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13 p, 912.5 KB Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans -Infection Through Recognition of Viral Membrane Gangliosides / Izquierdo-Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Lorizate, Maier (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Rodriguez-Plata, Maria T. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Zangger, Nadine (Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland) ; Erikson, Elina (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Pino, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Glass, Bärbel (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Keppler, Oliver T. (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Telenti, Amalio (Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland) ; Kräusslich, Hans-Georg (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ; Universitat Autònoma de Barcelona
The novel dendritic cell receptor Siglec-1 binds sialyllactose moieties on HIV-1 membrane gangliosides, thereby enhancing HIV-1 transinfection. Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against pathogens. [...]
2012 - 10.1371/journal.pbio.1001448
PLoS biology, Vol. 10 (december 2012)  

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