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14 p, 5.1 MB |
Emergence of functionally aberrant and subsequent reduction of neuromuscular connectivity and improved motor performance after cervical spinal cord injury in Rhesus
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Wai, Gregory (University of California) ;
Zdunowski, Sharon (University of California) ;
Zhong, Hui (Rancho Research Institute) ;
Nielson, Jessica L. (University of Minnesota) ;
Ferguson, Adam R. (University of California) ;
Strand, Sarah C. (University of California) ;
Moseanko, Rod (University of California) ;
Hawbecker, Stephanie (University of California) ;
Nout-Lomas, Yvette S. (Colorado State University) ;
Rosenzweig, Ephron S. (Veterans Administration Medical Center) ;
Beattie, Michael S. (University of California) ;
Bresnahan, Jacqueline C. (University of California) ;
Tuszynski, Mark H. (University of California) ;
Roy, Roland R. (University of California) ;
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann) ;
Universitat Autònoma de Barcelona
The paralysis that occurs after a spinal cord injury, particularly during the early stages of post-lesion recovery (∼6 weeks), appears to be attributable to the inability to activate motor pools well beyond their motor threshold. [...]
2023 -  10.3389/fresc.2023.1205456
Frontiers in Rehabilitation Sciences, Vol. 4 (june 2023)
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7 p, 730.5 KB |
A pilot study combining noninvasive spinal neuromodulation and activity-based neurorehabilitation therapy in children with cerebral palsy
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Hastings, Susan (Susan Hastings Pediatric Physical Therapy) ;
Zhong, Hui (Rancho Research Institute) ;
Feinstein, Rochel (OPTimal care Therapy) ;
Zelczer, Gittel (OPTimal care Therapy) ;
Mitrovich, Christel (Reneu Health) ;
Gad, Parag (SpineX Inc.) ;
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann) ;
Universitat Autònoma de Barcelona
Cerebral Palsy (CP) is the most common pediatric motor disability with multiple symptoms and etiologies. CP is exhibited through sensorimotor delays, impaired posture resulting in limited activities and participation. [...]
2022 - 10.1038/s41467-022-33208-w
Nature communications, Vol. 13 (october 2022)
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9 p, 1.8 MB |
Noninvasive spinal neuromodulation mitigates symptoms of idiopathic overactive bladder
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Zhong, Hui (Rancho Los Amigos National Rehabilitation Center) ;
Liu, Emilie (SpineX (Estats Units d'Amèrica)) ;
Kohli, Priya (Keck School of Medicine of University of Southern California) ;
Perez, Laura (Keck School of Medicine of University of Southern California) ;
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann) ;
Ginsberg, David (Keck School of Medicine of University of Southern California) ;
Gad, Parag (SpineX (Estats Units d'Amèrica)) ;
Kreydin, Evgeniy (Keck School of Medicine of University of Southern California) ;
Universitat Autònoma de Barcelona
Overactive bladder (OAB) affects 12 to 30% of the world's population. The accompanying urinary urgency, frequency and incontinence can have a profound effect on quality of life, leading to depression, social isolation, avoidance of sexual activity and loss of productivity. [...]
2022 - 10.1186/s42234-022-00087-x
Bioelectronic Medicine, Vol. 8 (march 2022)
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10 p, 2.6 MB |
Transcutaneous Spinal Neuromodulation Reorganizes Neural Networks in Patients with Cerebral Palsy
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Gad, Parag (University of California. Department of Neurobiology) ;
Hastings, Susan (Susan Hastings Pediatric Physical Therapy (San Jose, Estats Units d'Amèrica)) ;
Zhong, Hui (University of California. Department of Neurobiology) ;
Seth, Gaurav (Banaras Hindu University. Indian Institute of Technology) ;
Kandhari, Sachin (Institute of Brain and Spine (Nova Delhi, India)) ;
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann) ;
Universitat Autònoma de Barcelona
Spinal neuromodulation and activity-based rehabilitation triggers neural network reorganization and enhances sensory-motor performances involving the lower limbs, the trunk, and the upper limbs. This study reports the acute efects of Transcutaneous Electrical Spinal Cord Neuromodulation (SCONE™, SpineX Inc. [...]
2021 - 10.1007/s13311-021-01087-6
Neurotherapeutics, Vol. 18 (july 2021) , p. 1953-1962
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7.
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4 p, 387.2 KB |
Home-Based SCONE TM Therapy Improves Symptoms of Neurogenic Bladder
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Gad, Parag (SpineX (California, Estats Units)) ;
Zhong, Hui (Rancho Research Institute, Rancho Los Amigos National Rehabilitation Center, Downey, California, USA) ;
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann) ;
Kreydin, Evgeniy (University of Southern California)
A wide range of dysfunction can occur after a stroke including symptoms such as urinary urgency, frequency, and urge incontinence. The Spinal Cord Neuromodulator (SCONE TM) reactivates and retrains spinal neural networks. [...]
2021 - 10.1089/neur.2020.0061
Neurotrauma Reports, Vol. 2 (march 2021) , p. 165-168
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11 p, 2.1 MB |
Transcutaneous Electrical Spinal Cord Neuromodulator (TESCoN) Improves Symptoms of Overactive Bladder
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Kreydin, Evgeniy (Rancho Research Institute, Rancho Los Amigos National Rehabilitation Center) ;
Zhong, Hui (Department of Neurobiology, University of California, Los Angeles) ;
Latack, Kyle (Rancho Research Institute, Rancho Los Amigos National Rehabilitation Center) ;
Ye, Shirley (Rancho Research Institute, Rancho Los Amigos National Rehabilitation Center) ;
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann) ;
Gad, Parag (The Centre for Neuroscience and Regenerative Medicine, Faculty of Science, University of Technology Sydney)
Non-Surgical modality to reduce incidence of urinary incontinence and improve neurogenic bladder symptom scores (NBSS) in individuals with neurogenic bladder due to spinal cord injury or stroke.
2020 - 10.3389/fnsys.2020.00001
Frontiers in Systems Neuroscience, Vol. 14 (february 2020)
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9.
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12 p, 6.8 MB |
Novel Activity Detection Algorithm to Characterize Spontaneous Stepping During Multimodal Spinal Neuromodulation After Mid-Thoracic Spinal Cord Injury in Rats
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Chia, Raymond (St Vincent's Centre for Applied Medical Research) ;
Zhong, Hui (Department of Integrative Biology and Physiology, University of California, Los Angeles) ;
Vissel, Bryce (St Vincent's Centre for Applied Medical Research) ;
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann) ;
Gad, Parag (Department of Neurobiology, University of California, Los Angeles) ;
Universitat Autònoma de Barcelona
A mid-thoracic spinal cord injury (SCI) severely impairs activation of the lower limb sensorimotor spinal networks, leading to paralysis. Various neuromodulatory techniques including electrical and pharmacological activation of the spinal networks have been successful in restoring locomotor function after SCI. [...]
2020 - 10.3389/fnsys.2019.00082
Frontiers in Systems Neuroscience, Vol. 13 (january 2020)
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