Mycobacteriology (Germany)) ;
Schaible, Ulrich E. (Research Center Borstel. Priority Area Infections. Molecular and Experimental Mycobacteriology (Germany)) ;
Steinmann, Jörg (Universitätsinstitut der Paracelsus Medizinischen Privatuniversität Klinikum Nürnberg. Institut für Klinikhygiene, Medizinische Mikrobiologie und Klinische Infektiologie (Germany)) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Kohl, Thomas A. (Research Center Borstel. Molecular and Experimental Mycobacteriology (Germany)) ;
Niemann, Stefan (Research Center Borstel. Molecular and Experimental Mycobacteriology (Germany)) ;
Gröschel, Matthias I. (Harvard Medical School. Department of Biomedical Informatics (USA)) ;
Haerdter, Johanna (Universität Hamburg. Institute of Organic Chemistry (Germany)) ;
Hackl, Thomas (Universität Hamburg. Institute of Organic Chemistry (Germany)) ;
Vollstedt, Christel (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Bömeke, Mechthild (Georg-August University of Göttingen. Institute of Microbiology and Genetics. Department of Genomic and Applied Microbiology (Germany)) ;
Egelkamp, Richard (Georg-August University of Göttingen. Institute of Microbiology and Genetics. Department of Genomic and Applied Microbiology (Germany)) ;
Daniel, Rolf (Georg-August University of Göttingen. Institute of Microbiology and Genetics. Department of Genomic and Applied Microbiology (Germany)) ;
Poehlein, Anja (Georg-August University of Göttingen. Institute of Microbiology and Genetics. Department of Genomic and Applied Microbiology (Germany)) ;
Streit, Wolfgang R. (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
Stenotrophomonas maltophilia is one of the most frequently isolated multidrug-resistant nosocomial opportunistic pathogens. It contributes to disease progression in cystic fibrosis (CF) patients and is frequently isolated from wounds, infected tissues, and catheter surfaces. [...]
2020 - 10.1128/AEM.02038-20
Applied and Environmental Microbiology, Vol. 86, Issue 24 (December 2020) , art. e02038
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10 p, 1.4 MB |
Heterogeneous colistin-resistance phenotypes coexisting in stenotrophomonas maltophiliaisolates influence colistin susceptibility testing
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Martínez-Servat, Sònia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Huedo Moreno, Pol (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Marquez, Roser (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Molina, Gara (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The polymyxin antibiotic colistin shows in vitro activity against Stenotrophomonas maltophilia. However, an increased incidence of colistin-resistant isolates has been recently observed. In addition, in vitro evaluation of colistin susceptibility for this organism has been problematic. [...]
2018 - 10.3389/fmicb.2018.02871
Frontiers in microbiology, Vol. 9 (Nov. 2018) , art. 2871
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6.
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14 p, 7.6 MB |
BPSL1626 : reverse and structural vaccinology reveal a novel candidate for vaccine design against Burkholderia pseudomallei
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Capelli, Riccardo (Center for Complexity and Biosystems and Dipartimento di Fisica, Università degli Studi di Milano) ;
Peri, Claudio (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ;
Villa, Riccardo (Department of Biosciences, Università degli Studi di Milano) ;
Nithichanon, Arnone (Khon Kaen University. Centre for Research and Development of Medical Diagnostic Laboratories) ;
Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gagni, Paola (Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche) ;
Chiari, Marcella (Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche) ;
Lertmemongkolchai, Ganjana (Center for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University) ;
Cretich, Marina (Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bolognesi, Martino (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati) ;
Colombo, Giorgio (Consiglio Nazionale delle Ricerche. Istituto di Chimica del Riconoscimento Molecolare) ;
Gourlay, Louise J. (Università degli Studi di Milano. Centro di Eccellenza Interdisciplinare Materiali e Interfacce Nanostrutturati)
Due to significant advances in computational biology, protein prediction, together with antigen and epitope design, have rapidly moved from conventional methods, based on experimental approaches, to in silico-based bioinformatics methods. [...]
2018 - 10.3390/antib7030026
Antibodies, Vol. 7 (2018) , p. 1-14
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14 p, 1.1 MB |
Complex evolutionary history of the mammalian histone H1.1-H1.5 gene family
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Ponte Marull, Immaculada (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Romero, Devani (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Suau León, Pere (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Roque Córdova, Alicia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
H1 is involved in chromatin higher-order structure and gene regulation. H1 has a tripartite structure. The central domain is stably folded in solution, while the N- and C-terminal domains are intrinsically disordered. [...]
2017 - 10.1093/molbev/msw241
Molecular biology and evolution, Vol. 34, issue 3 (March 2017) , p. 545-558
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9.
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33 p, 4.2 MB |
Nanostructured recombinant cytokines : A highly stable alternative to short-lived prophylactics
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Torrealba, Debora (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Parra, David (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Seras-Franzoso, Joaquin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vallejos Vidal, Eva Carolina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Garcia-Fruitos, Elena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Roher Armentia, Nerea (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Cytokines have been widely used as adjuvants and therapeutic agents in treatments of human diseases. Despite their recognized potential as drugs, the medical use of cytokines has considerable drawbacks, mainly related to their low stability and short half-life. [...]
2016 - 10.1016/j.biomaterials.2016.08.043
Biomaterials, Vol. 107 (Novembre 2016) , p. 102-114
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7 p, 544.8 KB |
Triclosan-induced genes Rv1686c-Rv1687c and Rv3161c are not involved in triclosan resistance in Mycobacterium tuberculosis
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Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Andreu Martín, Núria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ferrer-Navarro, Mario (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
A key issue towards developing new chemotherapeutic approaches to fight Mycobacterium tuberculosis is to understand the mechanisms underlying drug resistance. Previous studies have shown that genes Rv1686c-Rv1687c and Rv3161c, predicted to encode an ATP-binding cassette transporter and a dioxygenase respectively, are induced in the presence of triclosan and other antimicrobial compounds. [...]
2016 - 10.1038/srep26221
Scientific reports (Nature Publishing Group), Vol 6 (May 2016) , p. 26221
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