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Safety Outcomes During Pediatric GH Therapy : Final Results From the Prospective GeNeSIS Observational Program
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Child, Christopher J. (Eli Lilly and Company, Windlesham, Surrey, United Kingdom) ;
Zimmermann, Alan G. (Eli Lilly and Company, Indianapolis, Indiana) ;
Chrousos, George P. (National and Kapodistrian University of Athens, School of Medicine, Athens, Greece) ;
Cummings, Elisabeth (Dalhousie University/IWK Health Centre, Halifax, Nova Scotia, Canada) ;
Deal, Cheri L. (University of Montreal and CHU Ste-Justine, Montreal, Quebec, Canada) ;
Hasegawa, Tomonobu (Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan) ;
Jia, Nan (Eli Lilly and Company, Indianapolis, Indiana) ;
Lawrence, Sarah (Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada) ;
Linglart, Agnès (Hôpital Bicêtre Paris Sud, Paris, France) ;
Loche, Sandro (Ospedale Pediatrico Microcitemico "A. Cao," AO Brotzu, Cagliari, Italy) ;
Maghnie, Mohamad (Istituto Giannina Gaslini, University of Genova, Genoa, Italy) ;
Pérez Sánchez, Jacobo (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Polak, Michel (Hôpital Universitaire Necker Enfants Malades and Université Paris Descartes, Centre des Maladies Endocrines Rares de la Croissance, Paris, France) ;
Predieri, Barbara (University of Modena and Reggio Emilia, Modena, Italy) ;
Richter-Unruh, Annette (University Children's Hospital, Bochum, Germany) ;
Rosenfeld, Ron G. (Oregon Health and Science University, Portland, Oregon) ;
Yeste Fernández, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Yorifuji, Tohru (Osaka City General Hospital, Miyakojima-ku, Osaka, Japan) ;
Blum, Werner F.. (University of Giessen, Giessen, Germany) ;
Universitat Autònoma de Barcelona
Safety concerns have been raised regarding premature mortality, diabetes, neoplasia, and cerebrovascular disease in association with GH therapy. To assess incidence of key safety outcomes. Prospective, multinational, observational study (1999 to 2015). [...]
2018 -  10.1210/jc.2018-01189
The journal of clinical endocrinology & metabolism, Vol. 104 (september 2018) , p. 379-389
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