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9 p, 1.3 MB Probing a polar cluster in the retinal binding pocket of bacteriorhodopsin by a chemical design approach / Simón Vázquez, Rosana (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Domínguez, Marta (Universidad de Vigo. Departamento de Química Orgánica) ; Lórenz Fonfría, Víctor A. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Álvarez, Susana (Universidad de Vigo. Departamento de Química Orgánica) ; Bourdelande, J. L. (José Luis) Universitat Autònoma de Barcelona. Departament de Química ; de Lera, Ángel R. (Universidad de Vigo. Departamento de Química Orgánica) ; Padrós, Esteve (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Perálvarez Marín, Alejandro (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Bacteriorhodopsin has a polar cluster of amino acids surrounding the retinal molecule, which is responsible for light harvesting to fuel proton pumping. From our previous studies, we have shown that threonine 90 is the pivotal amino acid in this polar cluster, both functionally and structurally. [...]
2012 - 10.1371/journal.pone.0042447
PLoS one, Vol. 7, Issue 8 (August 2012) , p. e42447  

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